| Dataset | CM4AI KOLF21J CRISPRi Gene Perturbation Atlas |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | seizure threshold 2 homolog (mouse)|The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis. [provided by RefSeq, Jun 2011] (NCBI Entrez Gene Database, 23334) |
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85 genes differentially expressed following the SZT2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZIC1 | Zic family member 1 | 2.13212 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | 2.13212 |
| LSM11 | LSM11, U7 small nuclear RNA associated | 2.13212 |
| CP | ceruloplasmin (ferroxidase) | 2.13212 |
| GPRASP2 | G protein-coupled receptor associated sorting protein 2 | 2.13212 |
| RSPH1 | radial spoke head 1 homolog (Chlamydomonas) | 2.13212 |
| ATP8B3 | ATPase, aminophospholipid transporter, class I, type 8B, member 3 | 2.13212 |
| NDUFA6 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa | 2.13212 |
| EML5 | echinoderm microtubule associated protein like 5 | 2.13212 |
| CSMD3 | CUB and Sushi multiple domains 3 | 2.13212 |
| IQCE | IQ motif containing E | 2.13212 |
| TTC21A | tetratricopeptide repeat domain 21A | 2.13212 |
| CRYM | crystallin, mu | 2.13212 |
| MEP1B | meprin A, beta | 2.13212 |
| L1CAM | L1 cell adhesion molecule | 2.13212 |
| ACTL6B | actin-like 6B | 2.13212 |
| POU5F1 | POU class 5 homeobox 1 | 2.13212 |
| FST | follistatin | 2.13212 |
| ZNF784 | zinc finger protein 784 | 2.13212 |
| MAGEE1 | melanoma antigen family E1 | 2.13212 |
| SH3BGR | SH3 domain binding glutamate-rich protein | 2.13212 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 2.13212 |
| FNDC4 | fibronectin type III domain containing 4 | 2.13212 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 2.13212 |
| LAD1 | ladinin 1 | 2.13212 |
| TPT1 | tumor protein, translationally-controlled 1 | 2.13212 |
| C17ORF100 | chromosome 17 open reading frame 100 | 2.13212 |
| NKAIN4 | Na+/K+ transporting ATPase interacting 4 | 2.13212 |
| CACTIN | cactin, spliceosome C complex subunit | 2.12597 |
| SMIM22 | small integral membrane protein 22 | 2.12597 |
| NIBAN1 | niban apoptosis regulator 1 | 2.07336 |
| DARS1 | aspartyl-tRNA synthetase 1 | 2.07336 |
| GMPR | guanosine monophosphate reductase | 2.07336 |
| TACR1 | tachykinin receptor 1 | 2.07336 |
| CAPN2 | calpain 2, (m/II) large subunit | 2.07336 |
| TMLHE | trimethyllysine hydroxylase, epsilon | 2.07336 |
| DEPDC4 | DEP domain containing 4 | 2.07336 |
| FOSL1 | FOS-like antigen 1 | 2.07336 |
| UBL7 | ubiquitin-like 7 | 2.07336 |
| TMEM200B | transmembrane protein 200B | 2.07336 |
| PRRX2 | paired related homeobox 2 | 2.07336 |
| FRMPD3 | FERM and PDZ domain containing 3 | 2.07336 |
| ATP6V1C2 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | 2.07336 |
| GNB3 | guanine nucleotide binding protein (G protein), beta polypeptide 3 | 2.07336 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | 2.07336 |
| DCHS2 | dachsous cadherin-related 2 | 2.07336 |
| TP53I13 | tumor protein p53 inducible protein 13 | 2.07336 |
| FRMD5 | FERM domain containing 5 | 2.07336 |
| CPNE4 | copine IV | 2.07336 |
| FANCA | Fanconi anemia, complementation group A | 2.07336 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | 2.03163 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HDDC3 | HD domain containing 3 | -2.13212 |
| TMEM35B | transmembrane protein 35B | -2.13212 |
| SLC35B1 | solute carrier family 35, member B1 | -2.13212 |
| GUCY2C | guanylate cyclase 2C | -2.13212 |
| SLC2A12 | solute carrier family 2 (facilitated glucose transporter), member 12 | -2.13212 |
| ZNF48 | zinc finger protein 48 | -2.13212 |
| WDTC1 | WD and tetratricopeptide repeats 1 | -2.13212 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | -2.13212 |
| IFT27 | intraflagellar transport 27 | -2.13212 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | -2.13212 |
| BRSK1 | BR serine/threonine kinase 1 | -2.13212 |
| CCDC102B | coiled-coil domain containing 102B | -2.13212 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -2.13212 |
| MMP15 | matrix metallopeptidase 15 (membrane-inserted) | -2.13212 |
| ZC3H3 | zinc finger CCCH-type containing 3 | -2.13212 |
| RAD51AP1 | RAD51 associated protein 1 | -2.13212 |
| RRP1 | ribosomal RNA processing 1 | -2.13212 |
| ZBTB8B | zinc finger and BTB domain containing 8B | -2.13212 |
| SLCO5A1 | solute carrier organic anion transporter family, member 5A1 | -2.13212 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -2.13212 |
| PELO | pelota homolog (Drosophila) | -2.13212 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -2.07336 |
| MKS1 | Meckel syndrome, type 1 | -2.07336 |
| SLC66A2 | solute carrier family 66 member 2 | -2.07336 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | -2.07336 |
| RETSAT | retinol saturase (all-trans-retinol 13,14-reductase) | -2.07336 |
| PLEC | plectin | -2.07336 |
| MOCS3 | molybdenum cofactor synthesis 3 | -2.07336 |
| MME | membrane metallo-endopeptidase | -2.07336 |
| GALNT16 | polypeptide N-acetylgalactosaminyltransferase 16 | -2.07336 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -2.07336 |
| PXK | PX domain containing serine/threonine kinase | -2.07336 |
| GJB7 | gap junction protein, beta 7, 25kDa | -2.07336 |
| P2RY14 | purinergic receptor P2Y, G-protein coupled, 14 | -2.04001 |
