| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sapanisertib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.218846 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.171927 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0711778 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0576251 |
| SVIL | supervillin | 0.0550607 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0530353 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0506801 |
| FRMD5 | FERM domain containing 5 | 0.0450892 |
| ASPH | aspartate beta-hydroxylase | 0.0422628 |
| ATXN1 | ataxin 1 | 0.0406462 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0403059 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0390155 |
| VCL | vinculin | 0.0387147 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0255028 |
| ITGAV | integrin, alpha V | 0.024207 |
| GRB10 | growth factor receptor-bound protein 10 | 0.023799 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0229611 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0227577 |
| FAT1 | FAT atypical cadherin 1 | 0.0221512 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0215763 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0215537 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0208865 |
| GPC6 | glypican 6 | 0.0203879 |
| KYNU | kynureninase | 0.0202345 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0196756 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0192942 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0187631 |
| FILIP1L | filamin A interacting protein 1-like | 0.0185526 |
| MRTFA | myocardin related transcription factor A | 0.018384 |
| FOXP1 | forkhead box P1 | 0.0180569 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0175193 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0171757 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0159684 |
| DST | dystonin | 0.0153554 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0152585 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0151967 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.015151 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0149124 |
| FLNB | filamin B, beta | 0.0147557 |
| JAG1 | jagged 1 | 0.0145259 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0145076 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0143335 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0143092 |
| RASA2 | RAS p21 protein activator 2 | 0.0142832 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0137467 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0134822 |
| DIAPH1 | diaphanous-related formin 1 | 0.0133413 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0131438 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0130922 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0129265 |
| MYO1E | myosin IE | 0.0126693 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0125501 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0122423 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0120398 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | 0.011908 |
| PRKCA | protein kinase C, alpha | 0.0117597 |
| EHBP1 | EH domain binding protein 1 | 0.0114561 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0113658 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0112182 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0110344 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0110262 |
| TLE4 | transducin-like enhancer of split 4 | 0.0109281 |
| ITGA6 | integrin, alpha 6 | 0.0108647 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0108033 |
| ANXA5 | annexin A5 | 0.0107991 |
| ARFGEF3 | ARFGEF family member 3 | 0.0107371 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0105715 |
| RUNX1 | runt-related transcription factor 1 | 0.010533 |
| AHR | aryl hydrocarbon receptor | 0.0105181 |
| RPL3 | ribosomal protein L3 | 0.0104991 |
| HMGA1 | high mobility group AT-hook 1 | 0.0104922 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0103846 |
| RSU1 | Ras suppressor protein 1 | 0.0103196 |
| VCAN | versican | 0.0102126 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0101468 |
| FOXO1 | forkhead box O1 | 0.0101254 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0100653 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0099594 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.00969391 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.00965128 |
| GLIS3 | GLIS family zinc finger 3 | 0.00961213 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.00959322 |
| FHL2 | four and a half LIM domains 2 | 0.00950266 |
| PALLD | palladin, cytoskeletal associated protein | 0.0094905 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.00948281 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.00931361 |
| FERMT1 | fermitin family member 1 | 0.00925253 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.00923596 |
| ZNF804A | zinc finger protein 804A | 0.00916235 |
| PLEC | plectin | 0.00913079 |
| FLNA | filamin A, alpha | 0.00911191 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.00888496 |
| EXOC4 | exocyst complex component 4 | 0.00882129 |
| PDGFC | platelet derived growth factor C | 0.00878495 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.00877464 |
| MYO5B | myosin VB | 0.00873308 |
| NPAS2 | neuronal PAS domain protein 2 | 0.00870211 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | 0.00861961 |
| AFDN | afadin, adherens junction formation factor | 0.00859976 |
| OSMR | oncostatin M receptor | 0.0085844 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.209355 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.181878 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0689509 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0676337 |
| GPC3 | glypican 3 | -0.0641185 |
| APOA2 | apolipoprotein A-II | -0.0591887 |
| FTL | ferritin, light polypeptide | -0.0580182 |
| C3 | complement component 3 | -0.0565161 |
| AHSG | alpha-2-HS-glycoprotein | -0.0502891 |
| CP | ceruloplasmin (ferroxidase) | -0.0497328 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0468732 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0446852 |
| TF | transferrin | -0.0428059 |
| RPL11 | ribosomal protein L11 | -0.0417617 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0414887 |
| APOB | apolipoprotein B | -0.0400912 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0384903 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0377833 |
| TRIM26 | tripartite motif containing 26 | -0.0373925 |
| GNAS | GNAS complex locus | -0.0370361 |
| A2M | alpha-2-macroglobulin | -0.0367857 |
| APOE | apolipoprotein E | -0.0366438 |
| APOA1 | apolipoprotein A-I | -0.0361823 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0351067 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0315706 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0301726 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0291445 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0288922 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0288641 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0273931 |
| CPE | carboxypeptidase E | -0.0272485 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0264535 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0260506 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0258017 |
| RPLP1 | ribosomal protein, large, P1 | -0.0252479 |
| RPLP0 | ribosomal protein, large, P0 | -0.0248576 |
| RBM39 | RNA binding motif protein 39 | -0.0240014 |
| SDC4 | syndecan 4 | -0.0229334 |
| RPS24 | ribosomal protein S24 | -0.0225431 |
| MT2A | metallothionein 2A | -0.0224706 |
| RPS6 | ribosomal protein S6 | -0.0224322 |
| SELENOP | selenoprotein P | -0.0220079 |
| TMEM123 | transmembrane protein 123 | -0.0219245 |
| RPS19 | ribosomal protein S19 | -0.0217313 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0215624 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0209036 |
| LYZ | lysozyme | -0.0201119 |
| RRBP1 | ribosome binding protein 1 | -0.0195938 |
| RPL35A | ribosomal protein L35a | -0.0195574 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0194676 |
| WDR45B | WD repeat domain 45B | -0.0192159 |
| H1-0 | H1.0 linker histone | -0.0187433 |
| IER3 | immediate early response 3 | -0.0187424 |
| RPL34 | ribosomal protein L34 | -0.0185354 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0185338 |
| GDF15 | growth differentiation factor 15 | -0.0184584 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0183315 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0182194 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.017901 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.017638 |
| RPS23 | ribosomal protein S23 | -0.0174561 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0174237 |
| RPL12 | ribosomal protein L12 | -0.017297 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0171624 |
| RPS3 | ribosomal protein S3 | -0.0169546 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0168476 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.016733 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0166668 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0166192 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0165616 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0165027 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.016389 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0163159 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0162796 |
| JMJD1C | jumonji domain containing 1C | -0.0162118 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0161177 |
| OLA1 | Obg-like ATPase 1 | -0.0158565 |
| UBC | ubiquitin C | -0.0156809 |
| PTMA | prothymosin, alpha | -0.0156529 |
| NPR2 | natriuretic peptide receptor 2 | -0.0154503 |
| AGXT | alanine-glyoxylate aminotransferase | -0.0154359 |
| SETD5 | SET domain containing 5 | -0.0154065 |
| RPS25 | ribosomal protein S25 | -0.0154024 |
| RPS27A | ribosomal protein S27a | -0.015373 |
| RPL8 | ribosomal protein L8 | -0.0152752 |
| B2M | beta-2-microglobulin | -0.0152502 |
| RPS29 | ribosomal protein S29 | -0.0151688 |
| BPIFB2 | BPI fold containing family B, member 2 | -0.0151034 |
| FABP1 | fatty acid binding protein 1, liver | -0.0150853 |
| KLF6 | Kruppel-like factor 6 | -0.0148246 |
| MATR3 | matrin 3 | -0.0147962 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -0.014738 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.014711 |
| FUS | FUS RNA binding protein | -0.0144109 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0142247 |
| ITGA1 | integrin, alpha 1 | -0.0142103 |
| PFN1 | profilin 1 | -0.0141761 |
| CST3 | cystatin C | -0.0138846 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0138239 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0138066 |
