Salicylic acid_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.207934
LAMB3 laminin, beta 3 0.153443
SAMD4A sterile alpha motif domain containing 4A 0.153373
AHNAK AHNAK nucleoprotein 0.116583
MMP7 matrix metallopeptidase 7 0.0859793
LAMA4 laminin, alpha 4 0.0739518
LMO7 LIM domain 7 0.0617614
LAMC2 laminin, gamma 2 0.0610957
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0578457
DST dystonin 0.0555648
EFNA5 ephrin-A5 0.0540705
MAML2 mastermind-like 2 (Drosophila) 0.0534477
APOL1 apolipoprotein L, 1 0.0528806
LPP LIM domain containing preferred translocation partner in lipoma 0.0516671
ZSWIM6 zinc finger, SWIM-type containing 6 0.0507125
DTNA dystrobrevin, alpha 0.0498655
FNDC3B fibronectin type III domain containing 3B 0.0497174
PLEC plectin 0.0479104
AHNAK2 AHNAK nucleoprotein 2 0.0465303
MYO1E myosin IE 0.0463664
SMAD3 SMAD family member 3 0.0448495
EXT1 exostosin glycosyltransferase 1 0.0440921
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0423187
HLA-C major histocompatibility complex, class I, C 0.0419397
CMIP c-Maf inducing protein 0.0413639
AKAP12 A kinase (PRKA) anchor protein 12 0.0413056
APP amyloid beta (A4) precursor protein 0.0411904
TRIO trio Rho guanine nucleotide exchange factor 0.0402299
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0399612
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0392505
ASPH aspartate beta-hydroxylase 0.0388007
GRB10 growth factor receptor-bound protein 10 0.0386528
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0367263
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0366748
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0362457
RAD51B RAD51 paralog B 0.0358528
HMGA2 high mobility group AT-hook 2 0.0357211
BZW1 basic leucine zipper and W2 domains 1 0.0352614
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0342341
CANX calnexin 0.0339023
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0338313
PRKCA protein kinase C, alpha 0.0335385
PHF3 PHD finger protein 3 0.0333347
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0327437
AKAP13 A kinase (PRKA) anchor protein 13 0.0326663
KLF5 Kruppel-like factor 5 (intestinal) 0.032351
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0312551
ATXN1 ataxin 1 0.0310329
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0310289
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0308235
ANXA2 annexin A2 0.030643
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.030633
TBC1D22A TBC1 domain family, member 22A 0.0297016
HDLBP high density lipoprotein binding protein 0.0296223
BACE2 beta-site APP-cleaving enzyme 2 0.0288235
TTC3 tetratricopeptide repeat domain 3 0.0280871
VEGFA vascular endothelial growth factor A 0.028065
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0280505
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0279079
KYNU kynureninase 0.0278556
VMP1 vacuole membrane protein 1 0.0277059
UGDH UDP-glucose 6-dehydrogenase 0.027649
EZR ezrin 0.0274062
MACF1 microtubule-actin crosslinking factor 1 0.0273679
EGFR epidermal growth factor receptor 0.0273619
ARHGAP5 Rho GTPase activating protein 5 0.0273063
VCL vinculin 0.0270412
IGF1R insulin-like growth factor 1 receptor 0.0267815
BIRC3 baculoviral IAP repeat containing 3 0.0267604
SGMS2 sphingomyelin synthase 2 0.0267345
HDAC9 histone deacetylase 9 0.0264425
RUNX1 runt-related transcription factor 1 0.0262762
INTS6 integrator complex subunit 6 0.02625
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0261164
ZMIZ1 zinc finger, MIZ-type containing 1 0.0260171
DOCK5 dedicator of cytokinesis 5 0.0255015
F3 coagulation factor III (thromboplastin, tissue factor) 0.0254384
FAM107B family with sequence similarity 107, member B 0.0253605
BCAR3 breast cancer anti-estrogen resistance 3 0.0253558
ANXA1 annexin A1 0.025295
NCKAP5 NCK-associated protein 5 0.0251368
SEPTIN9 septin 9 0.0249205
SEC31A SEC31 homolog A (S. cerevisiae) 0.0246096
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0245773
MYH9 myosin, heavy chain 9, non-muscle 0.024155
CP ceruloplasmin (ferroxidase) 0.0238211
SDC4 syndecan 4 0.0237662
LASP1 LIM and SH3 protein 1 0.0236811
EHBP1 EH domain binding protein 1 0.0234681
SVIL supervillin 0.0232494
MYO5B myosin VB 0.0232178
NPAS2 neuronal PAS domain protein 2 0.0230135
GOLGB1 golgin B1 0.0229494
RNF213 ring finger protein 213 0.0228229
SMYD3 SET and MYND domain containing 3 0.0227826
RASAL2 RAS protein activator like 2 0.0221433
TPM4 tropomyosin 4 0.0219448
TMC5 transmembrane channel-like 5 0.0219405
IQGAP1 IQ motif containing GTPase activating protein 1 0.0216507
UBASH3B ubiquitin associated and SH3 domain containing B 0.0216229

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.268738
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.153572
PTMA prothymosin, alpha -0.144343
TMSB10 thymosin beta 10 -0.122
MT1X metallothionein 1X -0.114499
NAMPT nicotinamide phosphoribosyltransferase -0.112409
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.102152
B2M beta-2-microglobulin -0.0791027
NDRG1 N-myc downstream regulated 1 -0.0739995
EIF1 eukaryotic translation initiation factor 1 -0.0729888
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0721956
FTL ferritin, light polypeptide -0.058765
RTN4 reticulon 4 -0.0583308
TSC22D2 TSC22 domain family, member 2 -0.0560857
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0559068
RPL19 ribosomal protein L19 -0.0544726
ACTG1 actin gamma 1 -0.0529267
IFI27 interferon, alpha-inducible protein 27 -0.0516272
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0507065
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0482694
WSB1 WD repeat and SOCS box containing 1 -0.0481202
RPS6 ribosomal protein S6 -0.0479127
RPLP1 ribosomal protein, large, P1 -0.0478384
RPL11 ribosomal protein L11 -0.0476091
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0459604
RPS8 ribosomal protein S8 -0.0457831
RPS2 ribosomal protein S2 -0.0431228
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0430314
PRRC2C proline-rich coiled-coil 2C -0.0424831
TPT1 tumor protein, translationally-controlled 1 -0.0416944
HMGA1 high mobility group AT-hook 1 -0.0410728
RPL9 ribosomal protein L9 -0.0410438
PLAUR plasminogen activator, urokinase receptor -0.0410196
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0410122
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0396894
POTEF POTE ankyrin domain family, member F -0.0395827
KMT2E lysine (K)-specific methyltransferase 2E -0.039321
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0387652
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0386344
ISG15 ISG15 ubiquitin-like modifier -0.0384185
TOP1 topoisomerase (DNA) I -0.0370099
RPL23 ribosomal protein L23 -0.036023
FAM162A family with sequence similarity 162, member A -0.0358634
RPS19 ribosomal protein S19 -0.0345558
RPL37A ribosomal protein L37a -0.0344916
HLA-B major histocompatibility complex, class I, B -0.034371
RPLP0 ribosomal protein, large, P0 -0.0325059
PCBP2 poly(rC) binding protein 2 -0.032352
RPS29 ribosomal protein S29 -0.0316682
RPS21 ribosomal protein S21 -0.0315879
RPS23 ribosomal protein S23 -0.0310175
UBC ubiquitin C -0.0306892
TMEM165 transmembrane protein 165 -0.0303308
RPL34 ribosomal protein L34 -0.030084
LY6E lymphocyte antigen 6 complex, locus E -0.0299334
TFG TRK-fused gene -0.0293827
MCTP1 multiple C2 domains, transmembrane 1 -0.0293097
UGCG UDP-glucose ceramide glucosyltransferase -0.0287583
RBM39 RNA binding motif protein 39 -0.0286457
RPL35A ribosomal protein L35a -0.0282615
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.02807
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0279236
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0278872
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0277929
RPS24 ribosomal protein S24 -0.0277724
RPL5 ribosomal protein L5 -0.0276167
RBM25 RNA binding motif protein 25 -0.0276147
VIM vimentin -0.0276031
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0273527
C15ORF48 chromosome 15 open reading frame 48 -0.0273408
RPS12 ribosomal protein S12 -0.0271922
S100A6 S100 calcium binding protein A6 -0.0269504
CCNL1 cyclin L1 -0.0268852
PDIA3 protein disulfide isomerase family A, member 3 -0.0268725
BRD2 bromodomain containing 2 -0.0267524
DDIT4 DNA-damage-inducible transcript 4 -0.0265961
CSTB cystatin B (stefin B) -0.0262843
ARL5B ADP-ribosylation factor-like 5B -0.0261647
NUP58 nucleoporin 58 -0.0260139
PNN pinin, desmosome associated protein -0.0259209
LAMB1 laminin, beta 1 -0.0259051
ADM adrenomedullin -0.0256469
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.025394
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0253068
TRA2B transformer 2 beta homolog (Drosophila) -0.025146
CNRIP1 cannabinoid receptor interacting protein 1 -0.0249895
RAB6A RAB6A, member RAS oncogene family -0.0249765
RPS3 ribosomal protein S3 -0.024931
FOSL1 FOS-like antigen 1 -0.0247771
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.024696
NOP58 NOP58 ribonucleoprotein -0.0242515
CDCP1 CUB domain containing protein 1 -0.0238774
RPS14 ribosomal protein S14 -0.0235307
TXNIP thioredoxin interacting protein -0.0235221
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0234708
DSTN destrin (actin depolymerizing factor) -0.0234548
CCNI cyclin I -0.0231767
STRN3 striatin, calmodulin binding protein 3 -0.0231024
SLC38A1 solute carrier family 38, member 1 -0.0230866
ZNF292 zinc finger protein 292 -0.0229669