Salicylic acid_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.20442
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.170373
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.12102
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.110859
SMAD3 SMAD family member 3 0.107226
INTS6 integrator complex subunit 6 0.0917197
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0833426
MBNL2 muscleblind-like splicing regulator 2 0.0676755
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0513236
BTBD9 BTB (POZ) domain containing 9 0.0511085
SHB Src homology 2 domain containing adaptor protein B 0.049137
FNDC3B fibronectin type III domain containing 3B 0.0459939
DSCAM Down syndrome cell adhesion molecule 0.0405624
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.039452
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0391859
VEGFA vascular endothelial growth factor A 0.0390023
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0388522
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0381126
YAP1 Yes-associated protein 1 0.034687
RNF43 ring finger protein 43 0.0346162
AKAP13 A kinase (PRKA) anchor protein 13 0.0345208
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0341283
ATXN1 ataxin 1 0.0337418
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0335208
DSPP dentin sialophosphoprotein 0.0326454
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0319194
ARHGAP32 Rho GTPase activating protein 32 0.0317957
FNDC3A fibronectin type III domain containing 3A 0.0308907
TOX3 TOX high mobility group box family member 3 0.0305622
CEMIP2 cell migration inducing hyaluronidase 2 0.0294232
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0285883
EFNB2 ephrin-B2 0.0283397
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0277291
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0276874
AFF1 AF4/FMR2 family, member 1 0.0273169
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.02723
ZSWIM6 zinc finger, SWIM-type containing 6 0.0264993
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0264568
VMP1 vacuole membrane protein 1 0.0264187
EGLN3 egl-9 family hypoxia-inducible factor 3 0.026286
HKDC1 hexokinase domain containing 1 0.0255852
ABHD2 abhydrolase domain containing 2 0.0251348
MLPH melanophilin 0.0249587
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0248422
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0246771
CEMIP cell migration inducing protein, hyaluronan binding 0.0246653
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0242071
FAT1 FAT atypical cadherin 1 0.0241236
PDZD8 PDZ domain containing 8 0.0240811
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0239045
LURAP1L leucine rich adaptor protein 1-like 0.0237588
SH3PXD2A SH3 and PX domains 2A 0.0235649
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0234333
PRELID2 PRELI domain containing 2 0.0232461
ASPH aspartate beta-hydroxylase 0.0231795
CATSPERB catsper channel auxiliary subunit beta 0.0231598
SEC24D SEC24 family member D 0.0231324
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0230539
MCTP2 multiple C2 domains, transmembrane 2 0.0229494
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0229375
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0228821
CCNL1 cyclin L1 0.0226875
NCOA3 nuclear receptor coactivator 3 0.0221755
ZNF638 zinc finger protein 638 0.0221683
SORBS1 sorbin and SH3 domain containing 1 0.0219631
NRIP1 nuclear receptor interacting protein 1 0.0217104
SLK STE20-like kinase 0.0215198
USP9X ubiquitin specific peptidase 9, X-linked 0.0213923
APLP2 amyloid beta (A4) precursor-like protein 2 0.021355
KYNU kynureninase 0.0213174
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0211379
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0210504
UBE2H ubiquitin-conjugating enzyme E2H 0.0204384
IFNGR1 interferon gamma receptor 1 0.0203605
MYH9 myosin, heavy chain 9, non-muscle 0.0202897
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0202634
MYO1E myosin IE 0.0202551
DUSP10 dual specificity phosphatase 10 0.0201274
AHNAK AHNAK nucleoprotein 0.0197561
DST dystonin 0.0195223
PTBP3 polypyrimidine tract binding protein 3 0.0194501
PDLIM5 PDZ and LIM domain 5 0.019345
COG6 component of oligomeric golgi complex 6 0.0188674
EHF ets homologous factor 0.0186629
UTRN utrophin 0.0186613
HYOU1 hypoxia up-regulated 1 0.018561
KIF16B kinesin family member 16B 0.0183507
PLSCR2 phospholipid scramblase 2 0.0182627
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0180353
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0179016
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0178472
SEC23B Sec23 homolog B (S. cerevisiae) 0.0178405
SUCO SUN domain containing ossification factor 0.0178173
LNPEP leucyl/cystinyl aminopeptidase 0.0177941
PRSS22 protease, serine, 22 0.0177155
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0176172
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0175764
CADPS2 Ca++-dependent secretion activator 2 0.0174928
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0174852
SEPTIN9 septin 9 0.0174317

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.23761
PTMA prothymosin, alpha -0.166414
B2M beta-2-microglobulin -0.139389
EPSTI1 epithelial stromal interaction 1 (breast) -0.119074
LYZ lysozyme -0.109504
HLA-B major histocompatibility complex, class I, B -0.106701
IFI6 interferon, alpha-inducible protein 6 -0.103059
ZMYND8 zinc finger, MYND-type containing 8 -0.0964796
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0835606
LCN2 lipocalin 2 -0.0804523
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0799984
XAF1 XIAP associated factor 1 -0.0715336
FTL ferritin, light polypeptide -0.0650594
RPL35A ribosomal protein L35a -0.0631235
ACTG1 actin gamma 1 -0.0624762
SP100 SP100 nuclear antigen -0.0619954
TMSB10 thymosin beta 10 -0.0601001
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0599584
PERP PERP, TP53 apoptosis effector -0.0589608
RPL34 ribosomal protein L34 -0.056046
RPL7L1 ribosomal protein L7-like 1 -0.054876
NPSR1 neuropeptide S receptor 1 -0.0548248
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0547474
RIGI RNA sensor RIG-I -0.0522743
LOC102724023 ES1 protein homolog, mitochondrial -0.0510363
IFI27 interferon, alpha-inducible protein 27 -0.0503681
SLC38A1 solute carrier family 38, member 1 -0.0502675
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0501688
C6ORF132 chromosome 6 open reading frame 132 -0.0500573
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0488124
EGR1 early growth response 1 -0.0482537
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0469562
MUC20 mucin 20, cell surface associated -0.0468252
RPS6 ribosomal protein S6 -0.044839
TM4SF1 transmembrane 4 L six family member 1 -0.0437434
EIF1 eukaryotic translation initiation factor 1 -0.0436137
S100A6 S100 calcium binding protein A6 -0.0431818
MX2 MX dynamin-like GTPase 2 -0.0431758
RPL23 ribosomal protein L23 -0.0421806
MX1 MX dynamin-like GTPase 1 -0.0419625
RPL37A ribosomal protein L37a -0.0406023
GCC2 GRIP and coiled-coil domain containing 2 -0.0405662
EPCAM epithelial cell adhesion molecule -0.0399457
MPHOSPH8 M-phase phosphoprotein 8 -0.0391959
SQSTM1 sequestosome 1 -0.0382533
HLA-C major histocompatibility complex, class I, C -0.0381009
RPL31 ribosomal protein L31 -0.0365791
IFITM3 interferon induced transmembrane protein 3 -0.0350481
TJP1 tight junction protein 1 -0.0348184
RAB7A RAB7A, member RAS oncogene family -0.0347449
RRBP1 ribosome binding protein 1 -0.0347431
HLA-E major histocompatibility complex, class I, E -0.0347034
RPL19 ribosomal protein L19 -0.0346802
RPS8 ribosomal protein S8 -0.0342915
KPNB1 karyopherin (importin) beta 1 -0.0341247
PMP22 peripheral myelin protein 22 -0.034072
VCL vinculin -0.0339043
HLA-A major histocompatibility complex, class I, A -0.033845
SSH2 slingshot protein phosphatase 2 -0.0338212
VDAC1 voltage-dependent anion channel 1 -0.03364
MT2A metallothionein 2A -0.0334956
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0330546
ZNFX1 zinc finger, NFX1-type containing 1 -0.0321739
RPS19 ribosomal protein S19 -0.0317036
RPLP1 ribosomal protein, large, P1 -0.0314494
WSB1 WD repeat and SOCS box containing 1 -0.0313972
TPM4 tropomyosin 4 -0.0313017
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0309851
RABGAP1L RAB GTPase activating protein 1-like -0.0308256
AREG amphiregulin -0.0307844
RPS24 ribosomal protein S24 -0.0305143
ISG15 ISG15 ubiquitin-like modifier -0.030101
HMGB1 high mobility group box 1 -0.030021
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0291183
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0287101
RPL12 ribosomal protein L12 -0.0285458
RPL11 ribosomal protein L11 -0.0283472
TRIM56 tripartite motif containing 56 -0.0281235
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -0.027935
RPS3 ribosomal protein S3 -0.0278089
RPLP0 ribosomal protein, large, P0 -0.0277777
TFRC transferrin receptor -0.027721
BCL2L1 BCL2-like 1 -0.0276777
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0276698
RPL26 ribosomal protein L26 -0.0271146
RPL9 ribosomal protein L9 -0.0267293
RPL37 ribosomal protein L37 -0.0266915
UBE2B ubiquitin-conjugating enzyme E2B -0.0266762
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0266703
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.026648
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0264615
RPLP2 ribosomal protein, large, P2 -0.026425
NCOA7 nuclear receptor coactivator 7 -0.0263458
PRRC2C proline-rich coiled-coil 2C -0.0261857
IFIH1 interferon induced with helicase C domain 1 -0.0261528
RHOBTB3 Rho-related BTB domain containing 3 -0.0258267
CSTB cystatin B (stefin B) -0.0258185
STS steroid sulfatase (microsomal), isozyme S -0.0257676
HSH2D hematopoietic SH2 domain containing -0.0253335
RPL30 ribosomal protein L30 -0.0252562