SYK Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description spleen tyrosine kinase|This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 6850)
External Link http://www.ncbi.nlm.nih.gov/gene/6850
Similar Terms
Downloads & Tools

Genes

33 substrates of the kinase SYK from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD79A CD79a molecule, immunoglobulin-associated alpha
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
DBNL drebrin-like
DUSP3 dual specificity phosphatase 3
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
GCSAM germinal center-associated, signaling and motility
HCLS1 hematopoietic cell-specific Lyn substrate 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LAT2 linker for activation of T cells family, member 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPT microtubule-associated protein tau
NRIP1 nuclear receptor interacting protein 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PYCARD PYD and CARD domain containing
RHBG Rh family, B glycoprotein (gene/pseudogene)
SH3BP2 SH3-domain binding protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
STAT5A signal transducer and activator of transcription 5A
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYK spleen tyrosine kinase