| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sapanisertib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.203335 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.152844 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.131321 |
| NLGN1 | neuroligin 1 | 0.128768 |
| HMGA2 | high mobility group AT-hook 2 | 0.109613 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0856155 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0769623 |
| TMSB10 | thymosin beta 10 | 0.0757043 |
| ACTG1 | actin gamma 1 | 0.0701121 |
| PTMA | prothymosin, alpha | 0.0697559 |
| PCDH7 | protocadherin 7 | 0.0676358 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0655416 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0620498 |
| ASPH | aspartate beta-hydroxylase | 0.0620462 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0610806 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0557616 |
| EHBP1 | EH domain binding protein 1 | 0.0544154 |
| RPS12 | ribosomal protein S12 | 0.0538339 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0524069 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0515205 |
| INTS6 | integrator complex subunit 6 | 0.0507392 |
| RPS8 | ribosomal protein S8 | 0.0499482 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0488079 |
| YAP1 | Yes-associated protein 1 | 0.046481 |
| RPS3 | ribosomal protein S3 | 0.0444885 |
| RRM2 | ribonucleotide reductase M2 | 0.0440293 |
| NHSL1 | NHS-like 1 | 0.0436045 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.043419 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0419353 |
| RPL37A | ribosomal protein L37a | 0.0403084 |
| NEBL | nebulette | 0.0397054 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0390819 |
| RPL35A | ribosomal protein L35a | 0.0385006 |
| ADIPOR2 | adiponectin receptor 2 | 0.0375027 |
| JMJD1C | jumonji domain containing 1C | 0.0366073 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0362028 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0359582 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0359213 |
| CUX1 | cut-like homeobox 1 | 0.0351275 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0346372 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0346253 |
| PCDH9 | protocadherin 9 | 0.033812 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.033369 |
| RPS19 | ribosomal protein S19 | 0.0333305 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0328391 |
| RPS27A | ribosomal protein S27a | 0.0326374 |
| LDHA | lactate dehydrogenase A | 0.0323217 |
| MTAP | methylthioadenosine phosphorylase | 0.0321714 |
| CALR | calreticulin | 0.0315163 |
| RASAL2 | RAS protein activator like 2 | 0.0314658 |
| RPL23 | ribosomal protein L23 | 0.0309108 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0308268 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0306293 |
| IPO7 | importin 7 | 0.030132 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0300799 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0300368 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0300241 |
| ENO1 | enolase 1, (alpha) | 0.0298402 |
| TPI1 | triosephosphate isomerase 1 | 0.0296218 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0295901 |
| BCHE | butyrylcholinesterase | 0.0294047 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0287465 |
| TENM3 | teneurin transmembrane protein 3 | 0.0286259 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0286001 |
| PRDX1 | peroxiredoxin 1 | 0.028104 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0280468 |
| RPS6 | ribosomal protein S6 | 0.0276431 |
| LRRC23 | leucine rich repeat containing 23 | 0.0275921 |
| TPM3 | tropomyosin 3 | 0.0273854 |
| RPS13 | ribosomal protein S13 | 0.0270725 |
| RPL36 | ribosomal protein L36 | 0.0269838 |
| RPL12 | ribosomal protein L12 | 0.0268992 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | 0.0267626 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.026698 |
| EGR1 | early growth response 1 | 0.0260978 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0260774 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0259887 |
| TPM4 | tropomyosin 4 | 0.0254405 |
| RPLP2 | ribosomal protein, large, P2 | 0.0254155 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0252204 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0249017 |
| EXOC4 | exocyst complex component 4 | 0.0248858 |
| RPL31 | ribosomal protein L31 | 0.0247028 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0245066 |
| CMIP | c-Maf inducing protein | 0.0242374 |
| NAV3 | neuron navigator 3 | 0.0242086 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0241853 |
| CANX | calnexin | 0.0240073 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0239258 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0238368 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0237496 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0236676 |
| RPL26 | ribosomal protein L26 | 0.0236159 |
| ANK2 | ankyrin 2, neuronal | 0.0235323 |
| FTL | ferritin, light polypeptide | 0.0234944 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0230746 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0230456 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0230223 |
| RPS17 | ribosomal protein S17 | 0.0229461 |
| PDGFC | platelet derived growth factor C | 0.0228719 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | -0.0774114 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0596061 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0537525 |
| CCNL1 | cyclin L1 | -0.0516075 |
| MGAT4C | MGAT4 family, member C | -0.0437157 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0435811 |
| KLHL24 | kelch-like family member 24 | -0.0420832 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0395382 |
| NEK7 | NIMA-related kinase 7 | -0.0346228 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0325789 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0322614 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0298724 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0284193 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0269666 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.026854 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0268339 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0254679 |
| ECT2 | epithelial cell transforming 2 | -0.0254348 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0248623 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0243446 |
| MATR3 | matrin 3 | -0.0239145 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0237188 |
| PCM1 | pericentriolar material 1 | -0.0231769 |
| KIF5B | kinesin family member 5B | -0.0226567 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0217687 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0216574 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.021637 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0216198 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.021535 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.02133 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0211433 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0209584 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0209286 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0206949 |
| PCBP2 | poly(rC) binding protein 2 | -0.0205407 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0202948 |
| CPOX | coproporphyrinogen oxidase | -0.0201325 |
| TXNRD1 | thioredoxin reductase 1 | -0.0199562 |
| ZNF292 | zinc finger protein 292 | -0.0196403 |
| THOC2 | THO complex 2 | -0.0195539 |
| XPO1 | exportin 1 | -0.0194977 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0189664 |
| TFG | TRK-fused gene | -0.0187016 |
| CEP95 | centrosomal protein 95kDa | -0.0184337 |
| OGA | O-GlcNAcase | -0.0184094 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0181068 |
| THOC1 | THO complex 1 | -0.0180288 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0177856 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0175978 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0174461 |
| OXR1 | oxidation resistance 1 | -0.0173155 |
| ATP11A | ATPase, class VI, type 11A | -0.0173103 |
| MPG | N-methylpurine-DNA glycosylase | -0.0172687 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.016976 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0165207 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0162448 |
| WDR43 | WD repeat domain 43 | -0.0160891 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -0.0159169 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0158798 |
| NKTR | natural killer cell triggering receptor | -0.0156758 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0155831 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0155733 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0155271 |
| PHIP | pleckstrin homology domain interacting protein | -0.015449 |
| YTHDC1 | YTH domain containing 1 | -0.0152386 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0152372 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.0151752 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0149704 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | -0.0148799 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0147987 |
| CCNG1 | cyclin G1 | -0.0147605 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | -0.0147273 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0146417 |
| HBP1 | HMG-box transcription factor 1 | -0.0145726 |
| CDK17 | cyclin-dependent kinase 17 | -0.0145685 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0145324 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0144782 |
| LMO7 | LIM domain 7 | -0.014452 |
| QKI | QKI, KH domain containing, RNA binding | -0.014349 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0143301 |
| RBM39 | RNA binding motif protein 39 | -0.0142395 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0142269 |
| EDN1 | endothelin 1 | -0.0141152 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0140735 |
| AXIN2 | axin 2 | -0.0139129 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0139047 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0138294 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0138117 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0137829 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0136574 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0136445 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0135263 |
| RNF145 | ring finger protein 145 | -0.0135226 |
| TNPO1 | transportin 1 | -0.0134867 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0134232 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0134089 |
| TPR | translocated promoter region, nuclear basket protein | -0.0133868 |
| IPMK | inositol polyphosphate multikinase | -0.0132986 |
| ETNK1 | ethanolamine kinase 1 | -0.013289 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0132684 |
