Sapanisertib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sapanisertib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sapanisertib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.209157
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.201736
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.118593
LMO7 LIM domain 7 0.114457
PALM2AKAP2 PALM2 and AKAP2 fusion 0.113527
B2M beta-2-microglobulin 0.111926
MT2A metallothionein 2A 0.0955238
PDLIM5 PDZ and LIM domain 5 0.0934779
PODXL podocalyxin-like 0.0932057
CD44 CD44 molecule (Indian blood group) 0.0930898
SLC35F3 solute carrier family 35, member F3 0.0842578
PDE4D phosphodiesterase 4D, cAMP-specific 0.0826693
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0791393
HMGA2 high mobility group AT-hook 2 0.0762982
RASAL2 RAS protein activator like 2 0.0749437
HLA-B major histocompatibility complex, class I, B 0.070126
CDK6 cyclin-dependent kinase 6 0.0664613
RPS8 ribosomal protein S8 0.0632087
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0598853
ALCAM activated leukocyte cell adhesion molecule 0.0594586
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0576319
FTH1 ferritin, heavy polypeptide 1 0.0574691
MTSS1 metastasis suppressor 1 0.0572288
TPT1 tumor protein, translationally-controlled 1 0.0559832
RPS6 ribosomal protein S6 0.0539912
RPS13 ribosomal protein S13 0.0539286
SULF2 sulfatase 2 0.0535943
EFNA5 ephrin-A5 0.0523053
LDHA lactate dehydrogenase A 0.0505684
RPLP2 ribosomal protein, large, P2 0.0488206
IFITM1 interferon induced transmembrane protein 1 0.0479798
RPL37 ribosomal protein L37 0.047844
MT1E metallothionein 1E 0.047595
RPS12 ribosomal protein S12 0.0472803
THSD4 thrombospondin, type I, domain containing 4 0.0471776
LAMC2 laminin, gamma 2 0.0469024
PSD3 pleckstrin and Sec7 domain containing 3 0.0453099
BCAR3 breast cancer anti-estrogen resistance 3 0.0449287
EXT1 exostosin glycosyltransferase 1 0.0447828
POTEF POTE ankyrin domain family, member F 0.0446764
RPL37A ribosomal protein L37a 0.0440705
RPLP1 ribosomal protein, large, P1 0.0438928
ANO1 anoctamin 1, calcium activated chloride channel 0.0432651
KLF5 Kruppel-like factor 5 (intestinal) 0.0429308
PRSS23 protease, serine, 23 0.0426416
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0416896
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0413269
AMOTL1 angiomotin like 1 0.0403357
RPL35A ribosomal protein L35a 0.0403147
SAMD9 sterile alpha motif domain containing 9 0.0402591
OSMR oncostatin M receptor 0.0400301
RPL12 ribosomal protein L12 0.039423
IGF2 insulin-like growth factor 2 0.039077
AKAP13 A kinase (PRKA) anchor protein 13 0.0389308
ZSWIM6 zinc finger, SWIM-type containing 6 0.0384583
MBNL1 muscleblind-like splicing regulator 1 0.0384201
IFI6 interferon, alpha-inducible protein 6 0.0383597
RPL34 ribosomal protein L34 0.0382834
EGFR epidermal growth factor receptor 0.0381338
IFI44L interferon-induced protein 44-like 0.0370008
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0368962
RPS3 ribosomal protein S3 0.0368802
RAD51B RAD51 paralog B 0.0364347
SIK3 SIK family kinase 3 0.0362668
MPRIP myosin phosphatase Rho interacting protein 0.0360296
INTS6 integrator complex subunit 6 0.035755
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0352937
CSMD2 CUB and Sushi multiple domains 2 0.0351854
DST dystonin 0.0344317
RPL31 ribosomal protein L31 0.0340134
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0336627
MACF1 microtubule-actin crosslinking factor 1 0.0335553
IFITM3 interferon induced transmembrane protein 3 0.0332991
EEF2 eukaryotic translation elongation factor 2 0.0331181
CMIP c-Maf inducing protein 0.033117
RPS25 ribosomal protein S25 0.0330336
IFI27 interferon, alpha-inducible protein 27 0.0329255
ENO1 enolase 1, (alpha) 0.0328534
RPS19 ribosomal protein S19 0.0328392
PCDH1 protocadherin 1 0.0327448
RPL11 ribosomal protein L11 0.0325696
ASPH aspartate beta-hydroxylase 0.0319865
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0315766
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0313589
PLS3 plastin 3 0.0313037
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0312979
MECOM MDS1 and EVI1 complex locus 0.0310627
RPS21 ribosomal protein S21 0.0310345
RPS27 ribosomal protein S27 0.0309326
HSPG2 heparan sulfate proteoglycan 2 0.0307142
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.030342
DOCK5 dedicator of cytokinesis 5 0.030294
CUX1 cut-like homeobox 1 0.0301835
ACTG1 actin gamma 1 0.0300958
RPL5 ribosomal protein L5 0.0298779
DOK5 docking protein 5 0.0298237
EXOC4 exocyst complex component 4 0.029759
RPL36A ribosomal protein L36a 0.0291839
HDAC9 histone deacetylase 9 0.0290841
DPYD dihydropyrimidine dehydrogenase 0.0290202

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.081899
SOD2 superoxide dismutase 2, mitochondrial -0.0759772
MEF2A myocyte enhancer factor 2A -0.0738894
CLU clusterin -0.0678628
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0646338
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0573732
OGA O-GlcNAcase -0.0568978
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0567553
RBM39 RNA binding motif protein 39 -0.0544402
H1-0 H1.0 linker histone -0.0529928
TRIO trio Rho guanine nucleotide exchange factor -0.0529506
RAI14 retinoic acid induced 14 -0.0515658
ANLN anillin, actin binding protein -0.0509608
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0478855
GOLGA4 golgin A4 -0.0478585
EMP1 epithelial membrane protein 1 -0.0450164
KDM3A lysine (K)-specific demethylase 3A -0.0450102
ITCH itchy E3 ubiquitin protein ligase -0.0442267
SPAG9 sperm associated antigen 9 -0.0396164
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0381096
NPEPPS aminopeptidase puromycin sensitive -0.0378616
CANX calnexin -0.036127
DLG1 discs, large homolog 1 (Drosophila) -0.0359916
SUCO SUN domain containing ossification factor -0.0352309
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0350775
RLF rearranged L-myc fusion -0.0347752
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0338326
RAB6A RAB6A, member RAS oncogene family -0.033094
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0324095
GARS1 glycyl-tRNA synthetase 1 -0.0321408
KIAA1217 KIAA1217 -0.0312968
LMAN1 lectin, mannose-binding, 1 -0.0303415
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0303372
MORF4L2 mortality factor 4 like 2 -0.0302516
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0302365
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0300647
SQLE squalene epoxidase -0.0297957
KRT6A keratin 6A, type II -0.0296149
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0294584
ANXA1 annexin A1 -0.0289607
HELZ helicase with zinc finger -0.028636
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0285288
KDM5B lysine (K)-specific demethylase 5B -0.0282729
DENND4C DENN/MADD domain containing 4C -0.0279213
KDM6A lysine (K)-specific demethylase 6A -0.0275287
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0269958
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0269334
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0266599
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0265885
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.026328
CEMIP cell migration inducing protein, hyaluronan binding -0.0262193
SRP54 signal recognition particle 54kDa -0.0261656
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0260368
COG5 component of oligomeric golgi complex 5 -0.0257262
IFRD1 interferon-related developmental regulator 1 -0.0256603
EZR ezrin -0.0255457
ZNF292 zinc finger protein 292 -0.0255403
SBF2 SET binding factor 2 -0.025262
RNF145 ring finger protein 145 -0.0251083
CUL4B cullin 4B -0.0250667
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0245478
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0244818
DSTN destrin (actin depolymerizing factor) -0.0243655
ARHGAP12 Rho GTPase activating protein 12 -0.0242188
ARRDC3 arrestin domain containing 3 -0.0239758
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0239518
YBX3 Y box binding protein 3 -0.0237471
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0235292
USP3 ubiquitin specific peptidase 3 -0.0234975
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.023491
CDC73 cell division cycle 73 -0.0233988
ANKRD33B ankyrin repeat domain 33B -0.023115
COPA coatomer protein complex, subunit alpha -0.0230849
PHF21A PHD finger protein 21A -0.0230488
LIFR leukemia inhibitory factor receptor alpha -0.0229429
COPB1 coatomer protein complex, subunit beta 1 -0.0229246
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0223639
NUP58 nucleoporin 58 -0.0222538
BHLHE40 basic helix-loop-helix family, member e40 -0.0221911
GATA6 GATA binding protein 6 -0.0219954
BRWD3 bromodomain and WD repeat domain containing 3 -0.0219072
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0218099
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0217897
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0215196
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0211908
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0211218
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0210144
SKIC3 SKI3 subunit of superkiller complex -0.0208231
WTAP Wilms tumor 1 associated protein -0.0205729
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0204951
TOP2A topoisomerase (DNA) II alpha 170kDa -0.020482
NBAS neuroblastoma amplified sequence -0.0204277
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0204056
ZMYM2 zinc finger, MYM-type 2 -0.02028
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0201859
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0198941
PNISR PNN-interacting serine/arginine-rich protein -0.0197159
NCOA3 nuclear receptor coactivator 3 -0.0192776
TRA2A transformer 2 alpha homolog (Drosophila) -0.0192277
GLYAT glycine-N-acyltransferase -0.0191324