Salicylic acid_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRELID2 PRELI domain containing 2 0.162549
ASPH aspartate beta-hydroxylase 0.129547
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.100188
RAD51B RAD51 paralog B 0.0976293
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0836786
LPP LIM domain containing preferred translocation partner in lipoma 0.0776527
FHIT fragile histidine triad 0.0755695
PSD3 pleckstrin and Sec7 domain containing 3 0.0745523
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0741149
HMGA2 high mobility group AT-hook 2 0.0714424
FNDC3B fibronectin type III domain containing 3B 0.070665
AHNAK AHNAK nucleoprotein 0.0680026
ATXN1 ataxin 1 0.062379
OSBPL10 oxysterol binding protein-like 10 0.0599317
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0532413
SVIL supervillin 0.0525894
EGFR epidermal growth factor receptor 0.0520856
SMYD3 SET and MYND domain containing 3 0.0498577
LAMC2 laminin, gamma 2 0.0471502
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0463568
PLEC plectin 0.0458809
TBC1D22A TBC1 domain family, member 22A 0.0445252
PAX8 paired box 8 0.0445052
TRIO trio Rho guanine nucleotide exchange factor 0.0442237
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0439069
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0438839
INTS6 integrator complex subunit 6 0.0438211
SMAD3 SMAD family member 3 0.0430646
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.042969
MYH9 myosin, heavy chain 9, non-muscle 0.0426096
VCL vinculin 0.042
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0413917
TBC1D5 TBC1 domain family, member 5 0.0410101
SEPTIN9 septin 9 0.0407817
MACROD2 MACRO domain containing 2 0.0403703
EXOC4 exocyst complex component 4 0.0401987
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0396098
DLC1 DLC1 Rho GTPase activating protein 0.0387673
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0386567
ZBTB20 zinc finger and BTB domain containing 20 0.0382832
CREB5 cAMP responsive element binding protein 5 0.0375296
WWOX WW domain containing oxidoreductase 0.036665
ECT2 epithelial cell transforming 2 0.0360529
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0357254
RUNX1 runt-related transcription factor 1 0.0356743
CD44 CD44 molecule (Indian blood group) 0.0356156
EXT1 exostosin glycosyltransferase 1 0.0349694
CTBP2 C-terminal binding protein 2 0.0345176
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0339719
DIAPH3 diaphanous-related formin 3 0.0337429
LAMA4 laminin, alpha 4 0.0335989
DOCK1 dedicator of cytokinesis 1 0.0335004
IGFBP3 insulin-like growth factor binding protein 3 0.0334197
PATJ PATJ crumbs cell polarity complex component 0.0334129
DENND1A DENN/MADD domain containing 1A 0.0330082
GPR39 G protein-coupled receptor 39 0.0327723
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0327574
TTC3 tetratricopeptide repeat domain 3 0.0325707
FLNA filamin A, alpha 0.0324152
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0322975
ANKRD36 ankyrin repeat domain 36 0.0316308
BBS9 Bardet-Biedl syndrome 9 0.0311422
ZNF638 zinc finger protein 638 0.030932
LAMB3 laminin, beta 3 0.0306888
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.030558
MYO1E myosin IE 0.0303512
SPATA13 spermatogenesis associated 13 0.0303457
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0302452
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0300808
CMIP c-Maf inducing protein 0.0299458
THSD4 thrombospondin, type I, domain containing 4 0.0298841
MBD5 methyl-CpG binding domain protein 5 0.0298818
RNF213 ring finger protein 213 0.0298502
ANKRD11 ankyrin repeat domain 11 0.0298192
FNIP1 folliculin interacting protein 1 0.0295691
LINGO2 leucine rich repeat and Ig domain containing 2 0.0295113
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0293106
RBMS3 RNA binding motif, single stranded interacting protein 3 0.029147
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0284961
UBASH3B ubiquitin associated and SH3 domain containing B 0.0273782
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0272326
EHBP1 EH domain binding protein 1 0.0267631
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0266303
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0266117
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0264319
ALCAM activated leukocyte cell adhesion molecule 0.0263646
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0261919
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0261773
SUMF1 sulfatase modifying factor 1 0.0258899
FLNB filamin B, beta 0.0256344
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0255129
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0252961
TNIK TRAF2 and NCK interacting kinase 0.0249574
ITGB8 integrin, beta 8 0.0247551
BICD1 bicaudal D homolog 1 (Drosophila) 0.0247419
ITGA6 integrin, alpha 6 0.0245453
MYOF myoferlin 0.0243873
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0243495
MACF1 microtubule-actin crosslinking factor 1 0.0242652
KRT86 keratin 86, type II 0.0241608

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1523
FTL ferritin, light polypeptide -0.129238
B2M beta-2-microglobulin -0.109552
PTMA prothymosin, alpha -0.0930889
TPT1 tumor protein, translationally-controlled 1 -0.0880704
RPS6 ribosomal protein S6 -0.0792799
RPS8 ribosomal protein S8 -0.0730161
TMSB10 thymosin beta 10 -0.0720426
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0688373
RPS19 ribosomal protein S19 -0.0656881
GOLGA4 golgin A4 -0.0643553
MT2A metallothionein 2A -0.0641215
RPS27A ribosomal protein S27a -0.0624716
RPL12 ribosomal protein L12 -0.0607855
RPS12 ribosomal protein S12 -0.058187
RPL19 ribosomal protein L19 -0.0579436
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0544363
RPL23 ribosomal protein L23 -0.0530257
UBC ubiquitin C -0.0523943
ACTG1 actin gamma 1 -0.0518081
SEPTIN7 septin 7 -0.0517429
RPL9 ribosomal protein L9 -0.0516204
RPL32 ribosomal protein L32 -0.051262
RPL31 ribosomal protein L31 -0.0484387
RPL26 ribosomal protein L26 -0.0484339
RPLP1 ribosomal protein, large, P1 -0.0475184
RPS5 ribosomal protein S5 -0.045622
RPS3 ribosomal protein S3 -0.0450337
EIF1 eukaryotic translation initiation factor 1 -0.0445861
MATR3 matrin 3 -0.0435457
RPLP2 ribosomal protein, large, P2 -0.0429026
SET SET nuclear proto-oncogene -0.0428294
RACK1 receptor for activated C kinase 1 -0.0425964
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0422721
RPL35A ribosomal protein L35a -0.041591
RPL11 ribosomal protein L11 -0.0414549
PCBP2 poly(rC) binding protein 2 -0.0410677
RPLP0 ribosomal protein, large, P0 -0.0410304
ZNF292 zinc finger protein 292 -0.0406608
RPL28 ribosomal protein L28 -0.0400758
RPL34 ribosomal protein L34 -0.0399685
S100A6 S100 calcium binding protein A6 -0.03988
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0392683
UGCG UDP-glucose ceramide glucosyltransferase -0.037868
RPS2 ribosomal protein S2 -0.0374885
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0374612
RPS24 ribosomal protein S24 -0.0374012
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0369362
RPS14 ribosomal protein S14 -0.0368645
RPL35 ribosomal protein L35 -0.0364801
S100A9 S100 calcium binding protein A9 -0.036081
RPL5 ribosomal protein L5 -0.0351062
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0349821
RNF145 ring finger protein 145 -0.034858
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0348137
RPS11 ribosomal protein S11 -0.0345761
RPS13 ribosomal protein S13 -0.0343011
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0338847
KDM3A lysine (K)-specific demethylase 3A -0.0336767
RPL15 ribosomal protein L15 -0.0336582
NAP1L1 nucleosome assembly protein 1-like 1 -0.0333214
APP amyloid beta (A4) precursor protein -0.0326536
PKM pyruvate kinase, muscle -0.0324698
RPL18 ribosomal protein L18 -0.0324631
RPL7A ribosomal protein L7a -0.0323514
RPS25 ribosomal protein S25 -0.0319106
RPL7 ribosomal protein L7 -0.0318577
RPS16 ribosomal protein S16 -0.0310805
RPS29 ribosomal protein S29 -0.0308841
RPL37A ribosomal protein L37a -0.0303977
RLF rearranged L-myc fusion -0.0302657
RTN4 reticulon 4 -0.0301044
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0300096
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0297179
NPEPPS aminopeptidase puromycin sensitive -0.0296002
EEF2 eukaryotic translation elongation factor 2 -0.0293105
GNAS GNAS complex locus -0.0292058
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0291337
RPL8 ribosomal protein L8 -0.029116
KMT2E lysine (K)-specific methyltransferase 2E -0.0288527
RPL36 ribosomal protein L36 -0.0288192
MYL12B myosin, light chain 12B, regulatory -0.0285558
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0284734
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0281902
RPS10 ribosomal protein S10 -0.0279458
PDIA3 protein disulfide isomerase family A, member 3 -0.0278423
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0278109
RPS23 ribosomal protein S23 -0.0277471
WAC WW domain containing adaptor with coiled-coil -0.0275028
H3-3B H3.3 histone B -0.0271698
NCKAP1 NCK-associated protein 1 -0.0269029
NOP58 NOP58 ribonucleoprotein -0.0265613
EIF5B eukaryotic translation initiation factor 5B -0.0262322
DSTN destrin (actin depolymerizing factor) -0.0261657
RPS15 ribosomal protein S15 -0.0260982
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0259019
PRRC2C proline-rich coiled-coil 2C -0.0255126
RPS27 ribosomal protein S27 -0.0254037
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0253625
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0252602