Salicylic acid_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.162717
FN1 fibronectin 1 0.108856
SDK1 sidekick cell adhesion molecule 1 0.0945172
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0917816
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0874534
INTS6 integrator complex subunit 6 0.0865505
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0854763
PRELID2 PRELI domain containing 2 0.0847782
NAV2 neuron navigator 2 0.0833616
SMAD3 SMAD family member 3 0.0812717
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0673104
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0659066
COL7A1 collagen, type VII, alpha 1 0.0628486
CDH13 cadherin 13 0.0627075
ATXN1 ataxin 1 0.0611516
AADAC arylacetamide deacetylase 0.0568763
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0544868
MYH9 myosin, heavy chain 9, non-muscle 0.0532459
LOXL2 lysyl oxidase-like 2 0.0506551
DST dystonin 0.0499375
PDLIM5 PDZ and LIM domain 5 0.049683
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0496328
GRB10 growth factor receptor-bound protein 10 0.049417
ZSWIM6 zinc finger, SWIM-type containing 6 0.0490543
TRIO trio Rho guanine nucleotide exchange factor 0.0489871
APLP2 amyloid beta (A4) precursor-like protein 2 0.0467944
PRKCA protein kinase C, alpha 0.0465946
MACF1 microtubule-actin crosslinking factor 1 0.0457013
VEGFA vascular endothelial growth factor A 0.0437881
SYT1 synaptotagmin I 0.0432523
TGFB1 transforming growth factor, beta 1 0.0421883
ASPH aspartate beta-hydroxylase 0.0420867
GLS2 glutaminase 2 (liver, mitochondrial) 0.0416207
MAML3 mastermind-like 3 (Drosophila) 0.0411039
SEPTIN9 septin 9 0.040254
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0399079
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0393404
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0391775
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0373068
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0368975
PSD3 pleckstrin and Sec7 domain containing 3 0.0368101
EXT1 exostosin glycosyltransferase 1 0.0365392
FAM20C family with sequence similarity 20, member C 0.0364725
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0361463
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0361425
VCL vinculin 0.0346099
HMGA2 high mobility group AT-hook 2 0.0345676
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0336335
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0335247
SLIT2 slit homolog 2 (Drosophila) 0.0330146
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0329968
LRMDA leucine rich melanocyte differentiation associated 0.0324489
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0321318
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0317924
WLS wntless Wnt ligand secretion mediator 0.0315413
PFKP phosphofructokinase, platelet 0.0313825
CEP250 centrosomal protein 250kDa 0.0313733
CAPRIN2 caprin family member 2 0.0306784
IFI44L interferon-induced protein 44-like 0.0306523
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0306455
SOD2 superoxide dismutase 2, mitochondrial 0.0305148
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0304864
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0304015
RASAL2 RAS protein activator like 2 0.029544
ZNF638 zinc finger protein 638 0.0289248
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0286453
PTK2 protein tyrosine kinase 2 0.0285037
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.028231
DDIT3 DNA-damage-inducible transcript 3 0.0281927
CTBP2 C-terminal binding protein 2 0.0273342
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0271001
NAV1 neuron navigator 1 0.0270853
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0268507
FBN1 fibrillin 1 0.026757
SQSTM1 sequestosome 1 0.0265415
FAM13A family with sequence similarity 13, member A 0.0263115
RNF213 ring finger protein 213 0.0259337
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0256552
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0255213
PEAK1 pseudopodium-enriched atypical kinase 1 0.0248499
HDAC9 histone deacetylase 9 0.0244391
PCBP2 poly(rC) binding protein 2 0.023553
GPC6 glypican 6 0.0233046
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.023183
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0231204
PIAS2 protein inhibitor of activated STAT, 2 0.0229277
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0228646
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0227903
NEBL nebulette 0.0226926
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0222847
CDK6 cyclin-dependent kinase 6 0.0221677
ARHGAP32 Rho GTPase activating protein 32 0.0220367
SUMF1 sulfatase modifying factor 1 0.0219882
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0218178
MAML2 mastermind-like 2 (Drosophila) 0.02169
LDHA lactate dehydrogenase A 0.0216454
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0214981
MCL1 myeloid cell leukemia 1 0.0213685
STK38L serine/threonine kinase 38 like 0.0211875
TENT5A terminal nucleotidyltransferase 5A 0.0211052

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.234099
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.164153
OSMR oncostatin M receptor -0.149861
CD44 CD44 molecule (Indian blood group) -0.145147
CXCL8 chemokine (C-X-C motif) ligand 8 -0.127397
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0856044
ZMYND8 zinc finger, MYND-type containing 8 -0.0840874
STC1 stanniocalcin 1 -0.0818394
VIM vimentin -0.0787312
TFPI2 tissue factor pathway inhibitor 2 -0.0783496
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0756362
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0746738
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0703712
ZEB2 zinc finger E-box binding homeobox 2 -0.0656289
BASP1 brain abundant, membrane attached signal protein 1 -0.0630904
NPC1 Niemann-Pick disease, type C1 -0.0595358
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0593216
RNF24 ring finger protein 24 -0.0589069
ETV6 ets variant 6 -0.0561895
AKAP12 A kinase (PRKA) anchor protein 12 -0.0560797
KDM2A lysine (K)-specific demethylase 2A -0.0536106
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0528437
TMSB10 thymosin beta 10 -0.0522199
TM4SF1 transmembrane 4 L six family member 1 -0.0509704
WSB1 WD repeat and SOCS box containing 1 -0.0495139
RAB27B RAB27B, member RAS oncogene family -0.0487564
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0477573
NCOA7 nuclear receptor coactivator 7 -0.0476084
NRG1 neuregulin 1 -0.0472684
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0472526
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0460177
AOPEP aminopeptidase O (putative) -0.0454206
S100A6 S100 calcium binding protein A6 -0.0451709
LMAN1 lectin, mannose-binding, 1 -0.0447179
SYAP1 synapse associated protein 1 -0.0431945
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0430713
IER3 immediate early response 3 -0.0428468
ARHGAP5 Rho GTPase activating protein 5 -0.0421327
RAP1B RAP1B, member of RAS oncogene family -0.0418401
MT2A metallothionein 2A -0.0414079
EIF1 eukaryotic translation initiation factor 1 -0.0411204
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0409597
GOLGA4 golgin A4 -0.0408692
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0398727
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0384293
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0381397
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0380771
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0376471
DPYD dihydropyrimidine dehydrogenase -0.0375554
NRP1 neuropilin 1 -0.0373954
ELL2 elongation factor, RNA polymerase II, 2 -0.0362159
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0359044
GCC2 GRIP and coiled-coil domain containing 2 -0.0351686
KYNU kynureninase -0.0350802
VRK2 vaccinia related kinase 2 -0.034996
PID1 phosphotyrosine interaction domain containing 1 -0.0348388
EGR1 early growth response 1 -0.0342268
EREG epiregulin -0.0337212
ZC3H12C zinc finger CCCH-type containing 12C -0.0336737
C15ORF48 chromosome 15 open reading frame 48 -0.0336372
RAB1A RAB1A, member RAS oncogene family -0.0327306
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0320066
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0318602
NF1 neurofibromin 1 -0.0314901
RNF149 ring finger protein 149 -0.0313548
HEG1 heart development protein with EGF-like domains 1 -0.0310762
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0310165
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0305989
KLF6 Kruppel-like factor 6 -0.0303867
AKAP9 A kinase (PRKA) anchor protein 9 -0.0301102
ANKRD28 ankyrin repeat domain 28 -0.0299866
ZBTB20 zinc finger and BTB domain containing 20 -0.029587
FRMD4A FERM domain containing 4A -0.0290217
KMT2E lysine (K)-specific methyltransferase 2E -0.0289918
IGFBP3 insulin-like growth factor binding protein 3 -0.0287673
JMJD1C jumonji domain containing 1C -0.0286934
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0286309
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0284697
SNX9 sorting nexin 9 -0.0283699
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0280488
TMEM263 transmembrane protein 263 -0.0278123
DENND4A DENN/MADD domain containing 4A -0.0277868
KDM3A lysine (K)-specific demethylase 3A -0.0264827
ARID3B AT rich interactive domain 3B (BRIGHT-like) -0.0263831
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0262128
COL12A1 collagen, type XII, alpha 1 -0.0260663
TMEM87A transmembrane protein 87A -0.0259559
NPEPPS aminopeptidase puromycin sensitive -0.0256174
CDCP1 CUB domain containing protein 1 -0.0255676
VEZT vezatin, adherens junctions transmembrane protein -0.0255579
CLMP CXADR-like membrane protein -0.0255364
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0254716
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.025436
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0252686
SLC38A1 solute carrier family 38, member 1 -0.0252538
SREBF2 sterol regulatory element binding transcription factor 2 -0.0251995
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0251324
SOX4 SRY (sex determining region Y)-box 4 -0.0250224
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0246042
MX2 MX dynamin-like GTPase 2 -0.0243158