| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sapanisertib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC39A11 | solute carrier family 39, member 11 | 0.0554038 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0553602 |
| CDH13 | cadherin 13 | 0.0537793 |
| HDAC9 | histone deacetylase 9 | 0.0485856 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0484338 |
| CSTB | cystatin B (stefin B) | 0.0475364 |
| DST | dystonin | 0.0435374 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0343062 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0329561 |
| RND3 | Rho family GTPase 3 | 0.0300728 |
| CANX | calnexin | 0.030048 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0299878 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0295395 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0283381 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0282057 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.02797 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0272574 |
| PODXL | podocalyxin-like | 0.0267947 |
| EGFR | epidermal growth factor receptor | 0.0263644 |
| SQSTM1 | sequestosome 1 | 0.0263085 |
| NAV2 | neuron navigator 2 | 0.026225 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0259536 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0258976 |
| MSI2 | musashi RNA-binding protein 2 | 0.0241142 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0237997 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.023762 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0236044 |
| FNIP1 | folliculin interacting protein 1 | 0.0233952 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0233483 |
| TPM4 | tropomyosin 4 | 0.0231243 |
| SP100 | SP100 nuclear antigen | 0.0228173 |
| AUTS2 | autism susceptibility candidate 2 | 0.0222566 |
| RASAL2 | RAS protein activator like 2 | 0.0221488 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0219641 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0218742 |
| MMP12 | matrix metallopeptidase 12 | 0.0216125 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0215319 |
| LOX | lysyl oxidase | 0.0210799 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0210086 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.020816 |
| ASPH | aspartate beta-hydroxylase | 0.0206294 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0201887 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0201818 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0195422 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0191391 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0190552 |
| COPA | coatomer protein complex, subunit alpha | 0.0185983 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.0184298 |
| GOLGB1 | golgin B1 | 0.0183303 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0182547 |
| SLFN5 | schlafen family member 5 | 0.0181559 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0179308 |
| VIM | vimentin | 0.0179193 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0178208 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0168907 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0167183 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0164459 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0160457 |
| DSG2 | desmoglein 2 | 0.0159331 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0158955 |
| EFNA5 | ephrin-A5 | 0.0156541 |
| JMJD1C | jumonji domain containing 1C | 0.0154302 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0153858 |
| CALR | calreticulin | 0.0150392 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0147323 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0147201 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0147135 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0146627 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0146161 |
| ANKRD30B | ankyrin repeat domain 30B | 0.0144829 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0144657 |
| CRYM | crystallin, mu | 0.0144056 |
| GPC6 | glypican 6 | 0.0141938 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0141603 |
| DSPP | dentin sialophosphoprotein | 0.0141583 |
| CTSB | cathepsin B | 0.0141419 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0140529 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.013853 |
| CD109 | CD109 molecule | 0.0135456 |
| CYTH3 | cytohesin 3 | 0.0135343 |
| CEP170 | centrosomal protein 170kDa | 0.0134759 |
| VCL | vinculin | 0.0134745 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.013463 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0133888 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0133815 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0133228 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0132466 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0132223 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.012977 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0128726 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0127678 |
| MCL1 | myeloid cell leukemia 1 | 0.0126538 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0125615 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0124634 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0123771 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0122996 |
| ERBIN | erbb2 interacting protein | 0.0122865 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0122102 |
| DOCK9 | dedicator of cytokinesis 9 | 0.0120349 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0118924 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0577856 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0520516 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0415609 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0317873 |
| MT2A | metallothionein 2A | -0.0297182 |
| FBN1 | fibrillin 1 | -0.029383 |
| S100A10 | S100 calcium binding protein A10 | -0.0253031 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0252328 |
| COL1A2 | collagen, type I, alpha 2 | -0.0221016 |
| CD44 | CD44 molecule (Indian blood group) | -0.0199796 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0181105 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0169615 |
| MT1X | metallothionein 1X | -0.0162768 |
| PLAT | plasminogen activator, tissue | -0.0160321 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0141019 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0137619 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0133743 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0132383 |
| HLA-B | major histocompatibility complex, class I, B | -0.0130736 |
| ACTN4 | actinin, alpha 4 | -0.012396 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0118532 |
| FLNB | filamin B, beta | -0.0114675 |
| HLA-C | major histocompatibility complex, class I, C | -0.0112468 |
| GNAS | GNAS complex locus | -0.0111868 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0110533 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0106889 |
| NPR2 | natriuretic peptide receptor 2 | -0.0106677 |
| UBC | ubiquitin C | -0.0104542 |
| MB21D2 | Mab-21 domain containing 2 | -0.0100784 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0100221 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.00992827 |
| S100A4 | S100 calcium binding protein A4 | -0.00985156 |
| RRM2 | ribonucleotide reductase M2 | -0.0096054 |
| PXDN | peroxidasin | -0.00955381 |
| THBS2 | thrombospondin 2 | -0.0095373 |
| RBM25 | RNA binding motif protein 25 | -0.00940112 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00928934 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.00927876 |
| TMOD1 | tropomodulin 1 | -0.00920598 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.00879297 |
| PTMA | prothymosin, alpha | -0.00878281 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00877082 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.00852176 |
| SP3 | Sp3 transcription factor | -0.00852103 |
| TMSB4X | thymosin beta 4, X-linked | -0.00850081 |
| TUBB4B | tubulin, beta 4B class IVb | -0.00845619 |
| SEPTIN9 | septin 9 | -0.00822492 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.00807111 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.00806549 |
| XPO1 | exportin 1 | -0.00805092 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00802131 |
| COL3A1 | collagen, type III, alpha 1 | -0.00797042 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.00795158 |
| OGA | O-GlcNAcase | -0.00790226 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.00785378 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.00784439 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.00783387 |
| HMGB2 | high mobility group box 2 | -0.00768546 |
| RUNX1 | runt-related transcription factor 1 | -0.00765668 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.00765186 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.00762523 |
| SBF2 | SET binding factor 2 | -0.00744807 |
| RTN4 | reticulon 4 | -0.00743513 |
| TRIM22 | tripartite motif containing 22 | -0.00727994 |
| LOXL2 | lysyl oxidase-like 2 | -0.00715692 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.00694226 |
| RNF145 | ring finger protein 145 | -0.00687329 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0067526 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00665772 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | -0.00656107 |
| PRKD3 | protein kinase D3 | -0.00655063 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0065125 |
| C1D | C1D nuclear receptor corepressor | -0.0064741 |
| MAP4 | microtubule-associated protein 4 | -0.00645287 |
| GASK1B | golgi associated kinase 1B | -0.00633431 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.00629777 |
| LRRC49 | leucine rich repeat containing 49 | -0.00629509 |
| RRBP1 | ribosome binding protein 1 | -0.00626707 |
| YEATS2 | YEATS domain containing 2 | -0.00620849 |
| SDC4 | syndecan 4 | -0.00619774 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.00609046 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.00607852 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.00599695 |
| WDR41 | WD repeat domain 41 | -0.00599639 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.00598816 |
| SLC22A23 | solute carrier family 22, member 23 | -0.00598467 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.00596977 |
| MYL12B | myosin, light chain 12B, regulatory | -0.00596597 |
| WTAP | Wilms tumor 1 associated protein | -0.00593554 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0059116 |
| ZNF217 | zinc finger protein 217 | -0.00584502 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.00584457 |
| GSE1 | Gse1 coiled-coil protein | -0.00570898 |
| FAM162A | family with sequence similarity 162, member A | -0.005705 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.00569283 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.00567812 |
| APAF1 | apoptotic peptidase activating factor 1 | -0.00566896 |
| SMIM44 | small integral membrane protein 44 | -0.00561984 |
| PKM | pyruvate kinase, muscle | -0.0056024 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.00557699 |
