| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sapanisertib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.16157 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0932472 |
| EXT1 | exostosin glycosyltransferase 1 | 0.062684 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0607362 |
| VIM | vimentin | 0.0544869 |
| CD44 | CD44 molecule (Indian blood group) | 0.0509045 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0487303 |
| VEGFA | vascular endothelial growth factor A | 0.0471583 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0468518 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0450299 |
| NAV1 | neuron navigator 1 | 0.0446644 |
| NAV2 | neuron navigator 2 | 0.0442215 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0428928 |
| NDRG1 | N-myc downstream regulated 1 | 0.0412818 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0383249 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0369325 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0368875 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0359837 |
| MYO10 | myosin X | 0.0324941 |
| CDH13 | cadherin 13 | 0.0323479 |
| GLIS3 | GLIS family zinc finger 3 | 0.0311883 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0306759 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0291632 |
| ASPH | aspartate beta-hydroxylase | 0.0288492 |
| PTK2 | protein tyrosine kinase 2 | 0.0283465 |
| IL6 | interleukin 6 | 0.0281282 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0280199 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0280168 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0275497 |
| GOLGB1 | golgin B1 | 0.0273709 |
| CLMP | CXADR-like membrane protein | 0.0272255 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0270958 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0267814 |
| COL5A1 | collagen, type V, alpha 1 | 0.0259793 |
| ENO1 | enolase 1, (alpha) | 0.0259016 |
| CUX1 | cut-like homeobox 1 | 0.0254525 |
| RPS8 | ribosomal protein S8 | 0.0246853 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.023856 |
| PLEC | plectin | 0.0235805 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0233586 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0230909 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0230805 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.023003 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0223706 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0221544 |
| RUNX1 | runt-related transcription factor 1 | 0.0221493 |
| EGFR | epidermal growth factor receptor | 0.0218627 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.021533 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0214878 |
| RPL37A | ribosomal protein L37a | 0.0214643 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0213321 |
| SP100 | SP100 nuclear antigen | 0.0208807 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0208722 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0207929 |
| HDAC9 | histone deacetylase 9 | 0.0207337 |
| RPL35A | ribosomal protein L35a | 0.0207309 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.020096 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0198018 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0196005 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0194858 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0194296 |
| CNTN5 | contactin 5 | 0.0193164 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0190838 |
| ACTG1 | actin gamma 1 | 0.0185091 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0184279 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0183983 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0183107 |
| HM13 | histocompatibility (minor) 13 | 0.0181957 |
| STC1 | stanniocalcin 1 | 0.0179274 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0178003 |
| FAM107B | family with sequence similarity 107, member B | 0.0177343 |
| RACK1 | receptor for activated C kinase 1 | 0.017661 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0173346 |
| CMIP | c-Maf inducing protein | 0.0172157 |
| EGR1 | early growth response 1 | 0.0171624 |
| MTSS1 | metastasis suppressor 1 | 0.017078 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0170674 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0170304 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0167371 |
| PDE10A | phosphodiesterase 10A | 0.0166866 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0166393 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0164932 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0162282 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.01618 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0157596 |
| ANO6 | anoctamin 6 | 0.0156629 |
| FOXP1 | forkhead box P1 | 0.0154403 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0153362 |
| RPS6 | ribosomal protein S6 | 0.0153321 |
| FBN1 | fibrillin 1 | 0.0152949 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0152451 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0150959 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.014931 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0149025 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0148338 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0148052 |
| MTDH | metadherin | 0.014772 |
| SON | SON DNA binding protein | 0.0147628 |
| EPHB1 | EPH receptor B1 | 0.0147528 |
| VMP1 | vacuole membrane protein 1 | 0.0146694 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.218866 |
| COL1A1 | collagen, type I, alpha 1 | -0.104421 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0802516 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0644645 |
| COL1A2 | collagen, type I, alpha 2 | -0.0557849 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0547959 |
| ATP13A3 | ATPase type 13A3 | -0.0391686 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0351584 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0313408 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.029656 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0294701 |
| MT1X | metallothionein 1X | -0.0277629 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0276975 |
| POSTN | periostin, osteoblast specific factor | -0.0272431 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0263277 |
| IER3 | immediate early response 3 | -0.0260788 |
| PTMA | prothymosin, alpha | -0.0259769 |
| USP3 | ubiquitin specific peptidase 3 | -0.0247429 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0247157 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0234457 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0233895 |
| ANXA2 | annexin A2 | -0.0231955 |
| ZNF292 | zinc finger protein 292 | -0.0226317 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0204787 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0199873 |
| TMSB4X | thymosin beta 4, X-linked | -0.0195622 |
| OGA | O-GlcNAcase | -0.0188042 |
| SPAG9 | sperm associated antigen 9 | -0.0187601 |
| CAVIN1 | caveolae associated protein 1 | -0.0171717 |
| TFG | TRK-fused gene | -0.0166035 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0164276 |
| FSTL1 | follistatin-like 1 | -0.0161529 |
| LOX | lysyl oxidase | -0.0160079 |
| CALU | calumenin | -0.0158757 |
| CANX | calnexin | -0.0157614 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0152232 |
| SRGN | serglycin | -0.0151634 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0151036 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0150022 |
| SMAD3 | SMAD family member 3 | -0.0149624 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0147889 |
| RLF | rearranged L-myc fusion | -0.0147696 |
| PXDN | peroxidasin | -0.0146785 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0146764 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0145834 |
| QKI | QKI, KH domain containing, RNA binding | -0.0136508 |
| THY1 | Thy-1 cell surface antigen | -0.0134258 |
| MEDAG | mesenteric estrogen-dependent adipogenesis | -0.0133588 |
| COL3A1 | collagen, type III, alpha 1 | -0.0132608 |
| CALR | calreticulin | -0.0132027 |
| MATR3 | matrin 3 | -0.0129455 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0127206 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0126407 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0125089 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0124672 |
| RBM39 | RNA binding motif protein 39 | -0.0124293 |
| RRBP1 | ribosome binding protein 1 | -0.0122993 |
| SQLE | squalene epoxidase | -0.0122888 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0118284 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0117319 |
| AZIN1 | antizyme inhibitor 1 | -0.0117235 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0117049 |
| HMGB2 | high mobility group box 2 | -0.0116351 |
| SNX9 | sorting nexin 9 | -0.0116299 |
| SEPTIN7 | septin 7 | -0.0116221 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0116133 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0115096 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0115087 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.011258 |
| GNAS | GNAS complex locus | -0.0111608 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0111477 |
| RASA2 | RAS p21 protein activator 2 | -0.0110289 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0109092 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0107989 |
| INSIG1 | insulin induced gene 1 | -0.0107509 |
| ARRDC3 | arrestin domain containing 3 | -0.0106958 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0105879 |
| COL4A1 | collagen, type IV, alpha 1 | -0.0105373 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0104036 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0102566 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0101726 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.00997708 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.00997307 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0099182 |
| YBX1 | Y box binding protein 1 | -0.00986043 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0097979 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.00974579 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0097242 |
| TUBA1B | tubulin, alpha 1b | -0.00968521 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.00968484 |
| HELZ | helicase with zinc finger | -0.00967765 |
| AFAP1 | actin filament associated protein 1 | -0.00967011 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0096486 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.00957933 |
| RHEB | Ras homolog enriched in brain | -0.00951928 |
| WDR45B | WD repeat domain 45B | -0.00945429 |
| FAM162A | family with sequence similarity 162, member A | -0.00933379 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.00915225 |
| KAZN | kazrin, periplakin interacting protein | -0.00911855 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.00906593 |
