SYK Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description spleen tyrosine kinase|This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 6850)
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100 substrates of the kinase SYK from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
RNF2 ring finger protein 2 100.0
DPF2 D4, zinc and double PHD fingers family 2 99.98
THEMIS2 thymocyte selection associated family member 2 99.96
POLR1A polymerase (RNA) I polypeptide A, 194kDa 99.91
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 99.875
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 99.82
PELP1 proline, glutamate and leucine rich protein 1 99.8
MLEC malectin 99.78
IPO8 importin 8 99.74
ARID4B AT rich interactive domain 4B (RBP1-like) 99.71
F5 coagulation factor V (proaccelerin, labile factor) 99.61
ZNF598 zinc finger protein 598 99.58
SF3A3 splicing factor 3a, subunit 3, 60kDa 99.54
CEP43 centrosomal protein 43 99.5
PDCD5 programmed cell death 5 99.48
SH3BP2 SH3-domain binding protein 2 99.48
HBS1L HBS1-like translational GTPase 99.43
YEATS2 YEATS domain containing 2 99.39
EPB41L5 erythrocyte membrane protein band 4.1 like 5 99.23
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 99.23
MCEMP1 mast cell-expressed membrane protein 1 99.21
BYSL bystin-like 99.19
PRKACB protein kinase, cAMP-dependent, catalytic, beta 99.13
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 99.1
PRRC2B proline-rich coiled-coil 2B 99.06
UBR4 ubiquitin protein ligase E3 component n-recognin 4 99.04
MCC mutated in colorectal cancers 99.02
C9ORF78 chromosome 9 open reading frame 78 98.97
SHD Src homology 2 domain containing transforming protein D 98.93
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 98.9
GPATCH11 G patch domain containing 11 98.88
LNPEP leucyl/cystinyl aminopeptidase 98.855
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 98.8
GOLIM4 golgi integral membrane protein 4 98.67
ZNF326 zinc finger protein 326 98.66
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 98.64
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 98.6
CDK5RAP2 CDK5 regulatory subunit associated protein 2 98.58
PDS5B PDS5 cohesin associated factor B 98.56
IKZF3 IKAROS family zinc finger 3 (Aiolos) 98.53
RABL6 RAB, member RAS oncogene family-like 6 98.45
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 98.42
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 98.32
FAM107B family with sequence similarity 107, member B 98.31
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 98.29
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 98.25
PTPN7 protein tyrosine phosphatase, non-receptor type 7 98.2
ZSCAN25 zinc finger and SCAN domain containing 25 98.16
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 98.14
STEAP1 six transmembrane epithelial antigen of the prostate 1 98.09
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 98.07
CD79A CD79a molecule, immunoglobulin-associated alpha 98.03
TRAF3IP2 TRAF3 interacting protein 2 98.03
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 97.94
ARHGAP35 Rho GTPase activating protein 35 97.935
FUNDC1 FUN14 domain containing 1 97.92
PDZK1IP1 PDZK1 interacting protein 1 97.85
DPH6 diphthamine biosynthesis 6 97.74
SLCO3A1 solute carrier organic anion transporter family, member 3A1 97.62
PGRMC2 progesterone receptor membrane component 2 97.55
CHD1 chromodomain helicase DNA binding protein 1 97.505
PLD1 phospholipase D1, phosphatidylcholine-specific 97.42
LAX1 lymphocyte transmembrane adaptor 1 97.39
RBM25 RNA binding motif protein 25 97.37
RAD17 RAD17 homolog (S. pombe) 97.29
HTATSF1 HIV-1 Tat specific factor 1 97.27
RPL10 ribosomal protein L10 97.26
CENPE centromere protein E, 312kDa 97.22
HAVCR2 hepatitis A virus cellular receptor 2 97.21
FHOD1 formin homology 2 domain containing 1 97.16
TRIP11 thyroid hormone receptor interactor 11 97.09
ARHGAP5 Rho GTPase activating protein 5 97.07
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 97.02
BLNK B-cell linker 96.83
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 96.83
PARD6B par-6 family cell polarity regulator beta 96.67
TWF1 twinfilin actin binding protein 1 96.65
FHIT fragile histidine triad 96.59
MAGED2 melanoma antigen family D2 96.59
GAB3 GRB2-associated binding protein 3 96.585
CFAP97 cilia and flagella associated protein 97 96.58
CLNS1A chloride channel, nucleotide-sensitive, 1A 96.52
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 96.47
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 96.46
PRNP prion protein 96.45
CKAP4 cytoskeleton-associated protein 4 96.39
TASOR transcription activation suppressor 96.23
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 96.17
SH2D1B SH2 domain containing 1B 96.1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 96.1
C2CD2L C2CD2-like 96.08
STAP2 signal transducing adaptor family member 2 96.015
ZRANB2 zinc finger, RAN-binding domain containing 2 96.005
DMAP1 DNA methyltransferase 1 associated protein 1 95.97
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 95.89
ACOX1 acyl-CoA oxidase 1, palmitoyl 95.88
CEP68 centrosomal protein 68kDa 95.82
SHE Src homology 2 domain containing E 95.8
RABGAP1L RAB GTPase activating protein 1-like 95.77
GAPT GRB2-binding adaptor protein, transmembrane 95.75