SYK_druginhibition_281_GSE43510 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43510
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Genes

600 genes differentially expressed following the SYK_druginhibition_281_GSE43510 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
USP28 ubiquitin specific peptidase 28 5.07044
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.97021
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 3.85757
PTP4A2 protein tyrosine phosphatase type IVA, member 2 3.76793
CRYBG3 beta-gamma crystallin domain containing 3 3.60495
HMMR hyaluronan-mediated motility receptor (RHAMM) 3.29705
KNTC1 kinetochore associated 1 3.26073
SMIM20 small integral membrane protein 20 3.15964
METTL23 methyltransferase like 23 3.14882
BTN3A2 butyrophilin, subfamily 3, member A2 3.1399
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3.06624
RBM26-AS1 RBM26 antisense RNA 1 3.02275
STK24 serine/threonine kinase 24 2.96119
TMEM245 transmembrane protein 245 2.85805
IFT57 intraflagellar transport 57 2.84753
RGS1 regulator of G-protein signaling 1 2.83569
SERINC3 serine incorporator 3 2.60894
CREB3L2 cAMP responsive element binding protein 3-like 2 2.60327
GINS2 GINS complex subunit 2 (Psf2 homolog) 2.50886
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa 2.45713
DDB2 damage-specific DNA binding protein 2, 48kDa 2.38326
TRAPPC8 trafficking protein particle complex 8 2.32639
CCDC28A coiled-coil domain containing 28A 2.20964
TBRG1 transforming growth factor beta regulator 1 2.19588
OSR2 odd-skipped related transciption factor 2 2.18612
TULP3 tubby like protein 3 2.18409
CEP44 centrosomal protein 44kDa 2.17686
ZBTB48 zinc finger and BTB domain containing 48 2.16107
FAM134C family with sequence similarity 134, member C 2.14083
GSAP gamma-secretase activating protein 2.13991
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.11886
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2.07945
TMEM263 transmembrane protein 263 2.0719
TTC17 tetratricopeptide repeat domain 17 2.04143
NFS1 NFS1 cysteine desulfurase 2.03994
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 2.03346
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 2.02392
PLCL2 phospholipase C-like 2 1.99335
MAN1B1 mannosidase, alpha, class 1B, member 1 1.99293
DENND6A DENN/MADD domain containing 6A 1.94698
HEATR5B HEAT repeat containing 5B 1.92863
CIR1 corepressor interacting with RBPJ, 1 1.92035
NDC80 NDC80 kinetochore complex component 1.9018
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 1.89976
ECI1 enoyl-CoA delta isomerase 1 1.8942
ARHGAP19 Rho GTPase activating protein 19 1.89265
PCGF5 polycomb group ring finger 5 1.86528
KIF3A kinesin family member 3A 1.82878
RIMKLB ribosomal modification protein rimK-like family member B 1.79493
MAU2 MAU2 sister chromatid cohesion factor 1.7799
TCF4 transcription factor 4 1.73641
HSPA13 heat shock protein 70kDa family, member 13 1.73068
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 1.71669
ATM ATM serine/threonine kinase 1.71118
DSTN destrin (actin depolymerizing factor) 1.70686
APLP2 amyloid beta (A4) precursor-like protein 2 1.69046
UBXN6 UBX domain protein 6 1.68682
DYNLRB1 dynein, light chain, roadblock-type 1 1.66276
PNISR PNN-interacting serine/arginine-rich protein 1.65186
GATAD1 GATA zinc finger domain containing 1 1.6516
RNF13 ring finger protein 13 1.65076
COQ10A coenzyme Q10 homolog A (S. cerevisiae) 1.62764
ATMIN ATM interactor 1.62264
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 1.62215
PDE4B phosphodiesterase 4B, cAMP-specific 1.62017
PSAP prosaposin 1.61759
CD27 CD27 molecule 1.61643
HDDC3 HD domain containing 3 1.59879
MME membrane metallo-endopeptidase 1.59376
UBL7 ubiquitin-like 7 1.5937
REXO2 RNA exonuclease 2 1.58987
AGGF1 angiogenic factor with G patch and FHA domains 1 1.56481
GLT8D1 glycosyltransferase 8 domain containing 1 1.54862
PPP1R16B protein phosphatase 1, regulatory subunit 16B 1.54837
JAK1 Janus kinase 1 1.52543
SYNRG synergin, gamma 1.52397
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 1.51924
CRIPT cysteine-rich PDZ-binding protein 1.51676
MYNN myoneurin 1.49904
DGKD diacylglycerol kinase, delta 130kDa 1.49544
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 1.4634
MZT2B mitotic spindle organizing protein 2B 1.45824
CETN3 centrin, EF-hand protein, 3 1.4481
MTIF3 mitochondrial translational initiation factor 3 1.44205
SDCBP syndecan binding protein (syntenin) 1.43795
DMTF1 cyclin D binding myb-like transcription factor 1 1.4362
KATNB1 katanin p80 (WD repeat containing) subunit B 1 1.43075
MXI1 MAX interactor 1, dimerization protein 1.42551
PRDX5 peroxiredoxin 5 1.41659
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 1.41442
RSPRY1 ring finger and SPRY domain containing 1 1.4102
HINFP histone H4 transcription factor 1.40598
CDC16 cell division cycle 16 1.40446
ANAPC16 anaphase promoting complex subunit 16 1.40416
FANCG Fanconi anemia, complementation group G 1.40392
EIF1 eukaryotic translation initiation factor 1 1.40207
METTL3 methyltransferase like 3 1.40131
SDHAF4 succinate dehydrogenase complex assembly factor 4 1.38013
PEX1 peroxisomal biogenesis factor 1 1.37483
S100PBP S100P binding protein 1.37276
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 1.36749
GADD45A growth arrest and DNA-damage-inducible, alpha 1.35557
IGF2R insulin-like growth factor 2 receptor 1.34348
CRLF3 cytokine receptor-like factor 3 1.33739
UNKL unkempt family zinc finger-like 1.33583
HRK harakiri, BCL2 interacting protein 1.33273
EXOC4 exocyst complex component 4 1.33037
BICD2 bicaudal D homolog 2 (Drosophila) 1.326
MTERF4 mitochondrial transcription termination factor 4 1.3141
ANKIB1 ankyrin repeat and IBR domain containing 1 1.3083
FOXP1 forkhead box P1 1.30302
FAM8A1 family with sequence similarity 8, member A1 1.2902
CCNI cyclin I 1.28922
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 1.28882
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.28632
ITM2B integral membrane protein 2B 1.28451
SAV1 salvador family WW domain containing protein 1 1.28313
SNHG6 small nucleolar RNA host gene 6 1.28156
TMED1 transmembrane emp24 protein transport domain containing 1 1.27806
NOA1 nitric oxide associated 1 1.27226
CPSF3L cleavage and polyadenylation specific factor 3-like 1.27184
CREBL2 cAMP responsive element binding protein-like 2 1.26775
ZC3H14 zinc finger CCCH-type containing 14 1.25948
CLK2 CDC-like kinase 2 1.25586
CEP76 centrosomal protein 76kDa 1.25241
HDHD2 haloacid dehalogenase-like hydrolase domain containing 2 1.2487
RFC5 replication factor C (activator 1) 5, 36.5kDa 1.24733
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 1.24705
SQRDL sulfide quinone reductase-like (yeast) 1.24554
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 1.24373
HECA headcase homolog (Drosophila) 1.2419
BIRC2 baculoviral IAP repeat containing 2 1.23736
WASF2 WAS protein family, member 2 1.23609
HYLS1 hydrolethalus syndrome 1 1.23283
TMEM243 transmembrane protein 243, mitochondrial 1.22038
AACS acetoacetyl-CoA synthetase 1.21956
BBS2 Bardet-Biedl syndrome 2 1.21658
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 1.2159
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 1.21193
RCN2 reticulocalbin 2, EF-hand calcium binding domain 1.20833
DERA deoxyribose-phosphate aldolase (putative) 1.20726
TIFA TRAF-interacting protein with forkhead-associated domain 1.20512
GLTSCR2 glioma tumor suppressor candidate region gene 2 1.19613
LYPLAL1 lysophospholipase-like 1 1.19249
SEC11A SEC11 homolog A (S. cerevisiae) 1.18776
RPL30 ribosomal protein L30 1.18551
RRM2 ribonucleotide reductase M2 1.17638
TCF19 transcription factor 19 1.16946
TMEM50A transmembrane protein 50A 1.16816
MYLIP myosin regulatory light chain interacting protein 1.1656
MBTPS1 membrane-bound transcription factor peptidase, site 1 1.15581
GOLGA2 golgin A2 1.15524
ANKRD13A ankyrin repeat domain 13A 1.15182
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 1.15073
ZWINT ZW10 interacting kinetochore protein 1.14987
PILRB paired immunoglobin-like type 2 receptor beta 1.14923
TSNAX translin-associated factor X 1.14681
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 1.14581
NCAPD3 non-SMC condensin II complex, subunit D3 1.14512
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 1.14438
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 1.14214
B2M beta-2-microglobulin 1.14122
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 1.13647
CCNDBP1 cyclin D-type binding-protein 1 1.13008
KHNYN KH and NYN domain containing 1.12861
RPS27L ribosomal protein S27-like 1.12783
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 1.12467
COX6C cytochrome c oxidase subunit VIc 1.12444
HS1BP3 HCLS1 binding protein 3 1.12424
MRPL10 mitochondrial ribosomal protein L10 1.12404
CAPRIN2 caprin family member 2 1.12195
CBR4 carbonyl reductase 4 1.12179
SETD1B SET domain containing 1B 1.11767
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 1.10941
RBKS ribokinase 1.10941
NCAPG non-SMC condensin I complex, subunit G 1.10711
PAIP2 poly(A) binding protein interacting protein 2 1.10701
ZNF600 zinc finger protein 600 1.1057
MYO9A myosin IXA 1.10533
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 1.10234
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 1.09981
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 1.09848
SFR1 SWI5-dependent recombination repair 1 1.0933
ELP4 elongator acetyltransferase complex subunit 4 1.08457
PRKCB protein kinase C, beta 1.08415
E2F7 E2F transcription factor 7 1.0837
IGBP1 immunoglobulin (CD79A) binding protein 1 1.08336
TKFC triokinase/FMN cyclase 1.08171
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3 1.08018
BLCAP bladder cancer associated protein 1.06877
GLIPR1 GLI pathogenesis-related 1 1.0673
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 1.06729
NPEPPS aminopeptidase puromycin sensitive 1.06359
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) 1.06188
BCAP29 B-cell receptor-associated protein 29 1.06038
RASA1 RAS p21 protein activator (GTPase activating protein) 1 1.0587
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 1.05592
RNF115 ring finger protein 115 1.05572
FAM213A family with sequence similarity 213, member A 1.05486
NUDCD2 NudC domain containing 2 1.05433
PCYOX1L prenylcysteine oxidase 1 like 1.05254
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.05181
CENPF centromere protein F, 350/400kDa 1.04962
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase 1.04944
PDGFD platelet derived growth factor D 1.04901
SH3YL1 SH3 and SYLF domain containing 1 1.04412
FAM117A family with sequence similarity 117, member A 1.04397
ANKRD10 ankyrin repeat domain 10 1.04077
MOSPD2 motile sperm domain containing 2 1.04065
ATG2A autophagy related 2A 1.03941
KLHDC2 kelch domain containing 2 1.03902
BCAS4 breast carcinoma amplified sequence 4 1.03785
RGS10 regulator of G-protein signaling 10 1.03628
CCDC23 coiled-coil domain containing 23 1.03332
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 1.03314
UVSSA UV-stimulated scaffold protein A 1.02982
CREB3L4 cAMP responsive element binding protein 3-like 4 1.02976
TBCB tubulin folding cofactor B 1.0291
TOPBP1 topoisomerase (DNA) II binding protein 1 1.0289
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 1.02864
MYCBP MYC binding protein 1.02852
YIPF5 Yip1 domain family, member 5 1.02847
TRADD TNFRSF1A-associated via death domain 1.02719
WDFY4 WDFY family member 4 1.02684
NCK2 NCK adaptor protein 2 1.02564
MAN2B2 mannosidase, alpha, class 2B, member 2 1.02512
AP3M2 adaptor-related protein complex 3, mu 2 subunit 1.02491
ZNF274 zinc finger protein 274 1.02353
N4BP2 NEDD4 binding protein 2 1.01998
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 1.01993
RPL11 ribosomal protein L11 1.01867
CTSA cathepsin A 1.01721
C2CD5 C2 calcium-dependent domain containing 5 1.01348
RPL35A ribosomal protein L35a 1.01233
PTTG1IP pituitary tumor-transforming 1 interacting protein 1.01086
QARS glutaminyl-tRNA synthetase 1.00916
KCTD18 potassium channel tetramerization domain containing 18 1.00905
PTPRA protein tyrosine phosphatase, receptor type, A 1.00675
FN3KRP fructosamine 3 kinase related protein 1.00487
RAB2B RAB2B, member RAS oncogene family 1.00408
SLC35A5 solute carrier family 35, member A5 1.00395
LYN LYN proto-oncogene, Src family tyrosine kinase 1.00372
ERMP1 endoplasmic reticulum metallopeptidase 1 1.00249
RANBP9 RAN binding protein 9 1.00073
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.997409
TOP2A topoisomerase (DNA) II alpha 170kDa 0.996621
SLC25A40 solute carrier family 25, member 40 0.996354
WDR45B WD repeat domain 45B 0.995628
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.99468
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.990865
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.990417
SYK spleen tyrosine kinase 0.988592
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.987749
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.987061
DCTN3 dynactin 3 (p22) 0.986902
DVL2 dishevelled segment polarity protein 2 0.986557
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 0.981799
IST1 increased sodium tolerance 1 homolog (yeast) 0.981491
CLPS colipase, pancreatic 0.980603
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.979798
MED14 mediator complex subunit 14 0.976704
AHCYL1 adenosylhomocysteinase-like 1 0.976508
STAMBP STAM binding protein 0.975319
KRCC1 lysine-rich coiled-coil 1 0.97412
CRYGS crystallin, gamma S 0.97331
ZC3H7A zinc finger CCCH-type containing 7A 0.972522
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 0.972377
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.971185
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.969254
CEP19 centrosomal protein 19kDa 0.967819
C10ORF10 chromosome 10 open reading frame 10 0.966229
KLHL9 kelch-like family member 9 0.965501
C2ORF49 chromosome 2 open reading frame 49 0.96534
THOP1 thimet oligopeptidase 1 0.963405
CCDC112 coiled-coil domain containing 112 0.962503
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 0.962235
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 0.961158
CIRBP cold inducible RNA binding protein 0.9602
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) 0.951252
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.951025
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) 0.950543
C11ORF49 chromosome 11 open reading frame 49 0.94897
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.946147
HERPUD2 HERPUD family member 2 0.94318
ESR2 estrogen receptor 2 (ER beta) 0.943166
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.941387
CCDC90B coiled-coil domain containing 90B 0.939229
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.937558
TMEM60 transmembrane protein 60 0.937233
SPATA7 spermatogenesis associated 7 0.936685
POLR3GL polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like 0.935306
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 0.934108
TMEM14A transmembrane protein 14A 0.931451
WBP1L WW domain binding protein 1-like 0.929534
TMEM107 transmembrane protein 107 0.92888
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.928677
CXORF57 chromosome X open reading frame 57 0.927464
BMP7 bone morphogenetic protein 7 0.927034
MICB MHC class I polypeptide-related sequence B 0.924659
STK36 serine/threonine kinase 36 0.923854

decreased expression

Symbol Name Standardized Value
MEF2C myocyte enhancer factor 2C -4.51575
CERS2 ceramide synthase 2 -3.81011
LOC102725284 -3.56139
TCL1A T-cell leukemia/lymphoma 1A -3.55331
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -3.51559
UBE2J1 ubiquitin-conjugating enzyme E2, J1 -3.44965
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -3.42301
PWP1 PWP1 homolog (S. cerevisiae) -3.19651
WEE1 WEE1 G2 checkpoint kinase -3.19359
SRSF7 serine/arginine-rich splicing factor 7 -3.12684
FARSA phenylalanyl-tRNA synthetase, alpha subunit -3.00773
EBF1 early B-cell factor 1 -2.85011
LYAR Ly1 antibody reactive -2.77313
CLPTM1L CLPTM1-like -2.76051
CHD4 chromodomain helicase DNA binding protein 4 -2.72289
PNPT1 polyribonucleotide nucleotidyltransferase 1 -2.70625
MED27 mediator complex subunit 27 -2.70276
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.67422
MLX MLX, MAX dimerization protein -2.64516
PAK1IP1 PAK1 interacting protein 1 -2.63125
AK2 adenylate kinase 2 -2.59267
SMIM12 small integral membrane protein 12 -2.51563
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -2.44135
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 -2.42773
MEF2D myocyte enhancer factor 2D -2.42033
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -2.40628
SMAD3 SMAD family member 3 -2.36233
HSPA9 heat shock 70kDa protein 9 (mortalin) -2.34527
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.26254
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -2.24211
ZC3HC1 zinc finger, C3HC-type containing 1 -2.22352
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) -2.21637
CAPRIN1 cell cycle associated protein 1 -2.20485
TCP1 t-complex 1 -2.17782
HSPH1 heat shock 105kDa/110kDa protein 1 -2.17438
PPID peptidylprolyl isomerase D -2.17046
UBC ubiquitin C -2.15996
EBP emopamil binding protein (sterol isomerase) -2.15464
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.09205
GNAS GNAS complex locus -2.08793
PDK1 pyruvate dehydrogenase kinase, isozyme 1 -2.07755
IPO11 importin 11 -2.0736
SCO2 SCO2 cytochrome c oxidase assembly protein -2.06977
CCDC138 coiled-coil domain containing 138 -2.06502
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 -2.05107
RPP40 ribonuclease P/MRP 40kDa subunit -2.025
WDR43 WD repeat domain 43 -2.01394
EVI2B ecotropic viral integration site 2B -1.98919
SLC38A1 solute carrier family 38, member 1 -1.9762
KIAA0922 KIAA0922 -1.96911
MANF mesencephalic astrocyte-derived neurotrophic factor -1.93807
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -1.92718
TEX10 testis expressed 10 -1.92632
NOL7 nucleolar protein 7, 27kDa -1.89686
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -1.88039
DAAM1 dishevelled associated activator of morphogenesis 1 -1.87806
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -1.87191
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein -1.86794
TMEM97 transmembrane protein 97 -1.84787
METTL13 methyltransferase like 13 -1.84773
COPRS coordinator of PRMT5, differentiation stimulator -1.84353
COMMD10 COMM domain containing 10 -1.83559
CYTIP cytohesin 1 interacting protein -1.81704
SNHG15 small nucleolar RNA host gene 15 -1.80367
TRMT6 tRNA methyltransferase 6 -1.80256
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -1.75672
DOK3 docking protein 3 -1.75139
PDLIM1 PDZ and LIM domain 1 -1.74572
NIFK nucleolar protein interacting with the FHA domain of MKI67 -1.72765
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -1.72396
PDIA6 protein disulfide isomerase family A, member 6 -1.72285
SYPL1 synaptophysin-like 1 -1.71856
TMC8 transmembrane channel-like 8 -1.70629
PEMT phosphatidylethanolamine N-methyltransferase -1.70437
CD79A CD79a molecule, immunoglobulin-associated alpha -1.70103
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -1.69745
FAM107B family with sequence similarity 107, member B -1.66354
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -1.64733
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 -1.63968
IDI1 isopentenyl-diphosphate delta isomerase 1 -1.63371
CD52 CD52 molecule -1.6268
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -1.6187
PLAA phospholipase A2-activating protein -1.61547
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -1.61091
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -1.59279
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -1.58956
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -1.58834
MRPL34 mitochondrial ribosomal protein L34 -1.5875
NIP7 NIP7, nucleolar pre-rRNA processing protein -1.58536
SASH3 SAM and SH3 domain containing 3 -1.58457
YY1 YY1 transcription factor -1.58282
LRMP lymphoid-restricted membrane protein -1.58094
HDAC2 histone deacetylase 2 -1.57891
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 -1.55502
WAPAL wings apart-like homolog (Drosophila) -1.54063
CCNE1 cyclin E1 -1.52564
CIAPIN1 cytokine induced apoptosis inhibitor 1 -1.51343
TICAM1 toll-like receptor adaptor molecule 1 -1.51303
SEPT9 septin 9 -1.51126
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -1.50823
IQGAP2 IQ motif containing GTPase activating protein 2 -1.50772
GPER1 G protein-coupled estrogen receptor 1 -1.50321
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -1.50236
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -1.50093
RIOK1 RIO kinase 1 -1.49868
WWC3 WWC family member 3 -1.49206
MYH9 myosin, heavy chain 9, non-muscle -1.48962
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) -1.46675
STRBP spermatid perinuclear RNA binding protein -1.46402
JADE3 jade family PHD finger 3 -1.45916
KIAA0368 KIAA0368 -1.45692
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -1.45387
RAD23B RAD23 homolog B (S. cerevisiae) -1.43456
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) -1.43444
DLAT dihydrolipoamide S-acetyltransferase -1.42654
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -1.42578
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -1.42342
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -1.42037
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -1.41086
GPRIN1 G protein regulated inducer of neurite outgrowth 1 -1.40699
MYC v-myc avian myelocytomatosis viral oncogene homolog -1.40387
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -1.40165
NEK6 NIMA-related kinase 6 -1.4012
AVEN apoptosis, caspase activation inhibitor -1.39536
MRPS28 mitochondrial ribosomal protein S28 -1.38754
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -1.38506
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -1.37637
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -1.37446
SERBP1 SERPINE1 mRNA binding protein 1 -1.37389
BCL6 B-cell CLL/lymphoma 6 -1.36827
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -1.36732
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -1.36407
TM7SF3 transmembrane 7 superfamily member 3 -1.36185
SRFBP1 serum response factor binding protein 1 -1.36146
COA7 cytochrome c oxidase assembly factor 7 (putative) -1.35983
TRAF4 TNF receptor-associated factor 4 -1.35924
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -1.35724
CCDC86 coiled-coil domain containing 86 -1.35647
NUDCD1 NudC domain containing 1 -1.35359
POLR1B polymerase (RNA) I polypeptide B, 128kDa -1.34967
MRPL18 mitochondrial ribosomal protein L18 -1.34807
DAXX death-domain associated protein -1.34444
SEH1L SEH1-like (S. cerevisiae) -1.3442
SEPT6 septin 6 -1.34326
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -1.34275
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon -1.33997
TMPO thymopoietin -1.33888
LIMA1 LIM domain and actin binding 1 -1.3359
METTL16 methyltransferase like 16 -1.32782
HSPA4 heat shock 70kDa protein 4 -1.32341
ZFAND2A zinc finger, AN1-type domain 2A -1.32208
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino -1.32092
MTO1 mitochondrial tRNA translation optimization 1 -1.3198
GTPBP4 GTP binding protein 4 -1.31755
ZBTB2 zinc finger and BTB domain containing 2 -1.31686
PDCD2L programmed cell death 2-like -1.31369
SWAP70 SWAP switching B-cell complex 70kDa subunit -1.30795
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -1.30627
ASCC3 activating signal cointegrator 1 complex subunit 3 -1.30583
PNP purine nucleoside phosphorylase -1.29314
PLD6 phospholipase D family, member 6 -1.29033
TMEM33 transmembrane protein 33 -1.29023
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -1.29012
GSPT1 G1 to S phase transition 1 -1.28815
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) -1.28469
TM9SF2 transmembrane 9 superfamily member 2 -1.28469
FAM69A family with sequence similarity 69, member A -1.27971
GEMIN5 gem (nuclear organelle) associated protein 5 -1.27876
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -1.27129
PROSER1 proline and serine rich 1 -1.27046
FAM129C family with sequence similarity 129, member C -1.26832
BAG2 BCL2-associated athanogene 2 -1.26735
MAK16 MAK16 homolog (S. cerevisiae) -1.26691
ATAD3B ATPase family, AAA domain containing 3B -1.25996
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -1.25714
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 -1.24803
PHGDH phosphoglycerate dehydrogenase -1.24607
CCDC69 coiled-coil domain containing 69 -1.23714
SLC16A6 solute carrier family 16, member 6 -1.23627
MARS methionyl-tRNA synthetase -1.23625
HSPA14 heat shock 70kDa protein 14 -1.235
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -1.23312
FADS1 fatty acid desaturase 1 -1.22572
KPNB1 karyopherin (importin) beta 1 -1.21617
NAPSB napsin B aspartic peptidase, pseudogene -1.21491
DTX1 deltex 1, E3 ubiquitin ligase -1.2079
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils -1.20171
HPDL 4-hydroxyphenylpyruvate dioxygenase-like -1.20057
SF3A3 splicing factor 3a, subunit 3, 60kDa -1.20049
FCRLA Fc receptor-like A -1.19889
MRPS12 mitochondrial ribosomal protein S12 -1.19757
CDK4 cyclin-dependent kinase 4 -1.19523
DESI1 desumoylating isopeptidase 1 -1.19425
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -1.19325
GORASP2 golgi reassembly stacking protein 2, 55kDa -1.1903
GMFB glia maturation factor, beta -1.18851
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -1.18832
DNTT DNA nucleotidylexotransferase -1.18227
ZDHHC6 zinc finger, DHHC-type containing 6 -1.17985
STAT1 signal transducer and activator of transcription 1, 91kDa -1.17822
LDB1 LIM domain binding 1 -1.17665
SF3B3 splicing factor 3b, subunit 3, 130kDa -1.17411
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -1.17407
FADS3 fatty acid desaturase 3 -1.17153
BANK1 B-cell scaffold protein with ankyrin repeats 1 -1.17084
CD19 CD19 molecule -1.16555
SBNO1 strawberry notch homolog 1 (Drosophila) -1.1608
NUP85 nucleoporin 85kDa -1.15506
PTPRC protein tyrosine phosphatase, receptor type, C -1.15272
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -1.15271
KDM4B lysine (K)-specific demethylase 4B -1.15222
CCDC36 coiled-coil domain containing 36 -1.14926
FKBP4 FK506 binding protein 4, 59kDa -1.14534
UBQLN1 ubiquilin 1 -1.13997
CDC20 cell division cycle 20 -1.137
HEATR1 HEAT repeat containing 1 -1.13074
PPP1R18 protein phosphatase 1, regulatory subunit 18 -1.13013
REEP5 receptor accessory protein 5 -1.12583
WBP11 WW domain binding protein 11 -1.124
TCEAL1 transcription elongation factor A (SII)-like 1 -1.12308
SET SET nuclear proto-oncogene -1.11925
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -1.11768
SPATS2L spermatogenesis associated, serine-rich 2-like -1.11251
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -1.11242
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -1.11085
TMEM70 transmembrane protein 70 -1.11049
LIG4 ligase IV, DNA, ATP-dependent -1.10824
THUMPD1 THUMP domain containing 1 -1.10383
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -1.10338
VRK1 vaccinia related kinase 1 -1.10323
NF2 neurofibromin 2 (merlin) -1.10281
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -1.10255
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -1.10073
WARS tryptophanyl-tRNA synthetase -1.10043
EVI2A ecotropic viral integration site 2A -1.09828
LAPTM5 lysosomal protein transmembrane 5 -1.09637
CCNA2 cyclin A2 -1.09347
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -1.08941
PHF23 PHD finger protein 23 -1.08757
WDR36 WD repeat domain 36 -1.07992
USP16 ubiquitin specific peptidase 16 -1.07716
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -1.07692
USP39 ubiquitin specific peptidase 39 -1.07642
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -1.07608
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -1.07159
BCAT1 branched chain amino-acid transaminase 1, cytosolic -1.06959
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -1.0681
ATPIF1 ATPase inhibitory factor 1 -1.06698
SIDT2 SID1 transmembrane family, member 2 -1.06653
MIEF1 mitochondrial elongation factor 1 -1.0658
MEF2A myocyte enhancer factor 2A -1.06414
PTCD3 pentatricopeptide repeat domain 3 -1.06325
ATAD3A ATPase family, AAA domain containing 3A -1.05968
EIF3B eukaryotic translation initiation factor 3, subunit B -1.05579
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -1.05501
SYNGR1 synaptogyrin 1 -1.0533
CDC6 cell division cycle 6 -1.05326
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -1.04842
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 -1.04595
RMDN3 regulator of microtubule dynamics 3 -1.04344
MSMO1 methylsterol monooxygenase 1 -1.04053
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 -1.03696
ARL3 ADP-ribosylation factor-like 3 -1.03642
FERMT3 fermitin family member 3 -1.03481
NFE2L2 nuclear factor, erythroid 2-like 2 -1.0316
WDR1 WD repeat domain 1 -1.02881
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -1.02644
GPR18 G protein-coupled receptor 18 -1.02526
BID BH3 interacting domain death agonist -1.02453
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -1.0237
FTSJ3 FtsJ homolog 3 (E. coli) -1.02327
HN1 hematological and neurological expressed 1 -1.02258
NSDHL NAD(P) dependent steroid dehydrogenase-like -1.02193
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -1.0215
MRPL38 mitochondrial ribosomal protein L38 -1.01629
MRPS35 mitochondrial ribosomal protein S35 -1.01541
TUBA1C tubulin, alpha 1c -1.01258
MRPL16 mitochondrial ribosomal protein L16 -1.01232
CHMP2B charged multivesicular body protein 2B -1.00918
MRS2 MRS2 magnesium transporter -1.00864
CD5 CD5 molecule -1.00735
PNO1 partner of NOB1 homolog (S. cerevisiae) -1.00537
FAM208B family with sequence similarity 208, member B -1.00339
HK1 hexokinase 1 -1.00299
MRPL4 mitochondrial ribosomal protein L4 -1.0027
EBNA1BP2 EBNA1 binding protein 2 -1.00116
KCTD20 potassium channel tetramerization domain containing 20 -0.999739
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.999634
IKZF1 IKAROS family zinc finger 1 (Ikaros) -0.999465
BEND4 BEN domain containing 4 -0.996703
PGK1 phosphoglycerate kinase 1 -0.995169
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) -0.994492
SRSF6 serine/arginine-rich splicing factor 6 -0.99438
CTSC cathepsin C -0.993103
LY86 lymphocyte antigen 86 -0.990803
C3ORF58 chromosome 3 open reading frame 58 -0.989672
NUP205 nucleoporin 205kDa -0.987179
CLTC clathrin, heavy chain (Hc) -0.986711
SLC38A5 solute carrier family 38, member 5 -0.986638
HMGB1 high mobility group box 1 -0.985043
Funding