SYT11 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description synaptotagmin XI|This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010] (NCBI Entrez Gene Database, 23208)
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Genes

359 genes differentially expressed following the SYT11 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHB11 protocadherin beta 11 2.49344
LRRD1 leucine-rich repeats and death domain containing 1 2.49344
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.49344
FGD2 FYVE, RhoGEF and PH domain containing 2 2.49344
COLEC10 collectin sub-family member 10 (C-type lectin) 2.49344
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.49344
BTN1A1 butyrophilin, subfamily 1, member A1 2.49344
CABP4 calcium binding protein 4 2.49344
TSG101 tumor susceptibility 101 2.49344
ZNF467 zinc finger protein 467 2.49344
RRAD Ras-related associated with diabetes 2.49344
NAPSA napsin A aspartic peptidase 2.49344
RASL10A RAS-like, family 10, member A 2.49344
SLC35D3 solute carrier family 35, member D3 2.49344
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.49344
SYCP2 synaptonemal complex protein 2 2.49344
MEP1B meprin A, beta 2.49344
TMPRSS11B transmembrane protease, serine 11B 2.49344
HLX H2.0-like homeobox 2.49344
FOLR1 folate receptor 1 (adult) 2.49344
SLFN11 schlafen family member 11 2.49344
RHOXF2B Rhox homeobox family, member 2B 2.49344
AGTR1 angiotensin II receptor, type 1 2.49344
CXORF65 chromosome X open reading frame 65 2.49344
PROB1 proline-rich basic protein 1 2.49344
WT1 Wilms tumor 1 2.49344
SHISA7 shisa family member 7 2.49344
ZEB2 zinc finger E-box binding homeobox 2 2.49344
ADAT3 adenosine deaminase, tRNA-specific 3 2.49344
WNT8B wingless-type MMTV integration site family, member 8B 2.49344
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.49344
TAS2R13 taste receptor, type 2, member 13 2.49344
ACOT12 acyl-CoA thioesterase 12 2.49344
MPL MPL proto-oncogene, thrombopoietin receptor 2.49344
BMP5 bone morphogenetic protein 5 2.49344
FAM110D family with sequence similarity 110, member D 2.49344
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.49344
NRROS negative regulator of reactive oxygen species 2.49344
GJB5 gap junction protein, beta 5, 31.1kDa 2.49344
OSBPL7 oxysterol binding protein-like 7 2.49344
SIGLEC7 sialic acid binding Ig-like lectin 7 2.49344
LRG1 leucine-rich alpha-2-glycoprotein 1 2.49344
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.49344
NEU4 sialidase 4 2.49344
GPR20 G protein-coupled receptor 20 2.49344
ADAD2 adenosine deaminase domain containing 2 2.49344
SLC23A3 solute carrier family 23, member 3 2.49344
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) 2.49344
LVRN laeverin 2.49344
TRIM67 tripartite motif containing 67 2.49344
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.49344
ATP5F1E ATP synthase F1 subunit epsilon 2.49344
FYB1 FYN binding protein 1 2.49344
CCDC9B coiled-coil domain containing 9B 2.49344
ZNF728 zinc finger protein 728 2.49344
AVPR1A arginine vasopressin receptor 1A 2.49344
ADPRHL1 ADP-ribosylhydrolase like 1 2.49344
GPR35 G protein-coupled receptor 35 2.49344
ZG16 zymogen granule protein 16 2.49344
C9ORF43 chromosome 9 open reading frame 43 2.49344
TRIM31 tripartite motif containing 31 2.49344
DEPP1 DEPP autophagy regulator 1 2.49344
NSG2 neuronal vesicle trafficking associated 2 2.49344
DRC11L dynein regulatory complex subunit 11 like 2.49344
CIMIP2A ciliary microtubule inner protein 2A 2.49344
C8ORF90 chromosome 8 open reading frame 90 2.49344
GREP1 glycine rich extracellular protein 1 2.49344
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.49344
AKAIN1 A-kinase anchor inhibitor 1 2.49344
ARMH2 armadillo like helical domain containing 2 2.49344
H1-8 H1.8 linker histone 2.49344
CLXN calaxin 2.49344
CBLIF cobalamin binding intrinsic factor 2.49344
MYEOV myeloma overexpressed 2.49344
DOK7 docking protein 7 2.49344
GRAP GRB2-related adaptor protein 2.49344
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.49344
MIA melanoma inhibitory activity 2.49344
NHLRC4 NHL repeat containing 4 2.49344
S1PR4 sphingosine-1-phosphate receptor 4 2.49344
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.49344
AXDND1 axonemal dynein light chain domain containing 1 2.49344
CD47 CD47 molecule 2.49344
FAM43B family with sequence similarity 43, member B 2.49344
CLEC3A C-type lectin domain family 3, member A 2.49344
EDAR ectodysplasin A receptor 2.49344
GJD2 gap junction protein, delta 2, 36kDa 2.49344
S100B S100 calcium binding protein B 2.49344
CSAG1 chondrosarcoma associated gene 1 2.49344
HNF1B HNF1 homeobox B 2.49344
WNT9B wingless-type MMTV integration site family, member 9B 2.49344
PNPLA1 patatin-like phospholipase domain containing 1 2.49344
ABHD15 abhydrolase domain containing 15 2.49344
IL1R1 interleukin 1 receptor, type I 2.49344
C6 complement component 6 2.49344
C7 complement component 7 2.49344
TSPO2 translocator protein 2 2.49344
OVOL1 ovo-like zinc finger 1 2.49344
ITK IL2-inducible T-cell kinase 2.49344
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.49344
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.49344
S100Z S100 calcium binding protein Z 2.49344
GCOM1 GRINL1A complex locus 1 2.49344
NANOGNB NANOG neighbor homeobox 2.49344
NOX1 NADPH oxidase 1 2.49344
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.49344
KLF2 Kruppel-like factor 2 2.49344
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.49344
GML glycosylphosphatidylinositol anchored molecule like 2.49344
ADAM7 ADAM metallopeptidase domain 7 2.49344
CALHM2 calcium homeostasis modulator 2 2.49344
NPFFR1 neuropeptide FF receptor 1 2.49344
OR9A2 olfactory receptor, family 9, subfamily A, member 2 2.49344
AQP7 aquaporin 7 2.49344
A3GALT2 alpha 1,3-galactosyltransferase 2 2.49344
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.49344
APLNR apelin receptor 2.49344
MR1 major histocompatibility complex, class I-related 2.49344
RAD21L1 RAD21-like 1 (S. pombe) 2.49344
DNAH12 dynein, axonemal, heavy chain 12 2.49344
NXNL1 nucleoredoxin-like 1 2.49344
ZSCAN10 zinc finger and SCAN domain containing 10 2.49344
CLDN34 claudin 34 2.49344
GPR12 G protein-coupled receptor 12 2.49344
THTPA thiamine triphosphatase 2.49344
AKNAD1 AKNA domain containing 1 2.49344
PAGE4 P antigen family, member 4 (prostate associated) 2.49344
CD27 CD27 molecule 2.49344
RGS7 regulator of G-protein signaling 7 2.49344
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.49344
POU4F1 POU class 4 homeobox 1 2.49344
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.49344
ESPNL espin-like 2.49344
GAS2L2 growth arrest-specific 2 like 2 2.49344
ADAM18 ADAM metallopeptidase domain 18 2.49344
LMX1B LIM homeobox transcription factor 1, beta 2.49344
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.49344
DRC1 dynein regulatory complex subunit 1 2.49344
AFF3 AF4/FMR2 family, member 3 2.49344
DMRT1 doublesex and mab-3 related transcription factor 1 2.49344
CLEC4G C-type lectin domain family 4, member G 2.49344
MAB21L2 mab-21-like 2 (C. elegans) 2.49344
C2CD4A C2 calcium-dependent domain containing 4A 2.49344
PHOX2A paired-like homeobox 2a 2.49344
C8ORF89 chromosome 8 open reading frame 89 2.49344
KLK15 kallikrein-related peptidase 15 2.49344
CATIP ciliogenesis associated TTC17 interacting protein 2.49344
TTC16 tetratricopeptide repeat domain 16 2.49344
COPS4 COP9 signalosome subunit 4 2.49344
KLK2 kallikrein-related peptidase 2 2.49344
CFAP47 cilia and flagella associated protein 47 2.49344
CFH complement factor H 2.49344
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.49344
RERGL RERG/RAS-like 2.49344
GPR179 G protein-coupled receptor 179 2.49344
ASCL1 achaete-scute family bHLH transcription factor 1 2.49344
MAGEA12 melanoma antigen family A12 2.49344
BANF2 barrier to autointegration factor 2 2.49344
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.49344
SNTN sentan, cilia apical structure protein 2.49344
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.49344
TNS2 tensin 2 2.49344
TGM4 transglutaminase 4 2.49344
TEX38 testis expressed 38 2.49344
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2.49344
MT1A metallothionein 1A 2.49344
CARNS1 carnosine synthase 1 2.49344
KIF19 kinesin family member 19 2.49344
TMEM184B transmembrane protein 184B 2.49344
ERMN ermin, ERM-like protein 2.49344
WFDC11 WAP four-disulfide core domain 11 2.49344
BOLL boule-like RNA-binding protein 2.49344
NRGN neurogranin (protein kinase C substrate, RC3) 2.49344
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 2.49344
NEUROD2 neuronal differentiation 2 2.49344
TBC1D26 TBC1 domain family, member 26 2.49344
NLRP8 NLR family, pyrin domain containing 8 2.49344
DNAH8 dynein, axonemal, heavy chain 8 2.49344
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.49344
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.49344
CS citrate synthase 2.48561
SYCE2 synaptonemal complex central element protein 2 2.46983
ZNF425 zinc finger protein 425 2.45815
WASF3 WAS protein family, member 3 2.42649
MAMLD1 mastermind-like domain containing 1 2.41675
ZNF853 zinc finger protein 853 2.41675
MMP12 matrix metallopeptidase 12 2.41675
SLC26A7 solute carrier family 26 (anion exchanger), member 7 2.41675
PARD3B par-3 family cell polarity regulator beta 2.40643
TSEN15 TSEN15 tRNA splicing endonuclease subunit 2.40643
ZNF429 zinc finger protein 429 2.40631
ATPSCKMT ATP synthase c subunit lysine N-methyltransferase 2.40103
ZNF83 zinc finger protein 83 2.39383
RALY RALY heterogeneous nuclear ribonucleoprotein 2.3826
TTC29 tetratricopeptide repeat domain 29 2.37902
CREBRF CREB3 regulatory factor 2.37214
EXT2 exostosin glycosyltransferase 2 2.36391
DNALI1 dynein, axonemal, light intermediate chain 1 2.34758
THAP11 THAP domain containing 11 2.34748
ADGRV1 adhesion G protein-coupled receptor V1 2.3024
RAB25 RAB25, member RAS oncogene family 2.28001
DTNB dystrobrevin, beta 2.24442
RND1 Rho family GTPase 1 2.21244
METTL22 methyltransferase like 22 2.2019
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.20005
ZNF14 zinc finger protein 14 2.16895
LUC7L3 LUC7-like 3 (S. cerevisiae) 2.16088
PARD6B par-6 family cell polarity regulator beta 2.1556
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.13309
UBQLN1 ubiquilin 1 2.10407
LGI4 leucine-rich repeat LGI family, member 4 2.10405
ZNF681 zinc finger protein 681 2.07491
DMGDH dimethylglycine dehydrogenase 2.07314
SSUH2 ssu-2 homolog (C. elegans) 2.06985
RNF220 ring finger protein 220 2.05527
PGK1 phosphoglycerate kinase 1 2.05345
STXBP5L syntaxin binding protein 5-like 2.04663
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 2.04663
CMKLR2 chemerin chemokine-like receptor 2 2.04663
STS steroid sulfatase (microsomal), isozyme S 2.04663
KRABD5 KRAB domain containing 5 2.04663
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 2.04427
THOC3 THO complex 3 2.04427
SLC38A2 solute carrier family 38, member 2 2.04322
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 2.02501
ZMYM1 zinc finger, MYM-type 1 2.02133
TMEM231 transmembrane protein 231 2.01311
MTF1 metal-regulatory transcription factor 1 2.01311
MFAP3 microfibrillar-associated protein 3 2.00974
PAMR1 peptidase domain containing associated with muscle regeneration 1 2.00511
TFR2 transferrin receptor 2 2.00174
PLEKHM3 pleckstrin homology domain containing, family M, member 3 2.0003
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.0003

decreased expression

Symbol Name Standardized Value
CPM carboxypeptidase M -2.49344
PCDHB16 protocadherin beta 16 -2.49344
SH3RF3 SH3 domain containing ring finger 3 -2.49344
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -2.49344
PDCD2 programmed cell death 2 -2.49344
PADI3 peptidyl arginine deiminase, type III -2.49344
INHBA inhibin, beta A -2.49344
TMEM101 transmembrane protein 101 -2.49344
ZNF783 zinc finger family member 783 -2.49344
PRAM1 PML-RARA regulated adaptor molecule 1 -2.49344
PRKG2 protein kinase, cGMP-dependent, type II -2.49344
ZDHHC11B zinc finger, DHHC-type containing 11B -2.49344
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.49344
FSD2 fibronectin type III and SPRY domain containing 2 -2.49344
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.49344
DEPDC1 DEP domain containing 1 -2.49344
H2BC8 H2B clustered histone 8 -2.49344
CCDC196 coiled-coil domain containing 196 -2.49344
MYLK4 myosin light chain kinase family, member 4 -2.49344
HFE hemochromatosis -2.49344
VSTM4 V-set and transmembrane domain containing 4 -2.49344
AHR aryl hydrocarbon receptor -2.49344
RLN1 relaxin 1 -2.49344
DGKQ diacylglycerol kinase, theta 110kDa -2.49344
PIWIL4 piwi-like RNA-mediated gene silencing 4 -2.49344
PRKACB protein kinase, cAMP-dependent, catalytic, beta -2.4732
NRG4 neuregulin 4 -2.4339
ADORA1 adenosine A1 receptor -2.4339
TMEM221 transmembrane protein 221 -2.4339
PCGF5 polycomb group ring finger 5 -2.4339
CNTNAP1 contactin associated protein 1 -2.4339
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.4339
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -2.42649
ZNF740 zinc finger protein 740 -2.42649
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.41809
DCST1 DC-STAMP domain containing 1 -2.40643
PRMT2IP PRMT2 interacting protein -2.40643
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.40643
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.40643
PSORS1C2 psoriasis susceptibility 1 candidate 2 -2.40643
CA9 carbonic anhydrase IX -2.40643
HES2 hes family bHLH transcription factor 2 -2.40643
C2ORF80 chromosome 2 open reading frame 80 -2.40643
SLC39A5 solute carrier family 39 (zinc transporter), member 5 -2.40643
LRRC32 leucine rich repeat containing 32 -2.40643
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B -2.40643
PCDHA11 protocadherin alpha 11 -2.40643
ILDR2 immunoglobulin-like domain containing receptor 2 -2.40643
CFP complement factor properdin -2.40643
AMN amnion associated transmembrane protein -2.40643
PALLD palladin, cytoskeletal associated protein -2.40643
COX8C cytochrome c oxidase subunit VIIIC -2.40643
CFAP119 cilia and flagella associated protein 119 -2.40643
ATP5MGL ATP synthase membrane subunit g like -2.40643
CCDC178 coiled-coil domain containing 178 -2.40643
GJA4 gap junction protein, alpha 4, 37kDa -2.40643
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -2.40643
SLA2 Src-like-adaptor 2 -2.40643
GFAP glial fibrillary acidic protein -2.40643
WDR64 WD repeat domain 64 -2.40643
CYSLTR1 cysteinyl leukotriene receptor 1 -2.40643
DGCR6 DiGeorge syndrome critical region gene 6 -2.40643
ZFP57 ZFP57 zinc finger protein -2.40643
PLIN4 perilipin 4 -2.40643
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -2.40643
IHO1 interactor of HORMAD1 1 -2.40643
CORO1B coronin, actin binding protein, 1B -2.37394
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 -2.36391
ITPRIPL1 inositol 1,4,5-trisphosphate receptor interacting protein-like 1 -2.35938
UBC ubiquitin C -2.33984
BLM Bloom syndrome, RecQ helicase-like -2.33984
WDR11 WD repeat domain 11 -2.32633
PTDSS1 phosphatidylserine synthase 1 -2.321
ATOSB atos homolog B -2.31604
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.31604
SMC1B structural maintenance of chromosomes 1B -2.30879
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.3024
COMMD10 COMM domain containing 10 -2.27528
VCF1 VCP nuclear cofactor family member 1 -2.27528
ADCY2 adenylate cyclase 2 (brain) -2.27528
CSAD cysteine sulfinic acid decarboxylase -2.25861
PRICKLE3 prickle homolog 3 (Drosophila) -2.25354
SOS1 son of sevenless homolog 1 (Drosophila) -2.25354
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -2.24442
PRPF31 pre-mRNA processing factor 31 -2.24441
AMZ2 archaelysin family metallopeptidase 2 -2.24304
GPR155 G protein-coupled receptor 155 -2.23698
AAK1 AP2 associated kinase 1 -2.20436
TM6SF2 transmembrane 6 superfamily member 2 -2.19818
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -2.19818
CLOCK clock circadian regulator -2.19573
AP2A1 adaptor-related protein complex 2, alpha 1 subunit -2.18609
ASIC1 acid sensing (proton gated) ion channel 1 -2.17793
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -2.17619
COMMD2 COMM domain containing 2 -2.16088
PLTP phospholipid transfer protein -2.16049
E2F2 E2F transcription factor 2 -2.15845
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -2.13889
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) -2.13701
CHD2 chromodomain helicase DNA binding protein 2 -2.11804
NENF neudesin neurotrophic factor -2.10407
ATF6B activating transcription factor 6 beta -2.10405
RAB7A RAB7A, member RAS oncogene family -2.10088
SLC35D4 solute carrier family 35 member D4 -2.07332
TAC1 tachykinin, precursor 1 -2.07093
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled -2.07093
DHFR dihydrofolate reductase -2.07093
GARIN2 golgi associated RAB2 interactor family member 2 -2.07093
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -2.05527
IQANK1 IQ motif and ankyrin repeat containing 1 -2.05527
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -2.05284
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.04663
ESRRG estrogen-related receptor gamma -2.04457
DCBLD1 discoidin, CUB and LCCL domain containing 1 -2.03941
CAMKMT calmodulin-lysine N-methyltransferase -2.02829
ZNF182 zinc finger protein 182 -2.02829
TMEM14A transmembrane protein 14A -2.02501
C8ORF33 chromosome 8 open reading frame 33 -2.01362
RAD9A RAD9 homolog A (S. pombe) -2.01311
ZNF780A zinc finger protein 780A -2.00974
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -2.00974
ZNF658 zinc finger protein 658 -2.00174
SMIM36 small integral membrane protein 36 -2.00109
CEP43 centrosomal protein 43 -2.00101
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.0003
C11ORF24 chromosome 11 open reading frame 24 -2.0003