Salicylic acid_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.103451
NAV1 neuron navigator 1 0.0921321
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0888152
INTS6 integrator complex subunit 6 0.0878052
FMNL2 formin-like 2 0.0785699
EGR1 early growth response 1 0.0775258
DST dystonin 0.0769774
ZSWIM6 zinc finger, SWIM-type containing 6 0.0753176
SAMD4A sterile alpha motif domain containing 4A 0.0749686
TXNIP thioredoxin interacting protein 0.0725102
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0711384
AKAP12 A kinase (PRKA) anchor protein 12 0.0701106
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0665741
MSN moesin 0.0643209
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0612015
MCL1 myeloid cell leukemia 1 0.0610132
BRD2 bromodomain containing 2 0.0591815
MYH9 myosin, heavy chain 9, non-muscle 0.0585431
MACF1 microtubule-actin crosslinking factor 1 0.0565854
TRIO trio Rho guanine nucleotide exchange factor 0.0559288
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0556284
EEF1G eukaryotic translation elongation factor 1 gamma 0.0553638
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0552431
HSPA8 heat shock 70kDa protein 8 0.0551475
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.052982
PBX3 pre-B-cell leukemia homeobox 3 0.0523027
JUN jun proto-oncogene 0.052276
MYO10 myosin X 0.0513458
PTPRG protein tyrosine phosphatase, receptor type, G 0.0508767
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0500725
HSPH1 heat shock 105kDa/110kDa protein 1 0.0494523
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.049187
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0462486
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0455585
KDM4C lysine (K)-specific demethylase 4C 0.0436652
POTEF POTE ankyrin domain family, member F 0.0434272
LPP LIM domain containing preferred translocation partner in lipoma 0.0417158
ZNF638 zinc finger protein 638 0.0413024
ERRFI1 ERBB receptor feedback inhibitor 1 0.0411263
APLP2 amyloid beta (A4) precursor-like protein 2 0.0402434
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0399434
FTL ferritin, light polypeptide 0.0397599
RPL3 ribosomal protein L3 0.0393472
PCBP2 poly(rC) binding protein 2 0.0390058
ATXN1 ataxin 1 0.0388139
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0378998
LOC102724023 ES1 protein homolog, mitochondrial 0.0374957
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0366233
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0360232
TLN1 talin 1 0.0337313
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0335245
EIF4B eukaryotic translation initiation factor 4B 0.0335029
TRIP12 thyroid hormone receptor interactor 12 0.0332078
ANO6 anoctamin 6 0.03265
VEGFA vascular endothelial growth factor A 0.032387
PLEC plectin 0.0321183
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0318347
CCNL1 cyclin L1 0.0317602
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0314833
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0314564
SIK3 SIK family kinase 3 0.0311841
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0310611
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0306003
KTN1 kinectin 1 (kinesin receptor) 0.0302867
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0299302
GLS2 glutaminase 2 (liver, mitochondrial) 0.0298465
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0297639
RPL21 ribosomal protein L21 0.0296579
VMP1 vacuole membrane protein 1 0.0292986
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0291863
LDHA lactate dehydrogenase A 0.02876
CHD7 chromodomain helicase DNA binding protein 7 0.0286539
DOCK5 dedicator of cytokinesis 5 0.028447
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0283904
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0282818
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0275351
ENO2 enolase 2 (gamma, neuronal) 0.0270927
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0268882
PACS1 phosphofurin acidic cluster sorting protein 1 0.026689
FOXP1 forkhead box P1 0.0265997
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0265365
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0263865
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0261052
NDRG1 N-myc downstream regulated 1 0.0260142
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0259212
WNK1 WNK lysine deficient protein kinase 1 0.0256359
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0255968
EIF4A2 eukaryotic translation initiation factor 4A2 0.0254721
UTRN utrophin 0.0254097
FLNC filamin C, gamma 0.0250197
FAT1 FAT atypical cadherin 1 0.0247777
NCOR2 nuclear receptor corepressor 2 0.0246148
LMO7 LIM domain 7 0.0242726
TEX14 testis expressed 14 0.0242539
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0242111
RUNX1 runt-related transcription factor 1 0.0241629
RCOR1 REST corepressor 1 0.024007
NABP1 nucleic acid binding protein 1 0.0239151
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0237815
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0236573

decreased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha -0.154995
VIM vimentin -0.118853
TPT1 tumor protein, translationally-controlled 1 -0.11663
TMSB10 thymosin beta 10 -0.108023
CFAP251 cilia and flagella associated protein 251 -0.0844592
LSAMP limbic system-associated membrane protein -0.0736352
RPS24 ribosomal protein S24 -0.0676401
MMP12 matrix metallopeptidase 12 -0.0660867
OSMR oncostatin M receptor -0.063846
PTMA prothymosin, alpha -0.0637194
ANXA2 annexin A2 -0.0591854
RPL26 ribosomal protein L26 -0.0573188
NAP1L1 nucleosome assembly protein 1-like 1 -0.0573036
ENKUR enkurin, TRPC channel interacting protein -0.0560909
NAMPT nicotinamide phosphoribosyltransferase -0.0529883
NPC1 Niemann-Pick disease, type C1 -0.0529795
WSB1 WD repeat and SOCS box containing 1 -0.0524916
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.052443
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0520484
PRRC2B proline-rich coiled-coil 2B -0.0494713
ALCAM activated leukocyte cell adhesion molecule -0.0489582
PDE4D phosphodiesterase 4D, cAMP-specific -0.0488106
KPNB1 karyopherin (importin) beta 1 -0.0481637
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0480054
ANTXR2 anthrax toxin receptor 2 -0.047493
IFI16 interferon, gamma-inducible protein 16 -0.0470785
TXNRD1 thioredoxin reductase 1 -0.0470094
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0469346
RPLP0 ribosomal protein, large, P0 -0.0466645
NF1 neurofibromin 1 -0.0465611
KLF6 Kruppel-like factor 6 -0.0459757
TM4SF1 transmembrane 4 L six family member 1 -0.0459398
RPL35A ribosomal protein L35a -0.0457656
RPS27A ribosomal protein S27a -0.0457039
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0454524
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0451917
GPC6 glypican 6 -0.0451471
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0443986
RAD21 RAD21 homolog (S. pombe) -0.0442469
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0437204
RPL37A ribosomal protein L37a -0.043105
KIAA1217 KIAA1217 -0.043067
PTCHD4 patched domain containing 4 -0.0430504
RPL30 ribosomal protein L30 -0.0417589
RTN4 reticulon 4 -0.0405305
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.040462
PCNX4 pecanex 4 -0.0401511
VCL vinculin -0.0380218
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0376018
CAVIN1 caveolae associated protein 1 -0.0372716
RPL34 ribosomal protein L34 -0.0372155
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0368655
IL6ST interleukin 6 signal transducer -0.0365242
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0365202
GNAS GNAS complex locus -0.0363159
RPL36A ribosomal protein L36a -0.0361837
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0361747
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0355253
HAS2 hyaluronan synthase 2 -0.0353444
ELL2 elongation factor, RNA polymerase II, 2 -0.0351708
CXCL8 chemokine (C-X-C motif) ligand 8 -0.035124
TNNC1 troponin C type 1 (slow) -0.0348865
CSTB cystatin B (stefin B) -0.0347638
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0347114
RAP1B RAP1B, member of RAS oncogene family -0.0346176
CDK17 cyclin-dependent kinase 17 -0.0342836
MT2A metallothionein 2A -0.0342657
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0339596
BRWD3 bromodomain and WD repeat domain containing 3 -0.0339206
MSR1 macrophage scavenger receptor 1 -0.0338228
EXT1 exostosin glycosyltransferase 1 -0.0338176
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0337193
COLEC10 collectin sub-family member 10 (C-type lectin) -0.0334799
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.033474
RPL38 ribosomal protein L38 -0.0334647
PHACTR1 phosphatase and actin regulator 1 -0.0331201
APP amyloid beta (A4) precursor protein -0.0330645
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0325798
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0325201
PNISR PNN-interacting serine/arginine-rich protein -0.0323497
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0320915
RBM25 RNA binding motif protein 25 -0.0320271
KYNU kynureninase -0.0315405
ESM1 endothelial cell-specific molecule 1 -0.0314154
RPS19 ribosomal protein S19 -0.0310605
RPS21 ribosomal protein S21 -0.0309855
BLZF1 basic leucine zipper nuclear factor 1 -0.0306343
EIF3E eukaryotic translation initiation factor 3, subunit E -0.030426
ANKRD12 ankyrin repeat domain 12 -0.03035
KDM3A lysine (K)-specific demethylase 3A -0.0302254
MARCHF6 membrane associated ring-CH-type finger 6 -0.0301975
BMAL2 basic helix-loop-helix ARNT like 2 -0.030154
LMAN1 lectin, mannose-binding, 1 -0.0298004
RPL6 ribosomal protein L6 -0.0297937
MON2 MON2 homolog (S. cerevisiae) -0.0296633
VDAC1 voltage-dependent anion channel 1 -0.0295996
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0295323
RIGI RNA sensor RIG-I -0.0293802
PUM2 pumilio RNA-binding family member 2 -0.029052
WDR43 WD repeat domain 43 -0.0287194