Salicylic acid_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.166257
EXT1 exostosin glycosyltransferase 1 0.152003
ERBIN erbb2 interacting protein 0.12293
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0625672
MYH9 myosin, heavy chain 9, non-muscle 0.0619761
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0579419
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0579206
ASPH aspartate beta-hydroxylase 0.0578088
HSPH1 heat shock 105kDa/110kDa protein 1 0.0571479
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0567361
INTS6 integrator complex subunit 6 0.0558307
RND3 Rho family GTPase 3 0.0554269
VCL vinculin 0.0503513
ZSWIM6 zinc finger, SWIM-type containing 6 0.0503281
NAV2 neuron navigator 2 0.0496063
PICALM phosphatidylinositol binding clathrin assembly protein 0.045794
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0456306
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0453016
MSN moesin 0.0451549
TLE4 transducin-like enhancer of split 4 0.0448447
TXNRD1 thioredoxin reductase 1 0.0436002
CALD1 caldesmon 1 0.0432485
VMP1 vacuole membrane protein 1 0.0428937
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0421103
ZNF841 zinc finger protein 841 0.0418371
PDLIM5 PDZ and LIM domain 5 0.0411432
COL7A1 collagen, type VII, alpha 1 0.0408943
FNDC3B fibronectin type III domain containing 3B 0.0393086
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0389654
SLIT2 slit homolog 2 (Drosophila) 0.0387435
SMAD3 SMAD family member 3 0.0385441
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0370119
BCAR3 breast cancer anti-estrogen resistance 3 0.0363341
TUFT1 tuftelin 1 0.0356956
RBM39 RNA binding motif protein 39 0.0354996
DST dystonin 0.0350113
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0341063
SDC4 syndecan 4 0.0339305
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0332996
MCL1 myeloid cell leukemia 1 0.0321139
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0320865
VEGFA vascular endothelial growth factor A 0.031524
MACF1 microtubule-actin crosslinking factor 1 0.0314895
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0309064
APLP2 amyloid beta (A4) precursor-like protein 2 0.0307276
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0306889
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0306134
PLSCR1 phospholipid scramblase 1 0.0303776
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0298734
GLIPR1 GLI pathogenesis-related 1 0.0291428
MB21D2 Mab-21 domain containing 2 0.0290446
MYO10 myosin X 0.0289848
SH3RF1 SH3 domain containing ring finger 1 0.0288552
MBNL1 muscleblind-like splicing regulator 1 0.0279677
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.026897
TPM3 tropomyosin 3 0.0264162
LIMA1 LIM domain and actin binding 1 0.0263107
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.025624
PODXL podocalyxin-like 0.0254832
SMC4 structural maintenance of chromosomes 4 0.0252444
ZNF644 zinc finger protein 644 0.0250494
PUM1 pumilio RNA-binding family member 1 0.0250064
ATAD2 ATPase family, AAA domain containing 2 0.0248863
ACTN1 actinin, alpha 1 0.0247905
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0242376
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.024077
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0234606
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0234177
EIF4A2 eukaryotic translation initiation factor 4A2 0.023412
NABP1 nucleic acid binding protein 1 0.0233961
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.023381
ZEB1 zinc finger E-box binding homeobox 1 0.0233721
SAMD4A sterile alpha motif domain containing 4A 0.0230749
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.022949
SHB Src homology 2 domain containing adaptor protein B 0.0227906
JMJD1C jumonji domain containing 1C 0.0227672
TSC22D2 TSC22 domain family, member 2 0.022688
PRKCA protein kinase C, alpha 0.0226873
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0226526
AKAP13 A kinase (PRKA) anchor protein 13 0.0224298
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0221978
CEMIP2 cell migration inducing hyaluronidase 2 0.0216751
PTK2 protein tyrosine kinase 2 0.0216349
DOCK5 dedicator of cytokinesis 5 0.021302
BRD2 bromodomain containing 2 0.0212948
SFPQ splicing factor proline/glutamine-rich 0.0210714
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0199539
DSCAM Down syndrome cell adhesion molecule 0.0195941
LMO7 LIM domain 7 0.0195559
CSNK1A1 casein kinase 1, alpha 1 0.0194881
ANXA1 annexin A1 0.0194807
TRA2B transformer 2 beta homolog (Drosophila) 0.0191985
HMGA2 high mobility group AT-hook 2 0.0190638
SP100 SP100 nuclear antigen 0.0190296
RRM2 ribonucleotide reductase M2 0.0188712
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0187614
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0187502
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0187379
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0184997
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0184825

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.259131
FN1 fibronectin 1 -0.148127
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.141684
FTL ferritin, light polypeptide -0.137183
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.134885
IGFBP3 insulin-like growth factor binding protein 3 -0.109307
ABI3BP ABI family, member 3 (NESH) binding protein -0.105543
PHACTR1 phosphatase and actin regulator 1 -0.0873678
SLC12A8 solute carrier family 12, member 8 -0.0841683
DLG1 discs, large homolog 1 (Drosophila) -0.0799133
ENO1 enolase 1, (alpha) -0.0655916
RAI14 retinoic acid induced 14 -0.0630793
NDRG1 N-myc downstream regulated 1 -0.062797
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0536992
GLIS3 GLIS family zinc finger 3 -0.0534297
FTH1 ferritin, heavy polypeptide 1 -0.0529794
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0511444
PDIA3 protein disulfide isomerase family A, member 3 -0.0500807
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0495816
UGCG UDP-glucose ceramide glucosyltransferase -0.0494114
F3 coagulation factor III (thromboplastin, tissue factor) -0.0486919
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0486306
ZEB2 zinc finger E-box binding homeobox 2 -0.0467201
LOC112694756 uncharaterized LOC112694756 -0.0452467
OSMR oncostatin M receptor -0.0436671
SULF1 sulfatase 1 -0.0428725
MMP12 matrix metallopeptidase 12 -0.0418221
POSTN periostin, osteoblast specific factor -0.0411377
NAMPT nicotinamide phosphoribosyltransferase -0.0409768
CCBE1 collagen and calcium binding EGF domains 1 -0.0407601
DEK DEK proto-oncogene -0.0402683
TENM3 teneurin transmembrane protein 3 -0.0395026
PKM pyruvate kinase, muscle -0.0371463
VIM vimentin -0.0370486
PLCB4 phospholipase C, beta 4 -0.0367919
ATP13A3 ATPase type 13A3 -0.0364299
PLIN2 perilipin 2 -0.0362703
GNAS GNAS complex locus -0.033665
TPI1 triosephosphate isomerase 1 -0.033468
CUL4B cullin 4B -0.0333583
TUBB tubulin, beta class I -0.0332679
LDHA lactate dehydrogenase A -0.0331796
PGK1 phosphoglycerate kinase 1 -0.032743
COL5A2 collagen, type V, alpha 2 -0.032284
TMSB10 thymosin beta 10 -0.0322034
CTSD cathepsin D -0.0321996
RPL12 ribosomal protein L12 -0.0321702
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0317956
ZXDC ZXD family zinc finger C -0.0316956
ZBTB20 zinc finger and BTB domain containing 20 -0.0311365
MAP4 microtubule-associated protein 4 -0.0301627
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0301203
AFAP1 actin filament associated protein 1 -0.0294346
LMAN1 lectin, mannose-binding, 1 -0.0293677
TMSB4X thymosin beta 4, X-linked -0.0281213
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0279301
LCORL ligand dependent nuclear receptor corepressor-like -0.0274907
AKAP12 A kinase (PRKA) anchor protein 12 -0.0274213
CCDC14 coiled-coil domain containing 14 -0.0262634
FAM162A family with sequence similarity 162, member A -0.0262117
TKT transketolase -0.0258164
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0254415
COPB1 coatomer protein complex, subunit beta 1 -0.0254357
SDK1 sidekick cell adhesion molecule 1 -0.0250829
IFITM1 interferon induced transmembrane protein 1 -0.0249568
CUX1 cut-like homeobox 1 -0.0246011
PARD3B par-3 family cell polarity regulator beta -0.0244173
PDE10A phosphodiesterase 10A -0.0243447
SBF2 SET binding factor 2 -0.024308
RPS6 ribosomal protein S6 -0.0242568
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0238817
TMEM178B transmembrane protein 178B -0.0236249
ZFR zinc finger RNA binding protein -0.0235867
HMGB1 high mobility group box 1 -0.0235694
S100A6 S100 calcium binding protein A6 -0.0231744
ZNF292 zinc finger protein 292 -0.0229685
BMPER BMP binding endothelial regulator -0.0228437
ANXA2 annexin A2 -0.0226786
RPLP2 ribosomal protein, large, P2 -0.0225067
PRUNE2 prune homolog 2 (Drosophila) -0.0223476
PIAS2 protein inhibitor of activated STAT, 2 -0.022331
IFITM3 interferon induced transmembrane protein 3 -0.022205
MYLK myosin light chain kinase -0.0221236
FSTL1 follistatin-like 1 -0.0220144
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0219937
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.021964
SAMD12 sterile alpha motif domain containing 12 -0.0216297
LMNA lamin A/C -0.0215536
SOD2 superoxide dismutase 2, mitochondrial -0.0213694
RPL35A ribosomal protein L35a -0.0212717
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0208725
RPLP1 ribosomal protein, large, P1 -0.0205812
HEG1 heart development protein with EGF-like domains 1 -0.0204742
CLIP1 CAP-GLY domain containing linker protein 1 -0.0202971
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0202094
CENPF centromere protein F, 350/400kDa -0.0201995
ANKRD10 ankyrin repeat domain 10 -0.0201488
DIAPH3 diaphanous-related formin 3 -0.0199456
FOXN3 forkhead box N3 -0.0196727
S100A10 S100 calcium binding protein A10 -0.0190426