SW837 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-000421
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Genes

171 gene knockdowns changing fitness of SW837 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
DCAF4 DDB1 and CUL4 associated factor 4 8.8495
PASD1 PAS domain containing 1 7.58038
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 7.27318
JUP junction plakoglobin 7.16491
SEC14L6 SEC14-like 6 (S. cerevisiae) 6.70348
CCDC157 coiled-coil domain containing 157 5.92892
CNGA2 cyclic nucleotide gated channel alpha 2 5.85712
SGSM1 small G protein signaling modulator 1 5.79855
SMAD6 SMAD family member 6 5.63652
GPR50 G protein-coupled receptor 50 5.24519
MAGEA11 melanoma antigen family A11 4.83825
CABIN1 calcineurin binding protein 1 4.54304
TICAM1 toll-like receptor adaptor molecule 1 4.40118
CCDC116 coiled-coil domain containing 116 4.3334
MPPE1 metallophosphoesterase 1 4.26524
MAGEA1 melanoma antigen family A1 4.19689
SEC14L4 SEC14-like 4 (S. cerevisiae) 4.03271
FATE1 fetal and adult testis expressed 1 3.83834
KIAA1671 KIAA1671 3.68723
RNF215 ring finger protein 215 3.67718
OR10G7 olfactory receptor, family 10, subfamily G, member 7 3.66036
NSD3 nuclear receptor binding SET domain protein 3 3.64099
MMP11 matrix metallopeptidase 11 3.63877
MED16 mediator complex subunit 16 3.60686
ZNF70 zinc finger protein 70 3.49874
TKTL1 transketolase-like 1 3.4883
SYT17 synaptotagmin XVII 3.43083
ITPKA inositol-trisphosphate 3-kinase A 3.4066
ZC3H4 zinc finger CCCH-type containing 4 3.40213
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 3.38578
OR5AC2 olfactory receptor, family 5, subfamily AC, member 2 3.37741
PNMA6A paraneoplastic Ma antigen family member 6A 3.3145
ASF1B anti-silencing function 1B histone chaperone 3.27409
GUCD1 guanylyl cyclase domain containing 1 3.2663
TM2D1 TM2 domain containing 1 3.20452
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 3.1974
GGT5 gamma-glutamyltransferase 5 3.14903
BLM Bloom syndrome, RecQ helicase-like 3.14842
DCHS1 dachsous cadherin-related 1 3.12618
CENPJ centromere protein J 3.09062
AHCYL2 adenosylhomocysteinase-like 2 3.05236
NLRX1 NLR family member X1 3.01071
OSM oncostatin M 3.00772
AP1M2 adaptor-related protein complex 1, mu 2 subunit 2.97398
ZNF318 zinc finger protein 318 2.97007
ASCC2 activating signal cointegrator 1 complex subunit 2 2.96748
BASP1 brain abundant, membrane attached signal protein 1 2.96214
SRGN serglycin 2.96008
OR5AP2 olfactory receptor, family 5, subfamily AP, member 2 2.95615
RNF14 ring finger protein 14 2.95061
TUBA3E tubulin, alpha 3e 2.91532
IFI27 interferon, alpha-inducible protein 27 2.86184
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.8618
SUSD2 sushi domain containing 2 2.8405
PHYHD1 phytanoyl-CoA dioxygenase domain containing 1 2.81901
VPREB3 pre-B lymphocyte 3 2.81
KLHDC7A kelch domain containing 7A 2.79903
AP2B1 adaptor-related protein complex 2, beta 1 subunit 2.79154
DOT1L DOT1-like histone H3K79 methyltransferase 2.78996
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 2.78064
C22ORF15 chromosome 22 open reading frame 15 2.76882
USB1 U6 snRNA biogenesis 1 2.75282
ATP7A ATPase, Cu++ transporting, alpha polypeptide 2.73021
IRS1 insulin receptor substrate 1 2.72556
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 2.72162
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.70861
MAP3K2 mitogen-activated protein kinase kinase kinase 2 2.70825
MAPK7 mitogen-activated protein kinase 7 2.70301
MYRF myelin regulatory factor 2.70279
FBLN5 fibulin 5 2.69742
BMPR1A bone morphogenetic protein receptor, type IA 2.69292
SP1 Sp1 transcription factor 2.67395
ADAM32 ADAM metallopeptidase domain 32 2.63444
SPEM1 spermatid maturation 1 2.61895
RAB14 RAB14, member RAS oncogene family 2.61326
IFNA1 interferon, alpha 1 2.58324
ARHGAP4 Rho GTPase activating protein 4 2.57
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.56219
AMHR2 anti-Mullerian hormone receptor, type II 2.55708
IL21R interleukin 21 receptor 2.54184
LEMD2 LEM domain containing 2 2.53172
HVCN1 hydrogen voltage gated channel 1 2.5298
BAMBI BMP and activin membrane-bound inhibitor 2.50851
CRAMP1 cramped chromatin regulator homolog 1 2.50773
TUSC5 tumor suppressor candidate 5 2.50618
OR2A14 olfactory receptor, family 2, subfamily A, member 14 2.50405
MAGEA12 melanoma antigen family A12 2.50163
MAGEA10 melanoma antigen family A10 2.4989
STK32B serine/threonine kinase 32B 2.49437
CAB39 calcium binding protein 39 2.48207
THAP4 THAP domain containing 4 2.47215
UPB1 ureidopropionase, beta 2.47114
NMRK2 nicotinamide riboside kinase 2 2.45655
LCE3B late cornified envelope 3B 2.44107
GALP galanin-like peptide 2.43524
FAM151B family with sequence similarity 151, member B 2.41229
IL17A interleukin 17A 2.40974
APOC2 apolipoprotein C-II 2.40694
ZBTB7A zinc finger and BTB domain containing 7A 2.39566
BRPF1 bromodomain and PHD finger containing, 1 2.39231
C20ORF196 chromosome 20 open reading frame 196 2.38129
CIDEC cell death-inducing DFFA-like effector c 2.36588
EXOC7 exocyst complex component 7 2.3632
DAZAP1 DAZ associated protein 1 2.36163
TXNDC16 thioredoxin domain containing 16 2.34371
PPP1R32 protein phosphatase 1, regulatory subunit 32 2.33849
PTPRN protein tyrosine phosphatase, receptor type, N 2.33639
JUNB jun B proto-oncogene 2.31117
TBX1 T-box 1 2.30774
OR5P2 olfactory receptor, family 5, subfamily P, member 2 2.27867
DDRGK1 DDRGK domain containing 1 2.27545
MED23 mediator complex subunit 23 2.27513
DPEP2 dipeptidase 2 2.27434
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 2.26846
CCDC132 coiled-coil domain containing 132 2.26096
PSD4 pleckstrin and Sec7 domain containing 4 2.24057
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 2.23694
GRHL2 grainyhead-like 2 (Drosophila) 2.23013
KRTAP10-1 keratin associated protein 10-1 2.22694
CRIPT cysteine-rich PDZ-binding protein 2.22432
PNMA8A PNMA family member 8A 2.21385
RBM18 RNA binding motif protein 18 2.21179
KRT27 keratin 27, type I 2.20535
OVOL1 ovo-like zinc finger 1 2.19739
ALDOC aldolase C, fructose-bisphosphate 2.19621
NSRP1 nuclear speckle splicing regulatory protein 1 2.1944
PPHLN1 periphilin 1 2.1844
ANKRD24 ankyrin repeat domain 24 2.18211
ZNF77 zinc finger protein 77 2.17687
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.17655
LZTS2 leucine zipper, putative tumor suppressor 2 2.17624
SHD Src homology 2 domain containing transforming protein D 2.16564
RBM15 RNA binding motif protein 15 2.16346
NABP2 nucleic acid binding protein 2 2.15995
TADA3 transcriptional adaptor 3 2.15375
MIB1 mindbomb E3 ubiquitin protein ligase 1 2.14643
IFITM5 interferon induced transmembrane protein 5 2.14411
ARHGAP25 Rho GTPase activating protein 25 2.1439
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.13646
OR2M5 olfactory receptor, family 2, subfamily M, member 5 2.13463
PLA2G3 phospholipase A2, group III 2.13308
CHMP1A charged multivesicular body protein 1A 2.12986
ITPK1 inositol-tetrakisphosphate 1-kinase 2.12428
YAP1 Yes-associated protein 1 2.12097
FABP7 fatty acid binding protein 7, brain 2.12052
NPBWR1 neuropeptides B/W receptor 1 2.11771
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 2.10239
PALD1 phosphatase domain containing, paladin 1 2.09971
BAG4 BCL2-associated athanogene 4 2.09825
WASF2 WAS protein family, member 2 2.09495
IL17RA interleukin 17 receptor A 2.09382
PRAMEF20 PRAME family member 20 2.08321
ZNF442 zinc finger protein 442 2.08078
BET1 Bet1 golgi vesicular membrane trafficking protein 2.07458
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 2.07226
CCDC12 coiled-coil domain containing 12 2.05774
ASCL3 achaete-scute family bHLH transcription factor 3 2.05773
FANCD2OS FANCD2 opposite strand 2.04278
MEAF6 MYST/Esa1-associated factor 6 2.03671
INTS13 integrator complex subunit 13 2.03408
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.03404
PPP1R9A protein phosphatase 1, regulatory subunit 9A 2.03305
FSIP2 fibrous sheath interacting protein 2 2.02791
HEATR3 HEAT repeat containing 3 2.02684
HADH hydroxyacyl-CoA dehydrogenase 2.02666
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.02402
ADGRE5 adhesion G protein-coupled receptor E5 2.01296
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 2.01101
GAL3ST1 galactose-3-O-sulfotransferase 1 2.00983
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 2.00522
ZFP92 ZFP92 zinc finger protein 2.00411