Sapanisertib_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sapanisertib perturbation in KATO III cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sapanisertib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL35A ribosomal protein L35a 0.109668
FTH1 ferritin, heavy polypeptide 1 0.0766971
TPT1 tumor protein, translationally-controlled 1 0.0678267
RPS12 ribosomal protein S12 0.0648115
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0643223
MAML2 mastermind-like 2 (Drosophila) 0.062174
LCN2 lipocalin 2 0.0619684
GMDS GDP-mannose 4,6-dehydratase 0.0606337
FGFR2 fibroblast growth factor receptor 2 0.0561231
PTPRK protein tyrosine phosphatase, receptor type, K 0.0545033
NUPR1 nuclear protein, transcriptional regulator, 1 0.052073
RPL23 ribosomal protein L23 0.0500509
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0499858
MACC1 metastasis associated in colon cancer 1 0.0493708
RPS19 ribosomal protein S19 0.048703
FNDC3B fibronectin type III domain containing 3B 0.0483674
FRMD5 FERM domain containing 5 0.0479819
RPS3 ribosomal protein S3 0.0475439
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0442254
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0440578
FTL ferritin, light polypeptide 0.0435521
RPS8 ribosomal protein S8 0.0434389
RAB7A RAB7A, member RAS oncogene family 0.043035
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0407422
RPS6 ribosomal protein S6 0.040708
CLDN4 claudin 4 0.0395106
RPL37A ribosomal protein L37a 0.0388195
RPS25 ribosomal protein S25 0.0379928
RUNX1 runt-related transcription factor 1 0.0347689
ZSWIM6 zinc finger, SWIM-type containing 6 0.0338567
RPL26 ribosomal protein L26 0.0330884
HDAC9 histone deacetylase 9 0.032915
RPS27A ribosomal protein S27a 0.0324415
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0318525
RASEF RAS and EF-hand domain containing 0.0315844
INTS6 integrator complex subunit 6 0.0313607
RPL13A ribosomal protein L13a 0.0306875
EEF2 eukaryotic translation elongation factor 2 0.0304569
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0301441
AREG amphiregulin 0.0300779
RPL12 ribosomal protein L12 0.0297776
RPS17 ribosomal protein S17 0.0292759
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0291883
LPP LIM domain containing preferred translocation partner in lipoma 0.0289684
RPLP1 ribosomal protein, large, P1 0.0289676
MBNL2 muscleblind-like splicing regulator 2 0.0289023
RPL34 ribosomal protein L34 0.0287037
POF1B premature ovarian failure, 1B 0.0285187
CDK6 cyclin-dependent kinase 6 0.0278724
PDLIM5 PDZ and LIM domain 5 0.0277609
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0272089
COBL cordon-bleu WH2 repeat protein 0.027161
CATSPERB catsper channel auxiliary subunit beta 0.0271004
RPS13 ribosomal protein S13 0.0266197
SIK3 SIK family kinase 3 0.026534
BACE2 beta-site APP-cleaving enzyme 2 0.0264378
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0262572
MYO1E myosin IE 0.0261963
DST dystonin 0.0259936
FNIP1 folliculin interacting protein 1 0.0259638
RPS27 ribosomal protein S27 0.0259414
LMO7 LIM domain 7 0.0259317
RPL31 ribosomal protein L31 0.0258238
HKDC1 hexokinase domain containing 1 0.0253791
SQSTM1 sequestosome 1 0.0253006
MYOF myoferlin 0.0250048
RPL27 ribosomal protein L27 0.0245206
POTEF POTE ankyrin domain family, member F 0.0243913
CMIP c-Maf inducing protein 0.0242287
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0239265
RPS14 ribosomal protein S14 0.0238666
EGR1 early growth response 1 0.0230607
NCEH1 neutral cholesterol ester hydrolase 1 0.0228573
MCU mitochondrial calcium uniporter 0.0227734
MBNL1 muscleblind-like splicing regulator 1 0.0223977
UBAP2 ubiquitin associated protein 2 0.0223925
TJP1 tight junction protein 1 0.0217037
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0212754
RACK1 receptor for activated C kinase 1 0.0210038
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0208635
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.020666
SPDYA speedy/RINGO cell cycle regulator family member A 0.0206647
RPL7A ribosomal protein L7a 0.0206296
LOC102724023 ES1 protein homolog, mitochondrial 0.0204478
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0203738
IFI6 interferon, alpha-inducible protein 6 0.0203294
SP100 SP100 nuclear antigen 0.0203071
KLHL29 kelch-like family member 29 0.0200138
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0198064
KLF5 Kruppel-like factor 5 (intestinal) 0.0196043
ATF4 activating transcription factor 4 0.0191512
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0189012
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0188897
ENO2 enolase 2 (gamma, neuronal) 0.0188636
MT2A metallothionein 2A 0.018828
RPL5 ribosomal protein L5 0.0188044
EXT1 exostosin glycosyltransferase 1 0.0185895
RPL10A ribosomal protein L10a 0.0183372
PMM2 phosphomannomutase 2 0.0182423
DDIT3 DNA-damage-inducible transcript 3 0.0182149

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.223261
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110339
ANLN anillin, actin binding protein -0.0931053
PDIA3 protein disulfide isomerase family A, member 3 -0.0854806
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.08406
H1-0 H1.0 linker histone -0.0834459
NPSR1 neuropeptide S receptor 1 -0.0815019
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0810442
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0709528
PDIA4 protein disulfide isomerase family A, member 4 -0.0650012
AHNAK AHNAK nucleoprotein -0.0644543
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0607246
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0591819
ITGA6 integrin, alpha 6 -0.0574736
MKI67 marker of proliferation Ki-67 -0.0572526
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0555503
S100A10 S100 calcium binding protein A10 -0.05528
CD2AP CD2-associated protein -0.0545387
KDM3A lysine (K)-specific demethylase 3A -0.0539208
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0529722
TMSB4X thymosin beta 4, X-linked -0.0515741
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0489269
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0487439
EPCAM epithelial cell adhesion molecule -0.0480999
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0474059
SMC4 structural maintenance of chromosomes 4 -0.0473352
CLTC clathrin, heavy chain (Hc) -0.0468007
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0461289
PDIA6 protein disulfide isomerase family A, member 6 -0.0458859
DIAPH3 diaphanous-related formin 3 -0.045603
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0455556
XPO1 exportin 1 -0.0444331
EIF1 eukaryotic translation initiation factor 1 -0.0444294
RRBP1 ribosome binding protein 1 -0.0433649
BIRC6 baculoviral IAP repeat containing 6 -0.043299
ZFAND3 zinc finger, AN1-type domain 3 -0.0431987
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0421619
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0412409
OGA O-GlcNAcase -0.0409273
INSIG1 insulin induced gene 1 -0.0409255
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.040768
B2M beta-2-microglobulin -0.0406124
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.040299
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0401344
RBM39 RNA binding motif protein 39 -0.0390099
HMGB2 high mobility group box 2 -0.0387435
AGR2 anterior gradient 2 -0.0387386
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0387317
RAD21 RAD21 homolog (S. pombe) -0.038563
PHIP pleckstrin homology domain interacting protein -0.0385523
TMEM123 transmembrane protein 123 -0.038337
HYOU1 hypoxia up-regulated 1 -0.0379911
TXNRD1 thioredoxin reductase 1 -0.03765
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0375595
DSG2 desmoglein 2 -0.0375549
ANXA2 annexin A2 -0.037317
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0371797
DEK DEK proto-oncogene -0.0365608
KMT2A lysine (K)-specific methyltransferase 2A -0.0361459
DSCAM Down syndrome cell adhesion molecule -0.0354551
FLNB filamin B, beta -0.0354532
RB1CC1 RB1-inducible coiled-coil 1 -0.0354086
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0349662
NCOR1 nuclear receptor corepressor 1 -0.0345397
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0343891
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.034261
DLG1 discs, large homolog 1 (Drosophila) -0.0341535
TPX2 TPX2, microtubule-associated -0.0333762
THOC2 THO complex 2 -0.033285
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0332259
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0326265
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0326111
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0324647
AKAP9 A kinase (PRKA) anchor protein 9 -0.0322001
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0321476
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0312261
EMP1 epithelial membrane protein 1 -0.0309516
RPS2 ribosomal protein S2 -0.0308978
MYO6 myosin VI -0.0307585
KRT18 keratin 18, type I -0.0307501
PTMA prothymosin, alpha -0.0303247
PICALM phosphatidylinositol binding clathrin assembly protein -0.0298618
DSPP dentin sialophosphoprotein -0.0296904
ZC3H12B zinc finger CCCH-type containing 12B -0.0296203
UBC ubiquitin C -0.0295116
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0290583
GARS1 glycyl-tRNA synthetase 1 -0.02895
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0289274
CANX calnexin -0.028775
ANKRD11 ankyrin repeat domain 11 -0.0282634
GNAS GNAS complex locus -0.0282268
ARHGAP12 Rho GTPase activating protein 12 -0.0281543
CKAP5 cytoskeleton associated protein 5 -0.0280325
NF1 neurofibromin 1 -0.0279543
ECT2 epithelial cell transforming 2 -0.0278233
ESRP1 epithelial splicing regulatory protein 1 -0.0277438
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0277034
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.027664
KRT19 keratin 19, type I -0.0275575
RLF rearranged L-myc fusion -0.027423