Salicylic acid_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.0817871
EXT1 exostosin glycosyltransferase 1 0.067337
ZSWIM6 zinc finger, SWIM-type containing 6 0.056204
PMM2 phosphomannomutase 2 0.055693
PDLIM5 PDZ and LIM domain 5 0.0539231
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0501606
DOCK5 dedicator of cytokinesis 5 0.0455029
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0454205
EFNA5 ephrin-A5 0.0449899
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.044165
EGFR epidermal growth factor receptor 0.0435884
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0430983
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0400775
ABTB3 ankyrin repeat and BTB domain containing 3 0.0391758
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.038166
PPARD peroxisome proliferator-activated receptor delta 0.0380111
SAMD4A sterile alpha motif domain containing 4A 0.0371344
SMAD3 SMAD family member 3 0.0366692
PLEC plectin 0.035817
THSD4 thrombospondin, type I, domain containing 4 0.0339321
LAMC2 laminin, gamma 2 0.0325903
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0317873
INTS6 integrator complex subunit 6 0.0317228
AHNAK AHNAK nucleoprotein 0.0314733
TRRAP transformation/transcription domain-associated protein 0.0312232
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0312227
GREB1L growth regulation by estrogen in breast cancer-like 0.030732
RASAL2 RAS protein activator like 2 0.0296257
LARP4B La ribonucleoprotein domain family, member 4B 0.0295249
BMP6 bone morphogenetic protein 6 0.0283009
AKAP13 A kinase (PRKA) anchor protein 13 0.0281867
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0280819
CFLAR CASP8 and FADD-like apoptosis regulator 0.0277158
TRIP12 thyroid hormone receptor interactor 12 0.0266634
MACF1 microtubule-actin crosslinking factor 1 0.0250504
SND1 staphylococcal nuclease and tudor domain containing 1 0.0245794
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0241578
MPRIP myosin phosphatase Rho interacting protein 0.0236013
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0235366
ZFC3H1 zinc finger, C3H1-type containing 0.0235074
CDK13 cyclin-dependent kinase 13 0.0230139
BMAL2 basic helix-loop-helix ARNT like 2 0.0227372
HMGA2 high mobility group AT-hook 2 0.0226704
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0223286
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0218864
TTC3 tetratricopeptide repeat domain 3 0.0215297
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.0211689
HDAC9 histone deacetylase 9 0.0211447
LPP LIM domain containing preferred translocation partner in lipoma 0.021068
SEC31A SEC31 homolog A (S. cerevisiae) 0.0208284
NUP98 nucleoporin 98kDa 0.0207565
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0207032
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0202875
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0202499
UBAP2 ubiquitin associated protein 2 0.0200133
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0199396
FMNL2 formin-like 2 0.0199329
HDLBP high density lipoprotein binding protein 0.0197122
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0196828
ZFAND3 zinc finger, AN1-type domain 3 0.019469
GOLGA3 golgin A3 0.0193344
TGFA transforming growth factor, alpha 0.0192451
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0189464
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0188802
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0188516
AHRR aryl-hydrocarbon receptor repressor 0.0186053
NABP1 nucleic acid binding protein 1 0.018491
MYO5B myosin VB 0.0183864
FBXO11 F-box protein 11 0.0183394
LAMA4 laminin, alpha 4 0.0181833
RBM39 RNA binding motif protein 39 0.0180362
ZCCHC7 zinc finger, CCHC domain containing 7 0.0179328
RUNX1 runt-related transcription factor 1 0.0179319
SLC35F3 solute carrier family 35, member F3 0.017929
RCOR1 REST corepressor 1 0.017638
VMP1 vacuole membrane protein 1 0.0174066
SENP5 SUMO1/sentrin specific peptidase 5 0.0173989
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0173048
USP34 ubiquitin specific peptidase 34 0.0172686
DOCK1 dedicator of cytokinesis 1 0.0169053
FNIP1 folliculin interacting protein 1 0.0167266
KLC1 kinesin light chain 1 0.0164861
OSMR oncostatin M receptor 0.0164855
SIK3 SIK family kinase 3 0.0164378
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0164077
BTBD9 BTB (POZ) domain containing 9 0.0161594
TBC1D22A TBC1 domain family, member 22A 0.0161194
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0160575
ITPRID2 ITPR interacting domain containing 2 0.0159707
HSPA8 heat shock 70kDa protein 8 0.0158245
SGMS2 sphingomyelin synthase 2 0.0157188
BLCAP bladder cancer associated protein 0.0151843
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0151365
XYLT1 xylosyltransferase I 0.0150991
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0150686
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0149848
FLNA filamin A, alpha 0.014868
EFNB2 ephrin-B2 0.0147518
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.0145999
GOLGB1 golgin B1 0.0145233

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.242365
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.230758
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.198343
VIM vimentin -0.152862
POTEF POTE ankyrin domain family, member F -0.133641
PTMA prothymosin, alpha -0.133559
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.129099
BAIAP2L1 BAI1-associated protein 2-like 1 -0.124227
NDRG1 N-myc downstream regulated 1 -0.112891
S100A10 S100 calcium binding protein A10 -0.104427
HMGA1 high mobility group AT-hook 1 -0.0988462
FTH1 ferritin, heavy polypeptide 1 -0.0807091
TPT1 tumor protein, translationally-controlled 1 -0.0770801
AKAP12 A kinase (PRKA) anchor protein 12 -0.0747031
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0733215
FTL ferritin, light polypeptide -0.0725847
ITGA6 integrin, alpha 6 -0.0709913
B2M beta-2-microglobulin -0.0702062
LDHA lactate dehydrogenase A -0.0701865
S100A6 S100 calcium binding protein A6 -0.0678589
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0669305
RPL12 ribosomal protein L12 -0.0668668
S100A11 S100 calcium binding protein A11 -0.06536
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0616922
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0593111
UBC ubiquitin C -0.0563951
MUC17 mucin 17, cell surface associated -0.0552078
PGK1 phosphoglycerate kinase 1 -0.0548516
RPS3 ribosomal protein S3 -0.0548289
RPL37A ribosomal protein L37a -0.0540102
EIF1 eukaryotic translation initiation factor 1 -0.0536612
RPLP1 ribosomal protein, large, P1 -0.0532752
RPL35A ribosomal protein L35a -0.0530651
RPS6 ribosomal protein S6 -0.0523778
LOC112694756 uncharaterized LOC112694756 -0.0511194
RPS8 ribosomal protein S8 -0.0498833
RIOK3 RIO kinase 3 -0.0491799
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0484219
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.048074
RPL31 ribosomal protein L31 -0.0480374
RPL8 ribosomal protein L8 -0.0476104
VCAN versican -0.0469248
RPS13 ribosomal protein S13 -0.0462189
FOSL1 FOS-like antigen 1 -0.0452334
RPS12 ribosomal protein S12 -0.044734
RPLP2 ribosomal protein, large, P2 -0.0442418
ESYT2 extended synaptotagmin-like protein 2 -0.0434729
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0431035
RPL23 ribosomal protein L23 -0.0429604
RPS21 ribosomal protein S21 -0.0427294
PERP PERP, TP53 apoptosis effector -0.0422914
RPL34 ribosomal protein L34 -0.0422068
KRT19 keratin 19, type I -0.0420211
RPLP0 ribosomal protein, large, P0 -0.0419794
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0416564
RPL11 ribosomal protein L11 -0.0408781
TSC22D2 TSC22 domain family, member 2 -0.0404031
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0391825
VEZT vezatin, adherens junctions transmembrane protein -0.0382395
ADAM9 ADAM metallopeptidase domain 9 -0.0381737
RPS14 ribosomal protein S14 -0.0381513
S100A4 S100 calcium binding protein A4 -0.0373681
RPL30 ribosomal protein L30 -0.0373242
PKM pyruvate kinase, muscle -0.0370409
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0370051
RPS23 ribosomal protein S23 -0.0369455
PRRC2C proline-rich coiled-coil 2C -0.0368763
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0366375
RPS27 ribosomal protein S27 -0.0365757
ACTG1 actin gamma 1 -0.0365092
RPS27A ribosomal protein S27a -0.0361795
SLC38A2 solute carrier family 38, member 2 -0.0359869
CSTB cystatin B (stefin B) -0.0356347
FAM107B family with sequence similarity 107, member B -0.0353641
RPS19 ribosomal protein S19 -0.0350967
SEPTIN7 septin 7 -0.0348135
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.034807
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0346323
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0345218
PFN1 profilin 1 -0.0342308
KLF6 Kruppel-like factor 6 -0.034097
LY6E lymphocyte antigen 6 complex, locus E -0.033867
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0338071
RPS25 ribosomal protein S25 -0.0335306
EGR1 early growth response 1 -0.0332383
RACK1 receptor for activated C kinase 1 -0.0329888
DSTN destrin (actin depolymerizing factor) -0.032781
S100A9 S100 calcium binding protein A9 -0.0320956
KTN1 kinectin 1 (kinesin receptor) -0.0320595
RPL37 ribosomal protein L37 -0.0318534
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.031726
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0316757
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0316617
KLK10 kallikrein-related peptidase 10 -0.0315928
ENO1 enolase 1, (alpha) -0.0311639
UBE2B ubiquitin-conjugating enzyme E2B -0.0311631
ZNF292 zinc finger protein 292 -0.0310538
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0309791
RPL26 ribosomal protein L26 -0.0309309
DSG2 desmoglein 2 -0.0307023