| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sapanisertib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.0892723 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0727977 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0586052 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0524545 |
| SMAD3 | SMAD family member 3 | 0.0494603 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0397509 |
| NCKAP5 | NCK-associated protein 5 | 0.039011 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0387363 |
| VMP1 | vacuole membrane protein 1 | 0.0339923 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0337049 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0279153 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0272677 |
| CCNL1 | cyclin L1 | 0.027023 |
| MYO1E | myosin IE | 0.0267507 |
| YAP1 | Yes-associated protein 1 | 0.0267203 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.026427 |
| STK24 | serine/threonine kinase 24 | 0.0262665 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0250412 |
| RUNX1 | runt-related transcription factor 1 | 0.0248754 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0239913 |
| DUSP16 | dual specificity phosphatase 16 | 0.0224918 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0220183 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.021812 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0212314 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0206387 |
| CDHR2 | cadherin-related family member 2 | 0.0201971 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0199377 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0199367 |
| TRIM2 | tripartite motif containing 2 | 0.0198193 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0191997 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0191588 |
| ALPK1 | alpha-kinase 1 | 0.0186154 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0178515 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | 0.017849 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.017662 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.017607 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0174547 |
| ATP10B | ATPase, class V, type 10B | 0.0173909 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0173182 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0170986 |
| SYT1 | synaptotagmin I | 0.0166912 |
| ASPH | aspartate beta-hydroxylase | 0.0162392 |
| RBM26 | RNA binding motif protein 26 | 0.0161193 |
| MSI2 | musashi RNA-binding protein 2 | 0.015846 |
| AFAP1L2 | actin filament associated protein 1-like 2 | 0.0157862 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0157345 |
| ETV6 | ets variant 6 | 0.0155173 |
| FOSL2 | FOS-like antigen 2 | 0.0154703 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.015328 |
| KYNU | kynureninase | 0.0150014 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0149957 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0149517 |
| OCLN | occludin | 0.0148873 |
| ARGLU1 | arginine and glutamate rich 1 | 0.014832 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0147462 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0147377 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0147115 |
| PDZD8 | PDZ domain containing 8 | 0.0147088 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0146486 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0145433 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.014527 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0143094 |
| TMEM65 | transmembrane protein 65 | 0.0142524 |
| UBAC2 | UBA domain containing 2 | 0.0142125 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.014169 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0141608 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.014141 |
| TMEM51 | transmembrane protein 51 | 0.013984 |
| PTEN | phosphatase and tensin homolog | 0.013625 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0136213 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0135069 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0134893 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0133819 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0133458 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0133209 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0133195 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0132618 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0131411 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0131369 |
| XDH | xanthine dehydrogenase | 0.0131259 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0131179 |
| RAD51B | RAD51 paralog B | 0.0129753 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0128898 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.012758 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0127437 |
| FOXP1 | forkhead box P1 | 0.0126595 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0124717 |
| TMC5 | transmembrane channel-like 5 | 0.0124138 |
| SMYD3 | SET and MYND domain containing 3 | 0.0122663 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0122109 |
| SLTM | SAFB-like, transcription modulator | 0.0122081 |
| EFNB2 | ephrin-B2 | 0.01208 |
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.0120414 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.012002 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0119952 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.01198 |
| CLYBL | citrate lyase beta like | 0.0119176 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0119151 |
| EREG | epiregulin | 0.0118555 |
| ATP9A | ATPase, class II, type 9A | 0.0117214 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.153862 |
| B2M | beta-2-microglobulin | -0.121778 |
| PTMA | prothymosin, alpha | -0.115573 |
| RNF213 | ring finger protein 213 | -0.107833 |
| ANXA2 | annexin A2 | -0.100706 |
| LYZ | lysozyme | -0.0997726 |
| HLA-B | major histocompatibility complex, class I, B | -0.0974755 |
| INTS6 | integrator complex subunit 6 | -0.0972821 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0962826 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.094905 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0949021 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0943445 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0921928 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0895608 |
| SP100 | SP100 nuclear antigen | -0.0866524 |
| NPSR1 | neuropeptide S receptor 1 | -0.0848384 |
| SQSTM1 | sequestosome 1 | -0.0846436 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0831057 |
| XAF1 | XIAP associated factor 1 | -0.0802188 |
| RIGI | RNA sensor RIG-I | -0.077987 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0754481 |
| PERP | PERP, TP53 apoptosis effector | -0.0749266 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0739818 |
| PLSCR2 | phospholipid scramblase 2 | -0.0731616 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0731189 |
| MX2 | MX dynamin-like GTPase 2 | -0.0713742 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.070748 |
| PKM | pyruvate kinase, muscle | -0.0668438 |
| MX1 | MX dynamin-like GTPase 1 | -0.0667153 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0597759 |
| ACTG1 | actin gamma 1 | -0.0596252 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0578814 |
| AREG | amphiregulin | -0.0548078 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0523614 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0520891 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0516949 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0500721 |
| TXNIP | thioredoxin interacting protein | -0.047668 |
| FTL | ferritin, light polypeptide | -0.0454375 |
| EGR1 | early growth response 1 | -0.0452812 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0449057 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0448863 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0439924 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0439764 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0428634 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0421641 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0421106 |
| SSH2 | slingshot protein phosphatase 2 | -0.0412656 |
| MUC20 | mucin 20, cell surface associated | -0.0411816 |
| HLA-C | major histocompatibility complex, class I, C | -0.0410935 |
| RPL35A | ribosomal protein L35a | -0.0407898 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0403503 |
| H1-0 | H1.0 linker histone | -0.0400685 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0399224 |
| RPL34 | ribosomal protein L34 | -0.0397208 |
| S100A6 | S100 calcium binding protein A6 | -0.038272 |
| S100A10 | S100 calcium binding protein A10 | -0.0381244 |
| VCL | vinculin | -0.0380642 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0378607 |
| AHNAK | AHNAK nucleoprotein | -0.0373391 |
| ENO1 | enolase 1, (alpha) | -0.0371116 |
| ABLIM1 | actin binding LIM protein 1 | -0.0366127 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0364905 |
| SDC4 | syndecan 4 | -0.0357593 |
| PGK1 | phosphoglycerate kinase 1 | -0.035665 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0355394 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0353736 |
| PMP22 | peripheral myelin protein 22 | -0.0353318 |
| HLA-E | major histocompatibility complex, class I, E | -0.034387 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0341237 |
| IER3 | immediate early response 3 | -0.0335376 |
| RRBP1 | ribosome binding protein 1 | -0.0334401 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0332817 |
| GOLGB1 | golgin B1 | -0.0331497 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0328369 |
| APOL1 | apolipoprotein L, 1 | -0.0324353 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0324277 |
| PHF3 | PHD finger protein 3 | -0.032017 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0316803 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0316189 |
| MT2A | metallothionein 2A | -0.0313434 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0312857 |
| LIMA1 | LIM domain and actin binding 1 | -0.0310179 |
| RPS6 | ribosomal protein S6 | -0.0309456 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0308065 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0304493 |
| JUN | jun proto-oncogene | -0.0304314 |
| TMSB10 | thymosin beta 10 | -0.0303867 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0303153 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.02998 |
| ADAR | adenosine deaminase, RNA-specific | -0.0299067 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0298768 |
| RPL23 | ribosomal protein L23 | -0.0298738 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0297505 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0296381 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0294859 |
| RPS24 | ribosomal protein S24 | -0.0291753 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0291032 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0290175 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0289758 |
