| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sapanisertib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.11321 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.101071 |
| NRG1 | neuregulin 1 | 0.0909554 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0817404 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0792733 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0688206 |
| NDRG1 | N-myc downstream regulated 1 | 0.0660476 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0601116 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0540463 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0498313 |
| RPL37A | ribosomal protein L37a | 0.0462473 |
| CENPF | centromere protein F, 350/400kDa | 0.0440613 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0439281 |
| RPS3 | ribosomal protein S3 | 0.0419017 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0400736 |
| ATXN1 | ataxin 1 | 0.0389017 |
| ASPH | aspartate beta-hydroxylase | 0.0387413 |
| RPS12 | ribosomal protein S12 | 0.0381055 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0373272 |
| MEF2A | myocyte enhancer factor 2A | 0.0372777 |
| GDF15 | growth differentiation factor 15 | 0.0372597 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0366717 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0364023 |
| LSAMP | limbic system-associated membrane protein | 0.0362093 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0345076 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0344728 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0338383 |
| MCL1 | myeloid cell leukemia 1 | 0.0334741 |
| VIM | vimentin | 0.0334356 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.033144 |
| PCBP2 | poly(rC) binding protein 2 | 0.032149 |
| HELZ | helicase with zinc finger | 0.0314815 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0311922 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0308912 |
| HMGA2 | high mobility group AT-hook 2 | 0.0307289 |
| EXOC4 | exocyst complex component 4 | 0.0305679 |
| SMYD3 | SET and MYND domain containing 3 | 0.0305197 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0304379 |
| VEGFA | vascular endothelial growth factor A | 0.0302289 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0300076 |
| STC1 | stanniocalcin 1 | 0.0298818 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0297422 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0293935 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0291107 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0287959 |
| DPH6 | diphthamine biosynthesis 6 | 0.0286192 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0284047 |
| GOLGA4 | golgin A4 | 0.0282822 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0282141 |
| CDH13 | cadherin 13 | 0.0279921 |
| IGF2 | insulin-like growth factor 2 | 0.0277751 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | 0.0273722 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0273459 |
| RPL35A | ribosomal protein L35a | 0.0271229 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0268058 |
| SEPTIN9 | septin 9 | 0.0264633 |
| RAD51B | RAD51 paralog B | 0.0264181 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0262402 |
| ENO1 | enolase 1, (alpha) | 0.0255294 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0254193 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0253431 |
| NREP | neuronal regeneration related protein | 0.0253046 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0250297 |
| KCNIP4 | Kv channel interacting protein 4 | 0.0249116 |
| DIAPH2 | diaphanous-related formin 2 | 0.0248344 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0247182 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0246448 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0246416 |
| RPL31 | ribosomal protein L31 | 0.0241554 |
| RPS8 | ribosomal protein S8 | 0.0237904 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0236448 |
| CCDC88A | coiled-coil domain containing 88A | 0.0235711 |
| DACH2 | dachshund family transcription factor 2 | 0.0235516 |
| PTMA | prothymosin, alpha | 0.0235197 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0233162 |
| FAM13A | family with sequence similarity 13, member A | 0.0232862 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.023246 |
| DTNA | dystrobrevin, alpha | 0.0230848 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.023066 |
| ZNF638 | zinc finger protein 638 | 0.0230535 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.022986 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0227046 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0226368 |
| ENAH | enabled homolog (Drosophila) | 0.0224635 |
| COPA | coatomer protein complex, subunit alpha | 0.0220419 |
| TCF12 | transcription factor 12 | 0.0219267 |
| PLAT | plasminogen activator, tissue | 0.0217612 |
| ACTG1 | actin gamma 1 | 0.0217144 |
| PGK1 | phosphoglycerate kinase 1 | 0.0216979 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0216182 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.021517 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0215074 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0214621 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0214095 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0213824 |
| INTS6 | integrator complex subunit 6 | 0.0213384 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0208784 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0208421 |
| ZNF292 | zinc finger protein 292 | 0.0206802 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0206701 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.08318 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0802577 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0551662 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0520263 |
| COL1A1 | collagen, type I, alpha 1 | -0.0467378 |
| RIGI | RNA sensor RIG-I | -0.0452901 |
| RNF213 | ring finger protein 213 | -0.044452 |
| COL3A1 | collagen, type III, alpha 1 | -0.0438294 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0425507 |
| SP100 | SP100 nuclear antigen | -0.0367359 |
| FRMD4A | FERM domain containing 4A | -0.0358689 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0353162 |
| LPIN1 | lipin 1 | -0.0343956 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0326258 |
| GLCCI1 | glucocorticoid induced 1 | -0.0320445 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.031553 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0312214 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0302532 |
| SIK2 | salt-inducible kinase 2 | -0.0290576 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.02817 |
| NRP1 | neuropilin 1 | -0.0281435 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0275954 |
| NEK7 | NIMA-related kinase 7 | -0.0260678 |
| KLHL13 | kelch-like family member 13 | -0.0254054 |
| THBS1 | thrombospondin 1 | -0.0252804 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0251274 |
| AOPEP | aminopeptidase O (putative) | -0.024828 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0248059 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0246589 |
| PLPP1 | phospholipid phosphatase 1 | -0.0245928 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0234199 |
| MX2 | MX dynamin-like GTPase 2 | -0.02335 |
| PDE10A | phosphodiesterase 10A | -0.0231653 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0231268 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0229806 |
| FAM107B | family with sequence similarity 107, member B | -0.0227048 |
| HAS2 | hyaluronan synthase 2 | -0.0225686 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0225521 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.0223284 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0218892 |
| HAND2 | heart and neural crest derivatives expressed 2 | -0.0217018 |
| TLE4 | transducin-like enhancer of split 4 | -0.0214658 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0214137 |
| YME1L1 | YME1-like 1 ATPase | -0.0213704 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0213683 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0211769 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0210023 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0208933 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0207685 |
| H1-0 | H1.0 linker histone | -0.0206731 |
| FOXO3 | forkhead box O3 | -0.0205815 |
| IRS1 | insulin receptor substrate 1 | -0.0204795 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.020246 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0199339 |
| STOX2 | storkhead box 2 | -0.0196674 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | -0.0196595 |
| AHNAK | AHNAK nucleoprotein | -0.0196478 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0193564 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0191711 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.0190136 |
| ZFR | zinc finger RNA binding protein | -0.018643 |
| OGA | O-GlcNAcase | -0.0185469 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0184198 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0183009 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0178825 |
| MALT1 | MALT1 paracaspase | -0.0176616 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0176583 |
| MX1 | MX dynamin-like GTPase 1 | -0.0174924 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | -0.0173345 |
| CCND1 | cyclin D1 | -0.0170014 |
| RBM25 | RNA binding motif protein 25 | -0.0168153 |
| OLA1 | Obg-like ATPase 1 | -0.016802 |
| MAP1B | microtubule-associated protein 1B | -0.0167755 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0167348 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0166376 |
| RAB21 | RAB21, member RAS oncogene family | -0.0165923 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0165632 |
| H3-3B | H3.3 histone B | -0.0164942 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0162811 |
| RBM39 | RNA binding motif protein 39 | -0.0162433 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0161447 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0160539 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0160082 |
| GNG2 | guanine nucleotide binding protein (G protein), gamma 2 | -0.0159932 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0159498 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | -0.0159312 |
| TPM1 | tropomyosin 1 (alpha) | -0.0158292 |
| PCNX1 | pecanex 1 | -0.0157995 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.015623 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0155168 |
| LONRF2 | LON peptidase N-terminal domain and ring finger 2 | -0.0154769 |
| PHF3 | PHD finger protein 3 | -0.0153904 |
| NEO1 | neogenin 1 | -0.0153601 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0151255 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | -0.015059 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | -0.0148579 |
| GAB2 | GRB2-associated binding protein 2 | -0.0148044 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0147938 |
| PITPNB | phosphatidylinositol transfer protein, beta | -0.014726 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0146816 |
