Salicylic acid_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NEBL nebulette 0.136609
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.13424
SLIT2 slit homolog 2 (Drosophila) 0.100802
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0958529
TENM3 teneurin transmembrane protein 3 0.0910492
ZNF608 zinc finger protein 608 0.0869277
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0818271
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0703688
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.06978
SMYD3 SET and MYND domain containing 3 0.0690516
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0685686
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0676406
DENND1A DENN/MADD domain containing 1A 0.0635064
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0634428
CABIN1 calcineurin binding protein 1 0.0615747
HSPA8 heat shock 70kDa protein 8 0.0586699
ZNF638 zinc finger protein 638 0.0582167
FMNL2 formin-like 2 0.0558315
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0556237
RCC1 regulator of chromosome condensation 1 0.0497044
TTC28 tetratricopeptide repeat domain 28 0.0483594
DST dystonin 0.0478649
WLS wntless Wnt ligand secretion mediator 0.0466934
KMT2C lysine (K)-specific methyltransferase 2C 0.0464826
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0440317
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0431689
ENO1 enolase 1, (alpha) 0.0430996
UBE3C ubiquitin protein ligase E3C 0.0427197
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0425433
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0421146
NFIA nuclear factor I/A 0.0415866
TRIO trio Rho guanine nucleotide exchange factor 0.0415628
ARHGAP32 Rho GTPase activating protein 32 0.0409714
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0408102
AUTS2 autism susceptibility candidate 2 0.0405794
USP34 ubiquitin specific peptidase 34 0.03915
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0391345
PCM1 pericentriolar material 1 0.0388187
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.038791
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0385969
USP9X ubiquitin specific peptidase 9, X-linked 0.0371351
NSD2 nuclear receptor binding SET domain protein 2 0.0359783
INTS6 integrator complex subunit 6 0.0355119
PTK2 protein tyrosine kinase 2 0.0355062
ANKRD36 ankyrin repeat domain 36 0.0355018
GYS1 glycogen synthase 1 (muscle) 0.0354098
TBL1X transducin (beta)-like 1X-linked 0.0352455
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0351806
SRRM2 serine/arginine repetitive matrix 2 0.03481
MACF1 microtubule-actin crosslinking factor 1 0.0347929
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0346804
HELZ helicase with zinc finger 0.0345417
SPATS2 spermatogenesis associated, serine-rich 2 0.0336886
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0336742
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0336503
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0334122
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0332872
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0330725
TBC1D5 TBC1 domain family, member 5 0.0328385
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0327947
PRKCE protein kinase C, epsilon 0.0324896
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.032403
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0323556
MKI67 marker of proliferation Ki-67 0.0323519
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0322059
DSCAM Down syndrome cell adhesion molecule 0.0320899
COL5A2 collagen, type V, alpha 2 0.0318759
CENPF centromere protein F, 350/400kDa 0.0318723
CKAP5 cytoskeleton associated protein 5 0.0318228
RPL3 ribosomal protein L3 0.0315928
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0311768
VCL vinculin 0.0311634
ZCCHC7 zinc finger, CCHC domain containing 7 0.0310332
MYH10 myosin, heavy chain 10, non-muscle 0.030651
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0306376
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.030375
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0303378
EEF2 eukaryotic translation elongation factor 2 0.0302677
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0302517
OGA O-GlcNAcase 0.0301183
JARID2 jumonji, AT rich interactive domain 2 0.0291915
SIK3 SIK family kinase 3 0.0288219
EIF4B eukaryotic translation initiation factor 4B 0.0283736
RRM2 ribonucleotide reductase M2 0.0278817
FAM193A family with sequence similarity 193, member A 0.0278756
TNRC18 trinucleotide repeat containing 18 0.027371
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0271378
TBCD tubulin folding cofactor D 0.0269357
WNK1 WNK lysine deficient protein kinase 1 0.0268834
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0268503
ASPH aspartate beta-hydroxylase 0.0267581
ADARB1 adenosine deaminase, RNA-specific, B1 0.0267414
BABAM2 BRISC and BRCA1 A complex member 2 0.026678
SNX14 sorting nexin 14 0.0265533
KDM2A lysine (K)-specific demethylase 2A 0.0264589
PTPRG protein tyrosine phosphatase, receptor type, G 0.0264204
SFPQ splicing factor proline/glutamine-rich 0.0262202
BNC2 basonuclin 2 0.0259918
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0259602
CANX calnexin 0.0258157

decreased expression

Symbol Name Standardized Value
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.102402
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0591744
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0586356
RPS6 ribosomal protein S6 -0.0543539
TMSB10 thymosin beta 10 -0.051977
CADM2 cell adhesion molecule 2 -0.0516263
IFI6 interferon, alpha-inducible protein 6 -0.0507168
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0496257
RPL12 ribosomal protein L12 -0.0477669
RAP1B RAP1B, member of RAS oncogene family -0.0446301
EGR1 early growth response 1 -0.0435481
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0432723
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0426666
PTMA prothymosin, alpha -0.0415021
RPL34 ribosomal protein L34 -0.0410229
SLF1 SMC5-SMC6 complex localization factor 1 -0.0409703
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0403684
TMEM41B transmembrane protein 41B -0.0397789
GRID2 glutamate receptor, ionotropic, delta 2 -0.0387307
B2M beta-2-microglobulin -0.0386649
RAD51B RAD51 paralog B -0.0364428
SOX2 SRY (sex determining region Y)-box 2 -0.0364243
RPS24 ribosomal protein S24 -0.0361209
RPS19 ribosomal protein S19 -0.0350643
RPS21 ribosomal protein S21 -0.0343839
RPL36A ribosomal protein L36a -0.0341115
RPLP1 ribosomal protein, large, P1 -0.0336139
RPS8 ribosomal protein S8 -0.0334824
RPL26 ribosomal protein L26 -0.0328091
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0321511
RPS12 ribosomal protein S12 -0.0312293
RPS5 ribosomal protein S5 -0.0311105
TUBB tubulin, beta class I -0.0301817
RPL9 ribosomal protein L9 -0.0288289
RPL18 ribosomal protein L18 -0.0280631
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0276682
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0272995
JMJD1C jumonji domain containing 1C -0.0272234
VIM vimentin -0.0269021
TPT1 tumor protein, translationally-controlled 1 -0.0265052
MYL12B myosin, light chain 12B, regulatory -0.0262868
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0259886
PFN1 profilin 1 -0.0253163
RPL11 ribosomal protein L11 -0.0252996
RPS4X ribosomal protein S4, X-linked -0.0251701
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.025043
RPL37A ribosomal protein L37a -0.0250152
H1-0 H1.0 linker histone -0.0248468
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.02468
NOP58 NOP58 ribonucleoprotein -0.0246024
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.024373
ACTG1 actin gamma 1 -0.0242853
RPLP0 ribosomal protein, large, P0 -0.0242375
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0240584
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0239037
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0235819
RPL36 ribosomal protein L36 -0.0233618
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.023351
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0229036
GNAS GNAS complex locus -0.0225784
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0224463
RPL32 ribosomal protein L32 -0.0220839
RPL27A ribosomal protein L27a -0.0219967
ZNFX1 zinc finger, NFX1-type containing 1 -0.0219679
PDE4D phosphodiesterase 4D, cAMP-specific -0.0219511
FAM162A family with sequence similarity 162, member A -0.021759
HHIP hedgehog interacting protein -0.0217324
NAP1L1 nucleosome assembly protein 1-like 1 -0.0213465
RBM25 RNA binding motif protein 25 -0.0213318
CALD1 caldesmon 1 -0.0211939
ISG15 ISG15 ubiquitin-like modifier -0.0211779
HMGB1 high mobility group box 1 -0.0210543
RAB7A RAB7A, member RAS oncogene family -0.0210309
RPLP2 ribosomal protein, large, P2 -0.0207449
TPI1 triosephosphate isomerase 1 -0.0205664
RTN4 reticulon 4 -0.0203839
ARB2A ARB2 cotranscriptional regulator A -0.0203273
RACK1 receptor for activated C kinase 1 -0.0202337
WDR45B WD repeat domain 45B -0.0201965
RPL19 ribosomal protein L19 -0.0199004
S100A9 S100 calcium binding protein A9 -0.0198952
TOX thymocyte selection-associated high mobility group box -0.0197853
RPS25 ribosomal protein S25 -0.0197851
CBX3 chromobox homolog 3 -0.0195599
RPS23 ribosomal protein S23 -0.0195252
FTL ferritin, light polypeptide -0.0187739
RPL30 ribosomal protein L30 -0.0186511
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0185153
RPL31 ribosomal protein L31 -0.0184845
RPS13 ribosomal protein S13 -0.0183118
TJP1 tight junction protein 1 -0.018303
RPS28 ribosomal protein S28 -0.0182503
ATP5F1E ATP synthase F1 subunit epsilon -0.0180917
RPL35 ribosomal protein L35 -0.0178505
EIF1 eukaryotic translation initiation factor 1 -0.0178131
RPL35A ribosomal protein L35a -0.0176669
RPS27A ribosomal protein S27a -0.0176564
TMEM123 transmembrane protein 123 -0.0173525
RPS27 ribosomal protein S27 -0.0173112
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0172589