Salicylic acid_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Salicylic acid_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.120906
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.116361
NAV2 neuron navigator 2 0.083183
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0760914
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0726575
FLNB filamin B, beta 0.06955
NLGN1 neuroligin 1 0.0671959
ASPH aspartate beta-hydroxylase 0.0662998
SMAD3 SMAD family member 3 0.0605663
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0593839
ATXN1 ataxin 1 0.0583201
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0573044
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0571152
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0570431
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0554323
FMNL2 formin-like 2 0.0531778
MSI2 musashi RNA-binding protein 2 0.0530665
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0529899
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0512739
CFAP20DC CFAP20 domain containing 0.0509761
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0506655
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0504238
IGF1R insulin-like growth factor 1 receptor 0.0495122
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0491895
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0475546
SEPTIN9 septin 9 0.0471732
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0454651
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0447893
RNF213 ring finger protein 213 0.0441204
CABIN1 calcineurin binding protein 1 0.0438273
DST dystonin 0.0433031
NOTCH2 notch 2 0.0429636
PTK2 protein tyrosine kinase 2 0.0426258
LPP LIM domain containing preferred translocation partner in lipoma 0.0412506
TGFA transforming growth factor, alpha 0.0409315
PRELID2 PRELI domain containing 2 0.0408338
HDAC4 histone deacetylase 4 0.0402238
OGA O-GlcNAcase 0.0400157
CDH13 cadherin 13 0.0397548
CTBP2 C-terminal binding protein 2 0.0394926
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0394596
ICAM1 intercellular adhesion molecule 1 0.0393938
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0390909
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0390075
ZSWIM6 zinc finger, SWIM-type containing 6 0.0389926
BBX bobby sox homolog (Drosophila) 0.0380691
NRG3 neuregulin 3 0.0373227
EFCAB13 EF-hand calcium binding domain 13 0.0369775
LINGO2 leucine rich repeat and Ig domain containing 2 0.0367536
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0356826
NAV1 neuron navigator 1 0.0355202
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0352924
PFKP phosphofructokinase, platelet 0.0352301
IGFBP3 insulin-like growth factor binding protein 3 0.035211
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0350121
MYH9 myosin, heavy chain 9, non-muscle 0.0343349
FGGY FGGY carbohydrate kinase domain containing 0.0342939
PHF21A PHD finger protein 21A 0.0336421
LRMDA leucine rich melanocyte differentiation associated 0.0330985
MACF1 microtubule-actin crosslinking factor 1 0.0330486
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0329368
NDRG1 N-myc downstream regulated 1 0.0329337
MAML3 mastermind-like 3 (Drosophila) 0.0326102
SPAG9 sperm associated antigen 9 0.0325511
EXT1 exostosin glycosyltransferase 1 0.0324977
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0323698
ZNF638 zinc finger protein 638 0.0319298
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.03186
FLNA filamin A, alpha 0.0317008
CORO1C coronin, actin binding protein, 1C 0.0316431
PLEC plectin 0.0315423
AHNAK AHNAK nucleoprotein 0.0313724
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0308121
PDE4D phosphodiesterase 4D, cAMP-specific 0.0305573
MBNL1 muscleblind-like splicing regulator 1 0.0304742
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0303732
MSN moesin 0.0302347
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.030093
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0291196
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0290677
MED13L mediator complex subunit 13-like 0.0289526
CADM1 cell adhesion molecule 1 0.0285905
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.028554
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.028309
ANGPTL4 angiopoietin-like 4 0.0283074
ZMIZ1 zinc finger, MIZ-type containing 1 0.0280288
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0279237
ACTN4 actinin, alpha 4 0.0277417
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0276551
NHSL1 NHS-like 1 0.0270605
CA8 carbonic anhydrase VIII 0.0269142
NRP2 neuropilin 2 0.0268843
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0268234
CXCL8 chemokine (C-X-C motif) ligand 8 0.0267292
ANO6 anoctamin 6 0.0266023
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0263256
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0263188
RAD51B RAD51 paralog B 0.0262505
EFNA5 ephrin-A5 0.0260039
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0259683

decreased expression

Symbol Name Standardized Value
FMN1 formin 1 -0.152928
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.145228
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.142935
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0975675
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0812419
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0716646
FRMD4A FERM domain containing 4A -0.0716327
RPS3 ribosomal protein S3 -0.0707592
VIM vimentin -0.0650635
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0626148
TXNRD1 thioredoxin reductase 1 -0.0616568
AKAP12 A kinase (PRKA) anchor protein 12 -0.0515885
RPS6 ribosomal protein S6 -0.0491996
GOLGA4 golgin A4 -0.0470885
LSAMP limbic system-associated membrane protein -0.044801
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0411184
FRMD5 FERM domain containing 5 -0.0393614
EIF1 eukaryotic translation initiation factor 1 -0.0389049
RPS13 ribosomal protein S13 -0.0383597
RPL35A ribosomal protein L35a -0.0376219
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0376158
TPT1 tumor protein, translationally-controlled 1 -0.0374064
HDAC9 histone deacetylase 9 -0.0370311
KPNB1 karyopherin (importin) beta 1 -0.0363807
SNU13 small nuclear ribonucleoprotein 13 -0.0361373
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0361335
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0333012
RPL11 ribosomal protein L11 -0.0322213
MARCHF1 membrane associated ring-CH-type finger 1 -0.0320188
GARS1 glycyl-tRNA synthetase 1 -0.0317703
RPL36A ribosomal protein L36a -0.0313278
RPLP1 ribosomal protein, large, P1 -0.0295034
RPS12 ribosomal protein S12 -0.0291758
RPL34 ribosomal protein L34 -0.0289357
RPL12 ribosomal protein L12 -0.0286017
PDIA3 protein disulfide isomerase family A, member 3 -0.0270203
ZFAND6 zinc finger, AN1-type domain 6 -0.0268156
KAZN kazrin, periplakin interacting protein -0.0266963
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0265607
RPS24 ribosomal protein S24 -0.0258184
RPL31 ribosomal protein L31 -0.0251736
RACK1 receptor for activated C kinase 1 -0.024979
RPL37 ribosomal protein L37 -0.0248609
RPS23 ribosomal protein S23 -0.0247524
RPL37A ribosomal protein L37a -0.0246855
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0243336
PCLO piccolo presynaptic cytomatrix protein -0.0230193
RPS27A ribosomal protein S27a -0.0228032
RPS14 ribosomal protein S14 -0.0226246
ACTG1 actin gamma 1 -0.0223506
TMEM87A transmembrane protein 87A -0.0220586
RPLP0 ribosomal protein, large, P0 -0.0220454
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0219245
ZFYVE16 zinc finger, FYVE domain containing 16 -0.0218402
RPL32 ribosomal protein L32 -0.02161
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -0.0215594
RNF24 ring finger protein 24 -0.0215536
RTN4 reticulon 4 -0.0214086
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0213074
FTL ferritin, light polypeptide -0.0212799
RPS27 ribosomal protein S27 -0.0212242
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0212028
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0211701
RPS21 ribosomal protein S21 -0.0210863
SNX9 sorting nexin 9 -0.0209947
RPLP2 ribosomal protein, large, P2 -0.0207614
TRIQK triple QxxK/R motif containing -0.0207167
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0201541
PEX5L peroxisomal biogenesis factor 5-like -0.020139
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0200101
HM13 histocompatibility (minor) 13 -0.0197728
THOC2 THO complex 2 -0.019509
TPI1 triosephosphate isomerase 1 -0.0192221
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0191466
VDAC1 voltage-dependent anion channel 1 -0.0191099
ZC3H12B zinc finger CCCH-type containing 12B -0.0189833
RPL35 ribosomal protein L35 -0.0189363
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.018813
RPL4 ribosomal protein L4 -0.0187752
FILIP1 filamin A interacting protein 1 -0.0184852
FSTL5 follistatin-like 5 -0.0182464
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0182071
FBXO28 F-box protein 28 -0.0180737
TNNC1 troponin C type 1 (slow) -0.0179089
IARS1 isoleucyl-tRNA synthetase 1 -0.0178701
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.017837
RPL9 ribosomal protein L9 -0.0178141
FBXL2 F-box and leucine-rich repeat protein 2 -0.0176346
RPL23 ribosomal protein L23 -0.0175589
RPS8 ribosomal protein S8 -0.0174853
RPL27 ribosomal protein L27 -0.0174561
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0174115
PEA15 phosphoprotein enriched in astrocytes 15 -0.0174064
RHOA ras homolog family member A -0.0173636
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0170897
ERBIN erbb2 interacting protein -0.0168087
DNAH14 dynein, axonemal, heavy chain 14 -0.0166654
ACBD6 acyl-CoA binding domain containing 6 -0.016634
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0165401
ANKRD28 ankyrin repeat domain 28 -0.0163888