Salivary secretion Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP. (Kyoto Encyclopedia of Genes and Genomes, hsa04970)
External Link https://www.kegg.jp/entry/hsa04970
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89 proteins participating in the Salivary secretion pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AMY1A amylase, alpha 1A (salivary)
AMY1B amylase, alpha 1B (salivary)
AMY1C amylase, alpha 1C (salivary)
AMY2A amylase, alpha 2A (pancreatic)
AMY2B amylase, alpha 2B (pancreatic)
AQP5 aquaporin 5
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BEST2 bestrophin 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML4 calmodulin-like 4
CALML5 calmodulin-like 5
CALML6 calmodulin-like 6
CD38 CD38 molecule
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CHRM3 cholinergic receptor, muscarinic 3
CST1 cystatin SN
CST2 cystatin SA
CST3 cystatin C
CST4 cystatin S
CST5 cystatin D
DMBT1 deleted in malignant brain tumors 1
FXYD2 FXYD domain containing ion transport regulator 2
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1
HTN1 histatin 1
HTN3 histatin 3
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LPO lactoperoxidase
LYZ lysozyme
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MUC7 mucin 7, secreted
NANOS1 nanos homolog 1 (Drosophila)
PGAP1 post-GPI attachment to proteins 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PRB2 proline-rich protein BstNI subfamily 2
PRH1 proline-rich protein HaeIII subfamily 1
PRH2 proline-rich protein HaeIII subfamily 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PRKG1 protein kinase, cGMP-dependent, type I
PRKG2 protein kinase, cGMP-dependent, type II
RBL1 retinoblastoma-like 1
RYR3 ryanodine receptor 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
STATH statherin
TRPV6 transient receptor potential cation channel, subfamily V, member 6
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)