Salicylic acid_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.200248
EPS8 epidermal growth factor receptor pathway substrate 8 0.11368
LMO7 LIM domain 7 0.105558
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0767342
EXT1 exostosin glycosyltransferase 1 0.0664242
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0634562
AKAP13 A kinase (PRKA) anchor protein 13 0.0595208
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.054098
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0540617
MYO1E myosin IE 0.0524631
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0521954
EEF2 eukaryotic translation elongation factor 2 0.0516203
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.047013
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0438867
MYOF myoferlin 0.043721
DSCAM Down syndrome cell adhesion molecule 0.0409537
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0391262
OXSR1 oxidative stress responsive 1 0.0386567
SND1 staphylococcal nuclease and tudor domain containing 1 0.0376918
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0373549
INTS6 integrator complex subunit 6 0.0370882
PTPRK protein tyrosine phosphatase, receptor type, K 0.036764
PDLIM5 PDZ and LIM domain 5 0.0362062
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0361433
ASPH aspartate beta-hydroxylase 0.0359255
SEC31A SEC31 homolog A (S. cerevisiae) 0.0355918
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0351275
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0346116
CEMIP cell migration inducing protein, hyaluronan binding 0.0344288
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0341547
TRIM2 tripartite motif containing 2 0.03355
TNRC18 trinucleotide repeat containing 18 0.0324177
ITGA6 integrin, alpha 6 0.0321263
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0320802
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0318661
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0312072
MYO6 myosin VI 0.0309426
COPA coatomer protein complex, subunit alpha 0.0306961
PKP2 plakophilin 2 0.030126
MON2 MON2 homolog (S. cerevisiae) 0.0298222
DUSP4 dual specificity phosphatase 4 0.0290906
SHROOM3 shroom family member 3 0.0288627
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0279196
GARS1 glycyl-tRNA synthetase 1 0.0277102
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0275415
TTC3 tetratricopeptide repeat domain 3 0.0271301
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0266808
KDM4C lysine (K)-specific demethylase 4C 0.0265158
AKAP9 A kinase (PRKA) anchor protein 9 0.0264637
ITPRID2 ITPR interacting domain containing 2 0.0260403
SRRM2 serine/arginine repetitive matrix 2 0.0260169
GOLGB1 golgin B1 0.0259939
PRELID2 PRELI domain containing 2 0.0257385
MYH9 myosin, heavy chain 9, non-muscle 0.0256861
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.025638
RPL3 ribosomal protein L3 0.0254167
CCNYL1 cyclin Y-like 1 0.0252
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0246312
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0243574
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0243381
ZFC3H1 zinc finger, C3H1-type containing 0.0240189
KMT2E lysine (K)-specific methyltransferase 2E 0.0240127
ARHGAP26 Rho GTPase activating protein 26 0.0239643
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0238717
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0238425
VMP1 vacuole membrane protein 1 0.0231548
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0231372
CDK19 cyclin-dependent kinase 19 0.0227575
COG6 component of oligomeric golgi complex 6 0.0227491
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0227156
LPP LIM domain containing preferred translocation partner in lipoma 0.0222824
PARD3B par-3 family cell polarity regulator beta 0.0222653
PCBP2 poly(rC) binding protein 2 0.0222441
PTPRG protein tyrosine phosphatase, receptor type, G 0.0221347
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0219094
EIF4A2 eukaryotic translation initiation factor 4A2 0.021716
SEC24A SEC24 family member A 0.0215851
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0215271
CYSTM1 cysteine-rich transmembrane module containing 1 0.0215026
MLEC malectin 0.0212586
CTBP2 C-terminal binding protein 2 0.0210239
MYO5B myosin VB 0.0209771
ECT2 epithelial cell transforming 2 0.0204147
FBXO38 F-box protein 38 0.0202357
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0201948
VCL vinculin 0.0200795
SFPQ splicing factor proline/glutamine-rich 0.0200421
PTEN phosphatase and tensin homolog 0.0199984
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0198574
MCL1 myeloid cell leukemia 1 0.0197486
ERRFI1 ERBB receptor feedback inhibitor 1 0.0193821
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0193639
LRP6 low density lipoprotein receptor-related protein 6 0.0193499
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0191461
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0186245
POTEF POTE ankyrin domain family, member F 0.0186081
RNF145 ring finger protein 145 0.0185778
CAPRIN2 caprin family member 2 0.0185321
LDHA lactate dehydrogenase A 0.01835
VEGFA vascular endothelial growth factor A 0.0183451

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.216411
RPLP1 ribosomal protein, large, P1 -0.1563
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.125332
RPS6 ribosomal protein S6 -0.0983908
RPL34 ribosomal protein L34 -0.0819307
PDE4D phosphodiesterase 4D, cAMP-specific -0.0799115
RPS8 ribosomal protein S8 -0.079638
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0725693
RPL35A ribosomal protein L35a -0.0691449
FRMD5 FERM domain containing 5 -0.0630592
RPL37A ribosomal protein L37a -0.0627543
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0621031
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0620586
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0617707
RPLP0 ribosomal protein, large, P0 -0.0614219
RPL26 ribosomal protein L26 -0.0599407
PTMA prothymosin, alpha -0.0579196
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0575787
RPS24 ribosomal protein S24 -0.0544819
RPS12 ribosomal protein S12 -0.0541941
RPLP2 ribosomal protein, large, P2 -0.0526241
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0525121
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0524897
RPS27A ribosomal protein S27a -0.0514821
RPL31 ribosomal protein L31 -0.0507399
RPS25 ribosomal protein S25 -0.0470752
PERP PERP, TP53 apoptosis effector -0.0468037
NPSR1 neuropeptide S receptor 1 -0.0458667
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0456301
ACTG1 actin gamma 1 -0.0454853
F3 coagulation factor III (thromboplastin, tissue factor) -0.0451559
RPL37 ribosomal protein L37 -0.0444657
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0436599
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0435324
XAF1 XIAP associated factor 1 -0.043505
GMDS GDP-mannose 4,6-dehydratase -0.0432839
RPS19 ribosomal protein S19 -0.0431814
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0426285
RPS23 ribosomal protein S23 -0.042096
IFI6 interferon, alpha-inducible protein 6 -0.0417701
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0408825
AOPEP aminopeptidase O (putative) -0.0394424
HLA-B major histocompatibility complex, class I, B -0.0389855
RPL36A ribosomal protein L36a -0.0389768
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0378674
RPL4 ribosomal protein L4 -0.0377338
RPS21 ribosomal protein S21 -0.0371416
RPL38 ribosomal protein L38 -0.0370924
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.037009
RPS29 ribosomal protein S29 -0.0364289
RPL36 ribosomal protein L36 -0.0363319
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0359699
FHIT fragile histidine triad -0.0354937
RPL12 ribosomal protein L12 -0.0352695
MCU mitochondrial calcium uniporter -0.0352289
EIF5B eukaryotic translation initiation factor 5B -0.0346638
RPL28 ribosomal protein L28 -0.0346482
RPL11 ribosomal protein L11 -0.034028
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0331371
ANXA2 annexin A2 -0.0331352
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0325987
SVIL supervillin -0.0322261
TMSB10 thymosin beta 10 -0.0321333
DSG2 desmoglein 2 -0.0312856
RACK1 receptor for activated C kinase 1 -0.0312006
RREB1 ras responsive element binding protein 1 -0.0305154
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0304322
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0303937
BACE2 beta-site APP-cleaving enzyme 2 -0.0303398
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0303183
RIGI RNA sensor RIG-I -0.0301317
RPL27A ribosomal protein L27a -0.0299791
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0298347
RPL30 ribosomal protein L30 -0.0290395
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0283893
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.028243
PDIA3 protein disulfide isomerase family A, member 3 -0.0279065
SP100 SP100 nuclear antigen -0.027403
RPS16 ribosomal protein S16 -0.0273672
RPS13 ribosomal protein S13 -0.0271288
ESYT2 extended synaptotagmin-like protein 2 -0.0271206
RPL9 ribosomal protein L9 -0.0268909
FERMT1 fermitin family member 1 -0.0268338
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0266615
TAS2R14 taste receptor, type 2, member 14 -0.0264752
GNAS GNAS complex locus -0.0264744
THSD4 thrombospondin, type I, domain containing 4 -0.0264041
PSD3 pleckstrin and Sec7 domain containing 3 -0.0262048
RPS11 ribosomal protein S11 -0.0261414
RPL35 ribosomal protein L35 -0.0256749
EZR ezrin -0.025575
RPL19 ribosomal protein L19 -0.0251858
S100A11 S100 calcium binding protein A11 -0.0250509
RPS27 ribosomal protein S27 -0.0250162
LAMC2 laminin, gamma 2 -0.0247402
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0247392
RRBP1 ribosome binding protein 1 -0.0247071
PTPRR protein tyrosine phosphatase, receptor type, R -0.0245979
EGFR epidermal growth factor receptor -0.0242414
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0240438