Salicylic acid_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD6 FERM domain containing 6 0.150402
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.145431
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0951934
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0938569
MCTP1 multiple C2 domains, transmembrane 1 0.093086
SAMD4A sterile alpha motif domain containing 4A 0.0853591
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0817856
ZEB1 zinc finger E-box binding homeobox 1 0.0782915
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0781025
EXT1 exostosin glycosyltransferase 1 0.0708775
NAV3 neuron navigator 3 0.0637871
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0596624
HDAC9 histone deacetylase 9 0.058911
INTS6 integrator complex subunit 6 0.0572876
NAV2 neuron navigator 2 0.0513021
EEF2 eukaryotic translation elongation factor 2 0.0484221
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.047712
JMJD1C jumonji domain containing 1C 0.0460399
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0435816
KMT2E lysine (K)-specific methyltransferase 2E 0.0433152
CAPRIN2 caprin family member 2 0.0430745
ZSWIM6 zinc finger, SWIM-type containing 6 0.0427036
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0423759
ELL2 elongation factor, RNA polymerase II, 2 0.0414509
NUP58 nucleoporin 58 0.040962
ZFAND3 zinc finger, AN1-type domain 3 0.0386475
CORO1C coronin, actin binding protein, 1C 0.0385587
AHNAK AHNAK nucleoprotein 0.0384505
FNDC3B fibronectin type III domain containing 3B 0.0362457
NDRG1 N-myc downstream regulated 1 0.0358638
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0356114
RCOR1 REST corepressor 1 0.0355928
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0346384
AGO2 argonaute RISC catalytic component 2 0.0346382
SPRED2 sprouty-related, EVH1 domain containing 2 0.0343036
APLP2 amyloid beta (A4) precursor-like protein 2 0.0339179
RBM39 RNA binding motif protein 39 0.0333706
SGMS2 sphingomyelin synthase 2 0.0325511
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0325449
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.032516
CANX calnexin 0.032434
KDM3A lysine (K)-specific demethylase 3A 0.0320033
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.031837
DENND1A DENN/MADD domain containing 1A 0.0316151
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0315527
NABP1 nucleic acid binding protein 1 0.0310332
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0309069
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0297766
CLTC clathrin, heavy chain (Hc) 0.0295755
ADTRP androgen-dependent TFPI-regulating protein 0.0287301
MYH9 myosin, heavy chain 9, non-muscle 0.0286182
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0284525
PARD3 par-3 family cell polarity regulator 0.0284483
OGA O-GlcNAcase 0.0282619
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0280764
TRIO trio Rho guanine nucleotide exchange factor 0.0277394
HMGA2 high mobility group AT-hook 2 0.0275631
TTR transthyretin 0.0274596
ARHGAP22 Rho GTPase activating protein 22 0.0273763
TSC22D2 TSC22 domain family, member 2 0.027361
FMNL2 formin-like 2 0.0266573
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0266245
RYBP RING1 and YY1 binding protein 0.0264998
ANO6 anoctamin 6 0.0263367
ZNF438 zinc finger protein 438 0.0261929
RUNX1 runt-related transcription factor 1 0.0261079
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0260724
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0260108
RAD21 RAD21 homolog (S. pombe) 0.025831
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0253726
LPP LIM domain containing preferred translocation partner in lipoma 0.0253099
PSME4 proteasome (prosome, macropain) activator subunit 4 0.025227
IARS1 isoleucyl-tRNA synthetase 1 0.0251863
ATP13A3 ATPase type 13A3 0.0251355
CSNK1A1 casein kinase 1, alpha 1 0.025012
APP amyloid beta (A4) precursor protein 0.0248041
AKAP12 A kinase (PRKA) anchor protein 12 0.0247376
DGKI diacylglycerol kinase, iota 0.0244182
CCNY cyclin Y 0.0240762
SPAG9 sperm associated antigen 9 0.024065
NAMPT nicotinamide phosphoribosyltransferase 0.0240574
ZNF292 zinc finger protein 292 0.0240351
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0239457
SP100 SP100 nuclear antigen 0.02392
PICALM phosphatidylinositol binding clathrin assembly protein 0.0237952
PTPRG protein tyrosine phosphatase, receptor type, G 0.0235408
ANK2 ankyrin 2, neuronal 0.0232875
CDK17 cyclin-dependent kinase 17 0.0232152
PTK2 protein tyrosine kinase 2 0.0231852
LAMB3 laminin, beta 3 0.0230548
NCKAP1 NCK-associated protein 1 0.0230434
GARS1 glycyl-tRNA synthetase 1 0.0230031
USP9X ubiquitin specific peptidase 9, X-linked 0.0229433
OSBPL8 oxysterol binding protein-like 8 0.0229359
UBXN7 UBX domain protein 7 0.0228356
ZCCHC7 zinc finger, CCHC domain containing 7 0.0228298
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.022774
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0224653
HDLBP high density lipoprotein binding protein 0.0224189
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.022319

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.173304
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0758453
RPL35A ribosomal protein L35a -0.0709689
RPS6 ribosomal protein S6 -0.0674409
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0657783
RPL9 ribosomal protein L9 -0.0632864
TPT1 tumor protein, translationally-controlled 1 -0.0576236
RPL7A ribosomal protein L7a -0.0564528
ACTG1 actin gamma 1 -0.0516612
RPS8 ribosomal protein S8 -0.0512027
HMGA1 high mobility group AT-hook 1 -0.0489226
RPLP2 ribosomal protein, large, P2 -0.0485739
RPLP1 ribosomal protein, large, P1 -0.0480492
RPL12 ribosomal protein L12 -0.0474902
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0445343
IFI16 interferon, gamma-inducible protein 16 -0.0442718
RPL30 ribosomal protein L30 -0.0436703
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0436328
PFN1 profilin 1 -0.0398673
RPS13 ribosomal protein S13 -0.0390645
RPL37A ribosomal protein L37a -0.0390129
RPL8 ribosomal protein L8 -0.0386094
PTMA prothymosin, alpha -0.0380474
RPL11 ribosomal protein L11 -0.0371323
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0359517
RPL7 ribosomal protein L7 -0.0351229
RPS29 ribosomal protein S29 -0.0342264
RPL35 ribosomal protein L35 -0.0339825
RPS15 ribosomal protein S15 -0.0334171
RPS19 ribosomal protein S19 -0.0324075
RPS25 ribosomal protein S25 -0.0315903
ATP5F1B ATP synthase F1 subunit beta -0.0308906
TM4SF1 transmembrane 4 L six family member 1 -0.0308047
TMSB10 thymosin beta 10 -0.0304575
RPS24 ribosomal protein S24 -0.0300231
S100A2 S100 calcium binding protein A2 -0.029849
RPS27A ribosomal protein S27a -0.0285395
RPL26 ribosomal protein L26 -0.0285071
RPL36A ribosomal protein L36a -0.0283709
RPS10 ribosomal protein S10 -0.0273912
RPLP0 ribosomal protein, large, P0 -0.0273021
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0271615
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0271277
MT1X metallothionein 1X -0.0271254
G0S2 G0/G1 switch 2 -0.0267474
RPS23 ribosomal protein S23 -0.0266317
RPL34 ribosomal protein L34 -0.0265919
RPL28 ribosomal protein L28 -0.0263817
SHANK1 SH3 and multiple ankyrin repeat domains 1 -0.0260194
RPS21 ribosomal protein S21 -0.0256947
CALD1 caldesmon 1 -0.0251441
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0249139
KPNB1 karyopherin (importin) beta 1 -0.0238338
RPL32 ribosomal protein L32 -0.0237829
IFI6 interferon, alpha-inducible protein 6 -0.0234019
DEK DEK proto-oncogene -0.0233677
TUBA1B tubulin, alpha 1b -0.0231484
MTDH metadherin -0.0229066
LDHB lactate dehydrogenase B -0.0227622
RPL27A ribosomal protein L27a -0.0225933
FTL ferritin, light polypeptide -0.0225307
RPL5 ribosomal protein L5 -0.0224718
RPL23 ribosomal protein L23 -0.0224393
RPL10A ribosomal protein L10a -0.022295
TUBB4B tubulin, beta 4B class IVb -0.0219349
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.021527
PDIA3 protein disulfide isomerase family A, member 3 -0.021518
RPL19 ribosomal protein L19 -0.0214728
TXNRD1 thioredoxin reductase 1 -0.0211566
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.021118
RBM25 RNA binding motif protein 25 -0.0201867
RPL15 ribosomal protein L15 -0.0195569
RPS12 ribosomal protein S12 -0.0194275
GLRX glutaredoxin (thioltransferase) -0.0194227
RPS5 ribosomal protein S5 -0.0191229
COX6C cytochrome c oxidase subunit VIc -0.0187766
RPS14 ribosomal protein S14 -0.0187763
SLC38A2 solute carrier family 38, member 2 -0.0184363
ISG15 ISG15 ubiquitin-like modifier -0.0181487
ANTXR2 anthrax toxin receptor 2 -0.0178454
PA2G4 proliferation-associated 2G4, 38kDa -0.0176909
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0176329
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0175944
NOP56 NOP56 ribonucleoprotein -0.0175633
FOSL1 FOS-like antigen 1 -0.0173188
RAB3IP RAB3A interacting protein -0.0173076
RPL38 ribosomal protein L38 -0.0171348
IFITM2 interferon induced transmembrane protein 2 -0.0169515
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0165912
RPL36 ribosomal protein L36 -0.0165058
COX5A cytochrome c oxidase subunit Va -0.0162805
NUDCD1 NudC domain containing 1 -0.0161085
TMEM156 transmembrane protein 156 -0.0159342
TUBA1C tubulin, alpha 1c -0.0158989
EIF5B eukaryotic translation initiation factor 5B -0.0156597
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0156156
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0156001
ZBTB20 zinc finger and BTB domain containing 20 -0.0154749
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.015453
RPL31 ribosomal protein L31 -0.01535