SYK_knockdown_189_GSE54065 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE54065
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Genes

600 genes differentially expressed following the SYK_knockdown_189_GSE54065 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 4.55522
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 4.21078
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 3.97892
SNX3 sorting nexin 3 3.69891
SEPHS2 selenophosphate synthetase 2 3.48855
GSTO1 glutathione S-transferase omega 1 3.47912
HPS1 Hermansky-Pudlak syndrome 1 3.44594
DYNLRB1 dynein, light chain, roadblock-type 1 3.23464
BCL2A1 BCL2-related protein A1 3.18555
BECN1 beclin 1, autophagy related 3.05212
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 2.9988
VAMP4 vesicle-associated membrane protein 4 2.98421
VIM vimentin 2.9418
FAM168B family with sequence similarity 168, member B 2.90871
CES1 carboxylesterase 1 2.89221
RAB31 RAB31, member RAS oncogene family 2.80906
RAB5A RAB5A, member RAS oncogene family 2.78821
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 2.764
RAB27A RAB27A, member RAS oncogene family 2.72802
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.68384
ELF4 E74-like factor 4 (ets domain transcription factor) 2.68248
MVP major vault protein 2.66241
CD48 CD48 molecule 2.65531
TP53BP2 tumor protein p53 binding protein 2 2.64165
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.63899
RAB11B RAB11B, member RAS oncogene family 2.62187
C6ORF47 chromosome 6 open reading frame 47 2.58773
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.56751
GPX1 glutathione peroxidase 1 2.54207
SEC24D SEC24 family member D 2.51411
ANXA4 annexin A4 2.50188
STX7 syntaxin 7 2.50016
MBD4 methyl-CpG binding domain protein 4 2.50006
LOC392555 melanoma antigen family C2 pseudogene 2.48541
GPS2 G protein pathway suppressor 2 2.45952
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.45483
UBE4A ubiquitination factor E4A 2.45446
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 2.45287
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.42226
SRSF5 serine/arginine-rich splicing factor 5 2.40442
GCLM glutamate-cysteine ligase, modifier subunit 2.39664
BIRC2 baculoviral IAP repeat containing 2 2.3916
CLN3 ceroid-lipofuscinosis, neuronal 3 2.37258
MNDA myeloid cell nuclear differentiation antigen 2.36087
MAN1A2 mannosidase, alpha, class 1A, member 2 2.35733
COPB1 coatomer protein complex, subunit beta 1 2.34277
DOK2 docking protein 2, 56kDa 2.34016
RAB1A RAB1A, member RAS oncogene family 2.33906
DYNLT1 dynein, light chain, Tctex-type 1 2.33695
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.30396
MAGEH1 melanoma antigen family H1 2.29814
ADIPOR2 adiponectin receptor 2 2.29245
RAB20 RAB20, member RAS oncogene family 2.28678
CELF2 CUGBP, Elav-like family member 2 2.28671
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.28119
PAM peptidylglycine alpha-amidating monooxygenase 2.27807
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.25833
PRNP prion protein 2.24599
VAMP7 vesicle-associated membrane protein 7 2.24533
ADIPOR1 adiponectin receptor 1 2.23836
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 2.22432
RRAGD Ras-related GTP binding D 2.20479
NENF neudesin neurotrophic factor 2.20141
ACSL1 acyl-CoA synthetase long-chain family member 1 2.19661
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.18524
PYCARD PYD and CARD domain containing 2.17694
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.14435
HLA-DMA major histocompatibility complex, class II, DM alpha 2.13848
MLX MLX, MAX dimerization protein 2.13197
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.11593
NCOA4 nuclear receptor coactivator 4 2.11286
SAT1 spermidine/spermine N1-acetyltransferase 1 2.10789
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.10549
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.08921
MT1X metallothionein 1X 2.08596
CSTB cystatin B (stefin B) 2.06295
C18ORF8 chromosome 18 open reading frame 8 2.05037
LPXN leupaxin 2.04818
IFNGR1 interferon gamma receptor 1 2.04449
KLHL20 kelch-like family member 20 1.99279
USO1 USO1 vesicle transport factor 1.99249
GPX4 glutathione peroxidase 4 1.98811
BTBD1 BTB (POZ) domain containing 1 1.97649
FGR FGR proto-oncogene, Src family tyrosine kinase 1.97353
UBE2D3 ubiquitin-conjugating enzyme E2D 3 1.95493
RABEP2 rabaptin, RAB GTPase binding effector protein 2 1.9446
MGST2 microsomal glutathione S-transferase 2 1.94161
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.94091
SARS seryl-tRNA synthetase 1.93813
S100A4 S100 calcium binding protein A4 1.93692
CSTA cystatin A (stefin A) 1.90997
DCTN2 dynactin 2 (p50) 1.90964
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 1.89552
RPL36AL ribosomal protein L36a-like 1.88854
TRAPPC3 trafficking protein particle complex 3 1.88034
GHITM growth hormone inducible transmembrane protein 1.87964
RNF14 ring finger protein 14 1.87258
DENND2D DENN/MADD domain containing 2D 1.8707
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 1.85241
UBE2B ubiquitin-conjugating enzyme E2B 1.83383
TMEM245 transmembrane protein 245 1.83308
GLRX glutaredoxin (thioltransferase) 1.82953
MFSD1 major facilitator superfamily domain containing 1 1.8197
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 1.80645
GRIA4 glutamate receptor, ionotropic, AMPA 4 1.80533
MTMR4 myotubularin related protein 4 1.80062
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 1.79663
MT1E metallothionein 1E 1.79045
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 1.79025
B2M beta-2-microglobulin 1.78858
PRKCB protein kinase C, beta 1.78627
ABAT 4-aminobutyrate aminotransferase 1.78268
GYPA glycophorin A (MNS blood group) 1.77915
SAMD4A sterile alpha motif domain containing 4A 1.77824
NEU1 sialidase 1 (lysosomal sialidase) 1.77059
ANXA6 annexin A6 1.77031
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.76834
HK1 hexokinase 1 1.76556
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 1.7626
DBN1 drebrin 1 1.75011
M6PR mannose-6-phosphate receptor (cation dependent) 1.74303
ARMT1 acidic residue methyltransferase 1 1.74293
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 1.74237
AASS aminoadipate-semialdehyde synthase 1.73736
CFP complement factor properdin 1.73245
NEMF nuclear export mediator factor 1.72954
NRP2 neuropilin 2 1.72315
CTSO cathepsin O 1.72292
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.71985
C1QA complement component 1, q subcomponent, A chain 1.71821
SFRP4 secreted frizzled-related protein 4 1.70674
IPO7 importin 7 1.70509
TFE3 transcription factor binding to IGHM enhancer 3 1.70343
RRAGA Ras-related GTP binding A 1.69936
GMIP GEM interacting protein 1.69705
TMEM251 transmembrane protein 251 1.69639
GSTZ1 glutathione S-transferase zeta 1 1.69085
RAB7A RAB7A, member RAS oncogene family 1.6871
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 1.68161
TYROBP TYRO protein tyrosine kinase binding protein 1.68132
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 1.68094
AP5M1 adaptor-related protein complex 5, mu 1 subunit 1.68048
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5 1.67736
RNF111 ring finger protein 111 1.67162
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 1.66469
NPC2 Niemann-Pick disease, type C2 1.66404
KRT10 keratin 10, type I 1.66251
STX4 syntaxin 4 1.65456
LBP lipopolysaccharide binding protein 1.64749
SNX2 sorting nexin 2 1.64309
PMM2 phosphomannomutase 2 1.63763
MT1HL1 metallothionein 1H-like 1 1.63514
NPEPPS aminopeptidase puromycin sensitive 1.62408
NUP214 nucleoporin 214kDa 1.6225
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 1.61485
ST18 suppression of tumorigenicity 18, zinc finger 1.60926
MMP2 matrix metallopeptidase 2 1.60827
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 1.60568
MED6 mediator complex subunit 6 1.60211
SNN stannin 1.59977
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 1.59728
KIAA0319L KIAA0319-like 1.59694
BRD7 bromodomain containing 7 1.59436
DUSP6 dual specificity phosphatase 6 1.59378
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa 1.59269
NDEL1 nudE neurodevelopment protein 1-like 1 1.58822
UBXN1 UBX domain protein 1 1.58648
PEX16 peroxisomal biogenesis factor 16 1.5852
VCAN versican 1.57697
MRPL33 mitochondrial ribosomal protein L33 1.57658
MED28 mediator complex subunit 28 1.57252
FTH1 ferritin, heavy polypeptide 1 1.57233
ALOX5AP arachidonate 5-lipoxygenase-activating protein 1.57039
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.56971
ADGRG2 adhesion G protein-coupled receptor G2 1.5653
SEC24B SEC24 family member B 1.56433
SLA Src-like-adaptor 1.55615
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 1.55572
SIPA1L3 signal-induced proliferation-associated 1 like 3 1.54986
RABGAP1L RAB GTPase activating protein 1-like 1.54883
SAMM50 SAMM50 sorting and assembly machinery component 1.5461
SMAP1 small ArfGAP 1 1.54053
ITM2B integral membrane protein 2B 1.53782
TKT transketolase 1.5332
CD300A CD300a molecule 1.53201
IL1RN interleukin 1 receptor antagonist 1.53169
RAB11FIP2 RAB11 family interacting protein 2 (class I) 1.53067
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 1.5287
DKFZP434L187 uncharacterized LOC26082 1.52862
TBCB tubulin folding cofactor B 1.52618
IL10RA interleukin 10 receptor, alpha 1.52384
KATNA1 katanin p60 (ATPase containing) subunit A 1 1.51445
FOXG1 forkhead box G1 1.51288
TRIOBP TRIO and F-actin binding protein 1.50946
TPMT thiopurine S-methyltransferase 1.50122
TMEM87A transmembrane protein 87A 1.49589
RER1 retention in endoplasmic reticulum sorting receptor 1 1.49559
SIGLEC5 sialic acid binding Ig-like lectin 5 1.49247
TRIM62 tripartite motif containing 62 1.48776
ANXA5 annexin A5 1.47368
HEXA hexosaminidase A (alpha polypeptide) 1.47356
FAM63A family with sequence similarity 63, member A 1.46328
MADD MAP-kinase activating death domain 1.46207
EPM2AIP1 EPM2A (laforin) interacting protein 1 1.45947
ZNHIT1 zinc finger, HIT-type containing 1 1.45362
GPHN gephyrin 1.44989
MPV17 MpV17 mitochondrial inner membrane protein 1.44033
ADGRE5 adhesion G protein-coupled receptor E5 1.43728
HOXC6 homeobox C6 1.436
GNG11 guanine nucleotide binding protein (G protein), gamma 11 1.43524
RTN1 reticulon 1 1.42848
TMOD1 tropomodulin 1 1.42719
SMNDC1 survival motor neuron domain containing 1 1.42584
FAM21A family with sequence similarity 21, member A 1.4254
DHPS deoxyhypusine synthase 1.42395
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 1.42342
MSLN mesothelin 1.42202
AMPD1 adenosine monophosphate deaminase 1 1.41464
CHMP2B charged multivesicular body protein 2B 1.41186
SKAP2 src kinase associated phosphoprotein 2 1.4048
EIF3K eukaryotic translation initiation factor 3, subunit K 1.40439
TRPV6 transient receptor potential cation channel, subfamily V, member 6 1.40335
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 1.39858
SIRPA signal-regulatory protein alpha 1.39522
ARF1 ADP-ribosylation factor 1 1.39452
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 1.38873
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 1.38779
CPA1 carboxypeptidase A1 (pancreatic) 1.38367
WDR44 WD repeat domain 44 1.38296
CES2 carboxylesterase 2 1.38152
CTSH cathepsin H 1.37837
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 1.37638
TMCC1 transmembrane and coiled-coil domain family 1 1.37548
RNF114 ring finger protein 114 1.37271
NAGLU N-acetylglucosaminidase, alpha 1.3695
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 1.36713
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E 1.36711
TXN2 thioredoxin 2 1.36318
CPB1 carboxypeptidase B1 (tissue) 1.36314
S100A11 S100 calcium binding protein A11 1.36282
ATP8B4 ATPase, class I, type 8B, member 4 1.35574
COG4 component of oligomeric golgi complex 4 1.35226
BAK1 BCL2-antagonist/killer 1 1.35211
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 1.34941
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 1.34763
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 1.34719
FAM49B family with sequence similarity 49, member B 1.3461
RNF13 ring finger protein 13 1.34587
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.34345
TMEM214 transmembrane protein 214 1.33728
CPVL carboxypeptidase, vitellogenic-like 1.3359
SASH3 SAM and SH3 domain containing 3 1.33332
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 1.3231
TMEM50B transmembrane protein 50B 1.32051
SLC26A6 solute carrier family 26 (anion exchanger), member 6 1.31965
CDC42SE1 CDC42 small effector 1 1.31785
NKX2-2 NK2 homeobox 2 1.31658
NR2E3 nuclear receptor subfamily 2, group E, member 3 1.31077
SERF2 small EDRK-rich factor 2 1.30992
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 1.30263
GOLGA2 golgin A2 1.29954
CCR6 chemokine (C-C motif) receptor 6 1.29556
PRR13 proline rich 13 1.29517
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 1.2927
TGOLN2 trans-golgi network protein 2 1.29152
RBM5 RNA binding motif protein 5 1.28885
IMP3 IMP3, U3 small nucleolar ribonucleoprotein 1.28742
ADCY7 adenylate cyclase 7 1.28588
THEMIS2 thymocyte selection associated family member 2 1.28576
EIF1B eukaryotic translation initiation factor 1B 1.28337
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 1.27958
STX3 syntaxin 3 1.27839
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 1.27584
RNF11 ring finger protein 11 1.27477
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.27376
FAM49A family with sequence similarity 49, member A 1.27332
RGS5 regulator of G-protein signaling 5 1.27015
PDHX pyruvate dehydrogenase complex, component X 1.26571
RALY RALY heterogeneous nuclear ribonucleoprotein 1.2614
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 1.25981
SLC25A46 solute carrier family 25, member 46 1.25612
RPL19 ribosomal protein L19 1.25481
TIMP1 TIMP metallopeptidase inhibitor 1 1.25395
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 1.25345
FAM168A family with sequence similarity 168, member A 1.25344
MSL3 male-specific lethal 3 homolog (Drosophila) 1.25188
ARRB1 arrestin, beta 1 1.24677
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) 1.24606
CTSL cathepsin L 1.24466
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 1.24203
ISYNA1 inositol-3-phosphate synthase 1 1.24091
SPO11 SPO11 meiotic protein covalently bound to DSB 1.24077
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.23967
CHMP5 charged multivesicular body protein 5 1.23741
SH2B3 SH2B adaptor protein 3 1.23693
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 1.23584
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 1.23071
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 1.22961
STC2 stanniocalcin 2 1.22837
PYGB phosphorylase, glycogen; brain 1.22729

decreased expression

Symbol Name Standardized Value
DIEXF digestive organ expansion factor homolog (zebrafish) -4.06231
TMEM97 transmembrane protein 97 -4.04774
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -4.0234
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -3.81501
FAM35A family with sequence similarity 35, member A -3.68196
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -3.49497
FOCAD focadhesin -3.36645
CALR calreticulin -3.27559
CCND2 cyclin D2 -3.17672
ADSS adenylosuccinate synthase -3.05908
USP33 ubiquitin specific peptidase 33 -3.05402
PDIA6 protein disulfide isomerase family A, member 6 -2.98475
FCHSD2 FCH and double SH3 domains 2 -2.92693
ZNF706 zinc finger protein 706 -2.88155
CTBP1 C-terminal binding protein 1 -2.77178
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.70986
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.69962
GCAT glycine C-acetyltransferase -2.66646
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 -2.64968
PREPL prolyl endopeptidase-like -2.61725
MSL1 male-specific lethal 1 homolog (Drosophila) -2.55247
PCOLCE2 procollagen C-endopeptidase enhancer 2 -2.48265
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -2.45817
C21ORF59 chromosome 21 open reading frame 59 -2.38942
SOCS5 suppressor of cytokine signaling 5 -2.38548
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -2.33147
COPS3 COP9 signalosome subunit 3 -2.27299
RUNX3 runt-related transcription factor 3 -2.27204
C19ORF60 chromosome 19 open reading frame 60 -2.2662
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit -2.24494
MTDH metadherin -2.23879
FAAH fatty acid amide hydrolase -2.23211
ELAC2 elaC ribonuclease Z 2 -2.21094
APOM apolipoprotein M -2.20486
MME membrane metallo-endopeptidase -2.20434
CCDC51 coiled-coil domain containing 51 -2.1945
CUL3 cullin 3 -2.19032
ANXA7 annexin A7 -2.1789
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -2.17578
GMPS guanine monphosphate synthase -2.17093
NSFL1C NSFL1 (p97) cofactor (p47) -2.13921
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -2.11578
MED14 mediator complex subunit 14 -2.10388
BCL2 B-cell CLL/lymphoma 2 -2.09791
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.09743
LBR lamin B receptor -2.09693
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -2.08964
CALB1 calbindin 1, 28kDa -2.0661
PPDPF pancreatic progenitor cell differentiation and proliferation factor -2.06414
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -2.05148
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.05075
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -2.04592
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.04428
WIPF2 WAS/WASL interacting protein family, member 2 -2.04099
H2AFY H2A histone family, member Y -2.037
IFITM1 interferon induced transmembrane protein 1 -2.02314
KLHDC10 kelch domain containing 10 -2.02293
TBC1D31 TBC1 domain family, member 31 -2.01804
LRRN3 leucine rich repeat neuronal 3 -2.00967
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -2.0072
CST7 cystatin F (leukocystatin) -2.00036
PHF10 PHD finger protein 10 -1.99558
YY1 YY1 transcription factor -1.99311
RAB22A RAB22A, member RAS oncogene family -1.93177
GTF3A general transcription factor IIIA -1.90258
ITGA6 integrin, alpha 6 -1.89568
S100A5 S100 calcium binding protein A5 -1.89252
NEFL neurofilament, light polypeptide -1.88837
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D -1.88628
TRIM14 tripartite motif containing 14 -1.88211
GFOD1 glucose-fructose oxidoreductase domain containing 1 -1.85387
PUS7 pseudouridylate synthase 7 (putative) -1.84126
TRIM10 tripartite motif containing 10 -1.83147
ZNF500 zinc finger protein 500 -1.8289
NOP56 NOP56 ribonucleoprotein -1.81653
SF3B5 splicing factor 3b, subunit 5, 10kDa -1.81526
PTPN9 protein tyrosine phosphatase, non-receptor type 9 -1.80019
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -1.79977
METAP2 methionyl aminopeptidase 2 -1.79746
ICE1 interactor of little elongation complex ELL subunit 1 -1.79549
COIL coilin -1.79482
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -1.79083
GPR4 G protein-coupled receptor 4 -1.78856
MPZL1 myelin protein zero-like 1 -1.7849
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -1.77903
TMEM222 transmembrane protein 222 -1.77555
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) -1.76677
SOD1 superoxide dismutase 1, soluble -1.75796
MPPE1 metallophosphoesterase 1 -1.7556
ODC1 ornithine decarboxylase 1 -1.74874
RASL11B RAS-like, family 11, member B -1.74
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -1.73102
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -1.72446
EIF3B eukaryotic translation initiation factor 3, subunit B -1.713
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -1.71282
THEM6 thioesterase superfamily member 6 -1.70931
AKAP1 A kinase (PRKA) anchor protein 1 -1.70891
RPE65 retinal pigment epithelium-specific protein 65kDa -1.69789
PRDX2 peroxiredoxin 2 -1.69709
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -1.69185
TBC1D5 TBC1 domain family, member 5 -1.68864
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) -1.67939
KDM1A lysine (K)-specific demethylase 1A -1.65895
MCM3AP-AS1 MCM3AP antisense RNA 1 -1.6545
CBX5 chromobox homolog 5 -1.65426
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -1.63831
LZTFL1 leucine zipper transcription factor-like 1 -1.63499
PHKA2 phosphorylase kinase, alpha 2 (liver) -1.6348
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -1.63476
OGFR opioid growth factor receptor -1.63418
HNF4G hepatocyte nuclear factor 4, gamma -1.61954
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -1.61725
DDHD2 DDHD domain containing 2 -1.61086
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -1.60978
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -1.60375
BUB3 BUB3 mitotic checkpoint protein -1.59942
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -1.59881
NVL nuclear VCP-like -1.59652
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -1.59639
PPP2R2D protein phosphatase 2, regulatory subunit B, delta -1.59616
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -1.59206
SERBP1 SERPINE1 mRNA binding protein 1 -1.59171
CALML3 calmodulin-like 3 -1.58994
CCIN calicin -1.58964
GSTP1 glutathione S-transferase pi 1 -1.58925
TMEM257 transmembrane protein 257 -1.58793
RFC5 replication factor C (activator 1) 5, 36.5kDa -1.58485
INTS7 integrator complex subunit 7 -1.57141
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.56899
MAPK9 mitogen-activated protein kinase 9 -1.56623
FEM1B fem-1 homolog b (C. elegans) -1.56245
HILPDA hypoxia inducible lipid droplet-associated -1.55904
FOXO3 forkhead box O3 -1.55303
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -1.5518
PPP1R8 protein phosphatase 1, regulatory subunit 8 -1.54663
GH2 growth hormone 2 -1.54186
MFSD10 major facilitator superfamily domain containing 10 -1.52324
ETV5 ets variant 5 -1.52087
METAP1 methionyl aminopeptidase 1 -1.50745
PRMT7 protein arginine methyltransferase 7 -1.50048
SYNJ2 synaptojanin 2 -1.49993
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -1.49799
ATN1 atrophin 1 -1.49655
ICT1 immature colon carcinoma transcript 1 -1.49486
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -1.49467
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -1.49349
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 -1.49182
PRELP proline/arginine-rich end leucine-rich repeat protein -1.48794
NCK1 NCK adaptor protein 1 -1.48712
ANAPC5 anaphase promoting complex subunit 5 -1.48401
BRD9 bromodomain containing 9 -1.47089
RERE arginine-glutamic acid dipeptide (RE) repeats -1.46741
CSNK2A1 casein kinase 2, alpha 1 polypeptide -1.46273
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -1.46252
TMEM92-AS1 TMEM92 antisense RNA 1 -1.46052
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -1.45332
NXT2 nuclear transport factor 2-like export factor 2 -1.45195
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -1.45045
CA12 carbonic anhydrase XII -1.44978
REXO2 RNA exonuclease 2 -1.44427
NPR3 natriuretic peptide receptor 3 -1.43015
ZC3H4 zinc finger CCCH-type containing 4 -1.42988
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 -1.42797
ZNF107 zinc finger protein 107 -1.42536
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -1.42249
MLEC malectin -1.42186
CSPG4 chondroitin sulfate proteoglycan 4 -1.42146
ITK IL2-inducible T-cell kinase -1.41302
ADGRL2 adhesion G protein-coupled receptor L2 -1.40936
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -1.40783
FNTB farnesyltransferase, CAAX box, beta -1.40692
MRPS34 mitochondrial ribosomal protein S34 -1.39942
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -1.39586
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -1.3917
TUB tubby bipartite transcription factor -1.39086
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 -1.38992
RNASEH1 ribonuclease H1 -1.38947
RUFY3 RUN and FYVE domain containing 3 -1.38839
RBM8A RNA binding motif protein 8A -1.38831
ZC3H14 zinc finger CCCH-type containing 14 -1.38329
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -1.38263
ADGRA2 adhesion G protein-coupled receptor A2 -1.38082
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -1.37997
KIAA0922 KIAA0922 -1.37792
SZRD1 SUZ RNA binding domain containing 1 -1.37447
KATNB1 katanin p80 (WD repeat containing) subunit B 1 -1.37341
MYBBP1A MYB binding protein (P160) 1a -1.37332
EIF4A3 eukaryotic translation initiation factor 4A3 -1.37276
NUCB2 nucleobindin 2 -1.37017
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -1.36968
PIH1D1 PIH1 domain containing 1 -1.36735
ALMS1 Alstrom syndrome protein 1 -1.36499
ZNF44 zinc finger protein 44 -1.36161
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa -1.36103
ADNP2 ADNP homeobox 2 -1.36053
PMS2P1 postmeiotic segregation increased 2 pseudogene 1 -1.36016
AMBP alpha-1-microglobulin/bikunin precursor -1.35975
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -1.35257
PRSS1 protease, serine, 1 (trypsin 1) -1.34632
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -1.34007
SRP72 signal recognition particle 72kDa -1.33922
SCAMP1 secretory carrier membrane protein 1 -1.33748
LARP4 La ribonucleoprotein domain family, member 4 -1.33637
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -1.33451
RFXAP regulatory factor X-associated protein -1.33223
USP46 ubiquitin specific peptidase 46 -1.32957
RBM38 RNA binding motif protein 38 -1.32837
C1QBP complement component 1, q subcomponent binding protein -1.3271
ANGEL2 angel homolog 2 (Drosophila) -1.32236
AFF1 AF4/FMR2 family, member 1 -1.32226
ELANE elastase, neutrophil expressed -1.32119
VPRBP Vpr (HIV-1) binding protein -1.3136
EPHA3 EPH receptor A3 -1.3116
MVB12B multivesicular body subunit 12B -1.31083
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -1.30953
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -1.30605
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -1.30604
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -1.30274
IL37 interleukin 37 -1.30186
TIPRL TOR signaling pathway regulator -1.30118
RUVBL2 RuvB-like AAA ATPase 2 -1.30049
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -1.30025
SPATA6L spermatogenesis associated 6-like -1.29662
ZNF134 zinc finger protein 134 -1.29144
GAL galanin/GMAP prepropeptide -1.28957
RBM15 RNA binding motif protein 15 -1.28511
HN1L hematological and neurological expressed 1-like -1.28491
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) -1.28206
IDI1 isopentenyl-diphosphate delta isomerase 1 -1.28123
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -1.27767
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -1.2762
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -1.27503
TMEM106C transmembrane protein 106C -1.27299
PDIA5 protein disulfide isomerase family A, member 5 -1.27184
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -1.27143
WDR12 WD repeat domain 12 -1.26467
THOC2 THO complex 2 -1.26308
REEP4 receptor accessory protein 4 -1.26129
TSSC1 tumor suppressing subtransferable candidate 1 -1.26045
SYK spleen tyrosine kinase -1.25598
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -1.2555
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -1.25528
TCF3 transcription factor 3 -1.25479
SDHAP1 succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1 -1.25267
ALG8 ALG8, alpha-1,3-glucosyltransferase -1.25104
TTBK2 tau tubulin kinase 2 -1.24931
DUSP2 dual specificity phosphatase 2 -1.24301
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -1.24279
WIPI2 WD repeat domain, phosphoinositide interacting 2 -1.24212
U2SURP U2 snRNP-associated SURP domain containing -1.23471
HINT1 histidine triad nucleotide binding protein 1 -1.23407
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -1.23302
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -1.23133
MAT2A methionine adenosyltransferase II, alpha -1.23017
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -1.22992
GUF1 GUF1 GTPase homolog (S. cerevisiae) -1.22892
TTF2 transcription termination factor, RNA polymerase II -1.22673
KDM4A lysine (K)-specific demethylase 4A -1.22391
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -1.22091
DENND3 DENN/MADD domain containing 3 -1.21978
CAB39L calcium binding protein 39-like -1.2186
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -1.21838
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 -1.2168
STARD7 StAR-related lipid transfer (START) domain containing 7 -1.21603
KANK2 KN motif and ankyrin repeat domains 2 -1.21416
PREB prolactin regulatory element binding -1.21335
KIAA0226L KIAA0226-like -1.21295
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) -1.21275
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -1.212
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) -1.21076
MRPL22 mitochondrial ribosomal protein L22 -1.20975
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 -1.20934
BATF3 basic leucine zipper transcription factor, ATF-like 3 -1.20875
PEBP1 phosphatidylethanolamine binding protein 1 -1.20674
TLK2 tousled-like kinase 2 -1.20652
SMC4 structural maintenance of chromosomes 4 -1.20313
FKBP4 FK506 binding protein 4, 59kDa -1.20182
HLTF helicase-like transcription factor -1.19869
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -1.19667
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) -1.19297
TTLL5 tubulin tyrosine ligase-like family member 5 -1.19236
REST RE1-silencing transcription factor -1.19092
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -1.18986
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -1.18268
XCL2 chemokine (C motif) ligand 2 -1.18218
MYO9A myosin IXA -1.18197
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 -1.18027
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -1.17951
CIAO1 cytosolic iron-sulfur assembly component 1 -1.17
PGF placental growth factor -1.16927
DKC1 dyskeratosis congenita 1, dyskerin -1.16914
HTRA2 HtrA serine peptidase 2 -1.16908
DNPEP aspartyl aminopeptidase -1.16843
ORAI2 ORAI calcium release-activated calcium modulator 2 -1.16776
TMEM223 transmembrane protein 223 -1.16727
RITA1 RBPJ interacting and tubulin associated 1 -1.16624
AXIN1 axin 1 -1.16549
CETN2 centrin, EF-hand protein, 2 -1.16548
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -1.16461
NPY1R neuropeptide Y receptor Y1 -1.1619
Funding