Salicylic acid_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.059274
NKD1 naked cuticle homolog 1 (Drosophila) 0.0553619
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0522001
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.050217
TNS3 tensin 3 0.048391
AHNAK AHNAK nucleoprotein 0.0410647
ATXN1 ataxin 1 0.0401918
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.039829
INTS6 integrator complex subunit 6 0.0389383
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0387613
NAV2 neuron navigator 2 0.0386365
DST dystonin 0.0376861
CEMIP2 cell migration inducing hyaluronidase 2 0.0350526
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0346316
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0343007
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0341024
KIZ kizuna centrosomal protein 0.0323508
SMAD3 SMAD family member 3 0.0313408
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0310375
USP9X ubiquitin specific peptidase 9, X-linked 0.0306097
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0293979
MED13 mediator complex subunit 13 0.0293288
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0284546
PLEC plectin 0.027694
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0269698
ITPRID2 ITPR interacting domain containing 2 0.02673
TRIO trio Rho guanine nucleotide exchange factor 0.0264708
HDAC4 histone deacetylase 4 0.0263769
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0263413
MAML2 mastermind-like 2 (Drosophila) 0.0260552
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0259688
ZNF638 zinc finger protein 638 0.0255571
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0250593
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0250002
ZBTB20 zinc finger and BTB domain containing 20 0.0241833
ANO6 anoctamin 6 0.0240341
ASPH aspartate beta-hydroxylase 0.0239936
PGK1 phosphoglycerate kinase 1 0.0239337
EZR ezrin 0.0237322
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0237278
YAP1 Yes-associated protein 1 0.0233032
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0232142
RPL4 ribosomal protein L4 0.0231017
RICTOR RPTOR independent companion of MTOR, complex 2 0.0227862
PDLIM5 PDZ and LIM domain 5 0.0227187
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0226118
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.022296
VCL vinculin 0.0219831
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0219777
OGA O-GlcNAcase 0.0218034
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0217768
MACF1 microtubule-actin crosslinking factor 1 0.0211505
WNK1 WNK lysine deficient protein kinase 1 0.0211091
MYH9 myosin, heavy chain 9, non-muscle 0.0210856
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0210753
GLG1 golgi glycoprotein 1 0.0207316
MBNL2 muscleblind-like splicing regulator 2 0.0205934
DSPP dentin sialophosphoprotein 0.0203208
SVIL supervillin 0.0203117
NIPBL Nipped-B homolog (Drosophila) 0.0202006
KLF5 Kruppel-like factor 5 (intestinal) 0.0199222
EIF4B eukaryotic translation initiation factor 4B 0.019856
AKAP13 A kinase (PRKA) anchor protein 13 0.019634
AOPEP aminopeptidase O (putative) 0.0196075
RBM39 RNA binding motif protein 39 0.0193772
HSPA8 heat shock 70kDa protein 8 0.0192355
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0187607
EIF4A2 eukaryotic translation initiation factor 4A2 0.0185486
SYT1 synaptotagmin I 0.0183976
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0182774
ESYT2 extended synaptotagmin-like protein 2 0.0181459
KDM3A lysine (K)-specific demethylase 3A 0.0181299
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0179645
KMT2C lysine (K)-specific methyltransferase 2C 0.017903
AXIN2 axin 2 0.017812
PEAK1 pseudopodium-enriched atypical kinase 1 0.017696
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0175905
EFNB2 ephrin-B2 0.0175701
TTC3 tetratricopeptide repeat domain 3 0.0174637
ECT2 epithelial cell transforming 2 0.0173582
AFF1 AF4/FMR2 family, member 1 0.0173235
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0172371
HELZ helicase with zinc finger 0.0171321
DSCAM Down syndrome cell adhesion molecule 0.0170577
ARHGAP18 Rho GTPase activating protein 18 0.0170109
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0166643
MBD5 methyl-CpG binding domain protein 5 0.0166592
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0166299
KLF12 Kruppel-like factor 12 0.0165527
UTRN utrophin 0.0165095
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0165086
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0164459
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0164247
BMP5 bone morphogenetic protein 5 0.016414
CMIP c-Maf inducing protein 0.0163929
MSI2 musashi RNA-binding protein 2 0.0163118
ZFAND3 zinc finger, AN1-type domain 3 0.0161712
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0159689
CEMIP cell migration inducing protein, hyaluronan binding 0.0156687
EPS8 epidermal growth factor receptor pathway substrate 8 0.0154304

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.107963
RPS6 ribosomal protein S6 -0.0842358
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.071354
RPS3 ribosomal protein S3 -0.0621573
RPS19 ribosomal protein S19 -0.0580453
PTMA prothymosin, alpha -0.054986
RPS12 ribosomal protein S12 -0.0546105
RPL35A ribosomal protein L35a -0.052699
RPL26 ribosomal protein L26 -0.0521211
RPL23 ribosomal protein L23 -0.0494218
RPL37A ribosomal protein L37a -0.0455245
RPL12 ribosomal protein L12 -0.040148
MT2A metallothionein 2A -0.0394805
HMGA1 high mobility group AT-hook 1 -0.03715
FTL ferritin, light polypeptide -0.0362424
RPLP1 ribosomal protein, large, P1 -0.034803
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0340812
RPS14 ribosomal protein S14 -0.0332942
RPS21 ribosomal protein S21 -0.0314234
RPL19 ribosomal protein L19 -0.0313497
PFN1 profilin 1 -0.0304151
TPT1 tumor protein, translationally-controlled 1 -0.0301735
CBX3 chromobox homolog 3 -0.0300402
SDK1 sidekick cell adhesion molecule 1 -0.0290768
RPS17 ribosomal protein S17 -0.0290131
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0286441
RPLP2 ribosomal protein, large, P2 -0.0286433
RPL36 ribosomal protein L36 -0.0284179
TPI1 triosephosphate isomerase 1 -0.0281398
RPS8 ribosomal protein S8 -0.0281049
RPS24 ribosomal protein S24 -0.0276536
RACK1 receptor for activated C kinase 1 -0.0275586
LOC102724023 ES1 protein homolog, mitochondrial -0.027169
RPL35 ribosomal protein L35 -0.0263323
RPS27A ribosomal protein S27a -0.0261245
RPL18 ribosomal protein L18 -0.0257045
BCL2L1 BCL2-like 1 -0.0247969
RPL31 ribosomal protein L31 -0.0242703
RPS4X ribosomal protein S4, X-linked -0.0239592
RPL9 ribosomal protein L9 -0.0232559
RPLP0 ribosomal protein, large, P0 -0.0230781
RPL34 ribosomal protein L34 -0.0228432
RPL27 ribosomal protein L27 -0.0222119
ANO1 anoctamin 1, calcium activated chloride channel -0.0221339
KRT18 keratin 18, type I -0.0219431
RPS13 ribosomal protein S13 -0.0214909
CENPF centromere protein F, 350/400kDa -0.0213292
RPL11 ribosomal protein L11 -0.0212521
CCND1 cyclin D1 -0.0209227
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0204895
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0201547
EGR1 early growth response 1 -0.0199178
EIF5B eukaryotic translation initiation factor 5B -0.0198788
RPL36A ribosomal protein L36a -0.0197969
YBX1 Y box binding protein 1 -0.01963
VIM vimentin -0.0194024
YBX3 Y box binding protein 3 -0.0193441
RBM25 RNA binding motif protein 25 -0.0191668
B2M beta-2-microglobulin -0.018937
RPL28 ribosomal protein L28 -0.0186498
TUBA1B tubulin, alpha 1b -0.0185299
TUBB4B tubulin, beta 4B class IVb -0.0184478
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0181822
POTEF POTE ankyrin domain family, member F -0.0180872
RPL37 ribosomal protein L37 -0.0179728
RPL27A ribosomal protein L27a -0.0179493
RPS2 ribosomal protein S2 -0.017681
SET SET nuclear proto-oncogene -0.0172745
NTSR1 neurotensin receptor 1 (high affinity) -0.0168973
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.016847
ATP5F1E ATP synthase F1 subunit epsilon -0.0168263
UQCRB ubiquinol-cytochrome c reductase binding protein -0.016687
S100A6 S100 calcium binding protein A6 -0.0164128
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0162493
HMGB1 high mobility group box 1 -0.0162315
RPL5 ribosomal protein L5 -0.0161558
RPL32 ribosomal protein L32 -0.0157287
ITGB4 integrin, beta 4 -0.0154615
RPL7 ribosomal protein L7 -0.0153019
CCNL1 cyclin L1 -0.0152473
RBP1 retinol binding protein 1, cellular -0.0152273
FOSL1 FOS-like antigen 1 -0.0152139
FLNB filamin B, beta -0.0152139
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0145382
LDHB lactate dehydrogenase B -0.0143934
RPL36AL ribosomal protein L36a-like -0.0143531
PTMS parathymosin -0.0143437
RPS5 ribosomal protein S5 -0.014194
MRPS6 mitochondrial ribosomal protein S6 -0.0141286
TPM4 tropomyosin 4 -0.0141244
PLAUR plasminogen activator, urokinase receptor -0.0140202
KRT19 keratin 19, type I -0.0139587
CD9 CD9 molecule -0.0139194
BCAR3 breast cancer anti-estrogen resistance 3 -0.0138989
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0136015
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0135041
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0132305
HLA-A major histocompatibility complex, class I, A -0.0131253
MYL12B myosin, light chain 12B, regulatory -0.0129582
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0129328