SYDE1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description synapse defective 1, Rho GTPase, homolog 1 (C. elegans)| (NCBI Entrez Gene Database, 85360)
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Genes

343 genes differentially expressed following the SYDE1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.21008
CDCP2 CUB domain containing protein 2 3.21008
DNAH8 dynein, axonemal, heavy chain 8 3.21008
POU2F3 POU class 2 homeobox 3 3.21008
CA9 carbonic anhydrase IX 3.21008
ASCL3 achaete-scute family bHLH transcription factor 3 3.21008
C11ORF16 chromosome 11 open reading frame 16 3.21008
GPR75 G protein-coupled receptor 75 3.21008
POU3F2 POU class 3 homeobox 2 3.21008
USP26 ubiquitin specific peptidase 26 3.21008
REP15 RAB15 effector protein 3.21008
PRSS51 protease, serine, 51 3.21008
SPRN shadow of prion protein homolog (zebrafish) 3.21008
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.21008
CPB1 carboxypeptidase B1 (tissue) 3.21008
CFAP299 cilia and flagella associated protein 299 3.21008
CSDC2 cold shock domain containing C2, RNA binding 3.21008
FGF4 fibroblast growth factor 4 3.21008
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.21008
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.21008
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.18305
PDE7B phosphodiesterase 7B 3.18305
PLCH2 phospholipase C, eta 2 3.18305
GALR2 galanin receptor 2 3.18305
HES7 hes family bHLH transcription factor 7 3.18305
CPLX3 complexin 3 3.18305
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.18305
GPR151 G protein-coupled receptor 151 3.18305
FOXA2 forkhead box A2 3.18305
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 3.18305
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.18305
SLC46A2 solute carrier family 46, member 2 3.18305
CTRC chymotrypsin C (caldecrin) 3.18305
FAM180B family with sequence similarity 180, member B 3.18305
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.18305
TLX3 T-cell leukemia homeobox 3 3.18305
CRX cone-rod homeobox 3.18305
BIRC7 baculoviral IAP repeat containing 7 3.18305
SMIM9 small integral membrane protein 9 3.18305
TNS4 tensin 4 3.18305
TMEM71 transmembrane protein 71 3.18305
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.18305
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 3.18305
ZBED11 zinc finger BED-type containing 11 3.18305
ZNF556 zinc finger protein 556 3.18305
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.18305
GPR101 G protein-coupled receptor 101 3.18305
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.18305
TRPV3 transient receptor potential cation channel, subfamily V, member 3 3.18305
ATOH1 atonal homolog 1 (Drosophila) 3.18305
GFI1 growth factor independent 1 transcription repressor 3.18305
VSX1 visual system homeobox 1 3.18305
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 3.18305
TM4SF20 transmembrane 4 L six family member 20 3.18305
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.18305
MYMK myomaker, myoblast fusion factor 3.18305
ASB9 ankyrin repeat and SOCS box containing 9 3.18305
BDKRB1 bradykinin receptor B1 3.18305
FOXC1 forkhead box C1 3.18305
GRAP GRB2-related adaptor protein 3.18305
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.18305
LY6S lymphocyte antigen 6 family member S 3.18305
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 3.18305
SRARP steroid receptor associated and regulated protein 3.18305
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.18305
ADRB1 adrenoceptor beta 1 3.18305
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.18305
DNAAF6 dynein axonemal assembly factor 6 3.18305
H2AC1 H2A clustered histone 1 3.18305
H4C13 H4 clustered histone 13 3.18305
CATSPERZ catsper channel auxiliary subunit zeta 3.18305
DNAI7 dynein axonemal intermediate chain 7 3.18305
TASOR transcription activation suppressor 3.18305
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.18305
ROPN1B rhophilin associated tail protein 1B 3.18305
CLDN16 claudin 16 3.18305
GATA6 GATA binding protein 6 3.18305
PRG4 proteoglycan 4 3.18305
PCDHGC4 protocadherin gamma subfamily C, 4 3.18305
PRB2 proline-rich protein BstNI subfamily 2 3.18305
NKX2-5 NK2 homeobox 5 3.18305
GGTLC2 gamma-glutamyltransferase light chain 2 3.18305
FPR1 formyl peptide receptor 1 3.18305
PRB1 proline-rich protein BstNI subfamily 1 3.18305
TPBGL trophoblast glycoprotein-like 3.18305
GDF10 growth differentiation factor 10 3.18305
TMPRSS11A transmembrane protease, serine 11A 3.18305
RNF17 ring finger protein 17 3.18305
C4ORF17 chromosome 4 open reading frame 17 3.18305
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.18305
ZAR1L zygote arrest 1-like 3.18305
OR2D3 olfactory receptor, family 2, subfamily D, member 3 3.18305
STARD6 StAR-related lipid transfer (START) domain containing 6 3.18305
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 3.18305
CCR8 chemokine (C-C motif) receptor 8 3.18305
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 3.18305
TBX3 T-box 3 3.18305
SLPI secretory leukocyte peptidase inhibitor 3.18305
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.18305
CARD18 caspase recruitment domain family, member 18 3.18305
HHATL hedgehog acyltransferase-like 3.18305
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 3.18305
PLA1A phospholipase A1 member A 3.18305
ZNF474 zinc finger protein 474 3.18305
KLK12 kallikrein-related peptidase 12 3.18305
PDCD1 programmed cell death 1 3.18305
SLFN12L schlafen family member 12-like 3.18305
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.18305
CARD9 caspase recruitment domain family, member 9 3.18305
PAGE2B P antigen family, member 2B 3.18305
TEX11 testis expressed 11 3.18305
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.18305
POTEI POTE ankyrin domain family, member I 3.18305
TH tyrosine hydroxylase 3.18305
CBX8 chromobox homolog 8 3.18305
CPZ carboxypeptidase Z 3.18305
SMIM22 small integral membrane protein 22 3.18305
AQP6 aquaporin 6, kidney specific 3.18305
CNKSR3 CNKSR family member 3 3.18305
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.18305
OPRK1 opioid receptor, kappa 1 3.18305
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.18305
FAM177B family with sequence similarity 177, member B 3.18305
FNDC9 fibronectin type III domain containing 9 3.18305
SPZ1 spermatogenic leucine zipper 1 3.18305
A3GALT2 alpha 1,3-galactosyltransferase 2 3.18305
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.18305
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 3.18305
ZNF366 zinc finger protein 366 3.18305
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 3.18305
FGF10 fibroblast growth factor 10 3.18305
ZC3H12D zinc finger CCCH-type containing 12D 3.18305
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.18305
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.18305
PF4V1 platelet factor 4 variant 1 3.18305
MYF6 myogenic factor 6 (herculin) 3.18305
ZNF648 zinc finger protein 648 3.18305
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.18305
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.18305
MAGEC3 melanoma antigen family C3 3.18305
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 3.18305
CLEC2A C-type lectin domain family 2, member A 3.18305
LKAAEAR1 LKAAEAR motif containing 1 3.18305
RNASE6 ribonuclease, RNase A family, k6 3.18305
CCDC83 coiled-coil domain containing 83 3.18305
TYR tyrosinase 3.18305
GOLGA8R golgin A8 family, member R 3.18305
SDSL serine dehydratase-like 3.18305
C1ORF105 chromosome 1 open reading frame 105 3.18305
EFCC1 EF-hand and coiled-coil domain containing 1 3.18305
FGF16 fibroblast growth factor 16 3.18305
CLEC9A C-type lectin domain family 9, member A 3.18305
FOXS1 forkhead box S1 3.18305
LRRC1 leucine rich repeat containing 1 3.18305
CD8A CD8a molecule 3.18305
GRAP2 GRB2-related adaptor protein 2 3.18305
CLEC1A C-type lectin domain family 1, member A 3.18305
IFNK interferon, kappa 3.18305
CTH cystathionine gamma-lyase 3.11648
CYYR1 cysteine/tyrosine-rich 1 3.08959
PTAFR platelet-activating factor receptor 3.07906
MAP1A microtubule-associated protein 1A 3.07906
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 3.07906
KRT18 keratin 18, type I 3.03678
MCM6 minichromosome maintenance complex component 6 3.0015
BLZF1 basic leucine zipper nuclear factor 1 2.96612
ZBTB24 zinc finger and BTB domain containing 24 2.87148
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 2.86413
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.8633
USP49 ubiquitin specific peptidase 49 2.85277
CUL4B cullin 4B 2.75146
NNT nicotinamide nucleotide transhydrogenase 2.72692
CENPE centromere protein E, 312kDa 2.67392
HMGN3 high mobility group nucleosomal binding domain 3 2.6223
ZNF223 zinc finger protein 223 2.61296
MYH11 myosin, heavy chain 11, smooth muscle 2.53399
SATL1 spermidine/spermine N1-acetyl transferase-like 1 2.51955
GLRX glutaredoxin (thioltransferase) 2.49017
BRD9 bromodomain containing 9 2.47699
WRN Werner syndrome, RecQ helicase-like 2.47034
DDIT3 DNA-damage-inducible transcript 3 2.41094
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.38127
TAMALIN trafficking regulator and scaffold protein tamalin 2.36474
IL11 interleukin 11 2.34617
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.34617
GFY golgi-associated, olfactory signaling regulator 2.33905
ZNF534 zinc finger protein 534 2.32916
DCAF5 DDB1 and CUL4 associated factor 5 2.32632
MPV17L2 MPV17 mitochondrial membrane protein-like 2 2.32041
HAVCR2 hepatitis A virus cellular receptor 2 2.31125
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 2.28806
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 2.28806
SLC39A1 solute carrier family 39 (zinc transporter), member 1 2.27505
PP2D1 protein phosphatase 2C-like domain containing 1 2.25
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.22839
ADGRE3 adhesion G protein-coupled receptor E3 2.22839
CALHM2 calcium homeostasis modulator 2 2.22839
KLK4 kallikrein-related peptidase 4 2.22839
ASPA aspartoacylase 2.21367
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.21098
TACC3 transforming, acidic coiled-coil containing protein 3 2.19419
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 2.18566
EXOC6B exocyst complex component 6B 2.17446
ANKRD12 ankyrin repeat domain 12 2.17373
CENPL centromere protein L 2.16744
MAN2A2 mannosidase, alpha, class 2A, member 2 2.15901
M1AP meiosis 1 associated protein 2.15783
CCDC80 coiled-coil domain containing 80 2.15783
SLC25A53 solute carrier family 25, member 53 2.13229
THOC6 THO complex 6 2.12705
LIG4 ligase IV, DNA, ATP-dependent 2.12673
ARFIP1 ADP-ribosylation factor interacting protein 1 2.12316
LMO7 LIM domain 7 2.11284
POMK protein-O-mannose kinase 2.10458
EIF3J eukaryotic translation initiation factor 3, subunit J 2.09476
CXCR4 chemokine (C-X-C motif) receptor 4 2.09252
MACROD2 MACRO domain containing 2 2.09252
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.09252
CLCNKA chloride channel, voltage-sensitive Ka 2.09252
PSCA prostate stem cell antigen 2.09252
DRD3 dopamine receptor D3 2.09252
CAGE1 cancer antigen 1 2.09252
FLYWCH1 FLYWCH-type zinc finger 1 2.09252
ADD2 adducin 2 (beta) 2.09252
ARMC12 armadillo repeat containing 12 2.09252
ZNF473 zinc finger protein 473 2.09103
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2.07111
FANCI Fanconi anemia, complementation group I 2.06676
SFXN2 sideroflexin 2 2.06378
NALCN sodium leak channel, non selective 2.05538
PDLIM4 PDZ and LIM domain 4 2.0037
AK5 adenylate kinase 5 2.00174

decreased expression

Symbol Name Standardized Value
CCDC22 coiled-coil domain containing 22 -3.21008
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -3.21008
LOC124906010 uncharacterized LOC124906010 -3.21008
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -3.21008
ERAS ES cell expressed Ras -3.18305
LRRC43 leucine rich repeat containing 43 -3.18305
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -3.18305
SPMIP11 sperm microtubule inner protein 11 -3.18305
AMBP alpha-1-microglobulin/bikunin precursor -3.18305
CLIP4 CAP-GLY domain containing linker protein family, member 4 -3.18305
ACAD10 acyl-CoA dehydrogenase family, member 10 -3.18305
GH2 growth hormone 2 -3.18305
KLHL32 kelch-like family member 32 -3.18305
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -3.18305
IGFL4 IGF-like family member 4 -3.18305
SCGN secretagogin, EF-hand calcium binding protein -3.18305
IKZF3 IKAROS family zinc finger 3 (Aiolos) -3.18305
CABP4 calcium binding protein 4 -3.18305
HEPHL1 hephaestin-like 1 -3.18305
IL5RA interleukin 5 receptor, alpha -3.18305
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -3.18305
PLEKHN1 pleckstrin homology domain containing, family N member 1 -3.18305
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 -3.18305
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.18305
SPMIP5 sperm microtubule inner protein 5 -3.18305
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -3.18305
CSP2 CS pseudogene 2 -3.18305
LAMB3 laminin, beta 3 -3.18305
SFRP5 secreted frizzled-related protein 5 -3.18305
TERB1 telomere repeat binding bouquet formation protein 1 -3.18305
SEZ6L seizure related 6 homolog (mouse)-like -3.18305
NT5DC4 5'-nucleotidase domain containing 4 -3.18305
ACTA1 actin, alpha 1, skeletal muscle -3.18305
ZCCHC12 zinc finger, CCHC domain containing 12 -3.18305
THBD thrombomodulin -3.18305
RPL35A ribosomal protein L35a -2.91366
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.88723
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -2.86919
CASP2 caspase 2, apoptosis-related cysteine peptidase -2.82441
LMO2 LIM domain only 2 (rhombotin-like 1) -2.8131
KYAT1 kynurenine aminotransferase 1 -2.7734
WDR46 WD repeat domain 46 -2.74492
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -2.73587
MTARC1 mitochondrial amidoxime reducing component 1 -2.73587
CLDN1 claudin 1 -2.68058
CLCC1 chloride channel CLIC-like 1 -2.58679
C4ORF46 chromosome 4 open reading frame 46 -2.51618
IL4I1 interleukin 4 induced 1 -2.51438
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.49017
WDR27 WD repeat domain 27 -2.48494
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.48494
MEF2D myocyte enhancer factor 2D -2.48177
RALGDS ral guanine nucleotide dissociation stimulator -2.47699
ZNF324 zinc finger protein 324 -2.47034
WDR43 WD repeat domain 43 -2.44404
TXLNA taxilin alpha -2.41639
TMEM97 transmembrane protein 97 -2.40204
ELAC1 elaC ribonuclease Z 1 -2.40204
KLRG1 killer cell lectin-like receptor subfamily G, member 1 -2.32632
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -2.32516
TEX261 testis expressed 261 -2.32516
CFAP90 cilia and flagella associated protein 90 -2.31334
OPRM1 opioid receptor, mu 1 -2.31334
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -2.31125
MMP14 matrix metallopeptidase 14 (membrane-inserted) -2.31125
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.30749
CRACR2B calcium release activated channel regulator 2B -2.29015
ZNF772 zinc finger protein 772 -2.27615
ELAVL1 ELAV like RNA binding protein 1 -2.27615
PROCA1 protein interacting with cyclin A1 -2.26482
MEF2B myocyte enhancer factor 2B -2.26173
NBPF19 neuroblastoma breakpoint family, member 19 -2.25684
SNF8 SNF8, ESCRT-II complex subunit -2.25
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.22839
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -2.22589
PPP1R21 protein phosphatase 1, regulatory subunit 21 -2.20764
DGCR6L DiGeorge syndrome critical region gene 6-like -2.19419
STOML1 stomatin (EPB72)-like 1 -2.19419
MBNL3 muscleblind-like splicing regulator 3 -2.19223
ZNF628 zinc finger protein 628 -2.18566
RSPH9 radial spoke head 9 homolog (Chlamydomonas) -2.18566
SCT secretin -2.18566
SELENOW selenoprotein W -2.18537
PHPT1 phosphohistidine phosphatase 1 -2.18347
CBS cystathionine-beta-synthase -2.17326
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -2.17097
LETMD1 LETM1 domain containing 1 -2.1605
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -2.15783
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase -2.14781
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 -2.14598
PIR pirin (iron-binding nuclear protein) -2.13894
GUSB glucuronidase, beta -2.13229
CASC3 cancer susceptibility candidate 3 -2.11937
DNMBP dynamin binding protein -2.11284
SND1 staphylococcal nuclease and tudor domain containing 1 -2.1123
DCAF15 DDB1 and CUL4 associated factor 15 -2.10982
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -2.09476
ZWINT ZW10 interacting kinetochore protein -2.09476
SPATA5L1 spermatogenesis associated 5-like 1 -2.09252
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 -2.09252
ATF7 activating transcription factor 7 -2.09252
ASXL3 additional sex combs like transcriptional regulator 3 -2.09103
SEC14L6 SEC14-like 6 (S. cerevisiae) -2.07959
BAZ1A bromodomain adjacent to zinc finger domain, 1A -2.05985
ZNF205 zinc finger protein 205 -2.05822
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa -2.05822
PROM2 prominin 2 -2.03051
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.02891
PUM1 pumilio RNA-binding family member 1 -2.02826
ANKDD1B ankyrin repeat and death domain containing 1B -2.0239
SNX25 sorting nexin 25 -2.00174