Salicylic acid_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.12523
INTS6 integrator complex subunit 6 0.119742
SMAD3 SMAD family member 3 0.114526
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0937954
ZSWIM6 zinc finger, SWIM-type containing 6 0.0821275
TRIO trio Rho guanine nucleotide exchange factor 0.0814771
FNDC3B fibronectin type III domain containing 3B 0.0806026
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0787864
MACF1 microtubule-actin crosslinking factor 1 0.078762
NAV2 neuron navigator 2 0.0778039
LPP LIM domain containing preferred translocation partner in lipoma 0.0739409
MYO5B myosin VB 0.0725648
AFDN afadin, adherens junction formation factor 0.0701259
ARHGAP26 Rho GTPase activating protein 26 0.0696465
SVIL supervillin 0.0664472
SAMD4A sterile alpha motif domain containing 4A 0.0652304
TJP1 tight junction protein 1 0.0635036
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0625376
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0618083
VEGFA vascular endothelial growth factor A 0.0609504
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0609428
RNF213 ring finger protein 213 0.0593499
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0582801
MYH9 myosin, heavy chain 9, non-muscle 0.0578646
LMO7 LIM domain 7 0.0577782
CD44 CD44 molecule (Indian blood group) 0.055556
RUNX1 runt-related transcription factor 1 0.0548593
AKAP13 A kinase (PRKA) anchor protein 13 0.054368
SEPTIN9 septin 9 0.0542221
PLEC plectin 0.0541334
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0525321
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0520946
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0489638
APLP2 amyloid beta (A4) precursor-like protein 2 0.0457278
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0451063
BACE2 beta-site APP-cleaving enzyme 2 0.044483
FMNL2 formin-like 2 0.0433684
HSPA8 heat shock 70kDa protein 8 0.0418287
PPARD peroxisome proliferator-activated receptor delta 0.0408509
CTBP2 C-terminal binding protein 2 0.0404078
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0403655
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0403259
JARID2 jumonji, AT rich interactive domain 2 0.0398248
BCAR3 breast cancer anti-estrogen resistance 3 0.0396303
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0393459
SHB Src homology 2 domain containing adaptor protein B 0.038704
NRIP1 nuclear receptor interacting protein 1 0.038632
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0386238
EXT1 exostosin glycosyltransferase 1 0.0386206
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0381627
FHIT fragile histidine triad 0.0379069
POTEF POTE ankyrin domain family, member F 0.037691
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0376315
MYO1E myosin IE 0.0375881
CTNND1 catenin (cadherin-associated protein), delta 1 0.0375652
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.037528
CAPRIN2 caprin family member 2 0.0372176
VMP1 vacuole membrane protein 1 0.0371681
FAM3C family with sequence similarity 3, member C 0.0367825
GRB10 growth factor receptor-bound protein 10 0.0367791
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0366846
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0366471
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0365817
DIAPH1 diaphanous-related formin 1 0.0356487
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.035163
HDAC9 histone deacetylase 9 0.0350538
ANO6 anoctamin 6 0.034971
FLNA filamin A, alpha 0.0349051
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0348521
EIF4A2 eukaryotic translation initiation factor 4A2 0.0343763
DSPP dentin sialophosphoprotein 0.0343099
PTK2 protein tyrosine kinase 2 0.0337562
LAMC2 laminin, gamma 2 0.0335987
RAD51B RAD51 paralog B 0.0333763
DUSP10 dual specificity phosphatase 10 0.0333314
RASAL2 RAS protein activator like 2 0.0326799
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0326329
ETV6 ets variant 6 0.0326289
MAML2 mastermind-like 2 (Drosophila) 0.0325948
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0323093
PRELID2 PRELI domain containing 2 0.0320393
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0313995
KIAA1671 KIAA1671 0.0311005
TUFT1 tuftelin 1 0.0310692
SLC35F3 solute carrier family 35, member F3 0.0307703
MAST4 microtubule associated serine/threonine kinase family member 4 0.0305033
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0304002
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0300674
SMOC1 SPARC related modular calcium binding 1 0.0298906
WWTR1 WW domain containing transcription regulator 1 0.0298259
MYO6 myosin VI 0.0297018
PCLO piccolo presynaptic cytomatrix protein 0.0293053
DST dystonin 0.0289968
TGM2 transglutaminase 2 0.02874
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0286942
PICALM phosphatidylinositol binding clathrin assembly protein 0.0286031
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.028493
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0284235
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0278317
KLF12 Kruppel-like factor 12 0.0277764

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.189475
PTMA prothymosin, alpha -0.161685
TPT1 tumor protein, translationally-controlled 1 -0.0980354
TMSB10 thymosin beta 10 -0.0878789
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0786445
B2M beta-2-microglobulin -0.0782464
F3 coagulation factor III (thromboplastin, tissue factor) -0.0740679
ANLN anillin, actin binding protein -0.0713346
EIF1 eukaryotic translation initiation factor 1 -0.0663559
HMGA1 high mobility group AT-hook 1 -0.0636724
KRT17 keratin 17, type I -0.0598889
KRT19 keratin 19, type I -0.0577481
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0565444
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0547247
S100A6 S100 calcium binding protein A6 -0.0542473
PLAT plasminogen activator, tissue -0.0512255
TM4SF1 transmembrane 4 L six family member 1 -0.0500094
NPEPPS aminopeptidase puromycin sensitive -0.0483892
MKI67 marker of proliferation Ki-67 -0.0472121
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0454214
RPL35A ribosomal protein L35a -0.0451276
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0449897
MUC4 mucin 4, cell surface associated -0.0449743
GOLGA4 golgin A4 -0.0446784
HLA-A major histocompatibility complex, class I, A -0.044219
TPI1 triosephosphate isomerase 1 -0.0440144
RIOK3 RIO kinase 3 -0.0439665
LY6E lymphocyte antigen 6 complex, locus E -0.0439243
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0436669
TMSB4X thymosin beta 4, X-linked -0.0430453
TMEM123 transmembrane protein 123 -0.042908
C6ORF132 chromosome 6 open reading frame 132 -0.041791
RPS13 ribosomal protein S13 -0.041621
EMP1 epithelial membrane protein 1 -0.0410906
HLA-E major histocompatibility complex, class I, E -0.0407164
PGK1 phosphoglycerate kinase 1 -0.0404464
IGFBP3 insulin-like growth factor binding protein 3 -0.0399272
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0398647
HLA-B major histocompatibility complex, class I, B -0.0398033
DLG1 discs, large homolog 1 (Drosophila) -0.0394874
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0393676
FTH1 ferritin, heavy polypeptide 1 -0.038372
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0378898
SMC4 structural maintenance of chromosomes 4 -0.0373094
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0369319
FTL ferritin, light polypeptide -0.0365021
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0359289
RACK1 receptor for activated C kinase 1 -0.0358132
WFDC2 WAP four-disulfide core domain 2 -0.0348877
RPS8 ribosomal protein S8 -0.0336298
RPS19 ribosomal protein S19 -0.0330526
RPS3 ribosomal protein S3 -0.0329883
CANX calnexin -0.0329123
EPCAM epithelial cell adhesion molecule -0.0329042
RPS24 ribosomal protein S24 -0.0328688
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0322733
CAV1 caveolin 1, caveolae protein, 22kDa -0.0320744
CALR calreticulin -0.0319917
PRRC2C proline-rich coiled-coil 2C -0.0319189
RPL34 ribosomal protein L34 -0.0317042
KPNB1 karyopherin (importin) beta 1 -0.0315944
H3-3B H3.3 histone B -0.0312246
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0308575
DPYD dihydropyrimidine dehydrogenase -0.0307662
MIS18BP1 MIS18 binding protein 1 -0.0303611
LOC102724023 ES1 protein homolog, mitochondrial -0.0301903
RPLP1 ribosomal protein, large, P1 -0.030147
CD2AP CD2-associated protein -0.0299703
RPS6 ribosomal protein S6 -0.0299396
IFITM1 interferon induced transmembrane protein 1 -0.0296829
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0296428
RPS29 ribosomal protein S29 -0.029476
RPL36A ribosomal protein L36a -0.0292596
RPL12 ribosomal protein L12 -0.0291823
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0287998
RPS27A ribosomal protein S27a -0.0283814
CD63 CD63 molecule -0.0282745
TPM4 tropomyosin 4 -0.0282407
GCC2 GRIP and coiled-coil domain containing 2 -0.0282023
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0280355
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0274077
UGCG UDP-glucose ceramide glucosyltransferase -0.0273383
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0271648
COPB1 coatomer protein complex, subunit beta 1 -0.0271562
SLC38A1 solute carrier family 38, member 1 -0.0267312
DIAPH3 diaphanous-related formin 3 -0.0266039
NAMPT nicotinamide phosphoribosyltransferase -0.02657
IFITM3 interferon induced transmembrane protein 3 -0.0264656
MT2A metallothionein 2A -0.0261618
RAD21 RAD21 homolog (S. pombe) -0.0260265
WSB1 WD repeat and SOCS box containing 1 -0.0260262
RPS14 ribosomal protein S14 -0.0258474
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0258276
RPL31 ribosomal protein L31 -0.0252406
RPLP0 ribosomal protein, large, P0 -0.0252274
GNAS GNAS complex locus -0.025218
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0251465
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0251297
MYL12B myosin, light chain 12B, regulatory -0.0250479
WDR45B WD repeat domain 45B -0.0249731