SYT6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description synaptotagmin VI|The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011] (NCBI Entrez Gene Database, 148281)
Similar Terms
Downloads & Tools

Genes

327 genes differentially expressed following the SYT6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IRX5 iroquois homeobox 5 3.49345
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.49345
S100A5 S100 calcium binding protein A5 3.49345
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.49345
ACER1 alkaline ceramidase 1 3.49345
HTRA4 HtrA serine peptidase 4 3.49345
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.49345
SPRR2A small proline-rich protein 2A 3.49345
TAL2 T-cell acute lymphocytic leukemia 2 3.49345
GPR26 G protein-coupled receptor 26 3.49345
CCL3L3 chemokine (C-C motif) ligand 3-like 3 3.49345
OPRL1 opiate receptor-like 1 3.49345
LMNTD1 lamin tail domain containing 1 3.49345
XCL1 chemokine (C motif) ligand 1 3.49345
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 3.49345
TM4SF20 transmembrane 4 L six family member 20 3.49345
TAS2R19 taste receptor, type 2, member 19 3.49345
PRDM16 PR domain containing 16 3.49345
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.49345
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.49345
ANKRD30A ankyrin repeat domain 30A 3.49345
TSSK1B testis-specific serine kinase 1B 3.49345
CD34 CD34 molecule 3.49345
R3HDML R3H domain containing-like 3.49345
HBG2 hemoglobin, gamma G 3.49345
NPR3 natriuretic peptide receptor 3 3.49345
CYSRT1 cysteine-rich tail protein 1 3.49345
SCEL sciellin 3.49345
RXRG retinoid X receptor, gamma 3.49345
THEMIS thymocyte selection associated 3.49345
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.49345
C2ORF78 chromosome 2 open reading frame 78 3.49345
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.49345
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.49345
NCF1 neutrophil cytosolic factor 1 3.49345
MYEOV myeloma overexpressed 3.49345
LRRC70 leucine rich repeat containing 70 3.49345
C1QL4 complement component 1, q subcomponent-like 4 3.49345
KLHL33 kelch-like family member 33 3.49345
MTNR1B melatonin receptor 1B 3.49345
PRB4 proline-rich protein BstNI subfamily 4 3.49345
C3 complement component 3 3.49345
CLDN2 claudin 2 3.49345
PTGDR2 prostaglandin D2 receptor 2 3.49345
VSX2 visual system homeobox 2 3.49345
WNT11 wingless-type MMTV integration site family, member 11 3.49345
DSG1 desmoglein 1 3.49345
SIM2 single-minded family bHLH transcription factor 2 3.49345
CLEC17A C-type lectin domain family 17, member A 3.49345
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.49345
BHLHA9 basic helix-loop-helix family, member a9 3.49345
SBK3 SH3 domain binding kinase family, member 3 3.49345
CST11 cystatin 11 3.49345
LTA lymphotoxin alpha 3.49345
DYNLRB2 dynein, light chain, roadblock-type 2 3.49345
ADIPOQ adiponectin, C1Q and collagen domain containing 3.49345
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.49345
SCGB3A1 secretoglobin, family 3A, member 1 3.49345
SPINK6 serine peptidase inhibitor, Kazal type 6 3.49345
CD14 CD14 molecule 3.49345
HEATR9 HEAT repeat containing 9 3.49345
IGFL2 IGF-like family member 2 3.49345
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.49345
WDR87 WD repeat domain 87 3.49345
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.49345
ZNF503 zinc finger protein 503 3.49345
VTN vitronectin 3.49345
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.49345
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 3.49345
TBX3 T-box 3 3.49345
ROPN1B rhophilin associated tail protein 1B 3.49345
GOLGA8K golgin A8 family, member K 3.49345
DSC1 desmocollin 1 3.49345
BCO1 beta-carotene oxygenase 1 3.49345
APOC2 apolipoprotein C-II 3.49345
NPBWR1 neuropeptides B/W receptor 1 3.49345
GNG5B G protein subunit gamma 5B 3.49345
H2BW2 H2B.W histone 2 3.49345
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.49345
CTAGE9 CTAGE family, member 9 3.49345
THTPA thiamine triphosphatase 3.49345
H1-8 H1.8 linker histone 3.49345
OTC ornithine carbamoyltransferase 3.49345
POF1B premature ovarian failure, 1B 3.49345
LRTM2 leucine-rich repeats and transmembrane domains 2 3.49345
NXNL1 nucleoredoxin-like 1 3.49345
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.49345
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.49345
NOTCH2NLB notch 2 N-terminal like B 3.49345
ZNF596 zinc finger protein 596 3.49345
FAM90A11 family with sequence similarity 90 member A11 3.49345
EVI2A ecotropic viral integration site 2A 3.49345
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 3.49345
ZNF831 zinc finger protein 831 3.49345
LAMB4 laminin, beta 4 3.49345
TSPAN19 tetraspanin 19 3.49345
LY6S lymphocyte antigen 6 family member S 3.49345
PENK proenkephalin 3.49345
NT5C1B 5'-nucleotidase, cytosolic IB 3.49345
LYZ lysozyme 3.49345
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.49345
ZC3H11D zinc finger CCCH-type containing 11D 3.49345
MEPE matrix extracellular phosphoglycoprotein 3.49345
TEX50 testis expressed 50 3.49345
ASTL astacin-like metallo-endopeptidase (M12 family) 3.49345
GAGE10 G antigen 10 3.49345
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.49345
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.49345
GMCL2 germ cell-less 2, spermatogenesis associated 3.49345
RHAG Rh-associated glycoprotein 3.49345
GCM1 glial cells missing homolog 1 (Drosophila) 3.49345
STMND1 stathmin domain containing 1 3.49345
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.49345
MT3 metallothionein 3 3.49345
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.49345
DEFB134 defensin, beta 134 3.49345
PRRX1 paired related homeobox 1 3.49345
NLRP3 NLR family, pyrin domain containing 3 3.49345
PF4V1 platelet factor 4 variant 1 3.49345
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.49345
AMDHD1 amidohydrolase domain containing 1 3.49345
FCAR Fc fragment of IgA receptor 3.49345
PTH1R parathyroid hormone 1 receptor 3.49345
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.49345
RTN4RL1 reticulon 4 receptor-like 1 3.49345
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.49345
PADI6 peptidyl arginine deiminase, type VI 3.49345
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.49345
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.49345
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.49345
LGALS4 lectin, galactoside-binding, soluble, 4 3.47257
IDI2 isopentenyl-diphosphate delta isomerase 2 3.47257
PGF placental growth factor 3.38077
CHD1 chromodomain helicase DNA binding protein 1 3.38077
SEPTIN11 septin 11 3.32639
ZNRF3 zinc and ring finger 3 3.32055
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 3.22245
CACUL1 CDK2-associated, cullin domain 1 3.13884
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.99213
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.91842
GRIPAP1 GRIP1 associated protein 1 2.91229
A4GALT alpha 1,4-galactosyltransferase 2.9088
SAV1 salvador family WW domain containing protein 1 2.79949
VBP1 von Hippel-Lindau binding protein 1 2.77185
CASZ1 castor zinc finger 1 2.711
TMEM204 transmembrane protein 204 2.59621
ZNF260 zinc finger protein 260 2.50413
PRELID3B PRELI domain containing 3B 2.49547
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.4748
ATF7IP activating transcription factor 7 interacting protein 2.36369
NAAA N-acylethanolamine acid amidase 2.36369
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C 2.35447
PNLIPRP1 pancreatic lipase-related protein 1 2.35447
SPMIP10 sperm microtubule inner protein 10 2.35447
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.35343
MEGF6 multiple EGF-like-domains 6 2.35231
MBNL1 muscleblind-like splicing regulator 1 2.35196
POU3F2 POU class 3 homeobox 2 2.3471
MGAT4C MGAT4 family, member C 2.32269
ORC2 origin recognition complex, subunit 2 2.32269
DROSHA drosha, ribonuclease type III 2.32269
CIMAP1D CIMAP1 family member D 2.31485
RNF152 ring finger protein 152 2.31485
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.31485
SLC71A1 solute carrier family 71 member 1 2.31485
LMOD1 leiomodin 1 (smooth muscle) 2.31204
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 2.30509
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 2.2873
ENOX1 ecto-NOX disulfide-thiol exchanger 1 2.26741
NXN nucleoredoxin 2.26685
ESR2 estrogen receptor 2 (ER beta) 2.26529
FBXW2 F-box and WD repeat domain containing 2 2.2502
SEC24D SEC24 family member D 2.2502
JAZF1 JAZF zinc finger 1 2.24619
WDR13 WD repeat domain 13 2.23493
SNAP23 synaptosomal-associated protein, 23kDa 2.22431
ACVR1B activin A receptor, type IB 2.21671
ELOVL5 ELOVL fatty acid elongase 5 2.21436
MYH9 myosin, heavy chain 9, non-muscle 2.20886
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.20496
STAT1 signal transducer and activator of transcription 1, 91kDa 2.20041
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.17855
ADPRHL1 ADP-ribosylhydrolase like 1 2.17644
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.11475
RERE arginine-glutamic acid dipeptide (RE) repeats 2.11375
NRG4 neuregulin 4 2.11008
CBX2 chromobox homolog 2 2.08738
GALE UDP-galactose-4-epimerase 2.08569
NLRP7 NLR family, pyrin domain containing 7 2.08028
SCARA5 scavenger receptor class A, member 5 2.08028
XKR8 XK, Kell blood group complex subunit-related family, member 8 2.07699
RTL10 retrotransposon Gag like 10 2.07699
MVK mevalonate kinase 2.07293
PIH1D1 PIH1 domain containing 1 2.06061
PRRC2B proline-rich coiled-coil 2B 2.06047
PACRGL PARK2 co-regulated-like 2.05867
EML6 echinoderm microtubule associated protein like 6 2.05403
ZNF335 zinc finger protein 335 2.04214
FOXM1 forkhead box M1 2.03665
NPC1 Niemann-Pick disease, type C1 2.03478
LIN28A lin-28 homolog A (C. elegans) 2.02232
EMC1 ER membrane protein complex subunit 1 2.01978
ADIPOR2 adiponectin receptor 2 2.01879
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.01595
TMEM50B transmembrane protein 50B 2.01164
CDK9 cyclin-dependent kinase 9 2.00656
JADE2 jade family PHD finger 2 2.00517

decreased expression

Symbol Name Standardized Value
IFI16 interferon, gamma-inducible protein 16 -3.49345
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -3.49345
KLHL35 kelch-like family member 35 -3.49345
TMEM256 transmembrane protein 256 -3.49345
BBS5 Bardet-Biedl syndrome 5 -3.49345
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -3.49345
ADRA2A adrenoceptor alpha 2A -3.49345
LMNTD2 lamin tail domain containing 2 -3.49345
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -3.49345
ATP10B ATPase, class V, type 10B -3.49345
NOS2 nitric oxide synthase 2, inducible -3.40816
NPIPA8 nuclear pore complex interacting protein family, member A8 -3.38077
GALR2 galanin receptor 2 -3.38077
PPP1R3C protein phosphatase 1, regulatory subunit 3C -3.38077
CD86 CD86 molecule -3.38077
LAMP5 lysosomal-associated membrane protein family, member 5 -3.38077
CLEC20A C-type lectin domain containing 20A -3.38077
IL12A interleukin 12A -3.38077
SMIM22 small integral membrane protein 22 -3.38077
CNTF ciliary neurotrophic factor -3.38077
S100A1 S100 calcium binding protein A1 -3.38077
TRIM73 tripartite motif containing 73 -3.38077
SLC25A45 solute carrier family 25, member 45 -3.38077
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 -3.38077
DYNAP dynactin associated protein -3.38077
TACR2 tachykinin receptor 2 -3.38077
TUBA3D tubulin, alpha 3d -3.38077
WEE2 WEE1 homolog 2 (S. pombe) -3.38077
TSSK6 testis-specific serine kinase 6 -3.38077
GPR55 G protein-coupled receptor 55 -3.38077
SLC46A3 solute carrier family 46, member 3 -3.38077
BSND barttin CLCNK-type chloride channel accessory beta subunit -3.38077
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) -3.38077
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 -3.38077
HGD homogentisate 1,2-dioxygenase -3.38077
NLRC3 NLR family, CARD domain containing 3 -3.38077
CCDC27 coiled-coil domain containing 27 -3.38077
SPATA31H1 SPATA31 subfamily H member 1 -3.38077
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -3.38077
CNGB1 cyclic nucleotide gated channel beta 1 -3.38077
KLF4 Kruppel-like factor 4 (gut) -3.38077
GOLGA8H golgin A8 family, member H -3.38077
GLOD5 glyoxalase domain containing 5 -3.38077
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -3.38077
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -3.38077
SSC5D scavenger receptor cysteine rich family, 5 domains -3.28969
SYNE1 spectrin repeat containing, nuclear envelope 1 -3.21402
RPL29 ribosomal protein L29 -3.20877
GGCX gamma-glutamyl carboxylase -3.20505
COQ4 coenzyme Q4 -3.19087
PPP1R42 protein phosphatase 1, regulatory subunit 42 -3.01549
SRRM4 serine/arginine repetitive matrix 4 -2.99154
THYN1 thymocyte nuclear protein 1 -2.99154
TPT1 tumor protein, translationally-controlled 1 -2.98943
DEK DEK proto-oncogene -2.8714
RPS2 ribosomal protein S2 -2.85337
SPATA7 spermatogenesis associated 7 -2.7809
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.76183
KCTD15 potassium channel tetramerization domain containing 15 -2.74146
FGFR3 fibroblast growth factor receptor 3 -2.71328
HEBP2 heme binding protein 2 -2.69574
SCN2A sodium channel, voltage gated, type II alpha subunit -2.6942
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.62532
SNRPG small nuclear ribonucleoprotein polypeptide G -2.54139
ARMCX5 armadillo repeat containing, X-linked 5 -2.52821
NT5C 5', 3'-nucleotidase, cytosolic -2.51308
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.49344
ZNF33B zinc finger protein 33B -2.4748
SETD5 SET domain containing 5 -2.38388
GATAD1 GATA zinc finger domain containing 1 -2.36636
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.36369
GRHL3 grainyhead-like 3 (Drosophila) -2.35163
COMT catechol-O-methyltransferase -2.32269
RIOK1 RIO kinase 1 -2.31558
IFI35 interferon-induced protein 35 -2.28851
RPS28 ribosomal protein S28 -2.28818
C17ORF107 chromosome 17 open reading frame 107 -2.28818
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -2.28056
TMEM64 transmembrane protein 64 -2.26301
MRPL13 mitochondrial ribosomal protein L13 -2.2594
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.25882
CSDC2 cold shock domain containing C2, RNA binding -2.25585
DCDC2B doublecortin domain containing 2B -2.2502
NBPF8 neuroblastoma breakpoint family, member 8 -2.2502
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.2502
ZNF492 zinc finger protein 492 -2.2502
ZNF396 zinc finger protein 396 -2.2502
DRICH1 aspartate-rich 1 -2.2502
MEI1 meiosis inhibitor 1 -2.2502
B9D2 B9 protein domain 2 -2.24071
VGLL4 vestigial-like family member 4 -2.23026
CTXN1 cortexin 1 -2.21436
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -2.20546
ERBB4 erb-b2 receptor tyrosine kinase 4 -2.20496
RPSA ribosomal protein SA -2.20496
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.19454
OXCT2 3-oxoacid CoA transferase 2 -2.18851
ACVR1 activin A receptor, type I -2.17231
PEBP1 phosphatidylethanolamine binding protein 1 -2.1508
HMGA2 high mobility group AT-hook 2 -2.14044
CIAO2A cytosolic iron-sulfur assembly component 2A -2.14044
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.12571
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.07699
CAPN15 calpain 15 -2.06061
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.06061
PRCD progressive rod-cone degeneration -2.05255
TBC1D31 TBC1 domain family, member 31 -2.05255
RPS8 ribosomal protein S8 -2.03478
EDC3 enhancer of mRNA decapping 3 -2.03478
CNIH2 cornichon family AMPA receptor auxiliary protein 2 -2.03478
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 -2.03259
RPL18A ribosomal protein L18a -2.03259
CYFIP2 cytoplasmic FMR1 interacting protein 2 -2.03226
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -2.03226
RTTN rotatin -2.02854
MRPL27 mitochondrial ribosomal protein L27 -2.02232
SRA1 steroid receptor RNA activator 1 -2.02232
EML2 echinoderm microtubule associated protein like 2 -2.0191
MGLL monoglyceride lipase -2.01409
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial -2.01138