SYS1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Sys1 golgi trafficking protein|SYS1 forms a complex with ADP-ribosylation factor-related protein ARFRP1 (MIM 604699) and targets ARFRP1 to the Golgi apparatus (Behnia et al., 2004 [PubMed 15077113]).[supplied by OMIM, Aug 2009] (NCBI Entrez Gene Database, 90196)
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Genes

358 genes differentially expressed following the SYS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CDK3 cyclin-dependent kinase 3 2.51936
CD68 CD68 molecule 2.51936
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.51936
RHCG Rh family, C glycoprotein 2.51936
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 2.51936
LRRC38 leucine rich repeat containing 38 2.51936
SPNS2 spinster homolog 2 (Drosophila) 2.51936
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.51936
ADRB1 adrenoceptor beta 1 2.51936
ACVR1C activin A receptor, type IC 2.51936
WDR93 WD repeat domain 93 2.51936
GOLGA6L4 golgin A6 family-like 4 2.51936
SAMD10 sterile alpha motif domain containing 10 2.51936
FOXP2 forkhead box P2 2.51936
PP2D1 protein phosphatase 2C-like domain containing 1 2.51936
RNF222 ring finger protein 222 2.51936
DRD4 dopamine receptor D4 2.51936
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 2.51936
CDH26 cadherin 26 2.51936
GLIPR1 GLI pathogenesis-related 1 2.51936
ZDHHC11B zinc finger, DHHC-type containing 11B 2.51936
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.51936
RXFP1 relaxin/insulin-like family peptide receptor 1 2.51936
LMNTD1 lamin tail domain containing 1 2.51936
DNAAF11 dynein axonemal assembly factor 11 2.51936
TMEM191C transmembrane protein 191C 2.51936
IL23A interleukin 23, alpha subunit p19 2.51936
CRYBA4 crystallin, beta A4 2.51936
MMP20 matrix metallopeptidase 20 2.51936
RNF112 ring finger protein 112 2.51936
SREK1IP1 SREK1-interacting protein 1 2.42194
VCL vinculin 2.42194
APCDD1 adenomatosis polyposis coli down-regulated 1 2.42194
TERT telomerase reverse transcriptase 2.42172
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.42172
RIMBP2 RIMS binding protein 2 2.42172
SYNPO2L synaptopodin 2-like 2.42172
ALOX15 arachidonate 15-lipoxygenase 2.42172
SOX18 SRY (sex determining region Y)-box 18 2.42172
TM4SF1 transmembrane 4 L six family member 1 2.42172
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.42172
IGFL2 IGF-like family member 2 2.42172
CD14 CD14 molecule 2.42172
CD160 CD160 molecule 2.42172
NXPH4 neurexophilin 4 2.42172
MYBPC1 myosin binding protein C, slow type 2.42172
OR10A5 olfactory receptor, family 10, subfamily A, member 5 2.42172
COL15A1 collagen, type XV, alpha 1 2.42172
MMP28 matrix metallopeptidase 28 2.42172
ATOH8 atonal homolog 8 (Drosophila) 2.42172
ATOH7 atonal homolog 7 (Drosophila) 2.42172
MPZ myelin protein zero 2.42172
MRC1 mannose receptor, C type 1 2.42172
GYS2 glycogen synthase 2 (liver) 2.42172
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.42172
TMEM82 transmembrane protein 82 2.42172
PCGF1 polycomb group ring finger 1 2.42172
TTLL2 tubulin tyrosine ligase-like family member 2 2.42172
DUSP10 dual specificity phosphatase 10 2.42172
GSTM5 glutathione S-transferase mu 5 2.42172
TNC tenascin C 2.42172
ADAM33 ADAM metallopeptidase domain 33 2.42172
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 2.42172
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.42172
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.42172
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.42172
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.42172
LRRD1 leucine-rich repeats and death domain containing 1 2.42172
CIMIP2B ciliary microtubule inner protein 2B 2.42172
SEPTIN2 septin 2 2.42172
MACROH2A1 macroH2A.1 histone 2.42172
AANAT aralkylamine N-acetyltransferase 2.42172
PNLIPRP1 pancreatic lipase-related protein 1 2.42172
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.42172
STX12 syntaxin 12 2.42172
KRT86 keratin 86, type II 2.42172
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.42172
TMPRSS2 transmembrane protease, serine 2 2.42172
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.42172
H4C1 H4 clustered histone 1 2.42172
SMIM41 small integral membrane protein 41 2.42172
VEGFD vascular endothelial growth factor D 2.42172
NOTCH2NLB notch 2 N-terminal like B 2.42172
NHERF4 NHERF family PDZ scaffold protein 4 2.42172
NPIPA6 nuclear pore complex interacting protein family, member A6 2.42172
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.42172
H3-7 H3.7 histone (putative) 2.42172
IHO1 interactor of HORMAD1 1 2.42172
CFAP276 cilia and flagella associated protein 276 2.42172
TMEM225B transmembrane protein 225B 2.42172
H4C2 H4 clustered histone 2 2.42172
RTL5 retrotransposon Gag like 5 2.42172
SELL selectin L 2.42172
MROH5 maestro heat-like repeat family member 5 2.42172
LTB lymphotoxin beta (TNF superfamily, member 3) 2.42172
ACTL8 actin-like 8 2.42172
DNAI1 dynein, axonemal, intermediate chain 1 2.42172
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.42172
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.42172
TMEM145 transmembrane protein 145 2.42172
CCDC110 coiled-coil domain containing 110 2.42172
TMPRSS11D transmembrane protease, serine 11D 2.42172
CST11 cystatin 11 2.42172
ZC3H11A zinc finger CCCH-type containing 11A 2.42172
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.42172
PCDHA6 protocadherin alpha 6 2.42172
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.42172
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.42172
PRG4 proteoglycan 4 2.42172
IL1R1 interleukin 1 receptor, type I 2.42172
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.42172
SLAMF1 signaling lymphocytic activation molecule family member 1 2.42172
BHLHA9 basic helix-loop-helix family, member a9 2.42172
HAPLN2 hyaluronan and proteoglycan link protein 2 2.42172
NPIPB9 nuclear pore complex interacting protein family, member B9 2.42172
TMEM233 transmembrane protein 233 2.42172
LDHAL6A lactate dehydrogenase A-like 6A 2.42172
SP140 SP140 nuclear body protein 2.42172
MYO7A myosin VIIA 2.42172
UPP2 uridine phosphorylase 2 2.42172
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.42172
PCDHGA7 protocadherin gamma subfamily A, 7 2.42172
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 2.42172
ISL1 ISL LIM homeobox 1 2.42172
LIME1 Lck interacting transmembrane adaptor 1 2.42172
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.42172
CER1 cerberus 1, DAN family BMP antagonist 2.42172
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.42172
EMILIN1 elastin microfibril interfacer 1 2.42172
KLK12 kallikrein-related peptidase 12 2.42172
SPATA9 spermatogenesis associated 9 2.42172
LRRC15 leucine rich repeat containing 15 2.42172
TTC9B tetratricopeptide repeat domain 9B 2.42172
TBXA2R thromboxane A2 receptor 2.42172
UBQLNL ubiquilin-like 2.42172
BTNL2 butyrophilin-like 2 2.42172
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 2.42172
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.42172
F11 coagulation factor XI 2.42172
IL21R interleukin 21 receptor 2.42172
PLET1 placenta expressed transcript 1 2.42172
PKDREJ polycystin (PKD) family receptor for egg jelly 2.42172
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 2.42172
NPBWR1 neuropeptides B/W receptor 1 2.42172
CYS1 cystin 1 2.42172
CALR3 calreticulin 3 2.42172
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.42172
MXRA8 matrix-remodelling associated 8 2.42172
NYX nyctalopin 2.42172
CLUL1 clusterin-like 1 (retinal) 2.42172
INSL3 insulin-like 3 (Leydig cell) 2.42172
HLA-B major histocompatibility complex, class I, B 2.42172
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.42172
OPTC opticin 2.42172
OTP orthopedia homeobox 2.42172
MEPE matrix extracellular phosphoglycoprotein 2.42172
FBXO15 F-box protein 15 2.42172
STRC stereocilin 2.42172
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.42172
CFAP126 cilia and flagella associated protein 126 2.42172
PFN4 profilin family, member 4 2.42172
CFP complement factor properdin 2.42172
EPHA5 EPH receptor A5 2.42172
GFRAL GDNF family receptor alpha like 2.42172
AGER advanced glycosylation end product-specific receptor 2.42172
SIGLEC15 sialic acid binding Ig-like lectin 15 2.42172
CRHBP corticotropin releasing hormone binding protein 2.42172
PYGO1 pygopus family PHD finger 1 2.42172
TP63 tumor protein p63 2.42172
NT5C1B 5'-nucleotidase, cytosolic IB 2.42172
PLCD4 phospholipase C, delta 4 2.42172
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.42172
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 2.42172
MR1 major histocompatibility complex, class I-related 2.42172
CLIC2 chloride intracellular channel 2 2.42172
ECM1 extracellular matrix protein 1 2.42172
APOA1 apolipoprotein A-I 2.42172
ANKRD37 ankyrin repeat domain 37 2.42172
IRX5 iroquois homeobox 5 2.42172
ACKR3 atypical chemokine receptor 3 2.42172
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.42172
STARD5 StAR-related lipid transfer (START) domain containing 5 2.42172
FGF18 fibroblast growth factor 18 2.42172
RBM15B RNA binding motif protein 15B 2.42172
AOC1 amine oxidase, copper containing 1 2.42172
LAMP5 lysosomal-associated membrane protein family, member 5 2.42172
WFDC11 WAP four-disulfide core domain 11 2.42172
CD80 CD80 molecule 2.42172
FOXG1 forkhead box G1 2.42172
MEIOB meiosis specific with OB domains 2.42172
SHISA3 shisa family member 3 2.42172
RTN4RL1 reticulon 4 receptor-like 1 2.42172
TMEM154 transmembrane protein 154 2.42172
IL12A interleukin 12A 2.42172
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.42172
CTF1 cardiotrophin 1 2.42172
FGF10 fibroblast growth factor 10 2.42172
MYF5 myogenic factor 5 2.42172
EMCN endomucin 2.42172
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.42172
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.42172
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.42172
PARP15 poly (ADP-ribose) polymerase family, member 15 2.42172
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.42172
PSD2 pleckstrin and Sec7 domain containing 2 2.42172
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.42172
TPH1 tryptophan hydroxylase 1 2.42172
FBXO32 F-box protein 32 2.42172
CCDC51 coiled-coil domain containing 51 2.42172
TWIST1 twist family bHLH transcription factor 1 2.42172
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2.4108
DAPL1 death associated protein-like 1 2.37669
BAZ1B bromodomain adjacent to zinc finger domain, 1B 2.37321
NET1 neuroepithelial cell transforming 1 2.37237
ACYP1 acylphosphatase 1, erythrocyte (common) type 2.37168
BLTP2 bridge-like lipid transfer protein family member 2 2.36123
RIMS3 regulating synaptic membrane exocytosis 3 2.31749
SPAG16 sperm associated antigen 16 2.2998
MARCHF4 membrane associated ring-CH-type finger 4 2.2998
ALOX5 arachidonate 5-lipoxygenase 2.2998
PLEKHN1 pleckstrin homology domain containing, family N member 1 2.2998
C9ORF153 chromosome 9 open reading frame 153 2.2998
COL4A4 collagen, type IV, alpha 4 2.29571
PDE3B phosphodiesterase 3B, cGMP-inhibited 2.28007
FAM89B family with sequence similarity 89, member B 2.21483
GRIA3 glutamate receptor, ionotropic, AMPA 3 2.16231
RBBP7 retinoblastoma binding protein 7 2.1301
SLC38A10 solute carrier family 38, member 10 2.13002
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 2.13002
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 2.12266
CDK10 cyclin-dependent kinase 10 2.1132
ORAI1 ORAI calcium release-activated calcium modulator 1 2.11309
EIF3I eukaryotic translation initiation factor 3, subunit I 2.09166
TTC12 tetratricopeptide repeat domain 12 2.09023
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 2.06275
STC1 stanniocalcin 1 2.05834
RND3 Rho family GTPase 3 2.05521
PLD5 phospholipase D family, member 5 2.04749
SFRP4 secreted frizzled-related protein 4 2.04297
MIPOL1 mirror-image polydactyly 1 2.04297
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.01848
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.00936

decreased expression

Symbol Name Standardized Value
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit -2.51936
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 -2.51936
TRIM39 tripartite motif containing 39 -2.51936
ZNF182 zinc finger protein 182 -2.51936
AFAP1L2 actin filament associated protein 1-like 2 -2.51936
CLDN15 claudin 15 -2.42194
TCF24 transcription factor 24 -2.42194
FAAP24 FA core complex associated protein 24 -2.42194
IPO5 importin 5 -2.42172
WIPF3 WAS/WASL interacting protein family, member 3 -2.42172
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.42172
PARP2 poly (ADP-ribose) polymerase 2 -2.42172
ENOSF1 enolase superfamily member 1 -2.42172
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -2.42172
COX18 COX18 cytochrome c oxidase assembly factor -2.42172
SERTAD3 SERTA domain containing 3 -2.42172
RRAGA Ras-related GTP binding A -2.42172
ZNF667 zinc finger protein 667 -2.42172
AXIN2 axin 2 -2.42172
E2F7 E2F transcription factor 7 -2.42172
NRBP1 nuclear receptor binding protein 1 -2.42172
FMN1 formin 1 -2.42172
LNPK lunapark, ER junction formation factor -2.42172
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.42172
SLC38A5 solute carrier family 38, member 5 -2.42172
DPH2 DPH2 homolog (S. cerevisiae) -2.42172
ZBTB49 zinc finger and BTB domain containing 49 -2.42172
PNMA8A PNMA family member 8A -2.42172
GTPBP8 GTP-binding protein 8 (putative) -2.42172
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled -2.42172
ANTXR2 anthrax toxin receptor 2 -2.42172
CGAS cyclic GMP-AMP synthase -2.42172
MAP7D2 MAP7 domain containing 2 -2.42172
C8ORF58 chromosome 8 open reading frame 58 -2.42172
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.42172
SYNJ2BP synaptojanin 2 binding protein -2.42172
SLFNL1 schlafen-like 1 -2.42172
WDR5 WD repeat domain 5 -2.42105
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -2.39322
BVES blood vessel epicardial substance -2.37168
SOX15 SRY (sex determining region Y)-box 15 -2.37168
LINC02762 long intergenic non-protein coding RNA 2762 -2.37168
CRB2 crumbs family member 2 -2.37168
MEGF9 multiple EGF-like-domains 9 -2.37168
NAXD NAD(P)HX dehydratase -2.37168
ADGRG3 adhesion G protein-coupled receptor G3 -2.37168
MYZAP myocardial zonula adherens protein -2.37168
IGSF22 immunoglobulin superfamily, member 22 -2.37168
SMTNL2 smoothelin-like 2 -2.37168
POU2F3 POU class 2 homeobox 3 -2.37168
GDF5 growth differentiation factor 5 -2.37168
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 -2.37168
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -2.37168
ACTRT3 actin-related protein T3 -2.37168
KLK1 kallikrein 1 -2.37168
ZMAT1 zinc finger, matrin-type 1 -2.37168
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -2.37168
FLACC1 flagellum associated containing coiled-coil domains 1 -2.37168
SLC16A13 solute carrier family 16, member 13 -2.37168
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.37168
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -2.37168
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -2.37168
FOXJ1 forkhead box J1 -2.37168
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) -2.37168
BTBD19 BTB (POZ) domain containing 19 -2.37168
RLN1 relaxin 1 -2.37168
POU3F4 POU class 3 homeobox 4 -2.37168
ZNF34 zinc finger protein 34 -2.37168
CA3 carbonic anhydrase III -2.37168
KLHL10 kelch-like family member 10 -2.37168
KLHL18 kelch-like family member 18 -2.37168
TDRD12 tudor domain containing 12 -2.37168
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.37168
MEX3B mex-3 RNA binding family member B -2.37168
EFNA3 ephrin-A3 -2.37168
MAT2A methionine adenosyltransferase II, alpha -2.37028
ZBTB37 zinc finger and BTB domain containing 37 -2.36828
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -2.34964
GRSF1 G-rich RNA sequence binding factor 1 -2.33413
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 -2.32137
CCDC191 coiled-coil domain containing 191 -2.32137
SLCO4C1 solute carrier organic anion transporter family, member 4C1 -2.2781
ZNF589 zinc finger protein 589 -2.27599
SNAP47 synaptosomal-associated protein, 47kDa -2.26806
FMN2 formin 2 -2.26641
CEP15 centrosomal protein 15 -2.25511
TRAF3IP2 TRAF3 interacting protein 2 -2.2417
ARHGAP32 Rho GTPase activating protein 32 -2.22304
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -2.20999
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.20339
LSG1 large 60S subunit nuclear export GTPase 1 -2.19945
PTDSS1 phosphatidylserine synthase 1 -2.16231
TRIB3 tribbles pseudokinase 3 -2.15764
FBXO41 F-box protein 41 -2.15694
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -2.1514
ERCC1 excision repair cross-complementation group 1 -2.13808
WWTR1 WW domain containing transcription regulator 1 -2.13002
ANGPTL2 angiopoietin-like 2 -2.13002
NKAIN4 Na+/K+ transporting ATPase interacting 4 -2.1202
GXYLT1 glucoside xylosyltransferase 1 -2.11944
LSM11 LSM11, U7 small nuclear RNA associated -2.1058
MEPCE methylphosphate capping enzyme -2.10194
ATXN2L ataxin 2-like -2.09023
LGALS8 lectin, galactoside-binding, soluble, 8 -2.0703
CD37 CD37 molecule -2.06846
ENC1 ectodermal-neural cortex 1 (with BTB domain) -2.06051
LPAR3 lysophosphatidic acid receptor 3 -2.05834
OR52A1 olfactory receptor, family 52, subfamily A, member 1 -2.05834
TMUB1 transmembrane and ubiquitin-like domain containing 1 -2.05521
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -2.04297
NELL2 NEL-like 2 (chicken) -2.04297
TRIP12 thyroid hormone receptor interactor 12 -2.03726
CPNE3 copine III -2.02408
COL13A1 collagen, type XIII, alpha 1 -2.02345
RBM47 RNA binding motif protein 47 -2.01977
TARS1 threonyl-tRNA synthetase 1 -2.0117