Salicylic acid_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.304663
APLP2 amyloid beta (A4) precursor-like protein 2 0.0723946
MCL1 myeloid cell leukemia 1 0.0711311
DSCAM Down syndrome cell adhesion molecule 0.0689823
ASPH aspartate beta-hydroxylase 0.0647955
ZSWIM6 zinc finger, SWIM-type containing 6 0.0644792
INTS6 integrator complex subunit 6 0.0628863
VMP1 vacuole membrane protein 1 0.0622543
WWTR1 WW domain containing transcription regulator 1 0.0604269
MYH9 myosin, heavy chain 9, non-muscle 0.0592123
ITGAV integrin, alpha V 0.0589811
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0583341
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0520896
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0508172
ATXN1 ataxin 1 0.0505258
SPRED2 sprouty-related, EVH1 domain containing 2 0.0494035
BRD2 bromodomain containing 2 0.0470961
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0451875
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0427539
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0422989
NUP98 nucleoporin 98kDa 0.0417153
ANO6 anoctamin 6 0.0405621
CCNL1 cyclin L1 0.040217
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0401266
PDLIM5 PDZ and LIM domain 5 0.039942
VEGFA vascular endothelial growth factor A 0.0391049
JMJD1C jumonji domain containing 1C 0.0388901
SEPTIN9 septin 9 0.0385769
ANKRD11 ankyrin repeat domain 11 0.0374926
MSN moesin 0.0365601
EIF4A2 eukaryotic translation initiation factor 4A2 0.0362162
FNDC3B fibronectin type III domain containing 3B 0.0361518
ELL2 elongation factor, RNA polymerase II, 2 0.0339822
MYO1E myosin IE 0.0337646
CTNND1 catenin (cadherin-associated protein), delta 1 0.0334346
AFDN afadin, adherens junction formation factor 0.0325063
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0320293
RBM39 RNA binding motif protein 39 0.0318697
RRM2 ribonucleotide reductase M2 0.0312927
EGR1 early growth response 1 0.0304196
ATF6 activating transcription factor 6 0.0301063
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0298298
NCEH1 neutral cholesterol ester hydrolase 1 0.0297092
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0292419
ZNF644 zinc finger protein 644 0.0290367
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0289697
SAMD4B sterile alpha motif domain containing 4B 0.0285843
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0285016
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0284892
PRELID2 PRELI domain containing 2 0.028489
ZFAND3 zinc finger, AN1-type domain 3 0.0281479
HDAC9 histone deacetylase 9 0.027967
ZFP36 ZFP36 ring finger protein 0.0275382
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0273178
SLC38A2 solute carrier family 38, member 2 0.0269788
SMAD3 SMAD family member 3 0.0264901
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0262994
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0261273
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0261134
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0258319
YAP1 Yes-associated protein 1 0.0257886
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0257115
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0256452
PICALM phosphatidylinositol binding clathrin assembly protein 0.0256058
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0252266
WEE1 WEE1 G2 checkpoint kinase 0.0250241
DENND5A DENN/MADD domain containing 5A 0.0247892
SETD5 SET domain containing 5 0.0247036
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0246337
SFTPA2 surfactant protein A2 0.0240744
HOMER1 homer scaffolding protein 1 0.0240126
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0238632
OGA O-GlcNAcase 0.023463
ADAM10 ADAM metallopeptidase domain 10 0.0233204
KTN1 kinectin 1 (kinesin receptor) 0.0233096
UBAP2 ubiquitin associated protein 2 0.0227407
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0225344
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0225068
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0223328
SMYD3 SET and MYND domain containing 3 0.02231
TOP1 topoisomerase (DNA) I 0.0221114
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0220766
CUL3 cullin 3 0.0218887
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0218143
JUN jun proto-oncogene 0.0216056
STC2 stanniocalcin 2 0.0215674
DIAPH1 diaphanous-related formin 1 0.0215477
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0213885
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0213037
THOC2 THO complex 2 0.0212646
FERMT2 fermitin family member 2 0.0211759
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0209861
STK40 serine/threonine kinase 40 0.0209185
EHBP1L1 EH domain binding protein 1-like 1 0.0205293
RSRC2 arginine/serine-rich coiled-coil 2 0.020522
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0204224
MED13L mediator complex subunit 13-like 0.0204184
FLNB filamin B, beta 0.0203938
CA8 carbonic anhydrase VIII 0.0203537
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0203465

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.220398
RPS16 ribosomal protein S16 -0.209569
VIM vimentin -0.208544
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165198
AHNAK AHNAK nucleoprotein -0.133661
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0979478
PTMA prothymosin, alpha -0.0914334
SLC35F3 solute carrier family 35, member F3 -0.0884135
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0877068
FBL fibrillarin -0.0763778
THSD4 thrombospondin, type I, domain containing 4 -0.0763138
HSPG2 heparan sulfate proteoglycan 2 -0.057107
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0558783
SBF2 SET binding factor 2 -0.0480585
AFAP1 actin filament associated protein 1 -0.0476132
ATG7 autophagy related 7 -0.045593
RPL35A ribosomal protein L35a -0.0452098
S100A6 S100 calcium binding protein A6 -0.0449316
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0447613
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0439582
RPLP1 ribosomal protein, large, P1 -0.0438816
PDIA3 protein disulfide isomerase family A, member 3 -0.0427025
RNF220 ring finger protein 220 -0.0421309
MYOF myoferlin -0.04171
RPLP2 ribosomal protein, large, P2 -0.041122
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0404028
TMSB10 thymosin beta 10 -0.0395202
DIAPH2 diaphanous-related formin 2 -0.0392847
LOC112694756 uncharaterized LOC112694756 -0.0392198
EGFR epidermal growth factor receptor -0.0390231
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0370839
RPS24 ribosomal protein S24 -0.035788
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0345159
HM13 histocompatibility (minor) 13 -0.0340006
CANX calnexin -0.0337131
CARD18 caspase recruitment domain family, member 18 -0.0329922
PKM pyruvate kinase, muscle -0.0324664
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0322161
PGK1 phosphoglycerate kinase 1 -0.0317328
SEPTIN7 septin 7 -0.0306608
ENO1 enolase 1, (alpha) -0.0302016
CTSD cathepsin D -0.0286362
RPS5 ribosomal protein S5 -0.0284008
MAP4 microtubule-associated protein 4 -0.0278914
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0272724
HMGA2 high mobility group AT-hook 2 -0.0272584
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0267156
ZNF780B zinc finger protein 780B -0.0263961
NHSL1 NHS-like 1 -0.0261949
RPLP0 ribosomal protein, large, P0 -0.0260922
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0255158
RPL11 ribosomal protein L11 -0.0250477
FMNL2 formin-like 2 -0.0247252
CD44 CD44 molecule (Indian blood group) -0.0243698
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0239773
EHBP1 EH domain binding protein 1 -0.0239326
BMERB1 bMERB domain containing 1 -0.0237871
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0233537
RPS27A ribosomal protein S27a -0.0233081
RPL12 ribosomal protein L12 -0.0232633
HMGB1 high mobility group box 1 -0.0232391
ZNF546 zinc finger protein 546 -0.0226584
PRSS23 protease, serine, 23 -0.0224826
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0223469
ZMYND8 zinc finger, MYND-type containing 8 -0.0222395
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0221656
RPS25 ribosomal protein S25 -0.0215626
RPL26 ribosomal protein L26 -0.0212329
FTL ferritin, light polypeptide -0.0211145
RPL27A ribosomal protein L27a -0.0209696
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0208246
KRT19 keratin 19, type I -0.0207385
CDCP1 CUB domain containing protein 1 -0.0204678
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0203666
FBXO17 F-box protein 17 -0.0202598
RPL8 ribosomal protein L8 -0.0201375
RACK1 receptor for activated C kinase 1 -0.0201365
RPS8 ribosomal protein S8 -0.0200078
RPS21 ribosomal protein S21 -0.0197802
GNAS GNAS complex locus -0.019778
ACTG1 actin gamma 1 -0.019666
ATP5F1B ATP synthase F1 subunit beta -0.0194938
CAVIN1 caveolae associated protein 1 -0.0193034
PFN1 profilin 1 -0.0191961
TAS2R14 taste receptor, type 2, member 14 -0.0189168
RPL34 ribosomal protein L34 -0.0188798
CDK6 cyclin-dependent kinase 6 -0.0188796
TNS3 tensin 3 -0.0187759
TMEM123 transmembrane protein 123 -0.0187432
CCND1 cyclin D1 -0.0186217
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0185069
GOLGA4 golgin A4 -0.0185058
RPS14 ribosomal protein S14 -0.0183957
PTPRF protein tyrosine phosphatase, receptor type, F -0.0183616
IFITM3 interferon induced transmembrane protein 3 -0.0181931
HMGA1 high mobility group AT-hook 1 -0.0181884
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0180366
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0180312
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0179299
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0177223