Salicylic acid_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Salicylic acid perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Salicylic acid_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.102639
FN1 fibronectin 1 0.10102
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0902322
STC1 stanniocalcin 1 0.0747631
JARID2 jumonji, AT rich interactive domain 2 0.0745142
ELL2 elongation factor, RNA polymerase II, 2 0.0587147
MYO10 myosin X 0.0557392
SOD2 superoxide dismutase 2, mitochondrial 0.0555478
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0546795
MYH9 myosin, heavy chain 9, non-muscle 0.0540013
SPAG9 sperm associated antigen 9 0.0528997
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0510244
FNDC3B fibronectin type III domain containing 3B 0.0507596
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0493534
TRIO trio Rho guanine nucleotide exchange factor 0.0483815
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0448437
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0440821
FAM13A family with sequence similarity 13, member A 0.0432574
FMNL2 formin-like 2 0.0420941
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.042066
SMAD3 SMAD family member 3 0.0388822
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0379849
RUNX1 runt-related transcription factor 1 0.03681
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0362534
EXT1 exostosin glycosyltransferase 1 0.035136
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0316153
PICALM phosphatidylinositol binding clathrin assembly protein 0.030357
SLIT2 slit homolog 2 (Drosophila) 0.0297151
LOX lysyl oxidase 0.0292727
INTS6 integrator complex subunit 6 0.0289732
FNIP1 folliculin interacting protein 1 0.0288262
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0282652
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.028037
VEGFA vascular endothelial growth factor A 0.0280367
ANO6 anoctamin 6 0.0279815
ZSWIM6 zinc finger, SWIM-type containing 6 0.0279018
NOTCH2 notch 2 0.0277698
COPA coatomer protein complex, subunit alpha 0.0277246
ARHGAP21 Rho GTPase activating protein 21 0.0276888
VMP1 vacuole membrane protein 1 0.0275612
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0271126
ZNF638 zinc finger protein 638 0.0268117
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0267427
DSCAM Down syndrome cell adhesion molecule 0.0265586
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.026536
TNS1 tensin 1 0.0263775
VEGFC vascular endothelial growth factor C 0.0261683
MACF1 microtubule-actin crosslinking factor 1 0.0259056
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0247719
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0243485
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.024167
AKAP13 A kinase (PRKA) anchor protein 13 0.0241479
NAV2 neuron navigator 2 0.0237755
CD44 CD44 molecule (Indian blood group) 0.0230089
SETD5 SET domain containing 5 0.0227934
FNDC3A fibronectin type III domain containing 3A 0.0218975
USP34 ubiquitin specific peptidase 34 0.0218044
FAT1 FAT atypical cadherin 1 0.021473
FRMD6 FERM domain containing 6 0.0212843
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0212212
NGLY1 N-glycanase 1 0.0211813
ATP13A3 ATPase type 13A3 0.0208266
HIPK2 homeodomain interacting protein kinase 2 0.0205591
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0197831
PCBP3 poly(rC) binding protein 3 0.0197081
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0196802
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192267
ANTXR2 anthrax toxin receptor 2 0.0191362
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0190521
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0189509
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0188394
KMT2E lysine (K)-specific methyltransferase 2E 0.0185545
HDAC9 histone deacetylase 9 0.0184974
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0183454
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0182956
SEPTIN9 septin 9 0.0181706
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.0181608
BRD2 bromodomain containing 2 0.0180994
WAC WW domain containing adaptor with coiled-coil 0.0178982
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0175964
APP amyloid beta (A4) precursor protein 0.017365
ERBIN erbb2 interacting protein 0.0173643
UBA6 ubiquitin-like modifier activating enzyme 6 0.0173399
SAMD4A sterile alpha motif domain containing 4A 0.0172948
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0172427
MSN moesin 0.0171988
ZNF292 zinc finger protein 292 0.0171351
RASA2 RAS p21 protein activator 2 0.0170978
DUSP10 dual specificity phosphatase 10 0.0170272
AMPD3 adenosine monophosphate deaminase 3 0.0169861
ANKRD28 ankyrin repeat domain 28 0.0169392
YEATS2 YEATS domain containing 2 0.0168217
PTK2 protein tyrosine kinase 2 0.0167505
NRIP1 nuclear receptor interacting protein 1 0.0164846
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0164799
COG6 component of oligomeric golgi complex 6 0.0164715
EPAS1 endothelial PAS domain protein 1 0.0164101
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0163955
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0163066
VCL vinculin 0.0162429

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.202342
PRKG1 protein kinase, cGMP-dependent, type I -0.145732
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137666
TMSB10 thymosin beta 10 -0.12894
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.121975
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103162
COL1A1 collagen, type I, alpha 1 -0.0861292
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0800383
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0772
AKAP12 A kinase (PRKA) anchor protein 12 -0.0701266
OXR1 oxidation resistance 1 -0.0680711
NALF1 NALCN channel auxiliary factor 1 -0.0669978
GREM1 gremlin 1, DAN family BMP antagonist -0.0652934
INHBA inhibin, beta A -0.0637415
RPS6 ribosomal protein S6 -0.0617044
ADGRB3 adhesion G protein-coupled receptor B3 -0.0601103
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0583604
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0577071
MMP1 matrix metallopeptidase 1 -0.0575021
FTL ferritin, light polypeptide -0.0570894
COL1A2 collagen, type I, alpha 2 -0.0541051
TGFBI transforming growth factor, beta-induced, 68kDa -0.052302
TPT1 tumor protein, translationally-controlled 1 -0.0518173
B2M beta-2-microglobulin -0.0514968
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0503638
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0501315
RAI14 retinoic acid induced 14 -0.045333
RPS12 ribosomal protein S12 -0.0446304
NDRG1 N-myc downstream regulated 1 -0.0427359
MT2A metallothionein 2A -0.0397936
RPLP1 ribosomal protein, large, P1 -0.0391431
TPM4 tropomyosin 4 -0.0383499
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0381091
ACTG1 actin gamma 1 -0.0378437
RPL35A ribosomal protein L35a -0.0375982
CDH13 cadherin 13 -0.0372309
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0361897
RPL34 ribosomal protein L34 -0.0360366
FRMD4A FERM domain containing 4A -0.0354352
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0347862
LGALS1 lectin, galactoside-binding, soluble, 1 -0.034251
RPL37A ribosomal protein L37a -0.0341972
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0337992
RPS8 ribosomal protein S8 -0.0335612
PRSS23 protease, serine, 23 -0.0330374
S100A6 S100 calcium binding protein A6 -0.0316851
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0307552
WSB1 WD repeat and SOCS box containing 1 -0.0298383
PTMA prothymosin, alpha -0.0296184
HLA-A major histocompatibility complex, class I, A -0.029154
NCKAP5 NCK-associated protein 5 -0.0283217
RTN4 reticulon 4 -0.0277058
RPL9 ribosomal protein L9 -0.0272632
RPS19 ribosomal protein S19 -0.0272153
GNAS GNAS complex locus -0.0271504
PFN1 profilin 1 -0.0262546
RPL26 ribosomal protein L26 -0.0262316
VCAN versican -0.0260614
RPL23 ribosomal protein L23 -0.0260404
FRMPD4 FERM and PDZ domain containing 4 -0.0260076
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0258345
RPL12 ribosomal protein L12 -0.0257627
CAVIN1 caveolae associated protein 1 -0.0254092
S100A9 S100 calcium binding protein A9 -0.0253025
NREP neuronal regeneration related protein -0.0252201
RPL36 ribosomal protein L36 -0.0250316
RPLP0 ribosomal protein, large, P0 -0.0245821
POTEF POTE ankyrin domain family, member F -0.0245293
TPI1 triosephosphate isomerase 1 -0.0244542
CAV1 caveolin 1, caveolae protein, 22kDa -0.0244175
RPL11 ribosomal protein L11 -0.0243592
KIAA1549L KIAA1549-like -0.0243152
CALR calreticulin -0.0232136
SORBS2 sorbin and SH3 domain containing 2 -0.0231731
EIF1 eukaryotic translation initiation factor 1 -0.0228092
LMAN1 lectin, mannose-binding, 1 -0.0227647
TTC23L tetratricopeptide repeat domain 23-like -0.0226319
RPL28 ribosomal protein L28 -0.0226152
RPL31 ribosomal protein L31 -0.0224161
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0220697
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0211756
RPLP2 ribosomal protein, large, P2 -0.0210296
FOXP1 forkhead box P1 -0.0210041
RPS13 ribosomal protein S13 -0.0209719
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0207009
PDIA3 protein disulfide isomerase family A, member 3 -0.020674
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0203616
RPS3 ribosomal protein S3 -0.0202111
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0201051
PKM pyruvate kinase, muscle -0.0199843
CCDC91 coiled-coil domain containing 91 -0.0197314
CLMP CXADR-like membrane protein -0.0193038
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0188895
RPL19 ribosomal protein L19 -0.0188646
ZEB1 zinc finger E-box binding homeobox 1 -0.0187122
TAGLN2 transgelin 2 -0.0186794
RPL32 ribosomal protein L32 -0.0185272
PRRX1 paired related homeobox 1 -0.0183976
PGK1 phosphoglycerate kinase 1 -0.0183967
AFF3 AF4/FMR2 family, member 3 -0.0182329