| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5152 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Salmeterol relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TUB | tubby bipartite transcription factor | 2.24 |
| EPHA4 | EPH receptor A4 | 2.2 |
| APOB | apolipoprotein B | 2.11 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 2.06 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.93 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 1.67 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 1.67 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.55 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 1.51 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.49 |
| MSMO1 | methylsterol monooxygenase 1 | 1.48 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.42 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 1.39 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 1.34 |
| SQLE | squalene epoxidase | 1.23 |
| NDFIP1 | Nedd4 family interacting protein 1 | 1.23 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.16 |
| KDM5B | lysine (K)-specific demethylase 5B | 1.15 |
| PRAME | preferentially expressed antigen in melanoma | 1.14 |
| PISD | phosphatidylserine decarboxylase | 1.09 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | 1.08 |
| MVK | mevalonate kinase | 0.97 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.94 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.9 |
| LDLR | low density lipoprotein receptor | 0.9 |
| NCOA4 | nuclear receptor coactivator 4 | 0.89 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.88 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.88 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.86 |
| FTL | ferritin, light polypeptide | 0.84 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.83 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.81 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 0.81 |
| TMEM135 | transmembrane protein 135 | 0.8 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.76 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.74 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.74 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 0.73 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.71 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.69 |
| CCAR2 | cell cycle and apoptosis regulator 2 | 0.69 |
| FADS1 | fatty acid desaturase 1 | 0.66 |
| LPIN1 | lipin 1 | 0.65 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.65 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.63 |
| H1-0 | H1.0 linker histone | 0.63 |
| AREG | amphiregulin | 0.63 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.62 |
| LSM10 | LSM10, U7 small nuclear RNA associated | 0.61 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.61 |
| HAL | histidine ammonia-lyase | 0.6 |
| HBA1 | hemoglobin, alpha 1 | 0.6 |
| TRIM2 | tripartite motif containing 2 | 0.6 |
| PLPP2 | phospholipid phosphatase 2 | 0.6 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.59 |
| MCL1 | myeloid cell leukemia 1 | 0.59 |
| FAM53C | family with sequence similarity 53, member C | 0.57 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.57 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.57 |
| PANK3 | pantothenate kinase 3 | 0.57 |
| RNF223 | ring finger protein 223 | 0.56 |
| PRELID1 | PRELI domain containing 1 | 0.56 |
| IGSF8 | immunoglobulin superfamily, member 8 | 0.56 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.56 |
| SC5D | sterol-C5-desaturase | 0.55 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.55 |
| APOE | apolipoprotein E | 0.54 |
| MVD | mevalonate (diphospho) decarboxylase | 0.54 |
| S100A14 | S100 calcium binding protein A14 | 0.53 |
| ALDOC | aldolase C, fructose-bisphosphate | 0.53 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.53 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.52 |
| PIP | prolactin-induced protein | 0.52 |
| ANKRD22 | ankyrin repeat domain 22 | 0.51 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | 0.51 |
| ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | 0.5 |
| POMT1 | protein-O-mannosyltransferase 1 | 0.49 |
| CFAP58 | cilia and flagella associated protein 58 | 0.49 |
| RUNDC1 | RUN domain containing 1 | 0.49 |
| TAF3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | 0.48 |
| NDRG1 | N-myc downstream regulated 1 | 0.48 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.48 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | 0.48 |
| H2AZ1 | H2A.Z variant histone 1 | 0.48 |
| ACOT8 | acyl-CoA thioesterase 8 | 0.48 |
| GPN3 | GPN-loop GTPase 3 | 0.47 |
| PGPEP1 | pyroglutamyl-peptidase I | 0.47 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.47 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 0.47 |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 | 0.46 |
| FDPS | farnesyl diphosphate synthase | 0.46 |
| SCARB1 | scavenger receptor class B, member 1 | 0.46 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.46 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | 0.46 |
| CD63 | CD63 molecule | 0.45 |
| EMP3 | epithelial membrane protein 3 | 0.45 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.45 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.44 |
| FAR1 | fatty acyl CoA reductase 1 | 0.44 |
| SLFN5 | schlafen family member 5 | 0.44 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | -1.62 |
| TMEM189 | transmembrane protein 189 | -1.35 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.3 |
| PROS1 | protein S (alpha) | -1.0 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -0.9 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | -0.86 |
| NAAA | N-acylethanolamine acid amidase | -0.86 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.86 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | -0.85 |
| GAS6 | growth arrest-specific 6 | -0.84 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | -0.75 |
| ZC3H14 | zinc finger CCCH-type containing 14 | -0.69 |
| SLC41A3 | solute carrier family 41, member 3 | -0.67 |
| PLIN2 | perilipin 2 | -0.67 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.67 |
| ELL3 | elongation factor RNA polymerase II-like 3 | -0.66 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.64 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | -0.64 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -0.62 |
| MSH5 | mutS homolog 5 | -0.62 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.61 |
| TMEM230 | transmembrane protein 230 | -0.6 |
| PXYLP1 | 2-phosphoxylose phosphatase 1 | -0.6 |
| METAP1D | methionyl aminopeptidase type 1D (mitochondrial) | -0.59 |
| FAT2 | FAT atypical cadherin 2 | -0.59 |
| KLHL29 | kelch-like family member 29 | -0.58 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -0.57 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.57 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.55 |
| HIPK1 | homeodomain interacting protein kinase 1 | -0.55 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | -0.53 |
| TMEM9 | transmembrane protein 9 | -0.53 |
| E2F8 | E2F transcription factor 8 | -0.52 |
| ZNF189 | zinc finger protein 189 | -0.52 |
| FASTKD3 | FAST kinase domains 3 | -0.52 |
| RAD52 | RAD52 homolog (S. cerevisiae) | -0.51 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | -0.51 |
| SLC22A5 | solute carrier family 22 (organic cation/carnitine transporter), member 5 | -0.51 |
| NKAPD1 | NKAP domain containing 1 | -0.51 |
| MTG1 | mitochondrial ribosome-associated GTPase 1 | -0.5 |
| MTRF1L | mitochondrial translational release factor 1-like | -0.5 |
| ODC1 | ornithine decarboxylase 1 | -0.5 |
| MTRF1 | mitochondrial translational release factor 1 | -0.5 |
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | -0.49 |
| ATPSCKMT | ATP synthase c subunit lysine N-methyltransferase | -0.49 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | -0.48 |
| MLYCD | malonyl-CoA decarboxylase | -0.48 |
| AADAT | aminoadipate aminotransferase | -0.48 |
| AXIN2 | axin 2 | -0.47 |
| MMAA | methylmalonic aciduria (cobalamin deficiency) cblA type | -0.46 |
| AKNA | AT-hook transcription factor | -0.45 |
| HIST3H2BB | histone cluster 3, H2bb | -0.45 |
| CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 | -0.45 |
| RPE | ribulose-5-phosphate-3-epimerase | -0.45 |
| DDN | dendrin | -0.45 |
| COQ7 | coenzyme Q7 homolog, ubiquinone (yeast) | -0.44 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.44 |
| PUSL1 | pseudouridylate synthase-like 1 | -0.43 |
| CCN1 | cellular communication network factor 1 | -0.43 |
| ZNF624 | zinc finger protein 624 | -0.43 |
| TSPAN4 | tetraspanin 4 | -0.43 |
| COPRS | coordinator of PRMT5, differentiation stimulator | -0.42 |
| ENDOV | endonuclease V | -0.42 |
| RARA | retinoic acid receptor, alpha | -0.42 |
| TSPAN31 | tetraspanin 31 | -0.42 |
| PARPBP | PARP1 binding protein | -0.42 |
| RGN | regucalcin | -0.42 |
| CST6 | cystatin E/M | -0.41 |
| SOX7 | SRY (sex determining region Y)-box 7 | -0.41 |
| SLC7A6 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | -0.41 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | -0.41 |
| BOD1 | biorientation of chromosomes in cell division 1 | -0.41 |
| ACAD10 | acyl-CoA dehydrogenase family, member 10 | -0.4 |
| ZNF12 | zinc finger protein 12 | -0.4 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.4 |
| CDC20 | cell division cycle 20 | -0.39 |
| ZIC2 | Zic family member 2 | -0.39 |
| TWF1 | twinfilin actin binding protein 1 | -0.39 |
| RUFY3 | RUN and FYVE domain containing 3 | -0.38 |
| IMPAD1 | inositol monophosphatase domain containing 1 | -0.38 |
| GSE1 | Gse1 coiled-coil protein | -0.38 |
| PLK1 | polo-like kinase 1 | -0.38 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.38 |
| ZNF7 | zinc finger protein 7 | -0.38 |
| ZNF227 | zinc finger protein 227 | -0.37 |
| CCDC138 | coiled-coil domain containing 138 | -0.37 |
| MRPL20 | mitochondrial ribosomal protein L20 | -0.37 |
| TCTEX1D2 | Tctex1 domain containing 2 | -0.37 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.37 |
| MRPL28 | mitochondrial ribosomal protein L28 | -0.37 |
| ZNF121 | zinc finger protein 121 | -0.37 |
| BAIAP2 | BAI1-associated protein 2 | -0.37 |
| MYOM2 | myomesin 2 | -0.37 |
| MRPL41 | mitochondrial ribosomal protein L41 | -0.36 |
| AEN | apoptosis enhancing nuclease | -0.36 |
| ALKBH7 | alkB, alkylation repair homolog 7 (E. coli) | -0.36 |
| MAPK12 | mitogen-activated protein kinase 12 | -0.36 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.36 |
