Salicylic acid_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

198 genes differentially expressed following the Salicylic acid_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.220198
LPP LIM domain containing preferred translocation partner in lipoma 0.171767
FNDC3B fibronectin type III domain containing 3B 0.171154
MYH9 myosin, heavy chain 9, non-muscle 0.13646
JMJD1C jumonji domain containing 1C 0.124513
ANO6 anoctamin 6 0.116534
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.116157
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.111441
SLTM SAFB-like, transcription modulator 0.111228
CDK13 cyclin-dependent kinase 13 0.109811
DOCK5 dedicator of cytokinesis 5 0.0946806
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0932862
GOLGA4 golgin A4 0.0905033
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0773032
EEF2 eukaryotic translation elongation factor 2 0.0766503
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0759902
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0753681
OGA O-GlcNAcase 0.0739601
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0726642
SMAD3 SMAD family member 3 0.0721445
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0713406
EZR ezrin 0.0694277
LMO7 LIM domain 7 0.0688578
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0667135
KMT2E lysine (K)-specific methyltransferase 2E 0.0649239
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0638237
KMT2C lysine (K)-specific methyltransferase 2C 0.06286
FN1 fibronectin 1 0.0615995
FAT1 FAT atypical cadherin 1 0.0604218
SND1 staphylococcal nuclease and tudor domain containing 1 0.0591202
MACF1 microtubule-actin crosslinking factor 1 0.0591165
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0587949
RBM39 RNA binding motif protein 39 0.0587125
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.058237
ZSWIM6 zinc finger, SWIM-type containing 6 0.0572837
PTK2 protein tyrosine kinase 2 0.0571106
DSCAM Down syndrome cell adhesion molecule 0.0568964
FNIP1 folliculin interacting protein 1 0.0567524
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0558427
PGK1 phosphoglycerate kinase 1 0.0544102
AKAP9 A kinase (PRKA) anchor protein 9 0.0539302
RPS3 ribosomal protein S3 0.0519278
LDHA lactate dehydrogenase A 0.0456172
FBXO11 F-box protein 11 0.0454786
RPS8 ribosomal protein S8 0.0440863
ZNF292 zinc finger protein 292 0.0438851
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0438177
PCBP2 poly(rC) binding protein 2 0.0433495
ENO1 enolase 1, (alpha) 0.0424541
FTH1 ferritin, heavy polypeptide 1 0.0418369
GLS2 glutaminase 2 (liver, mitochondrial) 0.0404967
EIF1 eukaryotic translation initiation factor 1 0.0381659
NIPBL Nipped-B homolog (Drosophila) 0.0378735
CANX calnexin 0.0378605
RPL35A ribosomal protein L35a 0.0365994
POTEF POTE ankyrin domain family, member F 0.0350749
RAD51B RAD51 paralog B 0.0349808
GOLGB1 golgin B1 0.0347115
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0337115
RPS17 ribosomal protein S17 0.0322881
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0318986
SETD5 SET domain containing 5 0.0309509
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0305507
MYO9A myosin IXA 0.0264952
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0262222
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0258331
KMT2A lysine (K)-specific methyltransferase 2A 0.023581
SYAP1 synapse associated protein 1 0.0222524
KTN1 kinectin 1 (kinesin receptor) 0.0211306
SQSTM1 sequestosome 1 0.0204231
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0191204
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0189598
PRRC2C proline-rich coiled-coil 2C 0.0185502
TTC3 tetratricopeptide repeat domain 3 0.0171318
SAMD4A sterile alpha motif domain containing 4A 0.0165926
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0165666
DOCK4 dedicator of cytokinesis 4 0.0149487
ZBTB20 zinc finger and BTB domain containing 20 0.0144186
ANKRD11 ankyrin repeat domain 11 0.014098
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.013968
RUNX1 runt-related transcription factor 1 0.0138832
ZFAND3 zinc finger, AN1-type domain 3 0.0134549
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.012151
ELL2 elongation factor, RNA polymerase II, 2 0.0114936
PKM pyruvate kinase, muscle 0.0112464
ANKRD12 ankyrin repeat domain 12 0.0108993
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0105962
PDE4D phosphodiesterase 4D, cAMP-specific 0.00985419
AFDN afadin, adherens junction formation factor 0.00949595
TPM4 tropomyosin 4 0.00897677
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00895529
VMP1 vacuole membrane protein 1 0.00885639
CSNK1A1 casein kinase 1, alpha 1 0.00858081
VCL vinculin 0.00808274
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.00766994
ATXN1 ataxin 1 0.00752932
KIAA1217 KIAA1217 0.00703124
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.00645244
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.00573913
TBC1D22A TBC1 domain family, member 22A 0.00378485

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.258329
PDE10A phosphodiesterase 10A -0.206672
RORA RAR-related orphan receptor A -0.204338
EFNA5 ephrin-A5 -0.197128
PSD3 pleckstrin and Sec7 domain containing 3 -0.159653
EXT1 exostosin glycosyltransferase 1 -0.128739
PTPRM protein tyrosine phosphatase, receptor type, M -0.124709
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.109815
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.10315
CDH13 cadherin 13 -0.100871
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0997183
RPS19 ribosomal protein S19 -0.0976454
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.092128
NDRG1 N-myc downstream regulated 1 -0.0915394
MT2A metallothionein 2A -0.0856902
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0830772
GPC6 glypican 6 -0.0761297
FGF14 fibroblast growth factor 14 -0.0751406
NAV2 neuron navigator 2 -0.0735305
STC1 stanniocalcin 1 -0.0726633
PCBP3 poly(rC) binding protein 3 -0.0718708
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0704377
RPS25 ribosomal protein S25 -0.0682291
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0639292
DIAPH2 diaphanous-related formin 2 -0.0622717
SEC31A SEC31 homolog A (S. cerevisiae) -0.0586175
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0567308
SMYD3 SET and MYND domain containing 3 -0.0557556
NAMPT nicotinamide phosphoribosyltransferase -0.0549585
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0547876
RPS27A ribosomal protein S27a -0.0500438
NKD1 naked cuticle homolog 1 (Drosophila) -0.0494679
PTMA prothymosin, alpha -0.0490682
RPL23 ribosomal protein L23 -0.04719
MORF4L2 mortality factor 4 like 2 -0.0462206
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0457818
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0457771
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0448515
NALF1 NALCN channel auxiliary factor 1 -0.0446459
PRKCA protein kinase C, alpha -0.0424061
RPS23 ribosomal protein S23 -0.042229
MBNL2 muscleblind-like splicing regulator 2 -0.0416483
RPLP1 ribosomal protein, large, P1 -0.0408516
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0408125
NCOR1 nuclear receptor corepressor 1 -0.0395123
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0391486
RAP1B RAP1B, member of RAS oncogene family -0.0391411
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0389552
TRIO trio Rho guanine nucleotide exchange factor -0.0388011
HMGA2 high mobility group AT-hook 2 -0.0385469
TPT1 tumor protein, translationally-controlled 1 -0.0381365
RPS12 ribosomal protein S12 -0.0342516
EGFR epidermal growth factor receptor -0.0337456
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0336839
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0334377
AHNAK AHNAK nucleoprotein -0.0333546
PUM2 pumilio RNA-binding family member 2 -0.0321567
MED13L mediator complex subunit 13-like -0.0317659
NPAS2 neuronal PAS domain protein 2 -0.0292513
COG5 component of oligomeric golgi complex 5 -0.0288279
ARHGAP32 Rho GTPase activating protein 32 -0.027596
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0270432
RPS29 ribosomal protein S29 -0.0249322
RIOK3 RIO kinase 3 -0.0244745
TXNRD1 thioredoxin reductase 1 -0.0234979
DST dystonin -0.0229836
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0223788
RPL37A ribosomal protein L37a -0.0222569
TMSB10 thymosin beta 10 -0.0211629
BPTF bromodomain PHD finger transcription factor -0.0209257
NHSL1 NHS-like 1 -0.0199513
PARD3 par-3 family cell polarity regulator -0.0197695
IGF2 insulin-like growth factor 2 -0.0186358
VIM vimentin -0.0171055
AKAP13 A kinase (PRKA) anchor protein 13 -0.0165268
RPS6 ribosomal protein S6 -0.0164588
ZNF638 zinc finger protein 638 -0.0146374
MAML2 mastermind-like 2 (Drosophila) -0.0145039
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0125287
ZMYND8 zinc finger, MYND-type containing 8 -0.0122859
ARL15 ADP-ribosylation factor-like 15 -0.0109003
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0104924
METTL15 methyltransferase like 15 -0.0101667
STAG2 stromal antigen 2 -0.0084049
COL5A1 collagen, type V, alpha 1 -0.0077011
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00694316
MCL1 myeloid cell leukemia 1 -0.00650543
RPL34 ribosomal protein L34 -0.00650535
CUX1 cut-like homeobox 1 -0.00595203
RPL26 ribosomal protein L26 -0.00585666
B2M beta-2-microglobulin -0.00547212
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.00444553
LAMB3 laminin, beta 3 -0.00388358
ANXA2 annexin A2 -0.00317294
NAP1L1 nucleosome assembly protein 1-like 1 -0.00283727
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0010915
RNF149 ring finger protein 149 -7.1853E-4
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -4.92551E-5