Salicylic acid_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.262868
IGFBP3 insulin-like growth factor binding protein 3 0.159351
VEGFA vascular endothelial growth factor A 0.0944806
TRIO trio Rho guanine nucleotide exchange factor 0.0917703
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0766945
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0634882
FNDC3B fibronectin type III domain containing 3B 0.0580127
MYH9 myosin, heavy chain 9, non-muscle 0.056963
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0550698
COL7A1 collagen, type VII, alpha 1 0.0518178
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0470928
PLEC plectin 0.0408511
ATXN1 ataxin 1 0.0402236
CDH13 cadherin 13 0.0397656
COL5A1 collagen, type V, alpha 1 0.0377045
EGFR epidermal growth factor receptor 0.0370196
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0347085
NAV2 neuron navigator 2 0.0345112
PDLIM5 PDZ and LIM domain 5 0.0322759
EXT1 exostosin glycosyltransferase 1 0.0319507
PRELID2 PRELI domain containing 2 0.0319043
MACF1 microtubule-actin crosslinking factor 1 0.0305867
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0283622
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0276313
HDAC9 histone deacetylase 9 0.0266215
SMAD3 SMAD family member 3 0.0263132
PICALM phosphatidylinositol binding clathrin assembly protein 0.0261331
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0257751
AHNAK AHNAK nucleoprotein 0.0254593
FAT1 FAT atypical cadherin 1 0.0253984
VCL vinculin 0.02487
MSN moesin 0.0246618
SFPQ splicing factor proline/glutamine-rich 0.0243747
TNS1 tensin 1 0.0234053
NAV1 neuron navigator 1 0.0217516
JARID2 jumonji, AT rich interactive domain 2 0.0213945
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0211575
INTS6 integrator complex subunit 6 0.0209542
CAMTA1 calmodulin binding transcription activator 1 0.0204663
PTPRG protein tyrosine phosphatase, receptor type, G 0.0202137
ZNF638 zinc finger protein 638 0.0200509
KMT2C lysine (K)-specific methyltransferase 2C 0.0198911
DST dystonin 0.0198631
GLS2 glutaminase 2 (liver, mitochondrial) 0.0193945
DOCK5 dedicator of cytokinesis 5 0.0192
RND3 Rho family GTPase 3 0.0189242
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0189068
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0188203
VMP1 vacuole membrane protein 1 0.018707
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0185948
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.018426
CABIN1 calcineurin binding protein 1 0.018412
PTK2 protein tyrosine kinase 2 0.0183064
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0180644
PGM3 phosphoglucomutase 3 0.0179951
ANO6 anoctamin 6 0.0178381
GRB10 growth factor receptor-bound protein 10 0.0177149
RICTOR RPTOR independent companion of MTOR, complex 2 0.0176257
RBM39 RNA binding motif protein 39 0.0176204
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0174543
FNIP1 folliculin interacting protein 1 0.0173633
HYOU1 hypoxia up-regulated 1 0.0173423
COPA coatomer protein complex, subunit alpha 0.0173416
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0172545
ADAM9 ADAM metallopeptidase domain 9 0.0172132
BRD2 bromodomain containing 2 0.0170945
FMNL2 formin-like 2 0.0170281
TBC1D22A TBC1 domain family, member 22A 0.0167825
EP300 E1A binding protein p300 0.0167294
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0165259
ANKRD11 ankyrin repeat domain 11 0.0164451
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0163277
USP34 ubiquitin specific peptidase 34 0.0163253
ZSWIM6 zinc finger, SWIM-type containing 6 0.0159753
EPHB1 EPH receptor B1 0.0159119
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0158628
ACTN1 actinin, alpha 1 0.0157005
YEATS2 YEATS domain containing 2 0.0156502
LPP LIM domain containing preferred translocation partner in lipoma 0.0156278
CCNL1 cyclin L1 0.0156248
COL6A1 collagen, type VI, alpha 1 0.0153527
STC2 stanniocalcin 2 0.0153338
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0149315
NCOR2 nuclear receptor corepressor 2 0.014917
PDE10A phosphodiesterase 10A 0.0149073
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0148799
FBXL7 F-box and leucine-rich repeat protein 7 0.0148733
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0148511
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0147499
SAMD4A sterile alpha motif domain containing 4A 0.0146867
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0145852
NOTCH2 notch 2 0.0144721
EIF4A2 eukaryotic translation initiation factor 4A2 0.0144449
RUNX1 runt-related transcription factor 1 0.0143381
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0143126
HSPA8 heat shock 70kDa protein 8 0.0142593
SMYD3 SET and MYND domain containing 3 0.0142345
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.014221
MYO10 myosin X 0.0142199
FLNB filamin B, beta 0.0141437

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.226446
VIM vimentin -0.204019
MT2A metallothionein 2A -0.199691
TMSB10 thymosin beta 10 -0.131811
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.12137
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.120677
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.115219
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0969931
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0881544
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0856129
CD44 CD44 molecule (Indian blood group) -0.0822288
COL1A2 collagen, type I, alpha 2 -0.0797553
FTL ferritin, light polypeptide -0.0794724
IER3 immediate early response 3 -0.075542
NDRG1 N-myc downstream regulated 1 -0.0727126
ENO1 enolase 1, (alpha) -0.0724453
RPS8 ribosomal protein S8 -0.0681246
TM4SF1 transmembrane 4 L six family member 1 -0.0672965
STC1 stanniocalcin 1 -0.0671705
FN1 fibronectin 1 -0.0636664
RPS6 ribosomal protein S6 -0.0632551
COL1A1 collagen, type I, alpha 1 -0.0630023
PTMA prothymosin, alpha -0.0609878
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0592639
B2M beta-2-microglobulin -0.0587787
TPM4 tropomyosin 4 -0.0581353
TGFBI transforming growth factor, beta-induced, 68kDa -0.0578638
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0554136
RPL35A ribosomal protein L35a -0.0553903
CALR calreticulin -0.0538497
LDHA lactate dehydrogenase A -0.0515116
EIF1 eukaryotic translation initiation factor 1 -0.0513279
TPT1 tumor protein, translationally-controlled 1 -0.049437
IGFBP7 insulin-like growth factor binding protein 7 -0.0490175
INHBA inhibin, beta A -0.0481806
S100A9 S100 calcium binding protein A9 -0.0478233
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0457755
IFI6 interferon, alpha-inducible protein 6 -0.0446622
RPS3 ribosomal protein S3 -0.04421
CAVIN1 caveolae associated protein 1 -0.043989
RPL26 ribosomal protein L26 -0.0430771
S100A6 S100 calcium binding protein A6 -0.0402139
RPL11 ribosomal protein L11 -0.0395254
RPL12 ribosomal protein L12 -0.0393318
RPL37A ribosomal protein L37a -0.0391789
ZBTB20 zinc finger and BTB domain containing 20 -0.0389814
TIMP1 TIMP metallopeptidase inhibitor 1 -0.038786
RPS12 ribosomal protein S12 -0.0385981
RACK1 receptor for activated C kinase 1 -0.0382094
RPS19 ribosomal protein S19 -0.0382079
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0375645
RPL7 ribosomal protein L7 -0.0371769
ACTG1 actin gamma 1 -0.0354807
RPL23 ribosomal protein L23 -0.0351627
RPL19 ribosomal protein L19 -0.0350839
CANX calnexin -0.0346766
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.034327
NAMPT nicotinamide phosphoribosyltransferase -0.0342896
RPL5 ribosomal protein L5 -0.0334439
RPL30 ribosomal protein L30 -0.0331849
RPL34 ribosomal protein L34 -0.0327817
ALCAM activated leukocyte cell adhesion molecule -0.0321405
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0313966
RPLP0 ribosomal protein, large, P0 -0.0308641
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0303085
DPYD dihydropyrimidine dehydrogenase -0.0296615
RPLP1 ribosomal protein, large, P1 -0.0294968
COL3A1 collagen, type III, alpha 1 -0.0288701
RPS13 ribosomal protein S13 -0.0288453
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0288339
GNAS GNAS complex locus -0.0286829
UBC ubiquitin C -0.028662
RPLP2 ribosomal protein, large, P2 -0.0281407
LMAN1 lectin, mannose-binding, 1 -0.0277076
PGK1 phosphoglycerate kinase 1 -0.0276622
RPL36 ribosomal protein L36 -0.0275724
YBX1 Y box binding protein 1 -0.0275296
IL6 interleukin 6 -0.027063
LOX lysyl oxidase -0.0269452
RPS24 ribosomal protein S24 -0.0267487
RPL8 ribosomal protein L8 -0.0267216
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0266097
HLA-A major histocompatibility complex, class I, A -0.0265863
RPS25 ribosomal protein S25 -0.0262513
RPS27A ribosomal protein S27a -0.026187
RPL37 ribosomal protein L37 -0.0261826
FAM162A family with sequence similarity 162, member A -0.02609
MTDH metadherin -0.025947
MARCKS myristoylated alanine-rich protein kinase C substrate -0.025648
LOC112694756 uncharaterized LOC112694756 -0.0253686
ADM adrenomedullin -0.0251069
TPI1 triosephosphate isomerase 1 -0.0249882
OSMR oncostatin M receptor -0.0249216
MT1X metallothionein 1X -0.0249068
RPS5 ribosomal protein S5 -0.0247627
SRGN serglycin -0.0245063
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0242646
KLF6 Kruppel-like factor 6 -0.0242094
RPL9 ribosomal protein L9 -0.023866
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0238659