Salicylic acid_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.218139
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.19592
LMO7 LIM domain 7 0.187364
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.179391
CEMIP cell migration inducing protein, hyaluronan binding 0.154103
SPTBN1 spectrin, beta, non-erythrocytic 1 0.131081
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.115074
MYO1E myosin IE 0.09291
EPS8 epidermal growth factor receptor pathway substrate 8 0.0831109
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0816496
ITGA6 integrin, alpha 6 0.0781999
MACF1 microtubule-actin crosslinking factor 1 0.0741177
RNF43 ring finger protein 43 0.0634843
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0618137
PRELID2 PRELI domain containing 2 0.0616713
LDHA lactate dehydrogenase A 0.0598909
VCL vinculin 0.0582668
EREG epiregulin 0.0537822
MED13 mediator complex subunit 13 0.0535814
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0534421
AREG amphiregulin 0.0534248
UBE2H ubiquitin-conjugating enzyme E2H 0.0531355
PDLIM5 PDZ and LIM domain 5 0.0527453
EXT1 exostosin glycosyltransferase 1 0.0525649
RBM39 RNA binding motif protein 39 0.0515904
TXNIP thioredoxin interacting protein 0.0512581
KLF5 Kruppel-like factor 5 (intestinal) 0.051211
ITPRID2 ITPR interacting domain containing 2 0.0504005
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0496817
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0489252
AFF1 AF4/FMR2 family, member 1 0.0480462
VMP1 vacuole membrane protein 1 0.0476309
ASPH aspartate beta-hydroxylase 0.0475698
EEF2 eukaryotic translation elongation factor 2 0.0474912
CEMIP2 cell migration inducing hyaluronidase 2 0.0456747
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0456705
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0444572
MYH9 myosin, heavy chain 9, non-muscle 0.043534
MYO5B myosin VB 0.0429236
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0420622
CADPS Ca++-dependent secretion activator 0.0419233
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0416667
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0414244
CTNND1 catenin (cadherin-associated protein), delta 1 0.0413946
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.041357
RNF145 ring finger protein 145 0.041304
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0411732
MBNL1 muscleblind-like splicing regulator 1 0.040471
AKAP13 A kinase (PRKA) anchor protein 13 0.0397309
ANTXR2 anthrax toxin receptor 2 0.0394461
ERRFI1 ERBB receptor feedback inhibitor 1 0.0389574
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.038657
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0382716
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0379789
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0360093
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0356328
ARHGAP26 Rho GTPase activating protein 26 0.035398
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0347119
CLCN3 chloride channel, voltage-sensitive 3 0.0344062
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0339554
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0339002
LURAP1L leucine rich adaptor protein 1-like 0.0330505
USP9X ubiquitin specific peptidase 9, X-linked 0.0328628
PDE10A phosphodiesterase 10A 0.0326128
PKP2 plakophilin 2 0.0324553
H1-0 H1.0 linker histone 0.0322465
SPRED2 sprouty-related, EVH1 domain containing 2 0.0320841
PDZD8 PDZ domain containing 8 0.0318254
DSPP dentin sialophosphoprotein 0.0314403
ECT2 epithelial cell transforming 2 0.0312341
OGA O-GlcNAcase 0.0309488
NCEH1 neutral cholesterol ester hydrolase 1 0.0309341
NRXN3 neurexin 3 0.0309337
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0309243
FTH1 ferritin, heavy polypeptide 1 0.0309063
PDIA4 protein disulfide isomerase family A, member 4 0.0308488
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0307586
TGFBR3 transforming growth factor, beta receptor III 0.0304852
KRT8 keratin 8, type II 0.0302432
TRIM2 tripartite motif containing 2 0.0302168
USP53 ubiquitin specific peptidase 53 0.0301059
DUSP4 dual specificity phosphatase 4 0.0293233
WDR45B WD repeat domain 45B 0.029096
LRRC1 leucine rich repeat containing 1 0.0289112
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0285974
CSNK1A1 casein kinase 1, alpha 1 0.0282912
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0280104
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0279851
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0278387
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0278312
PUM1 pumilio RNA-binding family member 1 0.027724
KMT2E lysine (K)-specific methyltransferase 2E 0.0277148
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0276376
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0274754
ARHGAP42 Rho GTPase activating protein 42 0.0274593
CD44 CD44 molecule (Indian blood group) 0.0272016
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0271946
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0271509
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0270452
APLP2 amyloid beta (A4) precursor-like protein 2 0.0264321

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.197279
TPT1 tumor protein, translationally-controlled 1 -0.128948
PTMA prothymosin, alpha -0.104127
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.100605
RPS6 ribosomal protein S6 -0.0976701
TMSB10 thymosin beta 10 -0.0795422
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0687012
NALF1 NALCN channel auxiliary factor 1 -0.0648981
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0638055
ALCAM activated leukocyte cell adhesion molecule -0.0558499
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0532702
RPL35A ribosomal protein L35a -0.0510139
RPL34 ribosomal protein L34 -0.0460704
MT2A metallothionein 2A -0.0447384
RPS8 ribosomal protein S8 -0.0441929
CCSER1 coiled-coil serine-rich protein 1 -0.0423307
MAML3 mastermind-like 3 (Drosophila) -0.0420125
BTBD9 BTB (POZ) domain containing 9 -0.0409877
RPL26 ribosomal protein L26 -0.0405308
S100A6 S100 calcium binding protein A6 -0.0400684
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0399258
RPL9 ribosomal protein L9 -0.0394078
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0379741
RPS12 ribosomal protein S12 -0.0360969
SLC35F3 solute carrier family 35, member F3 -0.0350382
BACE2 beta-site APP-cleaving enzyme 2 -0.0343988
CALB1 calbindin 1, 28kDa -0.0343862
RPL31 ribosomal protein L31 -0.0340809
NFIA nuclear factor I/A -0.0337842
MECOM MDS1 and EVI1 complex locus -0.0330147
SBF2 SET binding factor 2 -0.0322283
TFF1 trefoil factor 1 -0.0311733
PARD3B par-3 family cell polarity regulator beta -0.0310523
RPS27A ribosomal protein S27a -0.0303469
GOLGA4 golgin A4 -0.0300392
ACTG1 actin gamma 1 -0.0290749
RPS19 ribosomal protein S19 -0.0290181
CDK13 cyclin-dependent kinase 13 -0.0285845
CADPS2 Ca++-dependent secretion activator 2 -0.0284968
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0284806
HMGB1 high mobility group box 1 -0.0281551
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0279871
RPLP2 ribosomal protein, large, P2 -0.0267565
FAF1 Fas (TNFRSF6) associated factor 1 -0.0264688
CCDC91 coiled-coil domain containing 91 -0.0264203
RPL37A ribosomal protein L37a -0.0260204
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0259013
MAP4 microtubule-associated protein 4 -0.0253264
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0252098
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.024965
RPS24 ribosomal protein S24 -0.0248959
TAS2R14 taste receptor, type 2, member 14 -0.024635
EIF5B eukaryotic translation initiation factor 5B -0.0243234
RPLP1 ribosomal protein, large, P1 -0.0241216
EPB41 erythrocyte membrane protein band 4.1 -0.0240793
GCC2 GRIP and coiled-coil domain containing 2 -0.0238817
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.023552
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0235147
RPL13A ribosomal protein L13a -0.0233931
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0233665
PHKB phosphorylase kinase, beta -0.0231126
RPL36 ribosomal protein L36 -0.0230169
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0227871
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0227528
RPS21 ribosomal protein S21 -0.0225572
RAD51B RAD51 paralog B -0.0221949
DLG1 discs, large homolog 1 (Drosophila) -0.0220431
DYM dymeclin -0.0219358
KLK10 kallikrein-related peptidase 10 -0.0218509
FHIT fragile histidine triad -0.0218056
PERP PERP, TP53 apoptosis effector -0.0216743
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0216487
RPS13 ribosomal protein S13 -0.0213474
RPL37 ribosomal protein L37 -0.0210273
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0208381
DIAPH2 diaphanous-related formin 2 -0.0207083
ANO1 anoctamin 1, calcium activated chloride channel -0.0200602
FOXP2 forkhead box P2 -0.0197972
RPS3 ribosomal protein S3 -0.0196454
ZBTB20 zinc finger and BTB domain containing 20 -0.0195997
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0195532
REEP3 receptor accessory protein 3 -0.0194927
FRMD5 FERM domain containing 5 -0.0194749
RPL11 ribosomal protein L11 -0.0193799
TMEM165 transmembrane protein 165 -0.0191392
PDE4D phosphodiesterase 4D, cAMP-specific -0.019073
FBXL17 F-box and leucine-rich repeat protein 17 -0.0188974
FOXP1 forkhead box P1 -0.0187919
RPS25 ribosomal protein S25 -0.0187185
CAMKMT calmodulin-lysine N-methyltransferase -0.0185839
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0185829
CHD9 chromodomain helicase DNA binding protein 9 -0.0184032
COG5 component of oligomeric golgi complex 5 -0.0183324
TNRC6B trinucleotide repeat containing 6B -0.0183205
RRBP1 ribosome binding protein 1 -0.018195
S100A9 S100 calcium binding protein A9 -0.0181744
RPS17 ribosomal protein S17 -0.0178652
SORBS2 sorbin and SH3 domain containing 2 -0.0175375
HMGA1 high mobility group AT-hook 1 -0.0174183
GNAS GNAS complex locus -0.0173206