Salicylic acid_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.109132
LSAMP limbic system-associated membrane protein 0.0780607
AKAP12 A kinase (PRKA) anchor protein 12 0.0759465
FMN1 formin 1 0.0752253
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0627654
NALF1 NALCN channel auxiliary factor 1 0.0550507
TLE4 transducin-like enhancer of split 4 0.0527947
PRKCA protein kinase C, alpha 0.0495601
EXT1 exostosin glycosyltransferase 1 0.0452167
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0447846
RNF213 ring finger protein 213 0.0376767
NPAS2 neuronal PAS domain protein 2 0.0371877
PTPRM protein tyrosine phosphatase, receptor type, M 0.0370811
FNDC3A fibronectin type III domain containing 3A 0.0368627
ZSWIM6 zinc finger, SWIM-type containing 6 0.0343333
ANTXR1 anthrax toxin receptor 1 0.0333226
LINGO2 leucine rich repeat and Ig domain containing 2 0.0319429
TRIO trio Rho guanine nucleotide exchange factor 0.0308978
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0306949
INTS6 integrator complex subunit 6 0.0292831
CEMIP cell migration inducing protein, hyaluronan binding 0.028864
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0281174
PTPRD protein tyrosine phosphatase, receptor type, D 0.0273862
TPM1 tropomyosin 1 (alpha) 0.0273644
TENM4 teneurin transmembrane protein 4 0.0268345
MEF2A myocyte enhancer factor 2A 0.0266613
DPH6 diphthamine biosynthesis 6 0.0266569
PDLIM5 PDZ and LIM domain 5 0.026593
GPC5 glypican 5 0.0265394
VMP1 vacuole membrane protein 1 0.0264538
SMYD3 SET and MYND domain containing 3 0.0263897
PCBP3 poly(rC) binding protein 3 0.0258435
ADGRB3 adhesion G protein-coupled receptor B3 0.0244825
ZNF638 zinc finger protein 638 0.0238881
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.02376
AEBP2 AE binding protein 2 0.0237572
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0235657
NREP neuronal regeneration related protein 0.0231092
AUTS2 autism susceptibility candidate 2 0.0228291
MSI2 musashi RNA-binding protein 2 0.022815
PSD3 pleckstrin and Sec7 domain containing 3 0.0222938
STK38L serine/threonine kinase 38 like 0.0218146
COL4A1 collagen, type IV, alpha 1 0.0217053
FLT1 fms-related tyrosine kinase 1 0.0214498
RAD51B RAD51 paralog B 0.0211717
HOMER1 homer scaffolding protein 1 0.0210856
PDE10A phosphodiesterase 10A 0.0208337
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0207501
ASCC3 activating signal cointegrator 1 complex subunit 3 0.020527
PACS1 phosphofurin acidic cluster sorting protein 1 0.020209
ERRFI1 ERBB receptor feedback inhibitor 1 0.0195552
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0195216
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0192298
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0191357
FNDC3B fibronectin type III domain containing 3B 0.0191152
THSD4 thrombospondin, type I, domain containing 4 0.0191147
RPTOR regulatory associated protein of MTOR, complex 1 0.0191047
BPTF bromodomain PHD finger transcription factor 0.0188941
MACF1 microtubule-actin crosslinking factor 1 0.0188906
IGFBP3 insulin-like growth factor binding protein 3 0.0179405
CYTH1 cytohesin 1 0.0179336
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0177582
EPAS1 endothelial PAS domain protein 1 0.0176565
THBS1 thrombospondin 1 0.0173989
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0173205
ELL2 elongation factor, RNA polymerase II, 2 0.0172505
HSPA8 heat shock 70kDa protein 8 0.0171715
FERMT2 fermitin family member 2 0.0171007
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0170752
COL4A2 collagen, type IV, alpha 2 0.0168641
SYNPO2 synaptopodin 2 0.0168429
TUFT1 tuftelin 1 0.0167752
MYO1E myosin IE 0.0166283
KCTD16 potassium channel tetramerization domain containing 16 0.016494
VEGFA vascular endothelial growth factor A 0.0163001
KAT6B K(lysine) acetyltransferase 6B 0.0162942
DUSP10 dual specificity phosphatase 10 0.0161713
HDX highly divergent homeobox 0.0161638
LRRC7 leucine rich repeat containing 7 0.0159379
MYH9 myosin, heavy chain 9, non-muscle 0.0158136
ARID5B AT rich interactive domain 5B (MRF1-like) 0.015742
FRMD4A FERM domain containing 4A 0.01569
GREM2 gremlin 2, DAN family BMP antagonist 0.0156376
SMAD3 SMAD family member 3 0.0156339
SIK2 salt-inducible kinase 2 0.0156305
ZC3H11A zinc finger CCCH-type containing 11A 0.0154895
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0154889
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0154007
STXBP4 syntaxin binding protein 4 0.015317
SDK1 sidekick cell adhesion molecule 1 0.0153084
HDAC4 histone deacetylase 4 0.0153063
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0151019
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0150338
LPP LIM domain containing preferred translocation partner in lipoma 0.015004
WDFY3 WD repeat and FYVE domain containing 3 0.0147167
DNMBP dynamin binding protein 0.0146661
FAM13A family with sequence similarity 13, member A 0.0146379
TBC1D22A TBC1 domain family, member 22A 0.0146244
DNM3 dynamin 3 0.0146213
ITPRID2 ITPR interacting domain containing 2 0.0145713

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.366438
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169906
PTMA prothymosin, alpha -0.16677
VIM vimentin -0.142911
IGF2 insulin-like growth factor 2 -0.116972
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0829492
RPL23 ribosomal protein L23 -0.0828584
RPS6 ribosomal protein S6 -0.079284
TPT1 tumor protein, translationally-controlled 1 -0.0670928
TMSB10 thymosin beta 10 -0.0622153
RPS12 ribosomal protein S12 -0.0618232
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0615291
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0605628
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0594385
RPS24 ribosomal protein S24 -0.0558954
RPL37A ribosomal protein L37a -0.0532429
RPLP1 ribosomal protein, large, P1 -0.0509387
RPL34 ribosomal protein L34 -0.0495831
COL1A1 collagen, type I, alpha 1 -0.0487649
RPL35A ribosomal protein L35a -0.0474336
EIF1 eukaryotic translation initiation factor 1 -0.0470352
RPL19 ribosomal protein L19 -0.0465764
B2M beta-2-microglobulin -0.0457592
PRRC2C proline-rich coiled-coil 2C -0.0451418
RPS27A ribosomal protein S27a -0.0443519
RPL12 ribosomal protein L12 -0.0442389
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0413251
HMGB2 high mobility group box 2 -0.0395133
PKM pyruvate kinase, muscle -0.03783
RPLP0 ribosomal protein, large, P0 -0.0367385
GOLGA4 golgin A4 -0.0360072
FTL ferritin, light polypeptide -0.0359571
ACTG1 actin gamma 1 -0.0355741
RPL26 ribosomal protein L26 -0.0350644
RPS3 ribosomal protein S3 -0.0349017
RACK1 receptor for activated C kinase 1 -0.0346277
NAP1L1 nucleosome assembly protein 1-like 1 -0.0344674
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0339738
KPNB1 karyopherin (importin) beta 1 -0.033821
UBC ubiquitin C -0.0335763
ENO1 enolase 1, (alpha) -0.0333147
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0332785
MAP1B microtubule-associated protein 1B -0.0330449
LPIN1 lipin 1 -0.0328385
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0328295
RPS19 ribosomal protein S19 -0.0326757
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0314106
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0314103
RPL36 ribosomal protein L36 -0.0311201
LMNA lamin A/C -0.0308773
CENPF centromere protein F, 350/400kDa -0.0306889
WDR45B WD repeat domain 45B -0.0294098
PCBP2 poly(rC) binding protein 2 -0.0290411
GATA3 GATA binding protein 3 -0.0286284
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0283421
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0281632
LDHA lactate dehydrogenase A -0.0280313
H3-3B H3.3 histone B -0.0279691
S100A9 S100 calcium binding protein A9 -0.0278933
RPS17 ribosomal protein S17 -0.0278264
RPS25 ribosomal protein S25 -0.0277823
RPS27 ribosomal protein S27 -0.0276404
RPL37 ribosomal protein L37 -0.0274382
EEF2 eukaryotic translation elongation factor 2 -0.0273869
RPL32 ribosomal protein L32 -0.0272574
SRPK2 SRSF protein kinase 2 -0.0269492
RPL31 ribosomal protein L31 -0.0268989
AHNAK AHNAK nucleoprotein -0.0267482
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0266915
RBM25 RNA binding motif protein 25 -0.026529
RPL38 ribosomal protein L38 -0.0252629
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0251127
RPL9 ribosomal protein L9 -0.0250918
RPS8 ribosomal protein S8 -0.0248191
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0245314
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0244982
RHOA ras homolog family member A -0.0240798
NOP58 NOP58 ribonucleoprotein -0.0240798
RPL7A ribosomal protein L7a -0.0239608
SYT1 synaptotagmin I -0.0239353
ANKRD12 ankyrin repeat domain 12 -0.0235649
WSB1 WD repeat and SOCS box containing 1 -0.0234931
UBE2B ubiquitin-conjugating enzyme E2B -0.0234849
RPL5 ribosomal protein L5 -0.0232569
CD36 CD36 molecule (thrombospondin receptor) -0.0231966
RPS14 ribosomal protein S14 -0.0231583
SEPTIN7 septin 7 -0.0231455
RPS11 ribosomal protein S11 -0.0230531
GNAS GNAS complex locus -0.0228614
KTN1 kinectin 1 (kinesin receptor) -0.0227243
NAMPT nicotinamide phosphoribosyltransferase -0.0226719
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0225669
RPLP2 ribosomal protein, large, P2 -0.0225181
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0224878
S100A6 S100 calcium binding protein A6 -0.0223534
SQSTM1 sequestosome 1 -0.0222291
ZFAND3 zinc finger, AN1-type domain 3 -0.0220564
RPS29 ribosomal protein S29 -0.0218895
CADM2 cell adhesion molecule 2 -0.0216626
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0214079