Salicylic acid_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.166029
MEST mesoderm specific transcript 0.141475
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0847109
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0789327
PRELID2 PRELI domain containing 2 0.0734932
PDE4D phosphodiesterase 4D, cAMP-specific 0.0733054
NFIB nuclear factor I/B 0.0695644
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0551114
SPPL3 signal peptide peptidase like 3 0.0529175
KDM6A lysine (K)-specific demethylase 6A 0.0510659
SMYD3 SET and MYND domain containing 3 0.051011
USP9X ubiquitin specific peptidase 9, X-linked 0.0491916
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0487343
OGA O-GlcNAcase 0.0475439
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.047457
PCM1 pericentriolar material 1 0.0474526
MED13L mediator complex subunit 13-like 0.047222
PDE10A phosphodiesterase 10A 0.0452957
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0446082
APLP2 amyloid beta (A4) precursor-like protein 2 0.0435889
DMXL1 Dmx-like 1 0.0430576
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0425906
FBXL7 F-box and leucine-rich repeat protein 7 0.0421402
QKI QKI, KH domain containing, RNA binding 0.0420975
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0419298
SSBP2 single-stranded DNA binding protein 2 0.0412248
ZNF608 zinc finger protein 608 0.0402468
GSE1 Gse1 coiled-coil protein 0.0399703
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0397469
TRIO trio Rho guanine nucleotide exchange factor 0.0394469
ELOVL5 ELOVL fatty acid elongase 5 0.0384924
EXOC4 exocyst complex component 4 0.0377847
ZNF292 zinc finger protein 292 0.0371999
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0369976
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0355944
SKIL SKI-like proto-oncogene 0.0352568
AFF4 AF4/FMR2 family, member 4 0.0350392
FNIP1 folliculin interacting protein 1 0.0343144
UST uronyl-2-sulfotransferase 0.0337091
ZEB1 zinc finger E-box binding homeobox 1 0.0335565
NCOR2 nuclear receptor corepressor 2 0.0335551
EEF2 eukaryotic translation elongation factor 2 0.0334077
PRKG1 protein kinase, cGMP-dependent, type I 0.0328082
KMT2E lysine (K)-specific methyltransferase 2E 0.0326525
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0324054
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0321996
WNK1 WNK lysine deficient protein kinase 1 0.0318197
TNIP1 TNFAIP3 interacting protein 1 0.0318089
MYOF myoferlin 0.0316601
LCOR ligand dependent nuclear receptor corepressor 0.0312726
SND1 staphylococcal nuclease and tudor domain containing 1 0.0308926
SRRM2 serine/arginine repetitive matrix 2 0.0308048
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0306377
THSD4 thrombospondin, type I, domain containing 4 0.0306181
HELZ helicase with zinc finger 0.0305636
PICALM phosphatidylinositol binding clathrin assembly protein 0.0305066
TOP2B topoisomerase (DNA) II beta 180kDa 0.0297594
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0296892
GMDS GDP-mannose 4,6-dehydratase 0.0296737
ANO6 anoctamin 6 0.0293777
MACF1 microtubule-actin crosslinking factor 1 0.0292568
EXOC6B exocyst complex component 6B 0.0290084
PCCA propionyl CoA carboxylase, alpha polypeptide 0.028821
RPL3 ribosomal protein L3 0.0287692
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0287331
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0286203
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.0284238
ERBIN erbb2 interacting protein 0.0282638
SRPK2 SRSF protein kinase 2 0.0275198
CTBP2 C-terminal binding protein 2 0.0274335
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.027427
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0273547
TLN1 talin 1 0.0273528
TTC3 tetratricopeptide repeat domain 3 0.0271548
KDM4C lysine (K)-specific demethylase 4C 0.0270493
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0270358
KMT2C lysine (K)-specific methyltransferase 2C 0.026992
ZFAND3 zinc finger, AN1-type domain 3 0.026971
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0268314
PHF3 PHD finger protein 3 0.0266922
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0260989
OSBPL10 oxysterol binding protein-like 10 0.0260095
SIK3 SIK family kinase 3 0.0260012
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.025938
ZNF516 zinc finger protein 516 0.0257801
RYBP RING1 and YY1 binding protein 0.0256022
FLNB filamin B, beta 0.0254995
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0252483
ADAM10 ADAM metallopeptidase domain 10 0.0250943
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0249567
GLS2 glutaminase 2 (liver, mitochondrial) 0.0246871
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0243921
DENND5A DENN/MADD domain containing 5A 0.0240666
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0239181
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0238881
YAP1 Yes-associated protein 1 0.023724
PTK2 protein tyrosine kinase 2 0.0237157
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0234809
FMNL2 formin-like 2 0.0233611
TSC22D2 TSC22 domain family, member 2 0.0232947

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.19127
PTMA prothymosin, alpha -0.12856
PEG10 paternally expressed 10 -0.12285
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.118566
MGP matrix Gla protein -0.0882965
MT2A metallothionein 2A -0.0860236
RPS24 ribosomal protein S24 -0.0815052
RPS6 ribosomal protein S6 -0.0811378
RPS8 ribosomal protein S8 -0.0665645
TMSB10 thymosin beta 10 -0.0663202
TPT1 tumor protein, translationally-controlled 1 -0.064025
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0608908
CENPF centromere protein F, 350/400kDa -0.0604207
RPL34 ribosomal protein L34 -0.0597802
RPLP1 ribosomal protein, large, P1 -0.0582781
RPL26 ribosomal protein L26 -0.0569566
RPL37A ribosomal protein L37a -0.0560306
KPNB1 karyopherin (importin) beta 1 -0.0543702
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0543325
RPL35A ribosomal protein L35a -0.0529585
RPLP0 ribosomal protein, large, P0 -0.0524572
IER3 immediate early response 3 -0.0510568
ACTG1 actin gamma 1 -0.0497401
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0479603
RANBP17 RAN binding protein 17 -0.0467294
HMGA1 high mobility group AT-hook 1 -0.0456029
RPL12 ribosomal protein L12 -0.0435221
RACK1 receptor for activated C kinase 1 -0.043411
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0407696
NAP1L1 nucleosome assembly protein 1-like 1 -0.0384501
CBX3 chromobox homolog 3 -0.0382683
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0379979
RPS27A ribosomal protein S27a -0.0373505
RPS25 ribosomal protein S25 -0.0372051
S100A9 S100 calcium binding protein A9 -0.0370505
RPL37 ribosomal protein L37 -0.0368911
CADM2 cell adhesion molecule 2 -0.0368262
RPL7 ribosomal protein L7 -0.0362986
RPLP2 ribosomal protein, large, P2 -0.0360783
RPS12 ribosomal protein S12 -0.0355522
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0355398
COL1A2 collagen, type I, alpha 2 -0.0354476
RSL1D1 ribosomal L1 domain containing 1 -0.0349396
SLC38A2 solute carrier family 38, member 2 -0.0348584
RPS16 ribosomal protein S16 -0.0343662
RPS14 ribosomal protein S14 -0.0342902
DEK DEK proto-oncogene -0.0342209
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0332482
RAD21 RAD21 homolog (S. pombe) -0.0327987
FOXC1 forkhead box C1 -0.0327791
RPL30 ribosomal protein L30 -0.032538
TUBB tubulin, beta class I -0.0321378
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0318605
RPS10 ribosomal protein S10 -0.0317153
RPS13 ribosomal protein S13 -0.0315945
RPL19 ribosomal protein L19 -0.0311966
RPS20 ribosomal protein S20 -0.0309075
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0306501
RPL9 ribosomal protein L9 -0.0306401
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0305225
HMGB2 high mobility group box 2 -0.0304382
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0300121
RBM25 RNA binding motif protein 25 -0.0293715
RPL27A ribosomal protein L27a -0.0292231
KIF5B kinesin family member 5B -0.0282558
COTL1 coactosin-like F-actin binding protein 1 -0.0277368
MEOX2 mesenchyme homeobox 2 -0.0277192
TPK1 thiamin pyrophosphokinase 1 -0.027635
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0272065
RPS5 ribosomal protein S5 -0.0271844
RPS29 ribosomal protein S29 -0.0271675
HMGB1 high mobility group box 1 -0.0271436
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0267371
RPL38 ribosomal protein L38 -0.0265326
RPL23 ribosomal protein L23 -0.0261234
CALR calreticulin -0.0259728
FTL ferritin, light polypeptide -0.0258863
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0256489
RPL31 ribosomal protein L31 -0.0253207
MKI67 marker of proliferation Ki-67 -0.0252365
WSB1 WD repeat and SOCS box containing 1 -0.0251351
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0251286
RPS11 ribosomal protein S11 -0.0250862
VCL vinculin -0.0250088
VDAC1 voltage-dependent anion channel 1 -0.024777
RPL36A ribosomal protein L36a -0.0244686
THOC2 THO complex 2 -0.0242168
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.024201
RPL36 ribosomal protein L36 -0.0236372
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0235516
DSTN destrin (actin depolymerizing factor) -0.0234445
SMC3 structural maintenance of chromosomes 3 -0.0234389
CENPE centromere protein E, 312kDa -0.0234003
TCEAL9 transcription elongation factor A like 9 -0.023321
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0233076
RPS23 ribosomal protein S23 -0.0233006
RPS3 ribosomal protein S3 -0.0231722
RPL7A ribosomal protein L7a -0.0231234
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0230502
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.022479