SYT12 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description synaptotagmin XII|This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010] (NCBI Entrez Gene Database, 91683)
Similar Terms
Downloads & Tools

Genes

355 genes differentially expressed following the SYT12 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.97421
OSR2 odd-skipped related transciption factor 2 3.97421
AADACL3 arylacetamide deacetylase-like 3 3.97421
LRRC53 leucine rich repeat containing 53 3.97421
MTTP microsomal triglyceride transfer protein 3.97421
RSPO1 R-spondin 1 3.97421
RPE65 retinal pigment epithelium-specific protein 65kDa 3.97421
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.97421
GPR26 G protein-coupled receptor 26 3.97421
TNIP3 TNFAIP3 interacting protein 3 3.97421
UNC13C unc-13 homolog C (C. elegans) 3.97421
SSTR1 somatostatin receptor 1 3.97421
HGD homogentisate 1,2-dioxygenase 3.97421
VTN vitronectin 3.97421
USP26 ubiquitin specific peptidase 26 3.97421
GIP gastric inhibitory polypeptide 3.97421
SLC46A3 solute carrier family 46, member 3 3.97421
IGFL2 IGF-like family member 2 3.97421
TRIM15 tripartite motif containing 15 3.97421
MAGEA8 melanoma antigen family A8 3.97421
ADRB2 adrenoceptor beta 2, surface 3.97421
GFRA3 GDNF family receptor alpha 3 3.97421
GMFG glia maturation factor, gamma 3.97421
OR1L8 olfactory receptor, family 1, subfamily L, member 8 3.97421
TNS4 tensin 4 3.97421
NKD2 naked cuticle homolog 2 (Drosophila) 3.97421
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.97421
HRG histidine-rich glycoprotein 3.97421
EBI3 Epstein-Barr virus induced 3 3.97421
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.97421
SPDEF SAM pointed domain containing ETS transcription factor 3.97421
GRM6 glutamate receptor, metabotropic 6 3.97421
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.97421
RBP4 retinol binding protein 4, plasma 3.97421
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.97421
RNF39 ring finger protein 39 3.97421
TSHZ1 teashirt zinc finger homeobox 1 3.97421
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.97421
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.97421
DPPA3 developmental pluripotency associated 3 3.97421
CX3CR1 chemokine (C-X3-C motif) receptor 1 3.97421
TMEM82 transmembrane protein 82 3.97421
MIOX myo-inositol oxygenase 3.97421
LRRC63 leucine rich repeat containing 63 3.97421
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 3.97421
LGALS9 lectin, galactoside-binding, soluble, 9 3.97421
WFDC13 WAP four-disulfide core domain 13 3.97421
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 3.97421
SPMAP1 sperm microtubule associated protein 1 3.97421
PLCZ1 phospholipase C, zeta 1 3.97421
IQCF1 IQ motif containing F1 3.97421
ASB4 ankyrin repeat and SOCS box containing 4 3.97421
LY6K lymphocyte antigen 6 complex, locus K 3.97421
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 3.97421
PARVG parvin, gamma 3.97421
TUBA4B tubulin, alpha 4b 3.97421
CNTN3 contactin 3 (plasmacytoma associated) 3.97421
PCDHGC4 protocadherin gamma subfamily C, 4 3.97421
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.97421
FIMP1 fertilization-influencing membrane protein 1 3.97421
KRT86 keratin 86, type II 3.97421
TNS1-AS1 TNS1 antisense RNA 1 3.97421
PRRT1B proline rich transmembrane protein 1B 3.97421
CFAP97D2 CFAP97 domain containing 2 3.97421
CD8B2 CD8b2 molecule 3.97421
SMIM31 small integral membrane protein 31 3.97421
JAML junction adhesion molecule like 3.97421
PLPP4 phospholipid phosphatase 4 3.97421
OTOF otoferlin 3.97421
CAPN3 calpain 3, (p94) 3.97421
ASIC3 acid sensing (proton gated) ion channel 3 3.97421
PGA5 pepsinogen 5, group I (pepsinogen A) 3.97421
GTSF1 gametocyte specific factor 1 3.97421
PRB4 proline-rich protein BstNI subfamily 4 3.97421
PCDHA3 protocadherin alpha 3 3.97421
LIPK lipase, family member K 3.97421
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 3.97421
ERAS ES cell expressed Ras 3.97421
KLHL35 kelch-like family member 35 3.97421
PLVAP plasmalemma vesicle associated protein 3.97421
COL7A1 collagen, type VII, alpha 1 3.97421
UPK3B uroplakin 3B 3.97421
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.97421
WDR38 WD repeat domain 38 3.97421
C5ORF58 chromosome 5 open reading frame 58 3.97421
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 3.97421
SLAMF6 SLAM family member 6 3.97421
MIA melanoma inhibitory activity 3.97421
GGACT gamma-glutamylamine cyclotransferase 3.97421
TMEM236 transmembrane protein 236 3.97421
SCN10A sodium channel, voltage gated, type X alpha subunit 3.97421
HPR haptoglobin-related protein 3.97421
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 3.97421
EDAR ectodysplasin A receptor 3.97421
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.97421
ZNF366 zinc finger protein 366 3.97421
AQP7 aquaporin 7 3.97421
DUOX2 dual oxidase 2 3.97421
TPSG1 tryptase gamma 1 3.97421
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 3.97421
AKNAD1 AKNA domain containing 1 3.97421
APOC2 apolipoprotein C-II 3.97421
CAGE1 cancer antigen 1 3.97421
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 3.97421
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 3.97421
C2CD4D C2 calcium-dependent domain containing 4D 3.97421
AQP4 aquaporin 4 3.97421
BTNL2 butyrophilin-like 2 3.97421
RPA4 replication protein A4, 30kDa 3.97421
TAT tyrosine aminotransferase 3.97421
LRCOL1 leucine rich colipase-like 1 3.97421
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.97421
ENDOU endonuclease, polyU-specific 3.97421
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.97421
CNTF ciliary neurotrophic factor 3.97421
RAD21L1 RAD21-like 1 (S. pombe) 3.97421
EDN3 endothelin 3 3.97421
EFCAB9 EF-hand calcium binding domain 9 3.97421
MUC13 mucin 13, cell surface associated 3.97421
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 3.97421
KLK6 kallikrein-related peptidase 6 3.97421
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.97421
NYX nyctalopin 3.97421
MSMP microseminoprotein, prostate associated 3.97421
ABLIM3 actin binding LIM protein family, member 3 3.97421
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.97421
PCDHAC1 protocadherin alpha subfamily C, 1 3.97421
MEIS1 Meis homeobox 1 3.97421
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.97421
OR52N1 olfactory receptor, family 52, subfamily N, member 1 3.97421
SIDT1 SID1 transmembrane family, member 1 3.97421
TCAP titin-cap 3.97421
PRTN3 proteinase 3 3.97421
RELN reelin 3.97421
LENEP lens epithelial protein 3.97421
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.97421
CTXN2 cortexin 2 3.97421
RBM20 RNA binding motif protein 20 3.97421
RASL11A RAS-like, family 11, member A 3.97421
TPPP2 tubulin polymerization-promoting protein family member 2 3.97421
DMRT1 doublesex and mab-3 related transcription factor 1 3.97421
TSPYL6 TSPY-like 6 3.97421
DLX5 distal-less homeobox 5 3.97421
ITGA8 integrin, alpha 8 3.97421
ABHD1 abhydrolase domain containing 1 3.97421
ARGFX arginine-fifty homeobox 3.97421
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.97421
GGN gametogenetin 3.97421
AOC3 amine oxidase, copper containing 3 3.97421
IL17B interleukin 17B 3.97421
ANGPTL3 angiopoietin-like 3 3.97421
TAS2R46 taste receptor, type 2, member 46 3.97421
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.97421
POPDC2 popeye domain containing 2 3.97421
TMPRSS15 transmembrane protease, serine 15 3.97421
PMP2 peripheral myelin protein 2 3.97421
SYTL5 synaptotagmin-like 5 3.97421
TMEM52B transmembrane protein 52B 3.97421
FGF10 fibroblast growth factor 10 3.97421
PATE2 prostate and testis expressed 2 3.97421
CLCNKA chloride channel, voltage-sensitive Ka 3.97421
NLRP6 NLR family, pyrin domain containing 6 3.97421
BMX BMX non-receptor tyrosine kinase 3.97421
SDSL serine dehydratase-like 3.97421
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 3.9639
SFN stratifin 3.93238
RUMY1 regulator of UNG2 and MKLN1 interacting yippee protein 1 3.43717
FAM135A family with sequence similarity 135, member A 3.31946
MSANTD7 Myb/SANT DNA binding domain containing 7 3.22594
CRIP2 cysteine-rich protein 2 3.21083
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 3.21083
TOE1 target of EGR1, member 1 (nuclear) 3.06862
VSTM2L V-set and transmembrane domain containing 2 like 2.91057
BAIAP3 BAI1-associated protein 3 2.91057
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.91057
ZNF862 zinc finger protein 862 2.91057
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.796
PIAS3 protein inhibitor of activated STAT, 3 2.7919
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 2.71797
CENPF centromere protein F, 350/400kDa 2.67446
TIPIN TIMELESS interacting protein 2.64364
RMP64 ribonuclease MRP subunit p64 2.62828
CADM2 cell adhesion molecule 2 2.62162
ZNF354C zinc finger protein 354C 2.61235
SF3B5 splicing factor 3b, subunit 5, 10kDa 2.60453
MTG1 mitochondrial ribosome-associated GTPase 1 2.59919
PPIH peptidylprolyl isomerase H (cyclophilin H) 2.55779
LDB2 LIM domain binding 2 2.55779
COPS7A COP9 signalosome subunit 7A 2.52487
RNF216 ring finger protein 216 2.48846
CHMP2A charged multivesicular body protein 2A 2.48551
LRRC75A leucine rich repeat containing 75A 2.47909
TMEM80 transmembrane protein 80 2.47494
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 2.45528
STX18 syntaxin 18 2.39204
PDZD7 PDZ domain containing 7 2.38405
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.38405
CDHR1 cadherin-related family member 1 2.38405
MEIG1 meiosis/spermiogenesis associated 1 2.37818
FAM174B family with sequence similarity 174, member B 2.37093
GNA12 guanine nucleotide binding protein (G protein) alpha 12 2.35564
SYPL1 synaptophysin-like 1 2.3465
AKAP10 A kinase (PRKA) anchor protein 10 2.32758
LOXL1 lysyl oxidase-like 1 2.31775
VASH1 vasohibin 1 2.30679
DRC2 dynein regulatory complex subunit 2 2.2946
YAE1 YAE1 maturation factor of ABCE1 2.27843
SIM1 single-minded family bHLH transcription factor 1 2.27652
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.27652
NSG2 neuronal vesicle trafficking associated 2 2.27652
GPR78 G protein-coupled receptor 78 2.27652
KIAA1328 KIAA1328 2.2707
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.25565
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.2529
GRSF1 G-rich RNA sequence binding factor 1 2.2529
ATF7 activating transcription factor 7 2.24184
EFNA2 ephrin-A2 2.24184
ARID3A AT rich interactive domain 3A (BRIGHT-like) 2.19725
RAB21 RAB21, member RAS oncogene family 2.19371
ARF3 ADP-ribosylation factor 3 2.16821
CADPS2 Ca++-dependent secretion activator 2 2.16202
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 2.16202
TTL tubulin tyrosine ligase 2.14609
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae) 2.14262
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.14237
ARFIP1 ADP-ribosylation factor interacting protein 1 2.13929
SPDYE12 speedy/RINGO cell cycle regulator family member E12 2.07674
TPM2 tropomyosin 2 (beta) 2.03973
MXD4 MAX dimerization protein 4 2.03904
ZNF695 zinc finger protein 695 2.03904
MPP1 membrane protein, palmitoylated 1, 55kDa 2.02781
MORN4 MORN repeat containing 4 2.0278
NBPF15 neuroblastoma breakpoint family, member 15 2.0278
ARID5A AT rich interactive domain 5A (MRF1-like) 2.02341
RNF169 ring finger protein 169 2.02082
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2.01477
MED7 mediator complex subunit 7 2.01095
GRK6 G protein-coupled receptor kinase 6 2.00735
BKGD beta-keto-L-gulonate decarboxylase 2.00555
SRSF12 serine/arginine-rich splicing factor 12 2.00208

decreased expression

Symbol Name Standardized Value
RFX8 RFX family member 8, lacking RFX DNA binding domain -3.97421
CARD14 caspase recruitment domain family, member 14 -3.97421
CALHM2 calcium homeostasis modulator 2 -3.97421
C12ORF42 chromosome 12 open reading frame 42 -3.97421
MYL5 myosin, light chain 5, regulatory -3.97421
SNCG synuclein, gamma (breast cancer-specific protein 1) -3.97421
MUC4 mucin 4, cell surface associated -3.97421
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -3.97421
QRFPR pyroglutamylated RFamide peptide receptor -3.97421
CCDC194 coiled-coil domain containing 194 -3.97421
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -3.97421
LAMP5 lysosomal-associated membrane protein family, member 5 -3.95235
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -3.95235
POU3F2 POU class 3 homeobox 2 -3.95235
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -3.95235
CCDC17 coiled-coil domain containing 17 -3.95235
TRAF3IP3 TRAF3 interacting protein 3 -3.95235
CIITA class II, major histocompatibility complex, transactivator -3.95235
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -3.95235
ZNF492 zinc finger protein 492 -3.95235
TECTA tectorin alpha -3.95235
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -3.95235
DEGS2 delta(4)-desaturase, sphingolipid 2 -3.95235
BTC betacellulin -3.95235
HPCAL4 hippocalcin like 4 -3.95235
BRICD5 BRICHOS domain containing 5 -3.95235
MISP mitotic spindle positioning -3.95235
C1ORF167 chromosome 1 open reading frame 167 -3.95235
GHRHR growth hormone releasing hormone receptor -3.95235
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -3.95235
EFCAB12 EF-hand calcium binding domain 12 -3.95235
C4ORF50 chromosome 4 open reading frame 50 -3.95235
CALR3 calreticulin 3 -3.95235
CATSPERT catsper channel auxiliary subunit tau -3.95235
LTF lactotransferrin -3.95235
PMP22 peripheral myelin protein 22 -3.95235
C3 complement component 3 -3.95235
SPDYE16 speedy/RINGO cell cycle regulator family member E16 -3.95235
ERICH6 glutamate-rich 6 -3.95235
MYOT myotilin -3.95235
PGLYRP1 peptidoglycan recognition protein 1 -3.95235
CHEK2 checkpoint kinase 2 -3.89475
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -3.82193
ICOSLG inducible T-cell co-stimulator ligand -3.82193
GCC2 GRIP and coiled-coil domain containing 2 -3.63875
GLT8D2 glycosyltransferase 8 domain containing 2 -3.15404
TMEM238 transmembrane protein 238 -3.13115
ZBTB21 zinc finger and BTB domain containing 21 -3.10361
RIPOR1 RHO family interacting cell polarization regulator 1 -3.06243
NKAIN1 Na+/K+ transporting ATPase interacting 1 -3.02346
PRKCSH protein kinase C substrate 80K-H -2.91057
ANGEL1 angel homolog 1 (Drosophila) -2.88581
HSPB8 heat shock 22kDa protein 8 -2.88581
NFIL3 nuclear factor, interleukin 3 regulated -2.81726
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.7919
RIBC1 RIB43A domain with coiled-coils 1 -2.71936
ELL3 elongation factor RNA polymerase II-like 3 -2.71936
MYOM1 myomesin 1 -2.71936
CFAP53 cilia and flagella associated protein 53 -2.71936
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -2.71488
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.63539
FKBP11 FK506 binding protein 11, 19 kDa -2.59919
DYNLT5 dynein light chain Tctex-type family member 5 -2.59152
KIAA1671 KIAA1671 -2.57468
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 -2.56135
MTRF1 mitochondrial translational release factor 1 -2.55779
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -2.52017
PHF2 PHD finger protein 2 -2.48846
QPCTL glutaminyl-peptide cyclotransferase-like -2.48551
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -2.47529
SMN2 survival of motor neuron 2, centromeric -2.45783
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.45415
ABI3BP ABI family, member 3 (NESH) binding protein -2.42941
ADCK5 aarF domain containing kinase 5 -2.42941
FBP2 fructose-1,6-bisphosphatase 2 -2.42941
NCMAP noncompact myelin associated protein -2.42941
SKA2 spindle and kinetochore associated complex subunit 2 -2.42917
SYPL2 synaptophysin-like 2 -2.41757
XPO6 exportin 6 -2.41011
DOK5 docking protein 5 -2.4095
ISYNA1 inositol-3-phosphate synthase 1 -2.40019
CCDC178 coiled-coil domain containing 178 -2.39204
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -2.38405
ASB7 ankyrin repeat and SOCS box containing 7 -2.37183
STS steroid sulfatase (microsomal), isozyme S -2.33305
NOP53 NOP53 ribosome biogenesis factor -2.31742
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide -2.31
HDAC6 histone deacetylase 6 -2.2946
MELTF melanotransferrin -2.27843
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -2.27843
INAFM1 InaF-motif containing 1 -2.27843
CERS5 ceramide synthase 5 -2.26934
CHAMP1 chromosome alignment maintaining phosphoprotein 1 -2.25681
USP46 ubiquitin specific peptidase 46 -2.2529
MT2A metallothionein 2A -2.24479
SCOC short coiled-coil protein -2.21927
RBPJ recombination signal binding protein for immunoglobulin kappa J region -2.21382
PSRC1 proline/serine-rich coiled-coil 1 -2.19725
RCC1 regulator of chromosome condensation 1 -2.16821
FABP3 fatty acid binding protein 3, muscle and heart -2.16784
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.16426
CRYGS crystallin, gamma S -2.16275
ANXA4 annexin A4 -2.1505
ZNF611 zinc finger protein 611 -2.12999
CTSC cathepsin C -2.10807
ZNFX1 zinc finger, NFX1-type containing 1 -2.08836
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -2.06918
RCOR2 REST corepressor 2 -2.06507
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.03889
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.0278
MCRS1 microspherule protein 1 -2.0278
SHLD1 shieldin complex subunit 1 -2.0278
AR androgen receptor -2.0278
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.01477
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.01344