Salmonella infection Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars. Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV. (Kyoto Encyclopedia of Genes and Genomes, hsa05132)
External Link https://www.kegg.jp/entry/hsa05132
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Genes

244 proteins participating in the Salmonella infection pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABI1 abl-interactor 1
ACBD3 acyl-CoA binding domain containing 3
ACTG1 actin gamma 1
ACTR10 actin-related protein 10 homolog (S. cerevisiae)
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACTR3C ARP3 actin-related protein 3 homolog C (yeast)
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANXA2 annexin A2
ARF1 ADP-ribosylation factor 1
ARF6 ADP-ribosylation factor 6
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARL8A ADP-ribosylation factor-like 8A
ARL8B ADP-ribosylation factor-like 8B
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4-TTLL3 ARPC4-TTLL3 readthrough
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARPC5L actin related protein 2/3 complex, subunit 5-like
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CHUK conserved helix-loop-helix ubiquitous kinase
CLSTN1 calsyntenin 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
CYTH2 cytohesin 2
CYTH3 cytohesin 3
CYTH4 cytohesin 4
DCTN1 dynactin 1
DCTN2 dynactin 2 (p50)
DCTN3 dynactin 3 (p22)
DCTN4 dynactin 4 (p62)
DCTN5 dynactin 5 (p25)
DCTN6 dynactin 6
DNM2 dynamin 2
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
DYNLRB1 dynein, light chain, roadblock-type 1
DYNLRB2 dynein, light chain, roadblock-type 2
DYNLT1 dynein, light chain, Tctex-type 1
DYNLT3 dynein, light chain, Tctex-type 3
ELMO1 engulfment and cell motility 1
ELMO2 engulfment and cell motility 2
EXOC2 exocyst complex component 2
EXOC4 exocyst complex component 4
EXOC5 exocyst complex component 5
EXOC7 exocyst complex component 7
FADD Fas (TNFRSF6)-associated via death domain
FBXO22 F-box protein 22
FHOD1 formin homology 2 domain containing 1
FLNA filamin A, alpha
FOS FBJ murine osteosarcoma viral oncogene homolog
FYCO1 FYVE and coiled-coil domain containing 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GCC2 GRIP and coiled-coil domain containing 2
GSDMD gasdermin D
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL18 interleukin 18
IL1B interleukin 1, beta
IL6 interleukin 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
JUN jun proto-oncogene
KIF5A kinesin family member 5A
KIF5B kinesin family member 5B
KIF5C kinesin family member 5C
KLC1 kinesin light chain 1
KLC3 kinesin light chain 3
KLC4 kinesin light chain 4
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA3 karyopherin alpha 3 (importin alpha 4)
KPNA4 karyopherin alpha 4 (importin alpha 3)
LEF1 lymphoid enhancer-binding factor 1
LY96 lymphocyte antigen 96
M6PR mannose-6-phosphate receptor (cation dependent)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MLKL mixed lineage kinase domain-like
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
MYL10 myosin, light chain 10, regulatory
MYL11 myosin light chain 11
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL12B myosin, light chain 12B, regulatory
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYL5 myosin, light chain 5, regulatory
MYL7 myosin, light chain 7, regulatory
MYL9 myosin, light chain 9, regulatory
MYO6 myosin VI
NAIP NLR family, apoptosis inhibitory protein
NCKAP1 NCK-associated protein 1
NCKAP1L NCK-associated protein 1-like
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC4 NLR family, CARD domain containing 4
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
PFN1 profilin 1
PFN2 profilin 2
PFN3 profilin 3
PFN4 profilin family, member 4
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKN1 protein kinase N1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PODXL podocalyxin-like
POTEF POTE ankyrin domain family, member F
PRICKLE1 prickle homolog 1 (Drosophila)
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RAB5A RAB5A, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAB7B RAB7B, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAB9B RAB9B, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOG ras homolog family member G
RHOH ras homolog family member H
RHOJ ras homolog family member J
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE3 ribonuclease, RNase A family, 3
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS3 ribosomal protein S3
RRAS related RAS viral (r-ras) oncogene homolog
S100A10 S100 calcium binding protein A10
SKP1 S-phase kinase-associated protein 1
SNX18 sorting nexin 18
SNX33 sorting nexin 33
SNX9 sorting nexin 9
STX10 syntaxin 10
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TANK TRAF family member-associated NFKB activator
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRADD TNFRSF1A-associated via death domain
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
TUBA3E tubulin, alpha 3e
TUBA4A tubulin, alpha 4a
TUBA8 tubulin, alpha 8
TUBAL3 tubulin, alpha-like 3
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBB8 tubulin, beta 8 class VIII
TUBB8B tubulin beta 8B
TXN2 thioredoxin 2
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WASF3 WAS protein family, member 3
WASL Wiskott-Aldrich syndrome-like