Salicylic acid_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.130026
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.110779
FMNL2 formin-like 2 0.109965
DOCK4 dedicator of cytokinesis 4 0.090245
FNDC3B fibronectin type III domain containing 3B 0.0881164
IGFBP3 insulin-like growth factor binding protein 3 0.0872316
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0858761
TRIO trio Rho guanine nucleotide exchange factor 0.0723579
FLNB filamin B, beta 0.0712405
UBASH3B ubiquitin associated and SH3 domain containing B 0.0682364
CMIP c-Maf inducing protein 0.0676744
TPM3 tropomyosin 3 0.0641825
SMOC1 SPARC related modular calcium binding 1 0.0641039
AKAP12 A kinase (PRKA) anchor protein 12 0.0634187
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0629907
MACF1 microtubule-actin crosslinking factor 1 0.0611223
KTN1 kinectin 1 (kinesin receptor) 0.0610352
EGFR epidermal growth factor receptor 0.05744
AKAP13 A kinase (PRKA) anchor protein 13 0.0562559
COPA coatomer protein complex, subunit alpha 0.0558931
WAC WW domain containing adaptor with coiled-coil 0.0546562
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0545946
ARHGAP26 Rho GTPase activating protein 26 0.0513291
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0511055
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0507737
DOCK5 dedicator of cytokinesis 5 0.0507102
PYGL phosphorylase, glycogen, liver 0.0497978
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0494172
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0487456
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0481934
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.047374
CYTH1 cytohesin 1 0.0464195
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0458149
LPP LIM domain containing preferred translocation partner in lipoma 0.0451869
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0443516
NDRG1 N-myc downstream regulated 1 0.0424431
BRD2 bromodomain containing 2 0.0422239
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0421317
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0413345
BASP1 brain abundant, membrane attached signal protein 1 0.0408581
UTRN utrophin 0.0404755
ITCH itchy E3 ubiquitin protein ligase 0.0403313
ZFAND3 zinc finger, AN1-type domain 3 0.0402749
ERBIN erbb2 interacting protein 0.0401175
MCL1 myeloid cell leukemia 1 0.0399159
APP amyloid beta (A4) precursor protein 0.039685
APLP2 amyloid beta (A4) precursor-like protein 2 0.0395112
HLA-B major histocompatibility complex, class I, B 0.0390888
MYH9 myosin, heavy chain 9, non-muscle 0.0380642
PARD3 par-3 family cell polarity regulator 0.0380132
NEBL nebulette 0.0379664
GOLGA4 golgin A4 0.0375773
CCNL1 cyclin L1 0.0374697
ACTN1 actinin, alpha 1 0.0371951
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0369025
CTBP2 C-terminal binding protein 2 0.0368635
MSN moesin 0.0366114
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0362099
SOD2 superoxide dismutase 2, mitochondrial 0.0361441
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0359619
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0349922
BIRC6 baculoviral IAP repeat containing 6 0.0349266
FAM107B family with sequence similarity 107, member B 0.0346408
SLMAP sarcolemma associated protein 0.0343102
GLG1 golgi glycoprotein 1 0.0342954
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0334485
MYO1E myosin IE 0.0333239
EXT1 exostosin glycosyltransferase 1 0.0330101
KMT2C lysine (K)-specific methyltransferase 2C 0.0328504
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0325543
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0318512
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0316223
CCNY cyclin Y 0.031363
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0312912
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0311094
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0309053
PTPRM protein tyrosine phosphatase, receptor type, M 0.0308683
SBF2 SET binding factor 2 0.0306947
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0305864
ATXN1 ataxin 1 0.0304604
NUMB numb homolog (Drosophila) 0.0303833
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.030149
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0297894
THSD4 thrombospondin, type I, domain containing 4 0.0293912
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0289341
PICALM phosphatidylinositol binding clathrin assembly protein 0.0289093
RBM25 RNA binding motif protein 25 0.0289016
TPD52 tumor protein D52 0.028424
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0283782
ZC3H11A zinc finger CCCH-type containing 11A 0.0279793
RICTOR RPTOR independent companion of MTOR, complex 2 0.0279394
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.027774
ZSWIM6 zinc finger, SWIM-type containing 6 0.0273595
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0272388
BAIAP2L1 BAI1-associated protein 2-like 1 0.0270666
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0270393
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0270176
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0270098
SPDYA speedy/RINGO cell cycle regulator family member A 0.0269126
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0267708

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.192703
MT2A metallothionein 2A -0.136624
PM20D1 peptidase M20 domain containing 1 -0.122723
TM4SF1 transmembrane 4 L six family member 1 -0.121601
TFPI2 tissue factor pathway inhibitor 2 -0.117306
GRAMD1B GRAM domain containing 1B -0.105225
TXNRD1 thioredoxin reductase 1 -0.103525
FTL ferritin, light polypeptide -0.086391
TMSB10 thymosin beta 10 -0.0829966
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.062229
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0599138
RPL19 ribosomal protein L19 -0.0548081
VIM vimentin -0.0485955
OSMR oncostatin M receptor -0.0473747
EGR1 early growth response 1 -0.0467599
RPLP1 ribosomal protein, large, P1 -0.0435596
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0417084
PTMA prothymosin, alpha -0.039439
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0389667
SLC38A2 solute carrier family 38, member 2 -0.03808
RTN4 reticulon 4 -0.0372732
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0365063
RPS21 ribosomal protein S21 -0.0345376
EIF1 eukaryotic translation initiation factor 1 -0.0343195
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0335078
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.031401
TPT1 tumor protein, translationally-controlled 1 -0.0303523
RPLP0 ribosomal protein, large, P0 -0.0301253
KLF6 Kruppel-like factor 6 -0.0299897
RPL7 ribosomal protein L7 -0.0296337
NNMT nicotinamide N-methyltransferase -0.0295916
RAD21 RAD21 homolog (S. pombe) -0.0292048
FGB fibrinogen beta chain -0.0287765
RPS23 ribosomal protein S23 -0.0286704
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0284965
WWOX WW domain containing oxidoreductase -0.0279143
ACTG1 actin gamma 1 -0.0278352
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0273995
IER3 immediate early response 3 -0.0272664
NCOA7 nuclear receptor coactivator 7 -0.0271264
HDAC9 histone deacetylase 9 -0.0269634
RPS19 ribosomal protein S19 -0.0265198
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0264902
MKI67 marker of proliferation Ki-67 -0.0261281
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0257139
RPS8 ribosomal protein S8 -0.0250451
FTH1 ferritin, heavy polypeptide 1 -0.0246829
RPS25 ribosomal protein S25 -0.0245092
IGF2 insulin-like growth factor 2 -0.0243251
RHEB Ras homolog enriched in brain -0.0240108
FGG fibrinogen gamma chain -0.0238666
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0236676
RPL23 ribosomal protein L23 -0.0235884
NAMPT nicotinamide phosphoribosyltransferase -0.0233647
ZNF804A zinc finger protein 804A -0.0232648
RPL8 ribosomal protein L8 -0.0230934
TUBB tubulin, beta class I -0.0229816
RPL30 ribosomal protein L30 -0.0229345
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0228409
RSPO3 R-spondin 3 -0.0225504
ATP5F1B ATP synthase F1 subunit beta -0.0223938
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.022291
RPS29 ribosomal protein S29 -0.0222061
RPL26 ribosomal protein L26 -0.0218224
MIS18BP1 MIS18 binding protein 1 -0.0218127
RPS24 ribosomal protein S24 -0.0216851
RPL35A ribosomal protein L35a -0.0211173
HMGB1 high mobility group box 1 -0.0210504
RPS5 ribosomal protein S5 -0.0207585
ADGRG6 adhesion G protein-coupled receptor G6 -0.0207451
BICC1 BicC family RNA binding protein 1 -0.0206942
RPS12 ribosomal protein S12 -0.0204994
NTN4 netrin 4 -0.0204884
TUBA1B tubulin, alpha 1b -0.0202743
RPS15 ribosomal protein S15 -0.0200981
RPS16 ribosomal protein S16 -0.0199416
BIRC2 baculoviral IAP repeat containing 2 -0.0199247
CENPE centromere protein E, 312kDa -0.0197973
AGO2 argonaute RISC catalytic component 2 -0.0195563
IGF1R insulin-like growth factor 1 receptor -0.0195248
CENPF centromere protein F, 350/400kDa -0.0194876
BMP5 bone morphogenetic protein 5 -0.0194748
DENND4A DENN/MADD domain containing 4A -0.0192682
RPL32 ribosomal protein L32 -0.0190577
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0188522
RPL9 ribosomal protein L9 -0.0187852
RPL12 ribosomal protein L12 -0.018783
AREG amphiregulin -0.0186585
ATP5F1E ATP synthase F1 subunit epsilon -0.018563
RACK1 receptor for activated C kinase 1 -0.0184065
RPS20 ribosomal protein S20 -0.0182965
SRGN serglycin -0.018208
WDR43 WD repeat domain 43 -0.0173625
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0173183
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0171656
GNAS GNAS complex locus -0.0171495
RPS14 ribosomal protein S14 -0.0170688
KPNB1 karyopherin (importin) beta 1 -0.0167065
AK1 adenylate kinase 1 -0.016582
RPL11 ribosomal protein L11 -0.0163778