Salicylic acid_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0951008
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0924167
ASPH aspartate beta-hydroxylase 0.086652
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0749419
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0736658
EXT1 exostosin glycosyltransferase 1 0.0723618
GRB10 growth factor receptor-bound protein 10 0.0706283
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0586369
CD109 CD109 molecule 0.0522532
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0516672
COPA coatomer protein complex, subunit alpha 0.0515671
VIM vimentin 0.0514547
HILPDA hypoxia inducible lipid droplet-associated 0.0496449
MYH9 myosin, heavy chain 9, non-muscle 0.0485063
PDLIM5 PDZ and LIM domain 5 0.0465324
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0465232
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0457242
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0452647
EZR ezrin 0.0452457
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0449359
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0448088
MYOF myoferlin 0.0443262
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0424625
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0421867
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0417263
AFDN afadin, adherens junction formation factor 0.0414986
APLP2 amyloid beta (A4) precursor-like protein 2 0.0391243
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0388045
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0387908
ANXA2 annexin A2 0.0385026
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0384408
NDRG1 N-myc downstream regulated 1 0.0381546
RASAL2 RAS protein activator like 2 0.0381459
FLNB filamin B, beta 0.0373938
TRIO trio Rho guanine nucleotide exchange factor 0.0369447
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0364553
FAM13A family with sequence similarity 13, member A 0.0362858
WWTR1 WW domain containing transcription regulator 1 0.0361075
PRELID2 PRELI domain containing 2 0.0360296
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0359635
AKAP13 A kinase (PRKA) anchor protein 13 0.035869
VCL vinculin 0.0356374
AKAP12 A kinase (PRKA) anchor protein 12 0.0355305
SMAD3 SMAD family member 3 0.0350305
TUFT1 tuftelin 1 0.0349643
NTN4 netrin 4 0.0337061
FLNA filamin A, alpha 0.0334072
STC2 stanniocalcin 2 0.0324967
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0318434
MCL1 myeloid cell leukemia 1 0.0316013
FAT1 FAT atypical cadherin 1 0.0314696
SHB Src homology 2 domain containing adaptor protein B 0.0314336
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0314281
MYO10 myosin X 0.0313996
PTK2 protein tyrosine kinase 2 0.0312265
RBM39 RNA binding motif protein 39 0.0306135
INTS6 integrator complex subunit 6 0.02998
UBASH3B ubiquitin associated and SH3 domain containing B 0.0297253
DUSP10 dual specificity phosphatase 10 0.029514
PLEC plectin 0.0293255
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0286969
UBA6 ubiquitin-like modifier activating enzyme 6 0.0286532
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0286069
AHNAK AHNAK nucleoprotein 0.0280031
MACF1 microtubule-actin crosslinking factor 1 0.0278777
IQGAP1 IQ motif containing GTPase activating protein 1 0.0275333
NAV1 neuron navigator 1 0.0275141
KMT2C lysine (K)-specific methyltransferase 2C 0.027226
PER1 period circadian clock 1 0.0267155
TGFB1 transforming growth factor, beta 1 0.026415
CTBP2 C-terminal binding protein 2 0.0262751
RUNX1 runt-related transcription factor 1 0.0260404
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0257488
GPATCH2L G patch domain containing 2-like 0.0256581
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0255577
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0253182
ESYT2 extended synaptotagmin-like protein 2 0.0252885
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0252755
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0252212
TSC22D2 TSC22 domain family, member 2 0.0250416
MBNL1 muscleblind-like splicing regulator 1 0.0243799
DST dystonin 0.0243091
ABLIM1 actin binding LIM protein 1 0.0242479
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0240139
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0238315
SPATS2L spermatogenesis associated, serine-rich 2-like 0.023591
PCBP2 poly(rC) binding protein 2 0.0235111
CORO1C coronin, actin binding protein, 1C 0.0234565
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.023181
RAB31 RAB31, member RAS oncogene family 0.0230192
FOSL1 FOS-like antigen 1 0.0229662
PCM1 pericentriolar material 1 0.0229401
TPM3 tropomyosin 3 0.0228148
ENO2 enolase 2 (gamma, neuronal) 0.0226475
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0226217
CEMIP2 cell migration inducing hyaluronidase 2 0.022582
MEF2D myocyte enhancer factor 2D 0.0225562
CCNL1 cyclin L1 0.0224801
MSN moesin 0.0224637
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0224574

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.347973
NRG1 neuregulin 1 -0.290098
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.229438
NAMPT nicotinamide phosphoribosyltransferase -0.178075
SQSTM1 sequestosome 1 -0.135336
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.128138
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116495
ITGA1 integrin, alpha 1 -0.0944683
TMEM156 transmembrane protein 156 -0.0699974
OSMR oncostatin M receptor -0.0662537
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0659358
S100A6 S100 calcium binding protein A6 -0.0649187
TFPI2 tissue factor pathway inhibitor 2 -0.0645002
TMEM165 transmembrane protein 165 -0.0628521
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0617279
KLHL5 kelch-like family member 5 -0.0609782
CANX calnexin -0.0553642
RPL26 ribosomal protein L26 -0.0533971
TAS2R14 taste receptor, type 2, member 14 -0.0506813
CENPF centromere protein F, 350/400kDa -0.0497863
GCC2 GRIP and coiled-coil domain containing 2 -0.0474212
FN1 fibronectin 1 -0.0473866
TPT1 tumor protein, translationally-controlled 1 -0.0463016
SYT1 synaptotagmin I -0.0462878
MT2A metallothionein 2A -0.0441537
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0440021
RAI14 retinoic acid induced 14 -0.0418342
IFI27 interferon, alpha-inducible protein 27 -0.0414046
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0408338
GLIS3 GLIS family zinc finger 3 -0.0406773
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0401697
PRRC2C proline-rich coiled-coil 2C -0.0393495
SFTPA2 surfactant protein A2 -0.0388021
CDCP1 CUB domain containing protein 1 -0.0387397
AHR aryl hydrocarbon receptor -0.0386972
EREG epiregulin -0.0386639
DENND5B DENN/MADD domain containing 5B -0.0382595
FNBP1 formin binding protein 1 -0.037663
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0365378
TMSB4X thymosin beta 4, X-linked -0.0362298
ZBTB20 zinc finger and BTB domain containing 20 -0.0361275
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0356127
GOLT1B golgi transport 1B -0.0349336
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0345442
SMOX spermine oxidase -0.0335039
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0334366
RPS24 ribosomal protein S24 -0.0329476
DNAH5 dynein, axonemal, heavy chain 5 -0.0317202
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0312687
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0310148
RPS2 ribosomal protein S2 -0.030878
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0308103
CD63 CD63 molecule -0.0307271
IFI6 interferon, alpha-inducible protein 6 -0.0306408
RPL31 ribosomal protein L31 -0.0301156
PTMA prothymosin, alpha -0.0299503
SMIM14 small integral membrane protein 14 -0.029646
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0295333
NAP1L1 nucleosome assembly protein 1-like 1 -0.0293769
SOX5 SRY (sex determining region Y)-box 5 -0.0293391
EIF1 eukaryotic translation initiation factor 1 -0.029288
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0286016
CP ceruloplasmin (ferroxidase) -0.0274643
RACK1 receptor for activated C kinase 1 -0.0271864
RAB2A RAB2A, member RAS oncogene family -0.0270169
MMP13 matrix metallopeptidase 13 -0.0264649
RPL11 ribosomal protein L11 -0.0264184
ZMYND8 zinc finger, MYND-type containing 8 -0.0263569
ETV1 ets variant 1 -0.0260163
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0259099
ADAR adenosine deaminase, RNA-specific -0.0258425
ETV6 ets variant 6 -0.0255654
FAM114A1 family with sequence similarity 114, member A1 -0.0255109
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0255011
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0254531
B2M beta-2-microglobulin -0.025301
ZFR zinc finger RNA binding protein -0.0251685
UBXN4 UBX domain protein 4 -0.0249946
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0246863
CTSD cathepsin D -0.0241267
RPL34 ribosomal protein L34 -0.0236735
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0235867
AHI1 Abelson helper integration site 1 -0.0235464
IFI16 interferon, gamma-inducible protein 16 -0.0235438
RPL9 ribosomal protein L9 -0.0234926
ZNF217 zinc finger protein 217 -0.0233954
RPS12 ribosomal protein S12 -0.0233772
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0232669
CDK13 cyclin-dependent kinase 13 -0.0229891
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0228926
TENM4 teneurin transmembrane protein 4 -0.0228796
ANKRD12 ankyrin repeat domain 12 -0.0226312
TMEM263 transmembrane protein 263 -0.0224898
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0224359
FOXP1 forkhead box P1 -0.0223764
DPYD dihydropyrimidine dehydrogenase -0.0222186
LRRC23 leucine rich repeat containing 23 -0.0219003
NEMF nuclear export mediator factor -0.0214022
DNAH14 dynein, axonemal, heavy chain 14 -0.0213071
RPS27A ribosomal protein S27a -0.0212639