Salicylic acid_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.169805
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0899133
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0726539
PDIA4 protein disulfide isomerase family A, member 4 0.0666901
TMEM178B transmembrane protein 178B 0.0599932
IFRD1 interferon-related developmental regulator 1 0.0544179
LEF1 lymphoid enhancer-binding factor 1 0.046207
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0437798
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0430875
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.041011
CDC73 cell division cycle 73 0.040931
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0400168
FNDC3B fibronectin type III domain containing 3B 0.0399971
SPTBN1 spectrin, beta, non-erythrocytic 1 0.039048
ZSWIM6 zinc finger, SWIM-type containing 6 0.0389382
MACF1 microtubule-actin crosslinking factor 1 0.0386432
SETBP1 SET binding protein 1 0.0364311
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0359436
TLE4 transducin-like enhancer of split 4 0.0357344
UBE2H ubiquitin-conjugating enzyme E2H 0.0349466
FMNL2 formin-like 2 0.0349238
COPA coatomer protein complex, subunit alpha 0.0347163
DST dystonin 0.0345442
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0333816
EXOC4 exocyst complex component 4 0.0333667
CEMIP2 cell migration inducing hyaluronidase 2 0.0324118
GLS2 glutaminase 2 (liver, mitochondrial) 0.0323906
AHNAK AHNAK nucleoprotein 0.0307945
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0300637
UTRN utrophin 0.0298323
ACTN1 actinin, alpha 1 0.0296596
PDLIM5 PDZ and LIM domain 5 0.0295102
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0294198
KDM3A lysine (K)-specific demethylase 3A 0.0293385
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0292143
PRELID2 PRELI domain containing 2 0.0291882
LRMDA leucine rich melanocyte differentiation associated 0.0288438
INTS6 integrator complex subunit 6 0.0277373
KMT2E lysine (K)-specific methyltransferase 2E 0.0276198
MYH9 myosin, heavy chain 9, non-muscle 0.0273307
PAX3 paired box 3 0.0272707
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0272314
IGF1R insulin-like growth factor 1 receptor 0.0269533
DSCAM Down syndrome cell adhesion molecule 0.026474
CABIN1 calcineurin binding protein 1 0.0264
COG5 component of oligomeric golgi complex 5 0.0261248
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0260634
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0257207
SMAD3 SMAD family member 3 0.0256313
FLNB filamin B, beta 0.0253812
APLP2 amyloid beta (A4) precursor-like protein 2 0.025377
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0252861
DOCK4 dedicator of cytokinesis 4 0.0249515
SAMD4A sterile alpha motif domain containing 4A 0.0245981
SND1 staphylococcal nuclease and tudor domain containing 1 0.0245737
ZYX zyxin 0.0242831
UBASH3B ubiquitin associated and SH3 domain containing B 0.0242504
EFCAB13 EF-hand calcium binding domain 13 0.0241418
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0237281
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0234152
WWTR1 WW domain containing transcription regulator 1 0.0230702
PEAK1 pseudopodium-enriched atypical kinase 1 0.0230096
ZFAND3 zinc finger, AN1-type domain 3 0.0227799
EXT1 exostosin glycosyltransferase 1 0.0227507
VCL vinculin 0.0221606
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0220564
CUL3 cullin 3 0.0214249
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0211569
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0209532
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0208739
AFDN afadin, adherens junction formation factor 0.0208336
ANXA2 annexin A2 0.0204566
VGF VGF nerve growth factor inducible 0.0201817
ZC3H11A zinc finger CCCH-type containing 11A 0.0201536
MCL1 myeloid cell leukemia 1 0.020049
ERRFI1 ERBB receptor feedback inhibitor 1 0.0199278
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0198947
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0198852
ATXN1 ataxin 1 0.0198312
NEK7 NIMA-related kinase 7 0.0195767
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0195012
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0193768
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0193508
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0193446
PLEC plectin 0.0192834
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0191477
VMP1 vacuole membrane protein 1 0.0190316
HELZ helicase with zinc finger 0.0190183
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0187435
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0187019
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0186582
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0185659
APP amyloid beta (A4) precursor protein 0.0184461
SMYD3 SET and MYND domain containing 3 0.0183011
RYBP RING1 and YY1 binding protein 0.0181744
MAML2 mastermind-like 2 (Drosophila) 0.0180471
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0179698
MSI2 musashi RNA-binding protein 2 0.0178742
BHLHE40 basic helix-loop-helix family, member e40 0.0177713
NRIP1 nuclear receptor interacting protein 1 0.0175943

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.3269
VIM vimentin -0.208076
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.100375
S100A6 S100 calcium binding protein A6 -0.0796022
HLA-B major histocompatibility complex, class I, B -0.0754938
TMSB10 thymosin beta 10 -0.0705617
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.067753
ACTG1 actin gamma 1 -0.064387
ENO1 enolase 1, (alpha) -0.0642272
DCT dopachrome tautomerase -0.0624447
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0617522
IGFBP5 insulin-like growth factor binding protein 5 -0.0590376
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0581152
IFI16 interferon, gamma-inducible protein 16 -0.0535668
MT2A metallothionein 2A -0.0522349
HILPDA hypoxia inducible lipid droplet-associated -0.0522319
CALD1 caldesmon 1 -0.0509566
GDF15 growth differentiation factor 15 -0.0505457
TAGLN2 transgelin 2 -0.0503676
NLGN1 neuroligin 1 -0.0499671
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0445974
AKAP12 A kinase (PRKA) anchor protein 12 -0.0437288
PKM pyruvate kinase, muscle -0.0418447
GPC6 glypican 6 -0.0406351
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0406263
POTEF POTE ankyrin domain family, member F -0.0388114
VDAC1 voltage-dependent anion channel 1 -0.0369988
PLIN2 perilipin 2 -0.0366673
PTMA prothymosin, alpha -0.036468
CD109 CD109 molecule -0.0359499
PGK1 phosphoglycerate kinase 1 -0.0356307
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0347116
BACE2 beta-site APP-cleaving enzyme 2 -0.0346036
MTDH metadherin -0.0343147
CENPF centromere protein F, 350/400kDa -0.0341022
S100A9 S100 calcium binding protein A9 -0.0335001
CTSD cathepsin D -0.0326998
TPI1 triosephosphate isomerase 1 -0.0326033
RPS8 ribosomal protein S8 -0.0322649
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0312689
KTN1 kinectin 1 (kinesin receptor) -0.0299845
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0298422
ENO2 enolase 2 (gamma, neuronal) -0.0290421
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0289765
FRMD4A FERM domain containing 4A -0.0283829
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0279605
TRIM2 tripartite motif containing 2 -0.027931
RPL35A ribosomal protein L35a -0.0277216
IFI6 interferon, alpha-inducible protein 6 -0.0276156
FTL ferritin, light polypeptide -0.0273596
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0270864
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0270058
ZMYND8 zinc finger, MYND-type containing 8 -0.026965
RPLP1 ribosomal protein, large, P1 -0.0267355
GNAS GNAS complex locus -0.0265394
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0265177
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0264999
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0261637
RPL37A ribosomal protein L37a -0.0260448
PDIA3 protein disulfide isomerase family A, member 3 -0.0258769
HSPB1 heat shock 27kDa protein 1 -0.0256835
RPS19 ribosomal protein S19 -0.0255685
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0253692
ANKRD12 ankyrin repeat domain 12 -0.0251126
LMNA lamin A/C -0.0250566
B2M beta-2-microglobulin -0.0246553
MT1X metallothionein 1X -0.0246215
TPT1 tumor protein, translationally-controlled 1 -0.0244722
CYB5R3 cytochrome b5 reductase 3 -0.0241372
DSTN destrin (actin depolymerizing factor) -0.0235451
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0232731
CD63 CD63 molecule -0.0230273
IGFBP7 insulin-like growth factor binding protein 7 -0.0229845
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0228137
HLA-A major histocompatibility complex, class I, A -0.0226638
PTPRD protein tyrosine phosphatase, receptor type, D -0.0226573
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0224573
S100A10 S100 calcium binding protein A10 -0.0222597
PFN1 profilin 1 -0.022139
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0220814
RPL34 ribosomal protein L34 -0.02174
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0216109
SCFD2 sec1 family domain containing 2 -0.0214364
IFITM3 interferon induced transmembrane protein 3 -0.0213344
COL19A1 collagen, type XIX, alpha 1 -0.021135
MRPS6 mitochondrial ribosomal protein S6 -0.0210928
TM4SF1 transmembrane 4 L six family member 1 -0.0209235
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0208988
NPC1 Niemann-Pick disease, type C1 -0.0207815
RFX7 regulatory factor X, 7 -0.0204653
UBXN4 UBX domain protein 4 -0.0203738
RNF24 ring finger protein 24 -0.0203617
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0200005
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.019746
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0196821
MFSD12 major facilitator superfamily domain containing 12 -0.0196219
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0196074
RPLP2 ribosomal protein, large, P2 -0.0194417
CD59 CD59 molecule, complement regulatory protein -0.0193103
INSIG1 insulin induced gene 1 -0.0190751