Salicylic acid_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.126214
EXT1 exostosin glycosyltransferase 1 0.113004
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.099359
ADARB1 adenosine deaminase, RNA-specific, B1 0.0711716
SMAD3 SMAD family member 3 0.0545368
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0511118
ZSWIM6 zinc finger, SWIM-type containing 6 0.0469736
CTBP2 C-terminal binding protein 2 0.0453921
ERRFI1 ERBB receptor feedback inhibitor 1 0.0442972
ATXN1 ataxin 1 0.043287
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0416051
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0387563
VCL vinculin 0.0365726
LARP1B La ribonucleoprotein domain family, member 1B 0.0362135
VEGFA vascular endothelial growth factor A 0.0361027
HYOU1 hypoxia up-regulated 1 0.0350659
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0338699
FNDC3B fibronectin type III domain containing 3B 0.0337318
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0319777
TUFT1 tuftelin 1 0.0300957
PDLIM5 PDZ and LIM domain 5 0.0296524
LMO7 LIM domain 7 0.0295114
MCL1 myeloid cell leukemia 1 0.0279422
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.027579
P4HB prolyl 4-hydroxylase, beta polypeptide 0.026931
DST dystonin 0.0266048
CEMIP2 cell migration inducing hyaluronidase 2 0.0264302
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0261349
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0258846
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0254987
PLEC plectin 0.0252516
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0252468
MBNL2 muscleblind-like splicing regulator 2 0.0249032
POF1B premature ovarian failure, 1B 0.024716
APLP2 amyloid beta (A4) precursor-like protein 2 0.024452
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0244025
PDIA4 protein disulfide isomerase family A, member 4 0.0237081
TMCO3 transmembrane and coiled-coil domains 3 0.0234561
SPTBN1 spectrin, beta, non-erythrocytic 1 0.023272
EPS8L1 EPS8-like 1 0.0232237
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0230989
HM13 histocompatibility (minor) 13 0.0228633
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0228469
TLE4 transducin-like enhancer of split 4 0.0226733
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0225089
GOLGB1 golgin B1 0.0224397
UTRN utrophin 0.0222685
BTBD9 BTB (POZ) domain containing 9 0.0221552
SAMD4A sterile alpha motif domain containing 4A 0.021537
EGFR epidermal growth factor receptor 0.0207838
HOMER1 homer scaffolding protein 1 0.0204582
MYH9 myosin, heavy chain 9, non-muscle 0.0202787
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0201649
AEBP2 AE binding protein 2 0.019761
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0197547
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.019292
KDM6A lysine (K)-specific demethylase 6A 0.019291
PRR5L proline rich 5 like 0.0189765
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0189347
ARHGAP23 Rho GTPase activating protein 23 0.0189199
RUNX1 runt-related transcription factor 1 0.0188063
TTC3 tetratricopeptide repeat domain 3 0.018793
MACF1 microtubule-actin crosslinking factor 1 0.018776
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0187514
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0185888
SND1 staphylococcal nuclease and tudor domain containing 1 0.0185785
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0184575
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0184201
PGM3 phosphoglucomutase 3 0.0183167
RTN3 reticulon 3 0.0183137
NEBL nebulette 0.018281
FAM107B family with sequence similarity 107, member B 0.0182553
CCNYL1 cyclin Y-like 1 0.0176645
AGR2 anterior gradient 2 0.0171447
PTGES2 prostaglandin E synthase 2 0.0169707
SEC24D SEC24 family member D 0.0166894
PMM2 phosphomannomutase 2 0.0166647
RASEF RAS and EF-hand domain containing 0.0165933
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0165472
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0164378
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0163098
EIF4B eukaryotic translation initiation factor 4B 0.0161416
MYOF myoferlin 0.0160618
KIZ kizuna centrosomal protein 0.0160006
CNOT12 CCR4-NOT transcription complex subunit 12 0.015868
AFF1 AF4/FMR2 family, member 1 0.0157481
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0157453
AHNAK AHNAK nucleoprotein 0.0156327
HSPA8 heat shock 70kDa protein 8 0.0156286
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.015473
PDIA6 protein disulfide isomerase family A, member 6 0.0152712
ATF6 activating transcription factor 6 0.0151129
NUCB2 nucleobindin 2 0.0151036
DNHD1 dynein heavy chain domain 1 0.0150407
COPA coatomer protein complex, subunit alpha 0.0149998
LRRC23 leucine rich repeat containing 23 0.0148195
TRAPPC9 trafficking protein particle complex 9 0.0148001
PDIA5 protein disulfide isomerase family A, member 5 0.0147642
UBAP2 ubiquitin associated protein 2 0.0146509
NABP1 nucleic acid binding protein 1 0.0146439

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182743
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.145051
TPT1 tumor protein, translationally-controlled 1 -0.139957
TMSB10 thymosin beta 10 -0.116441
PTMA prothymosin, alpha -0.115332
LOC102724023 ES1 protein homolog, mitochondrial -0.0923408
FTL ferritin, light polypeptide -0.090925
NDRG1 N-myc downstream regulated 1 -0.0870341
S100A6 S100 calcium binding protein A6 -0.0849382
PLAUR plasminogen activator, urokinase receptor -0.0840691
ITPKC inositol-trisphosphate 3-kinase C -0.0823745
ACTG1 actin gamma 1 -0.0821202
RPS6 ribosomal protein S6 -0.0803152
LYZ lysozyme -0.0755055
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0738543
RPS19 ribosomal protein S19 -0.0733404
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0720361
ANXA2 annexin A2 -0.0714183
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0700031
RPLP1 ribosomal protein, large, P1 -0.0697938
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0650177
KRT19 keratin 19, type I -0.0641342
FTH1 ferritin, heavy polypeptide 1 -0.063939
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0626888
TXNRD1 thioredoxin reductase 1 -0.0619655
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0613011
S100A10 S100 calcium binding protein A10 -0.0609213
GARS1 glycyl-tRNA synthetase 1 -0.0589699
LAMA4 laminin, alpha 4 -0.0586257
RAB7A RAB7A, member RAS oncogene family -0.0583488
RPLP0 ribosomal protein, large, P0 -0.0578256
WASF2 WAS protein family, member 2 -0.0573841
RPL23 ribosomal protein L23 -0.056838
RPS21 ribosomal protein S21 -0.0553105
RPS24 ribosomal protein S24 -0.0530237
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0516876
B2M beta-2-microglobulin -0.0497425
HMGA1 high mobility group AT-hook 1 -0.0492858
RPS16 ribosomal protein S16 -0.0487599
TM4SF4 transmembrane 4 L six family member 4 -0.0485868
RPL12 ribosomal protein L12 -0.0484571
LMNA lamin A/C -0.0475458
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0475295
ACTN4 actinin, alpha 4 -0.0472678
EGR1 early growth response 1 -0.0467388
NAMPT nicotinamide phosphoribosyltransferase -0.0455354
RPL11 ribosomal protein L11 -0.0450131
MYL12B myosin, light chain 12B, regulatory -0.0449514
RPS5 ribosomal protein S5 -0.0445158
RPL18 ribosomal protein L18 -0.0434887
EZR ezrin -0.0420972
RAD21 RAD21 homolog (S. pombe) -0.0415945
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0414296
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0409303
JUP junction plakoglobin -0.0408112
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0403614
ZMYND8 zinc finger, MYND-type containing 8 -0.0403392
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0403363
RPL34 ribosomal protein L34 -0.0402719
PGK1 phosphoglycerate kinase 1 -0.0402036
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.03972
RPL9 ribosomal protein L9 -0.0395344
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0394974
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0388634
NECTIN2 nectin cell adhesion molecule 2 -0.0382831
PTK2 protein tyrosine kinase 2 -0.038188
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0381636
RPS11 ribosomal protein S11 -0.0378752
MKI67 marker of proliferation Ki-67 -0.037645
DIAPH2 diaphanous-related formin 2 -0.0374838
LOC112694756 uncharaterized LOC112694756 -0.0374307
RPLP2 ribosomal protein, large, P2 -0.0372282
JUN jun proto-oncogene -0.0372206
TPI1 triosephosphate isomerase 1 -0.0366847
RPS3 ribosomal protein S3 -0.0365209
TAGLN2 transgelin 2 -0.036441
CLDN4 claudin 4 -0.036211
CBX3 chromobox homolog 3 -0.0361777
ARL5B ADP-ribosylation factor-like 5B -0.0360386
CD2AP CD2-associated protein -0.0358396
KLF3 Kruppel-like factor 3 (basic) -0.0353482
KLF6 Kruppel-like factor 6 -0.0352589
RPS8 ribosomal protein S8 -0.0352447
ANKRD12 ankyrin repeat domain 12 -0.0351062
ZFP36 ZFP36 ring finger protein -0.0350682
CNRIP1 cannabinoid receptor interacting protein 1 -0.0347922
TRIB1 tribbles pseudokinase 1 -0.0347172
FRY furry homolog (Drosophila) -0.0343956
KLK10 kallikrein-related peptidase 10 -0.0341082
RNF24 ring finger protein 24 -0.0335113
STK24 serine/threonine kinase 24 -0.0332986
ESYT2 extended synaptotagmin-like protein 2 -0.032821
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0323694
RPL8 ribosomal protein L8 -0.0322226
KLF10 Kruppel-like factor 10 -0.032059
ITGA6 integrin, alpha 6 -0.0319779
EPCAM epithelial cell adhesion molecule -0.0319458
CENPF centromere protein F, 350/400kDa -0.0317812
POMP proteasome maturation protein -0.0317398
HMGB1 high mobility group box 1 -0.0317003