Salicylic acid_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.131077
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0919178
FAT1 FAT atypical cadherin 1 0.0805026
FGFR2 fibroblast growth factor receptor 2 0.0765757
CEMIP cell migration inducing protein, hyaluronan binding 0.0653159
VEGFA vascular endothelial growth factor A 0.0651021
PLEC plectin 0.0608253
MYOF myoferlin 0.0587862
HYOU1 hypoxia up-regulated 1 0.05605
MYH9 myosin, heavy chain 9, non-muscle 0.0558818
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0423781
GDA guanine deaminase 0.0422225
CTBP2 C-terminal binding protein 2 0.0397758
AKAP13 A kinase (PRKA) anchor protein 13 0.0383234
SEPTIN9 septin 9 0.0382109
DSPP dentin sialophosphoprotein 0.035961
MBNL2 muscleblind-like splicing regulator 2 0.0357897
SH3RF1 SH3 domain containing ring finger 1 0.0352503
PTPRK protein tyrosine phosphatase, receptor type, K 0.0339392
FNDC3B fibronectin type III domain containing 3B 0.0334438
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0326129
APLP2 amyloid beta (A4) precursor-like protein 2 0.0316811
ATXN1 ataxin 1 0.0300098
ADAM9 ADAM metallopeptidase domain 9 0.0297598
ANXA11 annexin A11 0.0295286
CEMIP2 cell migration inducing hyaluronidase 2 0.0291272
SMAD3 SMAD family member 3 0.0289404
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0286452
GMDS GDP-mannose 4,6-dehydratase 0.0276165
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0275648
CAPN8 calpain 8 0.0272996
YAP1 Yes-associated protein 1 0.0271187
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0266942
CTNND1 catenin (cadherin-associated protein), delta 1 0.0257807
VMP1 vacuole membrane protein 1 0.0257586
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.025204
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0249104
DST dystonin 0.0245517
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0238192
STK24 serine/threonine kinase 24 0.0237711
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.023642
AHNAK AHNAK nucleoprotein 0.0232683
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0232208
SNX9 sorting nexin 9 0.0227108
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0226663
TJP1 tight junction protein 1 0.0222879
SLK STE20-like kinase 0.0217654
ECT2 epithelial cell transforming 2 0.02156
EIF4A2 eukaryotic translation initiation factor 4A2 0.0214504
PMM2 phosphomannomutase 2 0.0213701
AFDN afadin, adherens junction formation factor 0.0212623
CCNL1 cyclin L1 0.0212343
NFE2L1 nuclear factor, erythroid 2-like 1 0.0212266
POTEF POTE ankyrin domain family, member F 0.0209022
LURAP1L leucine rich adaptor protein 1-like 0.0208545
MYO5B myosin VB 0.0206933
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0204041
OSBPL10 oxysterol binding protein-like 10 0.02027
GCLC glutamate-cysteine ligase, catalytic subunit 0.020219
SLTM SAFB-like, transcription modulator 0.0199087
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198927
TNRC18 trinucleotide repeat containing 18 0.019787
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0194611
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0193547
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0191374
RASEF RAS and EF-hand domain containing 0.0187979
MACF1 microtubule-actin crosslinking factor 1 0.0187076
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0184757
USP9X ubiquitin specific peptidase 9, X-linked 0.0180872
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0180188
EIF4B eukaryotic translation initiation factor 4B 0.0178536
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0178121
TMF1 TATA element modulatory factor 1 0.01778
IGSF9B immunoglobulin superfamily, member 9B 0.0175026
NCOR2 nuclear receptor corepressor 2 0.0174346
SIK3 SIK family kinase 3 0.0173239
MGAM2 maltase-glucoamylase 2 (putative) 0.0169922
TPM3 tropomyosin 3 0.0169632
TXNRD1 thioredoxin reductase 1 0.0168051
ANXA1 annexin A1 0.016748
SFPQ splicing factor proline/glutamine-rich 0.0166216
RPN1 ribophorin I 0.0164599
EZR ezrin 0.0163806
KDM6A lysine (K)-specific demethylase 6A 0.0162976
SGMS2 sphingomyelin synthase 2 0.016234
ASPH aspartate beta-hydroxylase 0.0161634
ANO6 anoctamin 6 0.0161151
KCNIP4 Kv channel interacting protein 4 0.015961
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0158409
NUMA1 nuclear mitotic apparatus protein 1 0.0158
ITGA6 integrin, alpha 6 0.0157642
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0155906
BCL2L1 BCL2-like 1 0.0150675
HELZ helicase with zinc finger 0.0147425
RBM39 RNA binding motif protein 39 0.014742
CLTC clathrin, heavy chain (Hc) 0.0146132
DOCK5 dedicator of cytokinesis 5 0.0145826
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0144787
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0143141
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0142252

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.226678
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.207039
TPT1 tumor protein, translationally-controlled 1 -0.192249
TMSB10 thymosin beta 10 -0.155467
PTMA prothymosin, alpha -0.145968
RPL35A ribosomal protein L35a -0.0988601
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0980653
EIF1 eukaryotic translation initiation factor 1 -0.094397
RPS6 ribosomal protein S6 -0.0910581
AGR2 anterior gradient 2 -0.0910238
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0825992
RPS25 ribosomal protein S25 -0.0824633
S100A6 S100 calcium binding protein A6 -0.0812627
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.080839
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0771532
B2M beta-2-microglobulin -0.0768121
RPLP1 ribosomal protein, large, P1 -0.0764379
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0729217
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.072225
FTL ferritin, light polypeptide -0.070319
RPL23 ribosomal protein L23 -0.0696905
RPS24 ribosomal protein S24 -0.067269
S100A10 S100 calcium binding protein A10 -0.0661429
RPL26 ribosomal protein L26 -0.0649441
RPS8 ribosomal protein S8 -0.0640355
EMP1 epithelial membrane protein 1 -0.0625698
HLA-A major histocompatibility complex, class I, A -0.0622275
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0595337
RPL34 ribosomal protein L34 -0.0582395
RPS3 ribosomal protein S3 -0.0568453
PDIA3 protein disulfide isomerase family A, member 3 -0.0562072
GNAS GNAS complex locus -0.0558299
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0556465
RPS19 ribosomal protein S19 -0.0555787
SLC38A1 solute carrier family 38, member 1 -0.0547372
TM4SF1 transmembrane 4 L six family member 1 -0.0544818
EPCAM epithelial cell adhesion molecule -0.0540193
RPL19 ribosomal protein L19 -0.0518874
RPS16 ribosomal protein S16 -0.051812
ACTG1 actin gamma 1 -0.0510235
RPS21 ribosomal protein S21 -0.0508797
INSIG1 insulin induced gene 1 -0.0499007
RPL11 ribosomal protein L11 -0.0493382
PGK1 phosphoglycerate kinase 1 -0.0485402
RPL12 ribosomal protein L12 -0.0481774
RPL9 ribosomal protein L9 -0.0474498
KPNB1 karyopherin (importin) beta 1 -0.0444141
RPL37A ribosomal protein L37a -0.0420476
TMEM123 transmembrane protein 123 -0.0420388
RPL36A ribosomal protein L36a -0.0417707
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0416757
RPL28 ribosomal protein L28 -0.0408757
RPL30 ribosomal protein L30 -0.0401856
RPS27A ribosomal protein S27a -0.0396818
LOC102724023 ES1 protein homolog, mitochondrial -0.0393807
RPS29 ribosomal protein S29 -0.0388128
RPLP0 ribosomal protein, large, P0 -0.0387321
IFI27 interferon, alpha-inducible protein 27 -0.0386291
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0385567
RPS11 ribosomal protein S11 -0.0383421
WDR45B WD repeat domain 45B -0.0380346
S100P S100 calcium binding protein P -0.0378131
LCN2 lipocalin 2 -0.0377629
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.037666
IFI6 interferon, alpha-inducible protein 6 -0.0375959
S100A9 S100 calcium binding protein A9 -0.037543
ANXA2 annexin A2 -0.0373406
ATF5 activating transcription factor 5 -0.0373091
DSTN destrin (actin depolymerizing factor) -0.0372894
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0370378
HLA-E major histocompatibility complex, class I, E -0.0367996
NDRG1 N-myc downstream regulated 1 -0.0361368
RPS12 ribosomal protein S12 -0.0357015
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.035221
RPL38 ribosomal protein L38 -0.0347887
TRPS1 trichorhinophalangeal syndrome I -0.0344973
RPL27 ribosomal protein L27 -0.0343897
RPL5 ribosomal protein L5 -0.034311
RPLP2 ribosomal protein, large, P2 -0.0337302
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0333433
LOC112694756 uncharaterized LOC112694756 -0.0333213
RPL8 ribosomal protein L8 -0.0329984
RPS5 ribosomal protein S5 -0.0329821
FDPS farnesyl diphosphate synthase -0.0328999
MYL12B myosin, light chain 12B, regulatory -0.0328137
RPS20 ribosomal protein S20 -0.032769
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0325476
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0319647
RAB1A RAB1A, member RAS oncogene family -0.0317768
PKM pyruvate kinase, muscle -0.0314853
HLA-B major histocompatibility complex, class I, B -0.0311523
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0311219
RPL32 ribosomal protein L32 -0.0308655
UBB ubiquitin B -0.0307883
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0301215
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0299996
RPL31 ribosomal protein L31 -0.0299331
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.029711
RPL7A ribosomal protein L7a -0.0297057
RRBP1 ribosome binding protein 1 -0.0294509