Salicylic acid_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.120916
THSD4 thrombospondin, type I, domain containing 4 0.0734463
FAM13A family with sequence similarity 13, member A 0.0481041
SMAD3 SMAD family member 3 0.0454525
MYH9 myosin, heavy chain 9, non-muscle 0.0451845
TXNRD1 thioredoxin reductase 1 0.0429682
CEMIP cell migration inducing protein, hyaluronan binding 0.0421702
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0410301
SLTM SAFB-like, transcription modulator 0.0410046
BCAR3 breast cancer anti-estrogen resistance 3 0.0409135
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0354549
CES1 carboxylesterase 1 0.034827
TBC1D22A TBC1 domain family, member 22A 0.0344754
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.034427
TOP1 topoisomerase (DNA) I 0.0338386
PM20D1 peptidase M20 domain containing 1 0.0338207
MYOF myoferlin 0.0338097
LMO7 LIM domain 7 0.0330854
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0326543
HSPA8 heat shock 70kDa protein 8 0.0305626
OGA O-GlcNAcase 0.0298665
ELL2 elongation factor, RNA polymerase II, 2 0.0298586
PLEC plectin 0.0286947
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0282616
HDLBP high density lipoprotein binding protein 0.0279018
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0276136
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0274835
SMYD3 SET and MYND domain containing 3 0.0270303
RIMS2 regulating synaptic membrane exocytosis 2 0.0260871
SAMD4A sterile alpha motif domain containing 4A 0.0258329
ERRFI1 ERBB receptor feedback inhibitor 1 0.0256149
HYOU1 hypoxia up-regulated 1 0.025017
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0244915
RUNX1 runt-related transcription factor 1 0.0242225
ATP11A ATPase, class VI, type 11A 0.0241902
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0237172
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0231249
UVRAG UV radiation resistance associated 0.0230698
ANKRD11 ankyrin repeat domain 11 0.0229878
CAMTA1 calmodulin binding transcription activator 1 0.0229098
ZC3H11A zinc finger CCCH-type containing 11A 0.0228031
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0227372
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0225968
BRWD3 bromodomain and WD repeat domain containing 3 0.0204432
NAMPT nicotinamide phosphoribosyltransferase 0.0203972
RAD51B RAD51 paralog B 0.0200135
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.019942
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0195892
AHNAK AHNAK nucleoprotein 0.0193022
HOOK2 hook microtubule-tethering protein 2 0.0192073
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0191841
ZNF638 zinc finger protein 638 0.019155
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0190277
KDM6A lysine (K)-specific demethylase 6A 0.0186157
LGALS12 lectin, galactoside-binding, soluble, 12 0.0183764
USP9X ubiquitin specific peptidase 9, X-linked 0.0183244
CSNK1A1 casein kinase 1, alpha 1 0.0181495
LRP12 low density lipoprotein receptor-related protein 12 0.0180642
DOCK1 dedicator of cytokinesis 1 0.0180314
AKAP12 A kinase (PRKA) anchor protein 12 0.0179726
GRB10 growth factor receptor-bound protein 10 0.0178286
HELZ helicase with zinc finger 0.0177914
CANX calnexin 0.017712
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.017609
PAPOLA poly(A) polymerase alpha 0.0175552
PUM2 pumilio RNA-binding family member 2 0.0175499
NGLY1 N-glycanase 1 0.0175428
ANO6 anoctamin 6 0.016932
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0168836
SPAG9 sperm associated antigen 9 0.0168608
ARRDC3 arrestin domain containing 3 0.0167898
MKI67 marker of proliferation Ki-67 0.0167645
NPTN neuroplastin 0.0165936
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0165487
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0165095
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.016363
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0163199
DTNA dystrobrevin, alpha 0.0163156
NCKAP1 NCK-associated protein 1 0.0161166
EXT1 exostosin glycosyltransferase 1 0.0161043
TRAPPC9 trafficking protein particle complex 9 0.0159904
EXOC6B exocyst complex component 6B 0.0156623
STK24 serine/threonine kinase 24 0.0155915
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0153829
MACF1 microtubule-actin crosslinking factor 1 0.0153301
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0152935
ATP13A3 ATPase type 13A3 0.0150265
KCMF1 potassium channel modulatory factor 1 0.0148848
SUCO SUN domain containing ossification factor 0.0147064
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0146438
GLS2 glutaminase 2 (liver, mitochondrial) 0.0145964
DNAH14 dynein, axonemal, heavy chain 14 0.0145613
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0145551
TMCO3 transmembrane and coiled-coil domains 3 0.0144736
TSC22D2 TSC22 domain family, member 2 0.0144072
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0142575
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0141143
RNF145 ring finger protein 145 0.0137282
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0137205
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0137012

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.235137
TMSB10 thymosin beta 10 -0.152887
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.101121
ACTG1 actin gamma 1 -0.0721171
CAV1 caveolin 1, caveolae protein, 22kDa -0.0669974
EGR1 early growth response 1 -0.0657012
S100A10 S100 calcium binding protein A10 -0.0650647
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0633845
CST3 cystatin C -0.0586858
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0585357
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0576182
TPT1 tumor protein, translationally-controlled 1 -0.0575856
AKR1C1 aldo-keto reductase family 1, member C1 -0.0544462
PTMA prothymosin, alpha -0.0521584
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0513657
MT2A metallothionein 2A -0.0493442
FTL ferritin, light polypeptide -0.0476392
NDRG1 N-myc downstream regulated 1 -0.0446278
LAMC2 laminin, gamma 2 -0.0439433
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0421439
RPL35A ribosomal protein L35a -0.0402254
ANKRD12 ankyrin repeat domain 12 -0.0396893
IFI6 interferon, alpha-inducible protein 6 -0.0384268
B2M beta-2-microglobulin -0.0375038
AREG amphiregulin -0.0370252
FTH1 ferritin, heavy polypeptide 1 -0.0337207
STC1 stanniocalcin 1 -0.0327152
PKM pyruvate kinase, muscle -0.03187
ZMYND8 zinc finger, MYND-type containing 8 -0.0309628
SLC38A1 solute carrier family 38, member 1 -0.0308053
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0304842
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0303104
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0301671
KRT7 keratin 7, type II -0.0301454
RPS25 ribosomal protein S25 -0.0298411
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0286568
RPS24 ribosomal protein S24 -0.0282104
S100A6 S100 calcium binding protein A6 -0.0277089
HLA-B major histocompatibility complex, class I, B -0.0273794
NSUN6 NOP2/Sun domain family, member 6 -0.0272714
RPL31 ribosomal protein L31 -0.0268656
SLC38A2 solute carrier family 38, member 2 -0.026571
HMGA1 high mobility group AT-hook 1 -0.0261344
CCND1 cyclin D1 -0.0260666
CAV2 caveolin 2 -0.0259466
LRP1B low density lipoprotein receptor-related protein 1B -0.0254457
CPE carboxypeptidase E -0.0254268
PTPRM protein tyrosine phosphatase, receptor type, M -0.0253069
S100P S100 calcium binding protein P -0.0249966
ANXA2 annexin A2 -0.0246894
RPL37A ribosomal protein L37a -0.024251
S100A11 S100 calcium binding protein A11 -0.0242485
RPL11 ribosomal protein L11 -0.0241233
RPL34 ribosomal protein L34 -0.0236106
PATJ PATJ crumbs cell polarity complex component -0.0234964
S100A9 S100 calcium binding protein A9 -0.0234116
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0231444
LOC102724023 ES1 protein homolog, mitochondrial -0.0229428
KRT19 keratin 19, type I -0.0228466
RPS8 ribosomal protein S8 -0.0224053
IGFBP5 insulin-like growth factor binding protein 5 -0.0219223
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0218832
BTG1 B-cell translocation gene 1, anti-proliferative -0.0215321
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0212353
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0208412
RPS6 ribosomal protein S6 -0.0208407
EIF1 eukaryotic translation initiation factor 1 -0.0205101
OSMR oncostatin M receptor -0.020019
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0198059
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0195788
SEC61G Sec61 gamma subunit -0.019215
BLZF1 basic leucine zipper nuclear factor 1 -0.0190955
GNAS GNAS complex locus -0.0187435
PERP PERP, TP53 apoptosis effector -0.0186447
EFNA5 ephrin-A5 -0.0184877
RPL37 ribosomal protein L37 -0.0178972
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0178558
RPS23 ribosomal protein S23 -0.0178376
SDC4 syndecan 4 -0.0177948
HLA-A major histocompatibility complex, class I, A -0.0176969
RPS12 ribosomal protein S12 -0.0176776
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0171051
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0170442
ENO2 enolase 2 (gamma, neuronal) -0.0169698
RPS29 ribosomal protein S29 -0.0168512
WASF2 WAS protein family, member 2 -0.0167519
POTEF POTE ankyrin domain family, member F -0.0166889
MAML2 mastermind-like 2 (Drosophila) -0.0166037
IGFBP3 insulin-like growth factor binding protein 3 -0.0165092
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0164762
RHOV ras homolog family member V -0.0163131
RPLP1 ribosomal protein, large, P1 -0.0163077
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0161865
IER3 immediate early response 3 -0.0160831
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0157192
IFI27 interferon, alpha-inducible protein 27 -0.0157004
PFN1 profilin 1 -0.0152329
MYL12B myosin, light chain 12B, regulatory -0.015162
RPL36A ribosomal protein L36a -0.0150909
MT1X metallothionein 1X -0.0149768