Salicylic acid_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.100422
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.100065
TRIO trio Rho guanine nucleotide exchange factor 0.0841306
POTEF POTE ankyrin domain family, member F 0.0835628
FNDC3B fibronectin type III domain containing 3B 0.0746803
DST dystonin 0.0729694
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0635152
PRELID2 PRELI domain containing 2 0.0631718
AHNAK AHNAK nucleoprotein 0.0624203
MYH9 myosin, heavy chain 9, non-muscle 0.0602701
NAV1 neuron navigator 1 0.0588584
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0480328
NAV2 neuron navigator 2 0.0476594
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0476555
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.046346
HDAC9 histone deacetylase 9 0.0459375
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0457539
LDHA lactate dehydrogenase A 0.0440486
VCL vinculin 0.0437736
TPM3 tropomyosin 3 0.0434739
MSN moesin 0.0428747
FLNA filamin A, alpha 0.0420272
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0417007
MYOF myoferlin 0.0416463
CDH13 cadherin 13 0.0388418
MAP1B microtubule-associated protein 1B 0.0382486
COL5A2 collagen, type V, alpha 2 0.0379373
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.036911
MACF1 microtubule-actin crosslinking factor 1 0.0359632
NEK7 NIMA-related kinase 7 0.0356652
RUNX1 runt-related transcription factor 1 0.0349758
INTS6 integrator complex subunit 6 0.0341174
PICALM phosphatidylinositol binding clathrin assembly protein 0.0338224
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0331538
VEGFA vascular endothelial growth factor A 0.0331294
PLEC plectin 0.032812
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0327918
PBX3 pre-B-cell leukemia homeobox 3 0.03231
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0322457
ADAM9 ADAM metallopeptidase domain 9 0.0315477
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0312351
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0311011
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0295158
GLIS3 GLIS family zinc finger 3 0.0294697
GLS2 glutaminase 2 (liver, mitochondrial) 0.0292155
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0291493
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0281133
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0280751
DOCK5 dedicator of cytokinesis 5 0.0280501
MBNL2 muscleblind-like splicing regulator 2 0.0279919
SDK1 sidekick cell adhesion molecule 1 0.0277419
SEPTIN9 septin 9 0.0277392
EFNA5 ephrin-A5 0.0275865
EGFR epidermal growth factor receptor 0.0275845
SAMD9 sterile alpha motif domain containing 9 0.0275215
DSPP dentin sialophosphoprotein 0.027503
GPC6 glypican 6 0.027481
TENM3 teneurin transmembrane protein 3 0.0274574
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0271031
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0269641
LNPEP leucyl/cystinyl aminopeptidase 0.0268659
FBXL7 F-box and leucine-rich repeat protein 7 0.0266265
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0264424
AUTS2 autism susceptibility candidate 2 0.0264281
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0264279
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0261942
ATXN1 ataxin 1 0.0259475
PTK2 protein tyrosine kinase 2 0.0257074
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0256628
CD44 CD44 molecule (Indian blood group) 0.0256314
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0253168
MBNL1 muscleblind-like splicing regulator 1 0.0251991
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0249988
ANO6 anoctamin 6 0.0249799
SMYD3 SET and MYND domain containing 3 0.0247918
ZSWIM6 zinc finger, SWIM-type containing 6 0.0246914
TAOK1 TAO kinase 1 0.0246306
APP amyloid beta (A4) precursor protein 0.0242642
LCOR ligand dependent nuclear receptor corepressor 0.0240785
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0240417
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0238728
NOTCH2 notch 2 0.0236031
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0235752
LPP LIM domain containing preferred translocation partner in lipoma 0.0232369
ANXA1 annexin A1 0.0230758
NFE2L1 nuclear factor, erythroid 2-like 1 0.0228068
TNIP1 TNFAIP3 interacting protein 1 0.0226345
MB21D2 Mab-21 domain containing 2 0.0225364
MCL1 myeloid cell leukemia 1 0.0222452
USP9X ubiquitin specific peptidase 9, X-linked 0.0222432
FLNB filamin B, beta 0.0217992
MPRIP myosin phosphatase Rho interacting protein 0.0216423
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0215384
ZC3H11A zinc finger CCCH-type containing 11A 0.021252
SMAD3 SMAD family member 3 0.0209315
SAMD4A sterile alpha motif domain containing 4A 0.0209224
ADD1 adducin 1 (alpha) 0.0207256
FAM219A family with sequence similarity 219, member A 0.0207096
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0206651
TRIP12 thyroid hormone receptor interactor 12 0.0206009

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.369627
TMSB10 thymosin beta 10 -0.191474
IGFBP3 insulin-like growth factor binding protein 3 -0.16837
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.118937
S100A6 S100 calcium binding protein A6 -0.111389
PLAT plasminogen activator, tissue -0.111387
CSTB cystatin B (stefin B) -0.109681
MT2A metallothionein 2A -0.105374
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0941667
S100A10 S100 calcium binding protein A10 -0.0935198
PTMA prothymosin, alpha -0.0826243
LMNA lamin A/C -0.081523
ABI3BP ABI family, member 3 (NESH) binding protein -0.0797465
SLC38A1 solute carrier family 38, member 1 -0.0759524
HLA-B major histocompatibility complex, class I, B -0.0729018
CAVIN1 caveolae associated protein 1 -0.0621293
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0579817
TPT1 tumor protein, translationally-controlled 1 -0.0567344
SUCNR1 succinate receptor 1 -0.0537905
NDRG1 N-myc downstream regulated 1 -0.0533406
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0526103
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0466119
S100A4 S100 calcium binding protein A4 -0.04531
PODXL podocalyxin-like -0.0442508
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0439367
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0427577
PRSS23 protease, serine, 23 -0.041085
CD99 CD99 molecule -0.0408552
AKAP12 A kinase (PRKA) anchor protein 12 -0.0407335
FN1 fibronectin 1 -0.040066
CCND1 cyclin D1 -0.0392988
FTL ferritin, light polypeptide -0.0390715
IFITM3 interferon induced transmembrane protein 3 -0.038546
MT1X metallothionein 1X -0.0373113
RRBP1 ribosome binding protein 1 -0.0359861
GNAS GNAS complex locus -0.0357835
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0357387
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0346038
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0342655
B2M beta-2-microglobulin -0.0330527
IFITM1 interferon induced transmembrane protein 1 -0.0328965
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0328364
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0328216
RPL35A ribosomal protein L35a -0.032815
HLA-C major histocompatibility complex, class I, C -0.0325263
TPM4 tropomyosin 4 -0.0324057
S100A11 S100 calcium binding protein A11 -0.031713
THBS2 thrombospondin 2 -0.0316776
COL1A2 collagen, type I, alpha 2 -0.0313642
EIF1 eukaryotic translation initiation factor 1 -0.0306828
WSB1 WD repeat and SOCS box containing 1 -0.030636
TM4SF1 transmembrane 4 L six family member 1 -0.0304231
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0302673
VDAC1 voltage-dependent anion channel 1 -0.0300605
ACTG1 actin gamma 1 -0.0293545
MYL12B myosin, light chain 12B, regulatory -0.0288093
IFI16 interferon, gamma-inducible protein 16 -0.0278924
RPS24 ribosomal protein S24 -0.0272431
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0269908
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0269539
RPL34 ribosomal protein L34 -0.0267199
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0258394
KPNB1 karyopherin (importin) beta 1 -0.0255535
KDM3A lysine (K)-specific demethylase 3A -0.0252944
CKAP4 cytoskeleton-associated protein 4 -0.0249868
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0248584
H3-3B H3.3 histone B -0.0246061
ACBD3 acyl-CoA binding domain containing 3 -0.0243532
COL3A1 collagen, type III, alpha 1 -0.0242775
RPS8 ribosomal protein S8 -0.0241768
ISG15 ISG15 ubiquitin-like modifier -0.0240096
MYADM myeloid-associated differentiation marker -0.0238731
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0238699
PRRC2C proline-rich coiled-coil 2C -0.0237762
LMAN1 lectin, mannose-binding, 1 -0.0237186
TUBB4B tubulin, beta 4B class IVb -0.0235601
IFI6 interferon, alpha-inducible protein 6 -0.0235027
MX2 MX dynamin-like GTPase 2 -0.0234721
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0229222
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0227693
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0226381
LRRC17 leucine rich repeat containing 17 -0.0224766
ZMYND8 zinc finger, MYND-type containing 8 -0.0223648
HLA-A major histocompatibility complex, class I, A -0.0222085
KRT81 keratin 81, type II -0.0220642
GCC2 GRIP and coiled-coil domain containing 2 -0.02205
HSPB1 heat shock 27kDa protein 1 -0.0218784
RAB1A RAB1A, member RAS oncogene family -0.0217647
PDIA3 protein disulfide isomerase family A, member 3 -0.0217637
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0214154
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0213431
COL1A1 collagen, type I, alpha 1 -0.0211043
SEC61G Sec61 gamma subunit -0.0208489
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0205542
PLAUR plasminogen activator, urokinase receptor -0.0203348
BTG1 B-cell translocation gene 1, anti-proliferative -0.0202305
SPAG9 sperm associated antigen 9 -0.0201754
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0200486
NAP1L1 nucleosome assembly protein 1-like 1 -0.0200389
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0198742