SW620 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-000651
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Genes

262 gene knockdowns changing fitness of SW620 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
PKD1L1 polycystic kidney disease 1 like 1 23.8598
ADCY1 adenylate cyclase 1 (brain) 15.4229
ZNF23 zinc finger protein 23 10.3134
C16ORF70 chromosome 16 open reading frame 70 10.0692
AGRP agouti related neuropeptide 9.79267
PARD6A par-6 family cell polarity regulator alpha 8.21215
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 7.94196
WWP2 WW domain containing E3 ubiquitin protein ligase 2 7.78701
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 7.64132
MTSS2 MTSS I-BAR domain containing 2 7.248
EBPL emopamil binding protein-like 6.56638
FCSK fucose kinase 6.52622
KLF12 Kruppel-like factor 12 6.46607
KRT84 keratin 84, type II 6.16594
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 6.16377
NRN1L neuritin 1-like 6.03602
POU6F1 POU class 6 homeobox 1 6.01554
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 5.76352
HSF4 heat shock transcription factor 4 5.70142
KIAA0895L KIAA0895-like 5.63177
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 5.52183
MLKL mixed lineage kinase domain-like 5.20271
IGFBP3 insulin-like growth factor binding protein 3 5.13406
CES3 carboxylesterase 3 5.12648
LCAT lecithin-cholesterol acyltransferase 4.92141
GANC glucosidase, alpha; neutral C 4.88225
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 4.87031
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 4.84277
TLE3 transducin-like enhancer of split 3 4.81772
RNF113B ring finger protein 113B 4.71946
ZNF821 zinc finger protein 821 4.70617
TSPAN11 tetraspanin 11 4.68993
C16ORF46 chromosome 16 open reading frame 46 4.56658
DZIP1 DAZ interacting zinc finger protein 1 4.40887
RRAD Ras-related associated with diabetes 4.36497
GPC3 glypican 3 4.30068
TMPRSS13 transmembrane protease, serine 13 4.2197
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 4.19423
PODN podocan 4.13716
CALCOCO1 calcium binding and coiled-coil domain 1 4.0567
COL4A2 collagen, type IV, alpha 2 3.9577
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 3.89526
KRT74 keratin 74, type II 3.89057
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 3.8746
STAT2 signal transducer and activator of transcription 2, 113kDa 3.79825
SP7 Sp7 transcription factor 3.75135
NF2 neurofibromin 2 (merlin) 3.7368
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 3.73554
TPPP3 tubulin polymerization-promoting protein family member 3 3.72844
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 3.72163
ZNF385A zinc finger protein 385A 3.72133
CCDC25 coiled-coil domain containing 25 3.71557
EXOC3L1 exocyst complex component 3-like 1 3.70017
CES4A carboxylesterase 4A 3.67746
SPARCL1 SPARC-like 1 (hevin) 3.60362
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 3.5845
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.5801
CKLF chemokine-like factor 3.57355
MYCBP MYC binding protein 3.56306
IRG1 immunoresponsive 1 homolog (mouse) 3.53749
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 3.53471
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 3.49358
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.48779
DNAJB8 DnaJ (Hsp40) homolog, subfamily B, member 8 3.4876
TRMT10A tRNA methyltransferase 10 homolog A (S. cerevisiae) 3.42235
PCDHB4 protocadherin beta 4 3.4085
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 3.392
CDCP2 CUB domain containing protein 2 3.37824
SHISA5 shisa family member 5 3.36916
ENKD1 enkurin domain containing 1 3.35783
TSNAXIP1 translin-associated factor X interacting protein 1 3.34559
KRT78 keratin 78, type II 3.33092
TNS3 tensin 3 3.32867
SCN8A sodium channel, voltage gated, type VIII alpha subunit 3.22951
KRT86 keratin 86, type II 3.18987
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 3.17394
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.16627
SH3RF2 SH3 domain containing ring finger 2 3.15944
FHOD1 formin homology 2 domain containing 1 3.15614
ARSI arylsulfatase family, member I 3.15534
MARCO macrophage receptor with collagenous structure 3.14702
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.13402
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 3.13
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 3.09941
TK2 thymidine kinase 2, mitochondrial 3.08903
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 3.07267
TMEM31 transmembrane protein 31 3.06755
KRTAP12-4 keratin associated protein 12-4 3.04846
IL21R interleukin 21 receptor 3.04563
GRTP1 growth hormone regulated TBC protein 1 3.03687
ILDR2 immunoglobulin-like domain containing receptor 2 3.03646
PCED1B PC-esterase domain containing 1B 3.02824
CA7 carbonic anhydrase VII 3.01829
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 3.01826
MPPE1 metallophosphoesterase 1 3.00632
RRBP1 ribosome binding protein 1 2.98468
C10ORF10 chromosome 10 open reading frame 10 2.97728
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1 2.97216
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2.96336
ASCL2 achaete-scute family bHLH transcription factor 2 2.96221
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.93449
PNMA8A PNMA family member 8A 2.93158
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.93114
DPEP2 dipeptidase 2 2.9154
DUS2 dihydrouridine synthase 2 2.91018
PCDHGA4 protocadherin gamma subfamily A, 4 2.88616
FBXL8 F-box and leucine-rich repeat protein 8 2.86653
CTRB2 chymotrypsinogen B2 2.86306
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 2.8484
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 2.83971
MX2 MX dynamin-like GTPase 2 2.83537
FIGNL1 fidgetin-like 1 2.83387
SMAGP small cell adhesion glycoprotein 2.83188
LAP3 leucine aminopeptidase 3 2.81743
ADPRHL1 ADP-ribosylhydrolase like 1 2.81036
CCDC51 coiled-coil domain containing 51 2.79191
TNP2 transition protein 2 (during histone to protamine replacement) 2.77382
RANBP10 RAN binding protein 10 2.76946
TMEM59L transmembrane protein 59-like 2.76116
GTPBP10 GTP-binding protein 10 (putative) 2.7523
GGT6 gamma-glutamyltransferase 6 2.74459
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.742
AVP arginine vasopressin 2.74167
GOT1 glutamic-oxaloacetic transaminase 1, soluble 2.73608
TDG thymine-DNA glycosylase 2.7356
ELL3 elongation factor RNA polymerase II-like 3 2.72897
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 2.72026
SUOX sulfite oxidase 2.71826
PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2.71623
PRSS50 protease, serine, 50 2.70343
FH fumarate hydratase 2.68536
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 2.68503
FAS Fas cell surface death receptor 2.66829
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2.66255
OR9A2 olfactory receptor, family 9, subfamily A, member 2 2.65687
PHC1 polyhomeotic homolog 1 (Drosophila) 2.6554
PIP prolactin-induced protein 2.64586
MYO10 myosin X 2.64572
COX14 COX14 cytochrome c oxidase assembly factor 2.64374
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 2.63415
CLN5 ceroid-lipofuscinosis, neuronal 5 2.62244
HPS1 Hermansky-Pudlak syndrome 1 2.60997
LAMA3 laminin, alpha 3 2.60866
HYDIN HYDIN, axonemal central pair apparatus protein 2.60263
ZBTB39 zinc finger and BTB domain containing 39 2.5843
PRR30 proline rich 30 2.56895
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 2.56333
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.56078
SEPTIN8 septin 8 2.55511
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.55021
CDH3 cadherin 3, type 1, P-cadherin (placental) 2.54338
C16ORF86 chromosome 16 open reading frame 86 2.54101
ACVR1B activin A receptor, type IB 2.52836
THBD thrombomodulin 2.52719
FHL2 four and a half LIM domains 2 2.52047
BPIFB3 BPI fold containing family B, member 3 2.52042
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 2.51441
RBP3 retinol binding protein 3, interstitial 2.51084
SLC25A51 solute carrier family 25, member 51 2.49897
PROX1 prospero homeobox 1 2.49816
RSPH3 radial spoke 3 homolog (Chlamydomonas) 2.4865
NIPAL3 NIPA-like domain containing 3 2.48185
ZNF322 zinc finger protein 322 2.47409
CLVS1 clavesin 1 2.47261
FLNB filamin B, beta 2.47087
GLUL glutamate-ammonia ligase 2.45737
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 2.4548
IL27 interleukin 27 2.44124
TRIM55 tripartite motif containing 55 2.43705
OLIG3 oligodendrocyte transcription factor 3 2.43309
KRT85 keratin 85, type II 2.41831
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 2.40386
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.39381
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.39276
PLA2G4E phospholipase A2, group IVE 2.38342
BCO1 beta-carotene oxygenase 1 2.38229
KRT73 keratin 73, type II 2.38222
FKBP8 FK506 binding protein 8, 38kDa 2.38002
ANTXRL anthrax toxin receptor-like 2.37847
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.37604
C20ORF194 chromosome 20 open reading frame 194 2.37268
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 2.35946
ATP11A ATPase, class VI, type 11A 2.35511
TMEM8B transmembrane protein 8B 2.35457
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.34968
ZNF646 zinc finger protein 646 2.34664
H1FNT H1 histone family, member N, testis-specific 2.33307
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.32887
XAF1 XIAP associated factor 1 2.32545
RHO rhodopsin 2.31139
CUL7 cullin 7 2.30697
IGFBP1 insulin-like growth factor binding protein 1 2.30684
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 2.30618
GAS6 growth arrest-specific 6 2.29779
CLYBL citrate lyase beta like 2.29632
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.29491
CES2 carboxylesterase 2 2.2937
SGPL1 sphingosine-1-phosphate lyase 1 2.2811
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.276
PDZK1 PDZ domain containing 1 2.26677
COX19 COX19 cytochrome c oxidase assembly factor 2.26604
ATF1 activating transcription factor 1 2.26483
NUBPL nucleotide binding protein-like 2.2562
GPR142 G protein-coupled receptor 142 2.24738
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 2.24587
JSRP1 junctional sarcoplasmic reticulum protein 1 2.24458
LYRM7 LYR motif containing 7 2.24393
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.24014
CTRB1 chymotrypsinogen B1 2.24005
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.23771
GPATCH1 G patch domain containing 1 2.22697
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.21261
WFDC12 WAP four-disulfide core domain 12 2.21103
TTC22 tetratricopeptide repeat domain 22 2.20765
MTFMT mitochondrial methionyl-tRNA formyltransferase 2.20382
NPFF neuropeptide FF-amide peptide precursor 2.19567
MMRN2 multimerin 2 2.19191
YBEY ybeY metallopeptidase (putative) 2.18453
SLC22A14 solute carrier family 22, member 14 2.17462
HOXC12 homeobox C12 2.17137
MAT1A methionine adenosyltransferase I, alpha 2.17085
OLFML3 olfactomedin-like 3 2.17037
SLC38A4 solute carrier family 38, member 4 2.16975
PROB1 proline-rich basic protein 1 2.14755
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 2.14279
RIOK3 RIO kinase 3 2.13933
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 2.10981
ZNF775 zinc finger protein 775 2.10498
KLHDC8B kelch domain containing 8B 2.10452
DUSP13 dual specificity phosphatase 13 2.10409
IGFL2 IGF-like family member 2 2.10065
CRYBA4 crystallin, beta A4 2.09852
BCL9L B-cell CLL/lymphoma 9-like 2.09191
PLPP3 phospholipid phosphatase 3 2.09065
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11 2.08699
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 2.08596
LIMA1 LIM domain and actin binding 1 2.08529
ABHD12B abhydrolase domain containing 12B 2.08107
BOLA3 bolA family member 3 2.07771
MMP14 matrix metallopeptidase 14 (membrane-inserted) 2.07532
OSM oncostatin M 2.07277
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.07264
PMEL premelanosome protein 2.07152
KRT79 keratin 79, type II 2.06994
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2.06648
SEZ6L2 seizure related 6 homolog (mouse)-like 2 2.06543
FAM155A family with sequence similarity 155, member A 2.06082
VSTM2L V-set and transmembrane domain containing 2 like 2.05699
CYB5RL cytochrome b5 reductase-like 2.05629
TBRG4 transforming growth factor beta regulator 4 2.05201
MAP1A microtubule-associated protein 1A 2.03472
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 2.02944
SURF1 surfeit 1 2.02829
RAB42 RAB42, member RAS oncogene family 2.02801
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 2.02074
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10 2.02052
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.00851
XKRX XK, Kell blood group complex subunit-related, X-linked 2.00401
SLC16A12 solute carrier family 16, member 12 2.00256
COL13A1 collagen, type XIII, alpha 1 2.00247
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 2.00214
SPACA7 sperm acrosome associated 7 2.002